Andreas Beyer Group
@beyerlab.bsky.social
We use computers to understand biology.
🚀 We’re excited to share the release of Bioconductor 3.23, featuring: ✅2418 software packages (94 new) ✅437 experiment data packages (5 new) ✅928 annotation packages ✅8 books (2 new) ✅28 workflows 🔗 Please see the full release announcement here: bioconductor.org/news/bioc_3_...
We are excited to announce the #CRC1678 Summer Symposium! 🗓️ June 22, 2026 📍 Auditorium, MPI for Biology of Ageing, Cologne A student‑organized day of scientific exchange featuring CRC researchers and international invited speakers. 🔗 More information on our event website: uni.koeln/U7FHR
SPACO, our tool for Spatial Component Analysis for Spatial Sequencing Data, is now available as R package on CRAN!🎉 Congratulations to the team!!! We also have a Docker image which is available on Zenodo. #SpatialTranscriptomics #DimensionalityReduction
📣#CECAD will host two exciting conferences 📆 11th - 14th October 2026 15th AHA Conference - “From mechanisms of age-associated diseases to healthy aging” uni.koeln/7X2K8 📆 14th - 16th October 2026 1stEFAR Conference - “On the Biology of Aging” uni.koeln/YGPMA 👉 Submit abstracts by May 31st
🚨 Publication Alert 🚨 New work from our #CRC1678 members @volkerboehm.bsky.social and Niels Gehring in @narjournal.bsky.social shows that SMG8 and SMG9 act as nonessential but crucial modulators safeguarding the efficiency and resilience of the NMD pathway. academic.oup.com/nar/article/...
SMG1:SMG8:SMG9-complex integrity supports efficient execution of nonsense-mediated mRNA decay
Abstract. Nonsense-mediated mRNA decay (NMD) is a translation-dependent mRNA turnover pathway, which degrades transcripts containing premature termination
academic.oup.com
🚨 Speaker Alert! 🚨 We’re excited to welcome Christina Leslie to our upcoming #CRC1678 Seminar. 🧬AI models for regulatory genomics and spatial biology 📅 March 17 📍Auditorium, MPI-Age ⏰ 3:00 PM Join us to explore cutting‑edge AI models shaping regulatory genomics and spatial biology!
Big congratulations to our #CRC1678 partner Niels Gehring! Isn't it amazing how little we understand about the molecular mechanisms of something as important as NMD? Read this: www.nature.com/articles/s41...
Composite SMG5-SMG6 PIN domain formation is essential for NMD - Nature Communications
Execution of mRNA cleavage in nonsense-mediated decay remained elusive. The authors show that SMG5 complements SMG6 to form a highly active, composite endonuclease with expanded catalytic center that ...
nature.com
Universität zu Köln@unicologne.bsky.social · 5mo ago🔬🧬Detecting and destroying defective RNA: that's what nonsense-mediated mRNA decay does Researchers #UniCologne have now identified the central mechanism of the control system. The two proteins—SMG5 and SMG6—together form a molecular “scissor” that cuts up the defective mRNA▶️ uni.koeln/HGW4Y
Thanks to @antebilab.bsky.social for involving us in this project! Beyer-lab member Francisco Lopes helped with the data analysis and came up with a cool way to study the stoichiometry control of ribosomal proteins. Read the preprint for more!
Antebi Lab@antebilab.bsky.social · 5mo ago1/4 Our preprint “Modulation of the RNase P/MRP complex and mitochondrial ribosome enhances cytosolic ribosome coordination and sustains longevity” is now live @biorxivpreprint.bsky.social 📄 #agingbiology #ribosome 👉https://www.biorxiv.org/content/10.64898/2026.02.23.707525v1
Together with @spanier55.bsky.social and Boris Pfander we put together a great program with support of @cecad.bsky.social Cologne, @mpiage.bsky.social and the Fritz Thyssen Stiftung. Meeting site: www.for-5504.com/en/197/Confe...
