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Boël Lab

@boellab.bsky.social

We are a research lab located in Paris, France. We work on the fundamental aspect of protein synthesis mechanisms and regulations.

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Tomek Wlodarski@twlodarski.bsky.social · 7mo ago

Just in time for 2026! 🎆 Presenting a nascent-centric view on the shape of the ribosomal exit tunnel topology, based on MD-derived occupancy maps for 55 distinct ribosomes. 🧶🧬🖥️ 📄 Read the preprint: biorxiv.org/content/10.6... #StructuralBiology #Ribosome #CryoEM #Evolution #Biophysics

Evolution of the ribosomal exit tunnel through the eyes of the nascent chain

The ribosomal exit tunnel is a universally conserved feature of the large subunit that directs the nascent polypeptide chain into the cellular environment and is involved in co-translational folding, ...

biorxiv.org

Heather Feaga@heatherfeaga.bsky.social · 7mo ago

This work was also our first time doing membrane localization (way to go Cassidy)! And so proud of Bella’s gorgeous Paenibacillus tree showing the distribution of the transmembrane containing Spo0B! Also it’s the lab’s first paper without ribosomes 🫨, but don’t worry - the ribosomes made the Spo0B!

Microscopy images showing membrane localization of Spo0B fused to GFPPhylogenetic tree showing that most species within Paenibacillus have a transmembrane domain containing Spo0B
Heather Feaga@heatherfeaga.bsky.social · 7mo ago

The sporulation phosphorelay protein Spo0B is membrane localized in Paenibacillus! The transmembrane domain appears to increase interaction with relay partners. Congrats to former lab undergrad @isabellalin.bsky.social and her grad mentor @cassidyprints.bsky.social journals.asm.org/doi/10.1128/...

Boël Lab@boellab.bsky.social · 8mo ago

This sequence optimization technique is also included in the overall sequence optimization tool available on our server: opt.williams.edu (See our publication: www.sciencedirect.com/science/arti...)

OPT codon optimization

opt.williams.edu

Boël Lab@boellab.bsky.social · 8mo ago

Our latest paper on protein expression and mRNA stability is out! academic.oup.com/nar/article/... Check out how to increase your protein output with a simple trick. Congratulations to first author @Anna Lipońska, it was a great collaboration with the Aalberts group. #RNAsky #ribosome #EGM

Boël Lab@boellab.bsky.social · 8mo ago

In this study, we highlight the importance of the base composition of the first codons for protein expression. An increased abundance of adenine (A) and a decrease in guanine (G) enhance expression and improve mRNA stability. The mediator of this effect is the ribosome.

Boël Lab@boellab.bsky.social · 8mo ago

Our latest paper on protein expression and mRNA stability is out! academic.oup.com/nar/article/... Check out how to increase your protein output with a simple trick. Congratulations to first author @Anna Lipońska, it was a great collaboration with the Aalberts group. #RNAsky #ribosome #EGM

Boël Lab@boellab.bsky.social · 8mo ago

Our latest paper on protein expression and mRNA stability is out! academic.oup.com/nar/article/... Check out how to increase your protein output with a simple trick. Congratulations to first author @Anna Lipońska, it was a great collaboration with the Aalberts group. #RNAsky #ribosome #EGM

Base composition at the start of the coding sequence controls the balance between translation initiation and mRNA degradation in E. coli

Abstract. Protein synthesis efficiency is highly dependent on the messenger RNA (mRNA) coding sequence. Furthermore, there is extensive evidence of a corre

academic.oup.com

Zeynep Baharoglu@zeynepbaharoglu.bsky.social · 11mo ago

So excited our antibiotic potentiation story is out 🤩 Led by the extraordinary @manonlang.bsky.social with @fox-science.bsky.social & @amazeld.bsky.social +amazing collaborators @immunobladder.bsky.social @imaneelmeouche.bsky.social 🦠 We believe it can make a difference in #AMR infections!

Uridine as a potentiator of aminoglycosides through activation of carbohydrate transporters

Uridine boosts aminoglycoside treatment efficiency against antibiotic-susceptible as well as antibiotic-resistant E. coli strains.

science.org

Cameron Thrash@jcamthrash.bsky.social · 3y ago

Direct RNA sequencing coupled with adaptive sampling enriches RNAs of interest in the transcriptome www.nature.com/articles/s41... #jcampubs

Direct RNA sequencing coupled with adaptive sampling enriches RNAs of interest in the transcriptome ...

It can be difficult to find rare transcripts when sequencing a transcriptome. Here the authors show adaptive sampling on direct RNA runs to increase the likelihood of finding less frequent ones while ...

nature.com

Boël Lab@boellab.bsky.social · 3y ago

Hi everyone, We are new on Bluesky 😀. We are a group of microbiologists 🧫🔬 interested in mRNA translation mechanisms and regulation. We wish you a wonderful year in 2024 🥳🍾 and will be back soon with more news.