🎀 Age influences breast cancer cell and molecular features 🎀 Congrats to our international team for the work featured in the December @nataging.nature.com issue! @vangalenlab.bsky.social @mgbresearch.bsky.social @harvardmed.bsky.social

Nature Aging@nataging.nature.com · 8mo ago

🗞️Our December issue is live, featuring the identification of age-related cell states in breast cancer on the cover!📷The issue also includes work on ECM aging, somatic mutations, epigenetic drift, intrinsic capacity and much more. Read it all here: nature.com/nataging/vol...

🟣🟣🟣 Check out this straightforward method of improving human hematopoietic stem cell expansion by inhibiting ferroptosis 🟣🟣🟣 thanks for including me @bloodgenes.bsky.social #hemesky 🧬🔬🧪

Vijay G. Sankaran@bloodgenes.bsky.social · 9mo ago

Excited to share our new study, led by @dellaVolpe_L, now out in @natcellbio.nature.com! Blocking #ferroptosis enhances human 🩸 stem cell expansion, with implications for transplantation and gene therapy. www.nature.com/articles/s41...

Exciting to see our latest story out in print — with @sandramcallister.bsky.social — on how breast cancer differs between younger and older patients, leading the way to tailored management to improve outcomes 💻🔬🧬🧪

Nature Aging@nataging.nature.com · 9mo ago

Online now!✨Parsons et al profile age-associated changes in the tumor microenvironment of triple-negative and estrogen receptor-positive breast cancer nature.com/articles/s43... rdcu.be/eOc8t @vangalenlab.bsky.social @sandramcallister.bsky.social @mgbresearch.bsky.social @harvardmed.bsky.social

Congratulations! * Rapid epigenomic classification of acute leukemia* — the most innovative and impactful application of long-read sequencing and machine learning I know. Happy to be included!! #hemesky 🩸🧬💻🔬

This new way of looking at cellular diversity in single-cell sequencing is transformative imo, which is why we've taken a similar approach to study aging blood stem cells. Congratulations @dkotliar.bsky.social and @soumya-boston.bsky.social! 🩸🧪🧬 #hemesky

@dkotliar.bsky.social · 11mo ago

Paper from me, Michelle Curtis, @soumya-boston.bsky.social and co out now in @natmethods.nature.com! We now call it starCAT instead of *CAT but the strategy is the same: Build a catalog of ~50 interpretable T cell gene expression programs + use them to interpret new data nature.com/articles/s41...

Excited to share our latest work on blood aging! To find out why the blood system changes as people age, we started at the source: hematopoietic stem cells (HSCs) #hemesky 🩸🧬 doi.org/10.1101/2025... 🧵 1/5

New insights into the Unfolded Protein Response in hematopoietic stem cells in @bloodjournal.bsky.social this week + commentary from @basitsalik.bsky.social and me🩸🐁 #hemesky doi.org/10.1182/bloo...

The PERKs of ER homeostasis for hematopoietic stem cells

In this issue of Blood, Zheng et al1 show that the unfolded protein response (UPR) sensor PERK (protein kinase R-like endoplasmic reticulum kinase) is disp

doi.org

Online today! *Aging, Immune Fitness and Cancer* 🔬 Learn the latest about the intersection between these processes in @natrevcancer.nature.com 🧬 Great to work with @sandramcallister.bsky.social lab again 😁 doi.org/10.1038/s415...

Sandra McAllister, PhD@sandramcallister.bsky.social · 12mo ago

It’s out!!!!! We hope our review on aging, immunity, and cancer is helpful. Such a rewarding group effort led by Melissa Dolan, with Kendra Libby, Alison Ringle, and @vangalenlab.bsky.social So grateful to @gabriellebrewer.bsky.social @natrevcancer.nature.com for her efforts and support

This may be my favorite paper of the year so far: integrating single-cell leukemia datasets to reveal how differentiation and mutations interact to drive disease, along with a tool that speeds up bone marrow cell annotation from ~4 weeks to ~4 hours..! aacrjournals.org/bloodcancerd... 🔬🩸🧬 #hemesky

Whenever the team @posit.co brings out a new feature, it’s exactly how I wished it would be. AI integration done right 🧠 positron.posit.co/assistant @anthropic.com

📣 New preprint 📣 We present a detailed map of nascent and mature ribosomal RNAs in mouse hematopoiesis and AML (including absolute rRNA molecule numbers), and outline principles of rDNA regulation. Work by Eleanor Sams (@eleanor44.bsky.social) & Victoria Feist (@victoriafeist.bsky.social). (1/x)

Dynamics of Ribosomal RNA Transcription and Abundance in Normal and Leukemic Hematopoiesis

Transcription of ribosomal RNAs (rRNAs) from rDNA repeats is the first step of ribosome biogenesis, accounting for a major portion of all cellular transcription. Often regarded as a housekeeping proce...

