🏆 Congratulations to our CGA alumni members Aishwarya Acharya @aishacharya.bsky.social and David Meyer @meyerdh.bsky.social on receiving the Klaus Liebrecht Award 2026 from the University of Cologne for their outstanding doctoral theses! 🎉 We are proud to celebrate this well-deserved success! 👏🧬

🚨Thrilled to share this exciting new paper by our #FOR5762 project leader @bjornschumacher.bsky.social, published in #NatureAging! The study uncovers neuron-specific aging patterns and points to potential neuroprotective interventions. Congratulations! 🎉 www.nature.com/articles/s43...

Aging clocks delineate neuron types vulnerable or resilient to neurodegeneration and identify neuroprotective interventions - Nature Aging

Gallrein et al. pair functional assays with clocks to compare chronological versus biological age of single neuron types in C. elegans, to probe their vulnerability or resilience to neurodegeneration,...

nature.com

🚨Excited to share this new review in @febsj.bsky.social by our #FOR5762 project leader @thevilchezlab.bsky.social! The article explores how organelle #proteostasis preserves cellular function, and how its decline contributes to #aging and disease. febs.onlinelibrary.wiley.com/doi/10.1111/...

FEBS Press

Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the n...

febs.onlinelibrary.wiley.com

🧠⏰our latest paper is out now: how each neuron ages differently allowed us to define in silico screens for new therapeutic molecules that could prevent neurodegeneration @cecad.bsky.social @unicologne.bsky.social @uniklinikkoeln.bsky.social @meyerdh.bsky.social www.nature.com/articles/s43...

Aging clocks delineate neuron types vulnerable or resilient to neurodegeneration and identify neuroprotective interventions - Nature Aging

Gallrein et al. pair functional assays with clocks to compare chronological versus biological age of single neuron types in C. elegans, to probe their vulnerability or resilience to neurodegeneration,...

nature.com

🚨Publication Alert🚨 New work from our #CRC1678 members @bjornschumacher.bsky.social and @meyerdh.bsky.social reveals why some neurons age faster. Using neuron‑specific aging clocks, they identified vulnerable neurons and highlight syringic acid and vanoxerine as promising neuroprotective hits.🧬

David Meyer@meyerdh.bsky.social · 6mo ago

Why do some neuron types degenerate early while others stay intact? We used transcriptomic aging clocks for single-neuron-types in C. elegans and found neuron-specific biological age predicts vulnerability. 🧪 www.nature.com/articles/s43... #Neurodegeneration 🧵👇 (1/n)

Why do some neuron types degenerate early while others stay intact? We used transcriptomic aging clocks for single-neuron-types in C. elegans and found neuron-specific biological age predicts vulnerability. 🧪 www.nature.com/articles/s43... #Neurodegeneration 🧵👇 (1/n)

A sex-adjusted 7-biomarker clinical aging clock for translational preventative medicine www.nature.com/articles/s41...

A sex-adjusted 7-biomarker clinical aging clock for translational preventative medicine - Scientific Reports

Scientific Reports - A sex-adjusted 7-biomarker clinical aging clock for translational preventative medicine

nature.com

Happy to share that this is now out in Microbial Ecology 🥳 Huge thanks to the whole team, especially @sultanova.bsky.social 🙌 link.springer.com/article/10.1... @leibnizfli.bsky.social @uniofeastanglia.bsky.social

Age-Dependent Gut Microbiota Dynamics and Their Association with Male Life-History Traits in Drosophila melanogaster - Microbial Ecology

Growing evidence suggests that the gut microbiota is closely intertwined with life-history evolution in a wide range of species, including well-studied model organisms like Drosophila melanogaster. Al...

link.springer.com

Melike Dönertaş@mdonertas.bsky.social · last yr.

Super happy to share our new preprint with Zahida Sultanova and an amazing team! We explored how age-related changes in gut microbiota associate with life history traits - lifespan, reproduction, and performance - in male Drosophila melanogaster. www.biorxiv.org/content/10.1...

1/6 In a new preprint we ask a question: Why do males and females so often age and die at different rates? We argue that sex-specific mutation accumulation may be the most parsimonious evolutionary explanation for sex-biased ageing: ecoevorxiv.org/repository/v...

Happy to share our recent publication, which grew out of a consulting job I did last year: www.nature.com/articles/s41... 🧵

New study by our #CRC1678 members @bjornschumacher.bsky.social, @meyerdh.bsky.social and Walter Sandt showing that C. elegans dauer stage decelerates aging and even reverses biological age upon exit, revealing natural gene patterns of rejuvenation. Congratulations! 🎉 #AgingResearch #Longevity

Björn Schumacher@bjornschumacher.bsky.social · 8mo ago

🚀 Now out in print: AGE DECELERATION AND REVERSAL GENE PATTERNS IN DAUER DIAPAUSE. How we can learn from nature of to slow aging and rejuvenate. Big congrats to Khrystyna Totska, João Barata, Walter Sandt, and @meyerdavid.bsky.social! @cecad.bsky.social onlinelibrary.wiley.com/doi/10.1111/...

