Out now in Nature Communications! We show that Dictyostelium vaults associate with ER and NE membranes in situ and encapsulate ribosomes with defined orientations, shining new light on their cellular function! #TeamTomo #TeamMassSpec #ProtistsOnSky www.nature.com/articles/s41...

That’s a wrap on our @embo.org #cryoFIB & #cryoET course! It was an incredible week of hands-on learning, collaboration, and shared expertise, made possible by dedicated organizers, incredible trainers, and an engaged group of participants.

We are having a very hands-on week at the @embo.org #cryoFIB & #cryoET course 🔬 Our participants are learning about sample vitrification, lamella milling, FLM, lift-out, data acquisition and more! We are learning by doing, troubleshooting, and sharing expertise across labs. 🧪

Great work by @tzujingyang.bsky.social and @melaniemcdowell.bsky.social!!

Melanie McDowell@melaniemcdowell.bsky.social · last yr.

Proud to share our first lab pre-print: “SND3 is the membrane insertase within a fungal multipass translocon” where @tzujingyang.bsky.social solved the structure of a ribosome-associated SND3-translocon complex involved in ER membrane protein insertion ➡️ doi.org/10.1101/2025...

Happy 99th birthday to the man who gave voice to the wild. 🎉 Sir David Attenborough, thank you for a lifetime dedicated to the natural world, and for sharing its story with wisdom, wonder, and grace. You've inspired generations to fall in love with nature.

Super excited to share this as my first post with the 🦋 world! In my first co-correspondent article, we (@Mayra Borrero @Agnieszka Chacińska @IMOL Institute) look at the roles of lipids in mitochondrial protein import complexes (spoiler: there are plenty!) &call for methods (spoiler: there are few!)

Trends in Biochemical Sciences@cp-trendsbiochem.bsky.social · last yr.

Available online - the Forum "#Lipids: emerging actors in mitochondrial protein import" from Vanessa Linke, Agnieszka Chacinska, et al. #ProteinLipidInteractions #MembraneComplexes #LipidScrambling Read it here: authors.elsevier.com/a/1kxPM_M0e4...

New preprint on 3D heterochromatin architecture in human cells! Great collab with @sergiocruzleon.bsky.social & @johannesbetz.bsky.social from @hummerlab.bsky.social, @marinalusic.bsky.social & the Turoňová lab. Many thanks to my supervisor @becklab.bsky.social. bioRxiv: tinyurl.com/3a74uanv 🧵👇

After the start of the AIDS epidemic, scientists revealed the atomic structures of the molecules in HIV, helping to design treatments Explore how PDB structures help our understanding of HIV at PDB-101 #CROI2025 pdb101.rcsb.org/brow... Images are free for use

PDB101: Browse: HIV and AIDS

PDB-101: Training, Outreach, and Education portal of RCSB PDB

pdb101.rcsb.org

Zhi Yang Tan & @shujuncai.bsky.social's comparative study of G0 (quiescent) and interphase fission yeast cells is out in @jcellsci.bsky.social doi.org/10.1242/jcs.263654. This study combines multiple cell-biological analyses with in situ cryo-ET. Raw data: www.ebi.ac.uk/empiar/EMPIAR-10339

Excited to share our new preprint "Dynamic nanoscale architecture of synaptic vesicle fusion in mouse hippocampal neurons" www.biorxiv.org/content/10.1... We combine optogenetic stimulation of neurons with in situ cryo-ET to characterize membrane dynamics during synaptic vesicle fusion ❄️🔬⏱️

It turns out this works well for improving segmentation, and Cellpose3 offers a general solution for many segmentation tasks. Please see the full paper for all the details. www.nature.com/articles/s41...

Cellpose3: one-click image restoration for improved cellular segmentation - Nature Methods

Cellpose3 employs deep-learning-based approaches for image restoration to improve cellular segmentation and shows strong generalized performance even on images degraded by noise, blurring or undersamp...

nature.com

After a long journey, Segment Anything for Microscopy is now published in Nature Methods! We significantly improve SAM for interactive and automatic segmentation in light and electron microscopy and build a user-friendly tool. www.nature.com/articles/s41...

Hot from the press for #CellMigration + #Nucleus aficionados Karling @helenweavers.bsky.social lab show *in vivo* how immune cell adapt quickly to confined microenvironments during motility. Live-cell imaging, image analysis, #Drosophila ! Full @emboreports.org www.embopress.org/doi/full/10....

These days at EMBL in Heidelberg for the EMBO Workshop “In situ structural biology: expanding the toolbox for structural cell biology” were amazing! I showed my work on the tetrameric serotonin receptor: www.embopress.org/doi/full/10.... #EMBOinsitu

#CellMigration happens all the time in our bodies. This may (or not) rely on adhesion molecules #Cancer cells switch strategies during metastasis to invade other tissues Naomi Wee (naomiwee.com) did this neat movie to explain it: www.youtube.com/watch?v=D9aD... #SciSky 🧪🔬 @cellcommlab.bsky.social

I am very happy to share our latest work on the detailed cryo-EM structure of the NDH-PSI supercomplex of spinach. Thanks to Werner Kühlbrandt, Alex Hahn and @mpibp.bsky.social ! 🍃❄️🔬 You can find the paper in open access in Nature Structural and Molecular Biology: www.nature.com/articles/s41...

Cryo-EM structure of the NDH–PSI–LHCI supercomplex from Spinacia oleracea - Nature Structural & Molecular Biology

Here, the authors report the structure of the nicotinamide adenine dinucleotide phosphate dehydrogenase–photosystem I–light-harvesting complex I supercomplex, providing insights into subunit interacti...

nature.com