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Didier Mazel

@amazeld.bsky.social

Bacterial geneticist, Prof @ Institut Pasteur.

45 Posts962 Follower254 Folgt
Didier Mazel@amazeld.bsky.social · 2d ago

A great work by @vincentburrus.bsky.social 's team. Fertility inhibition involves preventing relaxosome assembly by interfering between the relaxase and the mobilization factor! Bravo à tous!

Vincent Burrus 🇨🇦💙💛@vincentburrus.bsky.social · last wk.

#plasmidbiology #plasmid Just out! 🚀 Thrilled by our discovery: the function of the C-terminal domain of MOBH1 relaxases! We uncovered this thanks to a fertility inhibitor encoded by a parasitic mobile genetic element. Congrats to Florence on a great piece of work! 👏 academic.oup.com/nar/article/...

Didier Mazel@amazeld.bsky.social · 3w ago

Dear all, I have the pleasure to inform you that the online course "Resistance to Antibacterial Agents", produced by the Institut Pasteur, will start on November 3, 2026. How does ABR emerge and spread? ... 🔗 www.fun-mooc.fr/en/courses/r...

Resistance to antibacterial agents

The origin, risks, diagnosis, epidemiology of resistance to antibacterial agents in man and livestock worldwide, as well as preventive and countermeasures, in a « one health » perspective.

fun-mooc.fr

Marie-Eve VAL@val-meve.bsky.social · 5mo ago

This one means a lot. Our paper, “Large extrachromosomal replicons are widespread across bacterial lineages and show coordinated replication termination and spatial coupling with the chromosome,” is out! doi.org/10.1038/s414...

Large extrachromosomal replicons are widespread across bacterial lineages and show coordinated replication termination and spatial coupling with the chromosome - Nature Communications

Bacterial genomes often include extrachromosomal replicons, ranging from small plasmids to chromosome-scale replicons. Here, Czarnecki et al. analyse more than 40,000 complete bacterial genomes and sh...

doi.org

The Lambrechts Lab@lambrechtslab.bsky.social · 6mo ago

🚨 We're hiring! A #postdoc position is available @lambrechtslab.bsky.social @pasteur.fr ➡️ Come join our team to investigate the #genomic variations underlying the adaptive potential and vectorial capacity of Aedes aegypti #mosquitoes 🦟 More details at this link: research.pasteur.fr/b/1Cov

Postdoctoral position in mosquito population genomics at Institut Pasteur in Paris - Research

The Insect-Virus Interactions Unit is looking for a postdoctoral researcher to investigate the genomic variations underlying a mosquito’s capacity to transmit human arboviruses. Description Our resear...

research.pasteur.fr

Institut Pasteur | 130 years of biomedical research@pasteur.fr · 10mo ago

🔬 Call to create junior research groups at the Institut Pasteur Focus: Infectious diseases, host-microbe interactions, vaccines Special interest: AI methodologies 📅 Deadline: Feb 9, 2026 👥 2-12 years post-PhD Apply now 📝 research.pasteur.fr/en/call/crea... #JobOpportunity #Research

Creation of new junior research groups at the Institut Pasteur - Call for applications 2026 - Research

The Institut Pasteur is launching an international call to recruit new junior research group leaders leveraging cutting-edge transdisciplinary approaches to exploring infectious diseases, host-microbe...

research.pasteur.fr

Didier Mazel@amazeld.bsky.social · 10mo ago

We've come full circle! I began my postdoctoral career by identifying the peptidyl deformylase gene. Today, we show that half of bacterial species harbor multiple PDF genes (up to 7, for always a single Met-tRNA transformylase), and while the role of these PDFs ... academic.oup.com/mbe/article/...

Unraveling the Prevalence and Multifaceted Roles of Accessory Peptide Deformylases in Bacterial Adaptation and Resistance

Abstract. Peptide deformylases (PDFs) are enzymes that are essential for bacterial viability and attractive targets for antibiotic development. Yet, despit

academic.oup.com

Daniela Barillà@danielabarilla.bsky.social · 11mo ago

Let’s wrap things up: my commentary on the Asgard hypernucleosomes. Congratulations to all the authors of the paper 🍾! kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F... Cryo-EM reveals open and closed Asgard chromatin assemblies: Molecular Cell www.cell.com/molecular-ce...

