There are two types of people in academic medicine - those who are there because it is their lifetime calling, others who are there to take home a paycheck. The fundamental problem is that those there for the paycheck hold all of the power.
Grant Rowe
@bloodandtime.bsky.social
Physician-Scientist at Boston Children's/Dana-Farber. Pediatric bone marrow failure, hematopoietic stem cell transplantation, developmental hematopoiesis, disease modeling, pluripotent stem cells.
The ISEH just launched a brand new website! Check it out and join our society today to network with your colleagues and keep abreast of the latest advances in basic and translational experimental hematology research! iseh.org
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I really enjoyed reading this paper. Use of basic culture-based and in vivo differentiation models with targeted application of -omics.
Blood Journals Portfolio@bloodjournals.hematology.org · last yr.Cell cycle shortening precedes the restriction of lymphoid and myeloid potentials. buff.ly/a3DeNsO #hemesky
Excellent obituary summarizing the contributions of Dr Till's foundational work in defining the hematopoietic hierarchy in Experimental Hematology @isehsociety.bsky.social www.exphem.org/article/S030...
Remembering James Till, 1931-2025
It has been 64 years since the publication of the classic 1961 Till & McCulloch paper that described spleen colonies in lethally irradiated mice following a bone marrow transplant [1]. On May 18, 2024...
exphem.org
Here is the first in a planned series of article commentaries in Experimental Hematology @isehsociety.bsky.social - thanks to @challenlab.bsky.social and @lindemileslab.bsky.social! www.exphem.org/article/S030...
Cell-extrinsic factors contribute toward myeloid-biased expansion in Tet2-mutant clonal hematopoiesis
Hematopoietic stem cells (HSCs) acquire somatic mutations throughout life, with the frequency of mutational incidence increasing with age [1]. Occasionally, certain mutations confer a fitness advantag...
exphem.org
What an interesting read...did you know that Developmental Hematopoiesis pioneer Elaine Dzierzak was also an artist? Read on to learn more in a recent issue of Experimental Hematology! The developmental clock: where art and science meet - Experimental Hematology www.exphem.org/article/S030...
The developmental clock: where art and science meet
Elaine DzierzakDrs. Elaine Dzierzak and Anna Bigas recently edited a special collection for Experimental Hematology entitled “Making blood: mechanisms of early hematopoietic development” [1]. This is ...
exphem.org
Absolute pleasure to chat with those two brilliant scientists! Do yourself a favour and have a look at their preprints! #hemesky
ISEH - International Society for Experimental Hematology@isehsociety.bsky.social · 2y ago@alessandrodonada.bsky.social sat down with @dpastoors.bsky.social and @tjflemin.bsky.social for a deep dive on their latest AML biology preprints. Watch the #SimplyBlood 🩸 interview today https://www.simplyblood.org/
I failed a billing audit this week and it was like I had left the new coversheets off of my TPS reports #medicaladministrativestate
We are very proud of this new content spearheaded by @alessandrodonada.bsky.social! Our lab is very grateful to Alessandro for highlighting our two recent preprints.
ISEH - International Society for Experimental Hematology@isehsociety.bsky.social · 2y agoThis month's #PreprintWatch covers some exciting new results on the impact of microenvironment on hematopoietic progenitors and novel approaches to long-standing questions like self-renewal and stem cell activity! Read now on https://www.simplyblood.org/
@isehsociety.bsky.social community: if you’re interested in HSC research in humans then this is a must read from leaders in the field. www.exphem.org/article/S030...
Methodological Considerations on How to Identify Human Hematopoietic Stem Cells
The hematopoietic system is highly regenerative and is organized hierarchically with hematopoietic stem cells (HSCs) sitting at the apex. Despite being some of the most widely studied stem cells, ques...
exphem.org
Uridine Metabolism as a Targetable Metabolic Achilles' Heel for chemo-resistant B-ALL https://www.biorxiv.org/content/10.1101/2025.01.27.635108v1
Second preprint of the day: www.biorxiv.org/content/10.1...
Path of differentiation defines human macrophage identity
Macrophages play central roles in immunity, wound healing, and homeostasis - a functional diversity that is underpinned by varying developmental origins. The impact of ontogeny on properties of human ...
biorxiv.org
Look at that, a trifecta of ISEH member preprints @bloodandtime.bsky.social @dorrancelab.bsky.social @kentlab.bsky.social biorxiv.org/content/earl... biorxiv.org/content/earl... biorxiv.org/content/earl...
Here's a new preprint from our group. This manuscript continues our efforts to understand the mechanisms that distinguish fetal/juvenile versus adult hematopoiesis to better understand pediatric blood diseases. www.biorxiv.org/content/10.1...