Conference 2026
for-5504.com
🚨Publication Alert🚨 New work from our #CRC1678 members Niels Gehring and @volkerboehm.bsky.social published in @natcomms.nature.com shows that SMG5 & SMG6 PIN domains form a composite endonuclease (cPIN) enabling efficient mRNA cleavage🧬
Volker Boehm@volkerboehm.bsky.social · 5mo agoHow are faulty #RNA degraded? New mechanistic insight into NMD: 1️⃣SMG5 & SMG6 PIN domains form a composite endonuclease (cPIN) 2️⃣ SMG5 completes the SMG6 active site, enabling efficient mRNA cleavage Fantastic collaboration with @labconti.bsky.social 🙏 👉 www.nature.com/articles/s41... 1/n
Looking forward to continuing the collaboration with @pkdinternational.bsky.social in this new position.
PKD International @pkdinternational.bsky.social · 5mo agoPKD International warmly congratulates @muellerrom.bsky.social on this important new step. We are deeply grateful for his unwavering commitment to patient advocacy and for his continuous efforts to advance the interests of the PKD community.
🧬🧬🧬 REGISTRATION JUST OPENED! Make sure you join our DNA REPAIR MEETING 2026 ON PHYSIOLOGICAL CAUSES AND CONSEQUENCES OF GENOME INSTABILITY in Cologne, September 7-9, organized by the German Society for DNA Repair (DGDR) and the @dfg.de Research Unit 5504. www.for-5504.com/en/197/Confe...
📢 PhD Positions - CALL FOR APPLICATIONS - 26/01 (m/f/d) The Leibniz Graduate School on Aging (LGSA) is a joint program of the @leibnizfli.bsky.social and the @uni-jena.de (FSU) in #Jena. The School calls for #applications for #PhD positions. 👇 ➡️ More: jobs.leibniz-fli.de/jobposting/c...
26/01 - LGSA - PhD candidates (m/f/x)
The Leibniz Graduate School on Aging and Age-Related Diseases (LGSA) invites applications for a PhD candidate.
jobs.leibniz-fli.de
Beyer Group proudly presents: "Snow White and the Data Miners". It's so much fun to be part of Cologne Carnival! Thanks to all the costume designers and makers, especially to Paula and Jakub!!!
We are VERY much looking forward to the selection week and meeting the candidates! All of them are very smart people and we will have many inspiring discussions. 🎓
Cologne Graduate School of Ageing Research@cga-age.bsky.social · 6mo ago🌏 CGA Recruitment Week is just around the corner, and we’re looking forward to meeting the top 25 applicants from all over the world! But what actually happens during CGA Recruitment Week? And what other activities can our students enjoy once they’re part of the CGA? Find out more! 🎬
👩🔬 Today is International Day of Women and Girls in Science! Meet Lara Hitzemann @larahi.bsky.social , PhD student in the group of @beyerlab.bsky.social at the @unicologne.bsky.social
Big thank you to all those female researchers from #CRC1678 sharing their thoughts in this series! 🙏 #WomenInScience #GirlsInSTEM
CRC1678@crc1678.bsky.social · 6mo agoTo celebrate today’s International Day of Women and Girls in Science, we are spotlighting inspiring young female researchers from our #CRC1678, sharing their stories, motivations, and hopes to encourage the next generation to pursue science. 🧪🔬👩🔬 #WomenInScience #GirlsInSTEM
!!!!!!!!!!!! 👩🔬👩🔬👩🔬👩🔬 Imagine all of the Beyer Lab papers with female first authors were gone: what would our publication track record look like?