biorxiv.org

Had a great time catching up with friends and learning new science at FASEB Hematologic Malignancies! #hemesky @faseborg.bsky.social #HEMSRC

At the FASEB Heme Malignancies meeting with old friends and new - Pam Sung, Peter Van Galen (@vangalenlab.bsky.social), Julia Maxson (@juliamaxson.bsky.social), Johnathon Shafer. Trying out ales at the @treehousebrewing.bsky.social! #HEMSRC

#positron is rapidly replacing programs and websites I used with a customizable multilingual coding environment for data science (local+cluster+virtual machines) #bash #rstats #python @posit.co

Delighted to share our #hematology review article on mutant calreticulin in #MPN Congrats to co-authors Drs. Mifra Faiz, Merle Riedemann & Jonas Jutzi. We hope it’s a useful resource, link below! @stanforddeptmed.bsky.social link.springer.com/article/10.1...

Mutant Calreticulin in MPN: Mechanistic Insights and Therapeutic Implications - Current Hematologic Malignancy Reports

Purpose of Review More than a decade following the discovery of Calreticulin (CALR) mutations as drivers of myeloproliferative neoplasms (MPN), advances in the understanding of CALR-mutant MPN continu...

link.springer.com

Erasmus MC Hematology Lecture speaker lineup never fails to impress! #hemesky 🧪🩸 mcusercontent.com/71bcc0f3bb8a...

Just a reminder of what is easily in my top 5 of favorite papers from 2023 www.cell.com/iscience/ful... @bailee-kain.bsky.social @thekinglab.bsky.social

Our latest work is now available to read on bioRxiv! Very proud of this and its potential implications for patients with acute myeloid leukemia 🩸 🧪 🔬💊 **eIF4A-mediated translation initiation as an AML cell vulnerability that can be co-targeted with BCL-2 inhibition** www.biorxiv.org/content/10.1...

Boston’s North End ❄️

Our new review “Insights into Leukemia from Single-Cell Genomics” is out! Great work by Nurefsan Sariipek @nursariipek.bsky.social 📝 www.annualreviews.org/content/jour... #hemesky 🩸🧬

Office plants are watered, almost ready to hit the road #ASH24 🩸🧬 #HemeSky

www.exphem.org/article/S030...

Mick Milsom@milsommick.bsky.social · 2y ago

Confused about possible biomarkers for blood cell aging? Check out this review by Wolfgang Wagner, including exploration of how transferable such markers are between mice and humans - Experimental Hematology exphem.org/article/S0301-… @isehsociety.bsky.social

Interesting BMC Genomics paper filters "nucleus-free" low-quality cells using the number of intronic reads. MALAT1 expression may provide a shortcut, but I would be wary of filtering out meaningful data 1/3 🩸🧬 @tmontsay.bsky.social @annaesteveco.bsky.social www.ncbi.nlm.nih.gov/pubmed/39574...

On Thanksgiving day, what is the effect of frequent blood donations? Donors may have a higher prevalence of EPO-responsive clonal hematopoiesis, but there is no increased risk for malignant clones, underscoring safety of repetitive blood donations. www.medrxiv.org/content/10.1... 🩸🧪 #hemesky

1/ 🧬 Single-cell genomics reveals biological variations beyond cell types. Unveiling these in separate latent dim’s is known as disentanglement. Led by @AmirAliMoinfar, we develop DRVI to learn nonlinear, disentangled & interpretable latent spaces. biorxiv.org/content/10.1101/2024.11.06.622266v1

Bad use case 🫠 (and reminder to carefully check everything ChatGPT generates)

Finally- the starter pack we have all been waiting for is here … Hematopoiesis 🎉❤️🩸🦴 So excited to have reached a critical mass of this community on here. 🙌🏻 Let me know if you want to be added!! go.bsky.app/KWdX5w7

Not many papers change the way I think about AML, but this exceptional work shows how cell states and genetics intertwine to mediate venetoclax resistance, unifying previous studies by identifying RAS-mutated LSCs that are primed to produce myeloid cells #hemesky 🩸🧪 www.nature.com/articles/s41...

Ok let’s give social media another try. I’ll share advances in blood/cancer/aging/bioinformatics research and pictures of my daily commute along Boston’s Esplanade like this one

Python ≠ my forte, but with the help of ChatGPT I created this nice little script to count files stored in Google Cloud Storage (GCS) buckets, categorized by their storage class (e.g., STANDARD, NEARLINE, COLDLINE, ARCHIVE). I hope it helps someone like it does me! 🐍 github.com/petervangale...

GitHub - petervangalen/count_storage_classes: Count the number of files in Google Cloud Storage (GCS) buckets categorized by their storage class

Count the number of files in Google Cloud Storage (GCS) buckets categorized by their storage class - petervangalen/count_storage_classes

github.com