🎥 Meet the 2025 SIB Bioinformatics Awards laureates: ⭐ David Meyer @meyerdh.bsky.social, PhD Paper Award ⭐ Michael Skinnider @skinnider.bsky.social Early Career Award ⭐ scverse @scverse.bsky.social, Innovative Resource Award, accepted by Ilan Gold Watch their award ceremony talks👇& congrats to all!

Celebrating excellence: meet the 2025 SIB Bioinformatics Awards laureates

Two early career bioinformaticians have been recognized for their mathematical and AI models, along with a collaborative resource for single-cell data analyses. The three 2025 SIB Bioinformatics Award...

sib.swiss

🚀 🚀 🚀 Our latest paper is out now: Age Deceleration and Reversal Gene Patterns in Dauer Diapause. We can learn from nature how aging of a whole organism with completely differentiated tissues can be slowed and how that organism can be completely rejuvenated. onlinelibrary.wiley.com/doi/10.1111/...

Age Deceleration and Reversal Gene Patterns in Dauer Diapause

The dauer diapause is a naturally occurring extraordinarily long-lived alternative C. elegans larval stage that, upon dauer exit, lives a normal adult life with full reproductive capacity. Here, we d...

onlinelibrary.wiley.com

🚨🚨Job! 🚨🚨Permanent (75% time) job! We are a pretty awesome research group & seek a manager who deals with everything: personnel tasks, organizing retreats, preparing code for teaching / data structures for research... Fluency in German & English essential. stellenboerse.uni-mainz.de#/jgu/job/51527

Super grateful that our scETM work (from my summer internship with Dr. Yue Li, in collab. with Huiyu Cai and @tangjian.bsky.social) was recognized with an honourable mention at SIB PhD Paper Award competition. Many thanks to the jury and congrats to @meyerdh.bsky.social and Can Chen! #bc2basel

SIB Swiss Institute of Bioinformatics@sib.swiss · 11mo ago

The PhD Paper Award jury gives honourable mentions to: Can Chen for “Structure-Aware Protein Self-Supervised Learning” doi.org/10.1093/bioi... Yifan Zhao for “Learning interpretable cellular and gene signature embeddings from single-cell transcriptomic data” doi.org/10.1038/s414... #bc2basel

A fantastic few days of ageing talks, great people, and excellent food! Massive thanks to (Hanna!) @kokkonut.bsky.social, Margaux Bieuville, Victor Ronget, and the fantastic people at The Gutenberg Workshops in the Life Sciences

Ribonucleotide incorporation into mitochondrial DNA drives inflammation www.nature.com/articles/s41... Congratulations to the Langer lab @mpiage.bsky.social, Amir, and the rest of the team!

Ribonucleotide incorporation into mitochondrial DNA drives inflammation - Nature

Imbalanced nucleotide metabolism leads to age- and mtDNA-dependent inflammatory responses and senescence-associated secretory phenotype in senescence.

nature.com

This review of our @crc1678.bsky.social member @bjornschumacher.bsky.social and @meyerdh.bsky.social is greatly summarizing fundamentals of the molecular biology of aging. What causes aging? Read the answer!

Björn Schumacher@bjornschumacher.bsky.social · 11mo ago

🔥🔥🔥Out now: our Perspectives article in @nataging.nature.com outlining how aging is driven by molecular damage leading to increasing molecular noise whose quantification could track aging with the precision of a clock @meyerdh.bsky.social @alexeimaklakov.bsky.social www.nature.com/articles/s43...

🔥🔥🔥Out now: our Perspectives article in @nataging.nature.com outlining how aging is driven by molecular damage leading to increasing molecular noise whose quantification could track aging with the precision of a clock @meyerdh.bsky.social @alexeimaklakov.bsky.social www.nature.com/articles/s43...

Aging by the clock and yet without a program - Nature Aging

Meyer and colleagues refute the idea that, as aging can be tracked precisely by clocks, it must be driven by a biological program. They propose that imperfect maintenance and repair processes resultin...

nature.com

We argue that selection shadow - gradual decline in the force of selection after the onset of reproduction - is sufficient/parsimonious to explain why damage accumulates with age. 'Aging clocks' measure damage accumulation, they neither require nor support any kind of 'program'-based explanation.