Dynamic activity of Erg promotes aging of the hematopoietic system
Hematopoiesis changes to adapt to the physiology of development and aging. Temporal changes in hematopoiesis parallel age-dependent incidences of blood diseases. Several heterochronic regulators of he...
biorxiv.org
I really enjoy putting those together, please if you see your preprint in this list do not hesitate to get in touch! #hemesky 🔬🩸
ISEH - International Society for Experimental Hematology@isehsociety.bsky.social · 2y agoThe first Preprint Watch for 2025 is plentiful: 9 preprints focusing on Acute Myeloid Leukemia, but also spatial fate mapping meets barcoding, how cell fate decisions occur in hematopoietic progenitors, and more! Read now➡️ simplyblood.org
Winter break is good for catching up on some reading 😉! #ISEH #SimplyBlood @isehsociety.bsky.social
ISEH - International Society for Experimental Hematology@isehsociety.bsky.social · 2y agoThis week on Simply Blood, we're highlighting selected articles on HSC metabolism in Experimental Hematology. Read curated articles on this topic and explore new findings ➡️ www.simplyblood.org
Interesting mechanistic work on reticular dysgenesis from my former colleague Dr Weinacht @bloodjournal.bsky.social ashpublications.org/blood/articl...
Failure of metabolic checkpoint control during late-stage granulopoiesis drives neutropenia in reticular dysgenesis
Key PointsActive metabolic checkpoints respond to AK2 deficiency by decreasing anabolic pathways to maintain nutrient homeostasis and proliferation.When me
ashpublications.org
Our latest work is now available to read on bioRxiv! Very proud of this and its potential implications for patients with acute myeloid leukemia 🩸 🧪 🔬💊 **eIF4A-mediated translation initiation as an AML cell vulnerability that can be co-targeted with BCL-2 inhibition** www.biorxiv.org/content/10.1...
We are very proud of this new resource for the community. Thanks @alessandrodonada.bsky.social for leading this initiative!
ISEH - International Society for Experimental Hematology@isehsociety.bsky.social · 2y agoTraveling for the holidays? Take this time to read the last #PreprintWatch installment of 2024! This month on #SimplyBlood🩸 we're featuring 17 preprints, including a new community submission ➡️ www.simplyblood.org
I am very proud to direct the Bone Marrow Failure Clinic at Dana-Farber/Boston Children's. answers.childrenshospital.org/sadie-aplast...
A small act of kindness: Blood donations get Sadie off the sidelines after her aplastic anemia diagnosis - Boston Children's Answers Sadie thrives with aplastic anemia
Sadie was sidelined by aplastic anemia. Now she's back in the game, thanks to life-saving blood transfusions and expert care.
answers.childrenshospital.org
This paper still irritates me - harvesting marrow from one-day-old neonates (human!) www.cell.com/developmenta...
Temporal molecular program of human hematopoietic stem and progenitor cells after birth
Zhang et al. provided an integral transcriptomic analysis of HSPCs, defined their dynamics in post-natal steady-state hematopoiesis, and refined the heterogeneity of MPPs by CD52 expression. Neonate bone-marrow-derived HSCs exhibited higher reconstruction capability than cord blood HSCs. This resource will help understand hematopoiesis in development and disease.
cell.com
Hey all you #ASH24 people. You need to look at this new paper in @naturemethods.bsky.social by Heme extraordinaires Grant Rowe and the Bluesky-less #HojunLi. A paper that looks at Blood & Time from @bloodandtime.bsky.social himself! #scRNAseq #bioinformatics 🧬 💻 www.nature.com/articles/s41...
The dynamics of hematopoiesis over the human lifespan - Nature Methods
This Resource presents an atlas classifying the age-related changes in human hematopoietic stem and progenitor cells from gestation through aging.
nature.com
The nice thing about the jet lag is that I can watch Dr Ambros's Nobel lecture #ASH24
My #ASH24 is getting shorter by the minute. Sitting on the tarmac in Boston for the past two hours...
On your way to #ASH24🩸? Here is something to read for the road ;)
ISEH - International Society for Experimental Hematology@isehsociety.bsky.social · 2y agoThis week on #SimplyBlood🩸 learn more about the ISEH New Investigators Committee that organizes year-round education and networking opportunities to support early career researchers➡️ www.simplyblood.org
The other side of what I do - one of my favorite patients: answers.childrenshospital.org/diamond-blac...
Kit handles Diamond-Blackfan anemia - Boston Children's Answers
Kit is a happy and active 2-year-old who relies on blood transfusions to manage the rare genetic blood disorder Diamond-Blackfan anemia.
answers.childrenshospital.org
Just in time for #ASH24, our latest paper is out. We performed scRNA-seq on HSPCs over human development, maturation, and postnatal aging. We looked at dynamics of HSPC subsets, lineage biases, HSC level priming, and identified a developmentally restricted human HSC. www.nature.com/articles/s41...
The dynamics of hematopoiesis over the human lifespan - Nature Methods
This Resource presents an atlas classifying the age-related changes in human hematopoietic stem and progenitor cells from gestation through aging.
nature.com