Tessera
Folgen

Mick Milsom

@milsommick.bsky.social

Stem cell biologist at German Cancer Research Center & HI-STEM. Focussed on hematopoiesis, aging and cancer.

92 Posts939 Follower807 Folgt
Mick Milsom@milsommick.bsky.social · 6d ago

Exp Hem launches brand new article types focused on providing an outlet for important research that wouldn’t fit into conventional academic publishing formats. Submit now and claim one of 20 awards worth $650. @isehsociety.bsky.social

ISEH - International Society for Experimental Hematology@isehsociety.bsky.social · 6d ago

📢 Experimental Hematology, the official journal of ISEH, has launched new article types and author incentives! View the latest updates and submit your next manuscript: iseh.org/Publications...

Mick Milsom@milsommick.bsky.social · 3w ago

Discounted registration closes today. As well as saving on the registration fee, you can also be in with a shout of winning a $50 gift card if you register before midnight CT….not to mention being guaranteed attendance at an awesome meeting @isehsociety.bsky.social

ISEH - International Society for Experimental Hematology@isehsociety.bsky.social · 3w ago

Congratulations to yesterday's winner - Bettina Wingelhofer from @manmetuni.bsky.social! The last day of #ISEH2026 Race to Register continues with today's prize: A $50 gift card. Register by 11:59pm US CT to to win - it's your last chance! iseh.org/Annual-Meeti...

Mick Milsom@milsommick.bsky.social · 3w ago

Day two of our registration prize draw: today we’re giving away a one year ISEH membership. Register today for a chance to win it!!! @isehsociety.bsky.social

ISEH - International Society for Experimental Hematology@isehsociety.bsky.social · 3w ago

Congratulations to yesterday's winner - Adrián Madrigal from @carrerasijc.bsky.social! The #ISEH2026 Race to Register continues with today's prize: A free 2027 ISEH membership! Register by 11:59pm US CT to be entered to win! iseh.org/Annual-Meeti...

Nature Cell Biology@natcellbio.nature.com · last mo.

☕Single-cell transplantations of long-term HSCs, in-depth phenotyping and mathematical modeling identify reconstitution kinetics as a unifying metric of HSC potency and extrinsic regulation as a driver of lineage bias. @simonhaas.bsky.social @milsommick.bsky.social www.nature.com/articles/s41...

A kinetics-based model of haematopoiesis reveals extrinsic regulation of skewed lineage output from stem cells - Nature Cell Biology

Single-cell transplantations of long-term haematopoietic stem cells (HSCs), in-depth phenotyping and mathematical modelling identify reconstitution kinetics as a unifying metric of HSC potency and ext...

nature.com

Mick Milsom@milsommick.bsky.social · 3mo ago

Check out our new pre-print: dissecting mechanistic regulation of mutation acquisition in HSCs during aging. Fantastic collaboration with @atjcagan.bsky.social @imartincorena.bsky.social @sangerinstitute.bsky.social & @bb-610.bsky.social and my group @dkfz.bsky.social doi.org/10.64898/202...

Dormancy, not apoptosis, restricts hematopoietic stem cell mutagenesis during aging

Genome instability and mutagenesis are hallmarks of aging, acting as drivers of some age-associated pathologies, including cancer1-3. Somatic cells engage multiple layers of protection against mutagenesis, including detoxification of genotoxic metabolites; repair of DNA damage; and elimination of cells which suffer excessive damage4-7. In this context, the intrinsic apoptotic pathway is engaged in response to activation of the DNA damage response (DDR) and is thought to play a major role in limiting accumulation of mutations, particularly in cells that act as an origin for cancer, such as somatic stem cells8,9. However, the dissection of the relative contribution of different protective mechanisms that restrict mutagenesis in such cells is confounded by the long time frame of experiments; relatively low mutation burden in non-malignant cells; and high variance across individuals due to differences in germ line and environment. Here we employ deep whole-genome sequencing (WGS) combined with extended time-course sampling from a range of experimental mouse models to study mutation acquisition in hematopoietic stem cells (HSCs) during aging. Having validated that murine HSCs recapitulate mutation acquisition patterns observed in aged human HSCs, we made the surprising discovery that apoptosis has a negligible role in restricting mutagenesis. Instead, we found that HSC dormancy inhibits mutagenesis during normal aging, with dormant HSCs from old mice demonstrating a mutation burden akin to their young counterparts. Importantly, breaking HSC dormancy via induction of sterile inflammation led to a dramatic acceleration in mutation rate, demonstrating that non-genotoxic environmental stimuli can modulate genome stability. These findings provide new insights into the correlation between inflammation and both aging and carcinogenesis. ### Competing Interest Statement The authors have declared no competing interest.

doi.org

Mick Milsom@milsommick.bsky.social · 4mo ago

Amazing line up of invited speakers and, new for this year, DOUBLE THE NUMBER OF SHORT TALKS TO BE SELECTED FROM SUBMITTED ABSTRACTS. Only 3 days to go to get your chance to present in front of this audience!

ISEH - International Society for Experimental Hematology@isehsociety.bsky.social · 4mo ago

🕒 3 days left before the #ISEH2026 abstract deadline! Share your science with the global ISEH community - no extensions will be offered. 🔗 iseh.org/Annual-Meeti...

