Although plasmalogens are abundant in mammalian membranes, their functions are elusive. Genetic studies suggest that plasmalogens promote ferroptosis, but the directionality and existence of this relationship is controversial. Our latest paper addresses this controversy... (1/5)

15-LOX-catalytic bias towards ether-(alkenyl)-ETE-PEs oxidation bestows selectivity of PRO-ferroptotic cell death signaling - Nature Communications

New functions and (patho)physiological role of broadly represented in membrane ether phospholipids as substrates of 15-lipoxygenases have been established in health and several acute/chronic diseases:...

nature.com

Direct sensing of dietary ω-6 linoleic acid through FABP5-mTORC1 signaling | Science www.science.org/doi/10.1126/...

Direct sensing of dietary ω-6 linoleic acid through FABP5-mTORC1 signaling

Diet influences macronutrient availability to cells, and although mechanisms of sensing dietary glucose and amino acids are well characterized, less is known about sensing lipids. We defined a nutrien...

science.org

It’s hard to focus lately and feels wrong to talk about science when the whole system is under threat, but I’ve been reading Hans Krebs’ autobiography and it’s excellent. I highly recommend for all scientists, especially biochemists

Excited to share our new preprint! Exceptional work by @mikelangelipid.bsky.social identifies the first #LipidDroplet lipid quality control pathway! LD-localized FSP1 safeguards neutral lipids from peroxidation and prevents #ferroptosis. 🤩https://www.biorxiv.org/content/10.1101/2025.01.06.631537v1

FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis

Lipid droplets (LDs) are organelles that store and supply lipids based on cellular needs. While mechanisms preventing oxidative damage to membrane phospholipids are established, the vulnerability of L...

biorxiv.org

CRISPR screening in epithelial cells suggests that peroxisome-derived ether lipids alter cellular viability in response to lipotoxic stress. Fas-associated factor family member 2 (FAF2) appears to be a key regulator of this process. This is an interesting preprint! www.biorxiv.org/content/bior...

To my reading, this paper suggests a role for 'classic' #ferroptosis mechanisms (namely LPCAT3 and oxPL) in ASCVD in humans www.jlr.org/article/S002...

Aspirin modulates generation of procoagulant phospholipids in cardiovascular disease, by regulating LPCAT3

Enzymatically oxygenated phospholipids (eoxPL) from lipoxygenases (LOX) or cyclooxygenase (COX) are pro-thrombotic. Their generation in arterial disease, and their modulation by cardiovascular therapies is unknown. Furthermore, the Lands cycle acyl-transferases that catalyze their formation are unidentified.

jlr.org

Ok, trying to bring my community back together... I created a starter pack for lipids and membrane protein aficionados! Feel free to share, add and distribute, so we can come together again! 😍 go.bsky.app/AEeXh86

I have initiated this #StarterPack with #RedoxBio researchers. Feel free to suggest other users, or yourself, to be included! go.bsky.app/UoVRtXp

🎨 In case anyone need… The NIH BioArt Source is an awesome library of *free* professionally drawn illustrations for scientific presentations or figures. Downloadable in HD. Thank you NIH for this invaluable tool 🙏! Check it out 👇 bioart.niaid.nih.gov

mTORC1 activity licenses its own release from the lysosomal surface www.cell.com/molecular-ce...

mTORC1 activity licenses its own release from the lysosomal surface

The activation of mTORC1 is intricately linked to its subcellular localization, with the Rag GTPases controlling its lysosomal recruitment in response to nutrient cues. Acharya and Demetriades uncover...

cell.com

NLRP1 is activated by palmitic acid and induced in human metabolic dysfunction-associated steatohepatitis https://www.biorxiv.org/content/10.1101/2024.11.11.622769v1

NLRP1 is activated by palmitic acid and induced in human metabolic dysfunction-associated steatohepatitis https://www.biorxiv.org/content/10.1101/2024.11.11.622769v1

Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent cause of live

biorxiv.org

This is a really interesting new preprint by Peter Tontonoz's group at UCLA. They discover a PPARγ–LPCAT3 pathway that links dietary n–6 PUFA intake to adipose expandability and systemic energy balance through unique storage of triglycerides. www.biorxiv.org/content/10.1...

Dietary control of peripheral adipose storage capacity through membrane lipid remodelling

Complex genetic and dietary cues contribute to the development of obesity, but how these are integrated on a molecular level is incompletely understood. Here, we show that PPARγ supports hypertrophic ...

biorxiv.org

This was a good read - some very exciting translational science! "The PNPLA3 I148M variant increases ketogenesis and decreases hepatic de novo lipogenesis and mitochondrial function in humans"

The PNPLA3 I148M variant increases ketogenesis and decreases hepatic de novo lipogenesis and mitocho...

The PNPLA3 I148M variant is the major genetic risk factor for all stages of fatty liver disease, but the underlying pathophysiology remains unclear. W…

sciencedirect.com

Porphyromonas gingivalis is a gram-negative anaerobic bacterium which is commonly found in the oral cavity and has been implicated in the pathogenesis of chronic periodontitis, but is also associated with other conditions such as bacterial vaginosis and Alzheimer’s disease. Here, we perform ...

Lipidomic analysis of Porphyromonas gingivalis reveals novel glycerol bisphosphoceramide, phosphatid...

Porphyromonas gingivalis, like other members of the phylum Bacteroidetes (synonym Bacteroidota), synthesizes several classes of dihydroceramides and p…

sciencedirect.com

This summer I worked on a rotation project looking at the role of arachidonic acid (AA) remodeling into macrophage phospholipids in atherosclerosis, a topic about which there’s some interesting literature dating back to 1994 (PMID: 8181456)....

A very interesting idea: could adipose tissue cellularity be regulated by the terminal complement cascade? I’ve never thought about any components of the innate immune system in adipose tissue that weren’t macrophages…. www.nature.com/articles/s41...

Control of adipose tissue cellularity by the terminal complement cascade - Nature Reviews Endocrinol...

Adipocytes have high levels of many components of the complement system. These components are involved in antimicrobial activities, but also have the potential to regulate the maintenance and turn-ove...

nature.com