A dynamic gateway: Uncovering the expanded human TOM complex interactome and its regulatory complexity | Science Advances www.science.org/doi/10.1126/...

A dynamic gateway: Uncovering the expanded human TOM complex interactome and its regulatory complexity

Human TOM complex was revealed as a dynamic hub, with FKBP8 as a human-specific interactor shaping biogenesis.

science.org

We are highlighting voices from EU-LIFE member institutes that embody the alliance's priorities. Today, we showcase #Technology with Vanessa Linke, Head of the Mass Spectrometry Facility at @iimcb.bsky.social in #Warsaw ➡️ www.linkedin.com/feed/update/... #WeAreEULIFE

We were pleased to host a delegation from Baden-Württemberg 🇩🇪 led by Minister Petra Olschowski. The visit focused on how Polish researchers apply AI & ML in life sciences. Our guests learned about IIMCB’s mission, research, and Core Facilities — and we look forward to future collaboration! 🤝

Last week to apply!

Vanessa Linke@massspecvanili.bsky.social · last yr.

🤩 JOB ALERT 🤩 Come work with me and two cutting-edge LC-MS/MS systems at our brand new Mass Spectrometry Facility @iimcb.bsky.social in Warsaw! Apply here tinyurl.com/y47mzafa or send any questions my way. #TeamMassSpec please share widely!

▶️▶️ To all mass spec enthusiasts: A postdoc position (three years) is available in our international group. Please apply if you are interested in structural MS and in developing novel cross-link ing MS workflows!🧪 Thanks @diegofgar.bsky.social for sharing! #teammassspec #AcademicSky #ChemSky

Diego Fernando Garcia@diegofgar.bsky.social · last yr.

For more information, I've attached the call in German and translated to English. Feel free to contact me or @sinzandrea.bsky.social #Postdoc #MassSpec #Proteomics #Hiring

🕷️ Spiders from our blood 🕷️ Check out our new paper from @hecklab.bsky.social describing how the spider-like immune regulator C4BP interacts with its native binding partners. 🔗 www.mcponline.org/article/S153... #MassSpec #StructuralBiology

Structural Insights into Complement Inhibition: Visualizing Distinct Binding Modes of C4b-binding Protein Complexes with C4b and SAP

C4b-binding protein (C4BP) is an innate immune inhibitor found in serum. Human C4BP adopts spider-like higher-order structures (HOS) formed by disulfide-linked C4BPα and C4BPβ chains that non-covalent...

mcponline.org

🤩 JOB ALERT 🤩 Come work with me and two cutting-edge LC-MS/MS systems at our brand new Mass Spectrometry Facility @iimcb.bsky.social in Warsaw! Apply here tinyurl.com/y47mzafa or send any questions my way. #TeamMassSpec please share widely!

Mass Spectrometry Technology Specialist, Międzynarodowy Instytut Biologii Molekularnej i Komórkowej w Warszawie, Warszawa

Job offer Mass Spectrometry Technology Specialist, Międzynarodowy Instytut Biologii Molekularnej i Komórkowej w Warszawie, Warszawa

tinyurl.com

MitoRUSH as a tool to study the efficiency of mitochondrial import in complex I-deficient cells | Journal of Cell Science | The Company of Biologists journals.biologists.com/jcs/article-...

MitoRUSH as a tool to study the efficiency of mitochondrial import in complex I-deficient cells

Summary: Two assays are used to assess protein import into mitochondria in intact mammalian cells, demonstrating that it is affected in cells with dysfunctional respiratory complex I.

journals.biologists.com

🔬 What connects mitochondria and Goethe? Meet Vanessa Linke @massspecvanili.bsky.social sharing her path from a small German village to lipidomics and mass spectrometry - and how Faust inspired her to pursue science 🎭🧪 Read the interview in @J_Cell_Sci ⬇️ 🔗https://tinyurl.com/CHD-research

Out now: Another example of how lipidomics led us to see the full(er) picture - enigmatic membrane protein OCIAD1 has a functional role in peroxisomes. Great team work with students and collaborators alike 🧫👩‍🔬🔬

Journal of Cell Science@jcellsci.bsky.social · last yr.

Following lipidomic and proteomic analyses, Vanessa Linke @massspecvanili.bsky.social Agnieszka Chacinska and colleagues identify a role for OCIAD1 at the mitochondria-peroxisome intersection balancing lipid metabolism. journals.biologists.com/jcs/article/... #JCSMitoSI #Mitochondria

Exciting times for lipid cell biology! I am happy to share this viewpoint together with other colleagues on the challenges and exciting questions in lipid biology rdcu.be/d8K8P @saranowinski.bsky.social @fedorovalab.bsky.social

Time for lipid cell biology

Nature Cell Biology - It is an exciting time for lipid metabolism and membrane cell biologists as technological progress has increased our ability to study lipids in cells. We asked leaders...

rdcu.be

Happy to share our review about #mitochondrial respiratory complexes in #aging 😊

Trends in Cell Biology@cp-trendscellbio.bsky.social · last yr.

The fate of mitochondrial respiratory complexes in aging

My first first-author review is out—feeling all the science 🦋🦋! With @massspecvanili.bsky.social and @Agnieszka Chacińska we explore the fascinating role of lipids in mitochondrial protein import and why we need better tools to study them. So proud of this collaboration!

Vanessa Linke@massspecvanili.bsky.social · last yr.

Super excited to share this as my first post with the 🦋 world! In my first co-correspondent article, we (@Mayra Borrero @Agnieszka Chacińska @IMOL Institute) look at the roles of lipids in mitochondrial protein import complexes (spoiler: there are plenty!) &call for methods (spoiler: there are few!)

Dear proteomics aficionados, The famous MaxQuant Summer School is organized again July 21–25, 2025, but spots are filling up! Join the team of Jurgen Cox for hands-on training in MaxQuant, register here: www.eventbrite.de/e/maxquant-s... Best regards, Jürgen Cox, Albert Heck & Pavel Sinitcyn

Super excited to share this as my first post with the 🦋 world! In my first co-correspondent article, we (@Mayra Borrero @Agnieszka Chacińska @IMOL Institute) look at the roles of lipids in mitochondrial protein import complexes (spoiler: there are plenty!) &call for methods (spoiler: there are few!)

Trends in Biochemical Sciences@cp-trendsbiochem.bsky.social · last yr.

Available online - the Forum "#Lipids: emerging actors in mitochondrial protein import" from Vanessa Linke, Agnieszka Chacinska, et al. #ProteinLipidInteractions #MembraneComplexes #LipidScrambling Read it here: authors.elsevier.com/a/1kxPM_M0e4...