David Meyer@meyerdh.bsky.social · 11mo ago

🕰️ Is aging driven by a programmed/programmatic mechanism, or by the unavoidable burden of imperfect maintenance? Our perspective argues that aging reflects finite maintenance and reduced evolutionary pressure🧵🧪 www.nature.com/articles/s43... @bjornschumacher.bsky.social @alexeimaklakov.bsky.social

👵🏻⏰👴🏻 Is aging a programmed process? Check out this perspective article in Nature Aging by our two #CRC1678 members @meyerdh.bsky.social and @bjornschumacher.bsky.social. Congratulations! 🥳

David Meyer@meyerdh.bsky.social · 11mo ago

🕰️ Is aging driven by a programmed/programmatic mechanism, or by the unavoidable burden of imperfect maintenance? Our perspective argues that aging reflects finite maintenance and reduced evolutionary pressure🧵🧪 www.nature.com/articles/s43... @bjornschumacher.bsky.social @alexeimaklakov.bsky.social

You can also read it here rdcu.be/eG1N7 👇

patrick star from spongebob squarepants holding a piece of puzzle

ALT: patrick star from spongebob squarepants holding a piece of puzzle

media.tenor.com

David Meyer@meyerdh.bsky.social · 11mo ago

🕰️ Is aging driven by a programmed/programmatic mechanism, or by the unavoidable burden of imperfect maintenance? Our perspective argues that aging reflects finite maintenance and reduced evolutionary pressure🧵🧪 www.nature.com/articles/s43... @bjornschumacher.bsky.social @alexeimaklakov.bsky.social

🕰️ Is aging driven by a programmed/programmatic mechanism, or by the unavoidable burden of imperfect maintenance? Our perspective argues that aging reflects finite maintenance and reduced evolutionary pressure🧵🧪 www.nature.com/articles/s43... @bjornschumacher.bsky.social @alexeimaklakov.bsky.social

Aging by the clock and yet without a program - Nature Aging

Meyer and colleagues refute the idea that, as aging can be tracked precisely by clocks, it must be driven by a biological program. They propose that imperfect maintenance and repair processes resultin...

nature.com

💪🎉Congratulations to our #CRC1678 member @meyerdh.bsky.social for winning the SIB Bioinformatics PhD Paper Award 2025 for his work on Ageing Clocks ⏰ 👵🏻👴🏻

David Meyer@meyerdh.bsky.social · 11mo ago

✨ I’m honored and grateful to have received the SIB Bioinformatics PhD Paper Award 2025 for part of my PhD work. Thank you for your guidance and inspiration @bjornschumacher.bsky.social #SIBAwards #bc2basel #Bioinformatics

✨ I’m honored and grateful to have received the SIB Bioinformatics PhD Paper Award 2025 for part of my PhD work. Thank you for your guidance and inspiration @bjornschumacher.bsky.social #SIBAwards #bc2basel #Bioinformatics

SIB Swiss Institute of Bioinformatics@sib.swiss · 11mo ago

💫 The PhD Paper Award goes to @meyerdh.bsky.social from Uni-Köln 💫 “David Meyer’s paper ‘Aging clocks based on accumulating stochastic variation’ presents a completely novel concept and a fresh way to address the problem”. #Bioinformatics #SIBawards #bc2basel

Read David’s award winning article ‘Aging clocks based on accumulating stochastic variation’. www.nature.com/articles/s43... #bc2basel

Aging clocks based on accumulating stochastic variation - Nature Aging

Meyer and Schumacher use simulations to show that accumulation of stochastic variation is sufficient to build clocks that can measure both chronological and biological age, sensitive to changes induce...

nature.com

💫 The PhD Paper Award goes to @meyerdh.bsky.social from Uni-Köln 💫 “David Meyer’s paper ‘Aging clocks based on accumulating stochastic variation’ presents a completely novel concept and a fresh way to address the problem”. #Bioinformatics #SIBawards #bc2basel

#bc2basel @SIB PhD Paper Award 👏 David Meyer: Aging clocks based on accumulating variation https://doi.org/10.1038/s43587-024-00619-x

Aging clocks based on accumulating stochastic variation - Nature Aging

Meyer and Schumacher use simulations to show that accumulation of stochastic variation is sufficient to build clocks that can measure both chronological and biological age, sensitive to changes induced by smoking, calorie restriction, parabiosis and reprogramming.

nature.com

🚨 New from our lab: Here we explored how aging contributes to harmful protein aggregation in diseases like Huntington’s & ALS. The culprit? An overlooked aging factor — EPS8 and RAC signaling. #Aging #Longevity #Proteostasis #ALSResearch 🧵 www.nature.com/articles/s43...

The aging factor EPS8 induces disease-related protein aggregation through RAC signaling hyperactivation - Nature Aging

Aging is a risk factor for neurodegenerative diseases associated with protein aggregation. Here the authors identify age-related hyperactivation of EPS8/RAC signaling in C. elegans as a driver of path...

nature.com

New work from the lab! C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules - Bilican - FEBS Letters - Wiley Online Library febs.onlinelibrary.wiley.com/doi/10.1002/...

FEBS Press

Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient-derived neurons and C. elegans models, w...

febs.onlinelibrary.wiley.com