CRC1678@crc1678.bsky.social · 6mo ago👩🔬 Today is International Day of Women and Girls in Science! Meet Nisha Hemandhar Kumar @nishahemandhar.bsky.social, postdoctoral researcher in the group of @beyerlab.bsky.social at the @unicologne.bsky.social
Amazing to have you here! I am looking forward to work together on #RNA and #ageing @mpiage.bsky.social
Markus Schosserer@mschosserer.bsky.social · 6mo agoI’ve started my 6-month stay at @mpiage.bsky.social. It's now my first week here, and I’ve already been impressed by the incredibly friendly, open, and intellectually stimulating scientific environment. Thanks a lot to @inahuppertz.bsky.social, her lab and the institute for being so welcoming!
🚨 Publication alert 🚨 Check out this brand new review article about Proteostasis of organelles in aging and disease in @febsj.bsky.social. Congratulations to our #CRC1678 members @thevilchezlab.bsky.social and Yara Nabawi and everyone else involved🎉
David Vilchez@thevilchezlab.bsky.social · 6mo agoOur new review on proteostasis of organelles in aging & disease is now online in The FEBS Journal! We discuss recent insights on how #proteostasis safeguards organelle integrity and function across the cell in #aging and disease doi.org/10.1111/febs...
🚨Publication Alert🚨 New work from our #CRC1678 members @bjornschumacher.bsky.social and @meyerdh.bsky.social reveals why some neurons age faster. Using neuron‑specific aging clocks, they identified vulnerable neurons and highlight syringic acid and vanoxerine as promising neuroprotective hits.🧬
David Meyer@meyerdh.bsky.social · 6mo agoWhy do some neuron types degenerate early while others stay intact? We used transcriptomic aging clocks for single-neuron-types in C. elegans and found neuron-specific biological age predicts vulnerability. 🧪 www.nature.com/articles/s43... #Neurodegeneration 🧵👇 (1/n)
Big congrats to Domenico and the team!
CRC1678@crc1678.bsky.social · 6mo ago🚨 New @cp-cell.bsky.social paper with #CRC1678 member Domenico Di Fraia form @beyerlab.bsky.social ! 🚨 In this study published in Cell, a brain‑cell lysosome atlas reveals SLC45A1 as a neuron‑specific transporter linked to LSDs. Congratulations! 🎉 🔗 doi.org/10.1016/j.cell.2025.12.012
🚨Hot off the press from #CRC1678 's @ignatovalab.bsky.social 🚨 A brand‑new paper published in @narjournal.bsky.social introduces ADAM‑tRNA‑seq, a powerful framework that finally brings accuracy and scalability to Nanopore‑based direct tRNA sequencing. Congratulations! 🥳
IgnatovaLab@ignatovalab.bsky.social · 6mo agoInterested in direct tRNA-seq by Nanopore? We developed a new RNA-based barcoding aproach for seq parallelization; it is also cost-saving. Scripts available on github. #tRNA #Nanopore track.smtpsendmail.com/9032119/c?p=...
One of the greatest computational biologists of Germany - of the world I should say. He majorly shaped the field, never got stuck in one corner of science, but kept exploring new areas due to his curiosity, always aimed to understand the biology, and trained generations of scientists.
I’ve changed my header photo to this one. It shows my father Herbert and his sister Lotte with their parents Fritz and Marta in their Frankfurt apartment before Herbert and Lotte were sent to England on the Kindertransport, and later Fritz and Marta transported to Lodz Ghetto, final fate unknown.
We’re delighted to report a global structural proteome analysis within living cells! doi.org/10.1038/s443... #proteomics #structuralproteomics #massspectrometry #structuralbiology #ethz @imsb-eth.bsky.social
Congrats to our #crc1678 member Akis @akispapantonis.bsky.social for this very nice Christmas gift🎄
Akis (Argyris) Papantonis @akispapantonis.bsky.social · 7mo agoOur Xmas present all wrapped and nicely packaged, a collab with @karsten-rippe.bsky.social lab within the realm of the @spp2202.bsky.social
Happy to share our recent publication, which grew out of a consulting job I did last year: www.nature.com/articles/s41... 🧵
nature.com