Cryo-EM reveals open and closed Asgard chromatin assemblies

Ranawat et al. show the cryo-EM structures of Asgard archaeal chromatin assemblies, revealing that the histone HHoB assembles into both compact closed and extended open hypernucleosomes. The closed co...

cell.com

Kevin Debatisse@kdebatisse.bsky.social · 11mo ago

Our new paper is out in @narjournal.bsky.social We show that natural transformation enables bacteria to shuffle integron cassettes, boosting their phenotypic diversity. academic.oup.com/nar/article/... 1/5

Bacterial natural transformation drives cassette shuffling and simplifies recombination in chromosomal integrons

Abstract. Integrons act as biobanks of gene cassettes conferring functions crucial for bacterial defense, including protection against phages and antibioti

academic.oup.com

Didier Mazel@amazeld.bsky.social · last yr.

A fresh view on phage specificity, which challenges the traditional view of a narrow host spectrum of phages by unveiling that multihost associations are common across ecosystems kudos at @mmarbout.bsky.social & @rkoszul.bsky.social www.nature.com/articles/s41...

Phages with a broad host range are common across ecosystems - Nature Microbiology

Proximity-ligation-based sequencing from 111 samples and 5 environments reveals that a substantial proportion of phages infect multiple species.

nature.com

Didier Mazel@amazeld.bsky.social · last yr.

I am so proud to be part of this work, that we initiated Fernando de la Cruz and I, when he was on sabbatical in my lab in 2009... it took so much time for this achievement, 1000 thanks to Raúl Fernández-López! this brought me back to my PhD on cyanobacteria genetics. www.pnas.org/doi/10.1073/...

Mutations in the circadian cycle drive adaptive plasticity in cyanobacteria | PNAS

Circadian clocks allow organisms to anticipate daily fluctuations in light and temperature, but how this anticipatory role promotes adaptation to d...

pnas.org

Didier Mazel@amazeld.bsky.social · last yr.

Striking and frightening 😒 "They found multiple instances of insecticide-resistance variants in this malaria vector, although most of these weren’t shared with museum specimens collected as recently as 1967, suggesting rapid emergence" www.science.org/doi/10.1126/...

Genomic diversity of the African malaria vector Anopheles funestus

Anopheles funestus s.s. is a major human malaria vector across Africa. To study its evolution, especially under vector control pressure, we sequenced 656 modern specimens (collected 2014 to 2018) and ...

science.org

Marie-Eve VAL@val-meve.bsky.social · last yr.

Congratulations to PhD students Jasmin Ostermayer and Noa Guzzi (co–first authors 🎉), together with Jakub Czarnecki and Alfonso Soler-Bistué, for compressing the diverse, lineage-wide literature on large extrachromosomal replicons into <5000 words and 80 references 😅

Didier Mazel@amazeld.bsky.social · last yr.

A great step for archaea : connection between chromosome organization to genome segregation in Archaea www.nature.com/articles/s41... congrats to @danielabarilla.bsky.social

Coupling chromosome organization to genome segregation in Archaea - Nature Communications

Proteins SegA and SegB are important for chromosome segregation and organization in archaea of the order Sulfolobales, but mechanisms are unclear. Here, Kabli et al. uncover patterns and mechanisms th...

nature.com

Morgan Lamberioux@morgan-lamberioux.bsky.social · last yr.

Thrilled to share my first PhD paper, out of the Mazel lab! @amazeld.bsky.social We discovered that accessory peptide deformylases (PDFs) are widespread in bacteria and may provide resistance to natural inhibitors, posing a challenge to future antibiotic strategies doi.org/10.1101/2025...

Unraveling the prevalence and multifaceted roles of accessory peptide deformylases in bacterial adaptation and resistance

Peptide deformylases (PDFs) are enzymes that are essential for bacterial viability and attractive targets for antibiotic development. Yet, despite their conserved function, many bacteria encode multip...

doi.org

Jose A Escudero@jaescudero.bsky.social · last yr.

Our paper is published back2back with one from @amazeld.bsky.social and @epcrocha.bsky.social labs where @baptistedarracq.bsky.social, @eloilittner.bsky.social and co. show that Sedentary Chromosomal Integrons are biobanks of phage defense systems. www.science.org/doi/10.1126/...

Sedentary chromosomal integrons as biobanks of bacterial antiphage defense systems

Integrons are genetic systems that drive bacterial adaptation by acquiring, expressing, and shuffling gene cassettes. While mobile integrons are well known for spreading antibiotic resistance genes, t...

science.org