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@biomolstructure.bsky.social

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i3S - Institute for Research and Innovation in Health | UPorto@i3suporto.bsky.social · 7mo ago

IN THE NEWS 📰 #MachadoJosephDisease is a rare, inherited neurodegenerative disorder that, unfortunately, still has no cure or effective therapy. In a study led by #i3S researcher Sandra Ribeiro, a researchers identified a molecule that reduced disease severity and delay the onset of symptoms.

Cientistas identificam composto que pode atrasar sintomas da doença de Machado-Joseph

A doença de Machado-Joseph, uma doença neurológica rara, hereditária e degenerativa, apresenta uma prevalência significativa em Portugal e não tem ainda cura nem uma terapia eficaz.

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@biomolstructure.bsky.social · 8mo ago

I am happy to share that our new paper has been published in Advanced Science ! 👉https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202502216 Thank you to all co-authors and collaborators for their dedication, expertise, and enthusiasm throughout this project. @i3suporto.bsky.social

Allosteric Modulation of Pathological Ataxin‐3 Aggregation: A Path to Spinocerebellar Ataxia Type‐3 Therapies

This study uncovers a new allosteric site in the Josephin domain of ataxin-3 targeted by the molecular tweezer CLR01, which modulates protein aggregation, improves synaptic function in neuronal cells...

advanced.onlinelibrary.wiley.com

@alfanostrubiogroup.bsky.social · last yr.

⌛Deadline approaching! 1 July 2025 Don't miss out on the EMBO Workshop 2025: “When predictions meet experiments: next challenges in Structural Biology”, 9–12 September 2025 in Palermo, Sicily, at Palazzo Branciforte. 📌 More details, application & abstract submission here lnkd.in/gYHYTRCB

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RadfordLab@radford-lab.bsky.social · 2y ago

Are you interested in proteins as exciting, dynamic interacting species. Come and join our meeting on March 28th 2025. Places are limited so register ASAP (£25 only!) at sheena-radford-lab.uk/fida.php. New news- thanks to British Biophys Soc travel bursaries will be available for ECR registrants.

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i3S - Institute for Research and Innovation in Health | UPorto@i3suporto.bsky.social · 2y ago

Taking care of an Alzheimer's patient is often exhausting and expensive. With no affordable care available, patients and families place their hopes on science. Several research avenues are being explored, including the work developed by #i3S researchers Isabel Cardoso and Matthew Holt. 📰👀👇

“O contacto com familiares potencia emoções. Sem histórico, o doente é um enigma”: as novas estratégias na guerra contra o Alzheimer

<p>Enquanto familiares e cuidadores desesperam, cientistas e médicos tentam deslindar os mistérios do Alzheimer. Em Portugal há 200 mil pacientes de demências, nem todos com lugar em lares especializa...

tinyurl.com

European Commission@ec.europa.eu · 2y ago

Snowy greetings from our space sentinels! 🛰️ From Scandinavian fjords to Alpine peaks, Europe's snow-covered landscapes were captured by Copernicus satellites. Copernicus provides crucial data to monitor our planet’s health, track climate change, and support disaster response.

A satellite view of Scandinavia in winter, showcasing snow-covered land in white and surrounding water bodies in deep blue and black. The red tones highlight areas with vegetation, likely captured in infrared. The landscape features fjords, frozen lakes, and the Baltic Sea. EU and Copernicus logos are visible. Satellite image of Italy captured by the Copernicus Programme, showing the Italian peninsula surrounded by the blue waters of the Mediterranean Sea. The Alps in the north and the Apennine mountain range are visible, partially covered in snow. Cloud cover is scattered across parts of the landscape and sea, with vibrant turquoise hues along some coastal areas. The image includes the Copernicus Programme and European Union logos in the top-right corner. Satellite image of the Alps region captured by the Copernicus Programme, showing the snow-covered mountain range stretching across parts of Europe, including northern Italy, Switzerland, Austria, and Slovenia. Surrounding areas feature green lowlands, brownish terrain, and bodies of water like the Adriatic Sea to the southeast. Cloud cover is visible over parts of the landscape and coastlines. The image includes the Copernicus Programme and European Union logos in the top-left corner. A satellite image showing Mount Etna, Italy, with snow-covered areas visible in white, surrounded by volcanic terrain rendered in shades of red and brown to highlight vegetation and lava flows. The striking red tones indicate infrared data used to distinguish land features. The image includes a scale and Copernicus and EU program logos.
@biomolstructure.bsky.social · 2y ago

The "Biomolecular Structure and Function" and the "Macromolecular Structure" Groups from @i3suporto.bsky.social wish you a Merry Christmas and a Happy New Year. Thank you to all the lab members and visitors who contributed to this unique Christmas decoration!

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