Nick van Gastel@nickvangastel.bsky.social · 4mo ago

Join us in Frankfurt in August! @isehsociety.bsky.social is a tremendous society and the Annual Meeting is always packed with amazing science and numerous networking opportunities! If you’re doing basic or translational hematology research, this is the meeting to attend!!!

ISEH - International Society for Experimental Hematology@isehsociety.bsky.social · 4mo ago

🕔 5 days left to submit your abstract and apply for a travel grant for #ISEH2026! Don’t miss the opportunity to present your research at the ISEH 55th Annual Scientific Meeting. 🔗 iseh.org/Annual-Meeti...

Charlotta Böiers, MD, PhD@boierslab.bsky.social · 4mo ago

Don’t miss this opportunity. ISEH has been more than a society to me - it’s a community that has shaped my career through openness, mentorship, and the exchange of ideas across scientific boundaries. Be part of these conversations in Frankfurt at #ISEH2026. @isehsociety.bsky.social

ISEH - International Society for Experimental Hematology@isehsociety.bsky.social · 4mo ago

🕰️ There is still time to share your research at #ISEH2026! Submit by 17 April to be considered. Please note that no extensions will be offered. Learn more and submit: iseh.org/Annual-Meeti...

Mick Milsom@milsommick.bsky.social · 4mo ago

If you're on a budget, be sure to check out the institutional group discounts on registration. Also for trainees, remember to apply for our travel fellowships that are awarded to the best scoring abstracts. Many add-on trainee events are free!

ISEH - International Society for Experimental Hematology@isehsociety.bsky.social · 4mo ago

🕰️ There is still time to share your research at #ISEH2026! Submit by 17 April to be considered. Please note that no extensions will be offered. Learn more and submit: iseh.org/Annual-Meeti...

Mick Milsom@milsommick.bsky.social · 4mo ago

First (to my knowledge) manuscript describing a correlation between number of infections and incidence of clonal hematopoiesis (CHIP). Really important from the perspective of highlighting a possible modifiable driver of CHIP during aging. @isehsociety.bsky.social www.exphem.org/article/S030...

Association of Infection Frequency and Incident Clonal Hematopoiesis of Indeterminant Potential

Clonal hematopoiesis of Indeterminant Potential (CHIP) is an age-related phenomenon characterized by clonal expansion of hematopoietic stem cells (HSCs)1. CHIP results from a fitness advantage conferr...

exphem.org

Eirini Papapetrou@eirinipapapetrou.bsky.social · 4mo ago

It is an immense privilege and honor to be elected to the Board of Directors of @isehsociety.bsky.social alongside phenomenal colleagues @milsommick.bsky.social @louisepurton.bsky.social @katherineking.bsky.social @trowbridgelab.bsky.social @keisukeito-lab.bsky.social @ericpietras.bsky.social etc

ISEH - International Society for Experimental Hematology@isehsociety.bsky.social · 4mo ago

The results are in 🗳️ Congratulations to our incoming 2026-2027 Board of Directors who will start their terms at the conclusion of #ISEH2026 in August! 👏

Mick Milsom@milsommick.bsky.social · 5mo ago

Come see all three receive their awards and talk about their science @isehsociety.bsky.social annual meeting in Frankfurt: iseh.org/Annual-Meeting Come for the science and join our community.

Annual Meeting

iseh.org

Eirini Papapetrou@eirinipapapetrou.bsky.social · 5mo ago

Incredibly honored to receive the 2026 McCulloch & Till award by @isehsociety.bsky.social. Congratulations to Ellen Rothenberg and @bethpsaila.bsky.social - proud to be in such great company!

Mick Milsom@milsommick.bsky.social · 5mo ago

Join us this summer in Frankfurt for outstanding science and a great community…….so easy to travel to, and Heidelberg is only a short train ride away if you want to visit our historic old town located on the Neckar river.

ISEH - International Society for Experimental Hematology@isehsociety.bsky.social · 5mo ago

Registration is open for #ISEH2026! Register now to secure the lowest rate. We look forward to welcoming you to Germany - willkommen! 👉️ iseh.org/Annual-Meeti...

Mick Milsom@milsommick.bsky.social · 6mo ago

Abstract submission just opened for #ISEH2026 in Frankfurt. Outstanding scientific program; welcoming community; and more than double the number of short talk slots for abstract to be presented in. Looking forward to seeing you there. @isehsociety.bsky.social

ISEH - International Society for Experimental Hematology@isehsociety.bsky.social · 6mo ago

Submit an abstract by 2 April for opportunities to present your work at #ISEH2026 🏙️! With over 45 short talk slots, don't miss this opportunity to share your findings with the international scientific community. Learn more: iseh.org/Annual-Meeti...

Mick Milsom@milsommick.bsky.social · 7mo ago

Very early days, but delighted that our recent review on reevaluation of aging hematopoiesis published in Experimental Hematology, official journal of @isehsociety.bsky.social is classified as highly cited by web of science. Open access here: www.exphem.org/article/S030...

Reconsidering the usual suspects in age-related hematologic disorders: is stem cell dysfunction a root cause of aging?

The global trend toward an increasing aged population demographic raises significant societal challenges, particularly concerning health. As organisms age, progressive tissue dysfunction increases the...

exphem.org