@canaanlab.bsky.social
TB and related mycobacteria, Mycobacterial lipids, infection, development of new drugs, diagnosis and more
Once again a great collaboration with @ibmm-balard.bsky.social @map-proteomique.bsky.social and other !!!
J.-F. Cavalier@jefcavalier.bsky.social · last yr.Today is a great day! Our article accepted on March 19, 2025 is published in Wiley mLife journal. Great collaborative work with JM Bolla's lab, @map-proteomique.bsky.social @canaanlab.bsky.social Céline Crauste from @ibmm-balard.bsky.social, and more... 👉 onlinelibrary.wiley.com/doi/10.1002/...
Honored to award the title of Dr. honoris causa of the University of Toulouse to Dr. Manjula Reddy (CCMB, Hyderabad). A world-renowned microbiologist, Dr. Reddy has made major contributions to our understanding of bacterial cell division. 🇫🇷🇮🇳
newsable.asianetnews.com/internationa...
BREAKTHROUGH! Scientists discover Llama antibodies that can fight COVID and its future variants
Scientists have unearthed a rare class of ultra-potent antibodies derived from llamas that can neutralize a vast array of coronaviruses—including SARS-CoV-1 and multiple forms of SARS-CoV-2, both old ...
newsable.asianetnews.com
It is my real pleasure to share our ASAP article published in ACS Infect Dis. Another great collaboration with @pierresantucci.bsky.social @canaanlab.bsky.social @lkremer1.bsky.social @ibmm-balard.bsky.social @map-proteomique.bsky.social and more... Enjoy 😊 pubs.acs.org/doi/10.1021/...
Mapping of Mycobacterial Enzymes Involved in Triacylglycerol Accumulation as Intrabacterial Lipid Inclusions Using Activity-Based Multitarget Inhibitor Probes
Lipids play a critical role in the physiology, life cycle, and pathogenicity of mycobacteria. They largely participate in host–pathogen interactions and fulfill important functions ranging from cell w...
pubs.acs.org
We're always delighted to work together on these exciting projects @jefcavalier.bsky.social @canaanlab.bsky.social
J.-F. Cavalier@jefcavalier.bsky.social · last yr.⚠️ Breaking News ⚠️ Another great collaborative work with Victoria Magrioti, @canaanlab.bsky.social @map-proteomique.bsky.social now just published in @rscmedchem.rsc.org pubs.rsc.org/en/content/a...
⚠️ Breaking News ⚠️ Another great collaborative work with Victoria Magrioti, @canaanlab.bsky.social @map-proteomique.bsky.social now just published in @rscmedchem.rsc.org pubs.rsc.org/en/content/a...
Synthesis and Anti-mycobacterial Activity of Novel Medium-chain β-Lactone Derivatives: A Multi-Target Strategy to combat Mycobacterium abscessus
The constant emergence of drug-resistant mycobacteria, together with the lack of new antibiotics entering the market, has become a global public health problem that threatens the effective treatment o...
pubs.rsc.org
A new story on antimicrobial peptides published with great collaborators !!
J.-F. Cavalier@jefcavalier.bsky.social · last yr.Happy to share our new article in Current Research in Microbial Sciences @canaanlab.bsky.social Nice work with Priscille Brodin, Aurelie Tasiemski, Celine Boidin-Wichlacz @pasteurlille.bsky.social, and more, on the use of antimicrobial peptides against Mtb. www.sciencedirect.com/science/arti...
Two ERC-funded postdoc positions available in the team - one here and second to follow - please repost! jobs.ncl.ac.uk/job/Newcastl...
Research Associate Genetic and functional analysis of Gram positive secretion systems and substrates
Research Associate Genetic and functional analysis of Gram positive secretion systems and substrates
jobs.ncl.ac.uk
Great job!! Congratulations @pierresantucci.bsky.social from LISM Lab and @canaanlab.bsky.social
Pierre Santucci @pierresantucci.bsky.social · 2y agoHappy to see our work on Mycobacterial CRISPRI featured on the Cover of FEBS Letters 🍾🥳👌 @febspress.bsky.social @univ-amu.fr @cnrsbiologie.bsky.social @anrs-mie.bsky.social
Great job !!👏👏👏👏to all authors !
Laurent Kremer@lkremer1.bsky.social · last yr.Happy to let you know that our most recent paper describing the discovery, structure and biological functions of a new glycolipid in M. abscessus is now out ! This has only be possible thanks to a wonderful collaboration with the teams of JL Herrmann and Y Guerardel. rdcu.be/egVwe
Great job!! Congratulations @pierresantucci.bsky.social from LISM Lab and @canaanlab.bsky.social
Pierre Santucci @pierresantucci.bsky.social · 2y agoHappy to see our work on Mycobacterial CRISPRI featured on the Cover of FEBS Letters 🍾🥳👌 @febspress.bsky.social @univ-amu.fr @cnrsbiologie.bsky.social @anrs-mie.bsky.social
Happy to share our last paper published in mBio. A new APEX story !! journals.asm.org/doi/10.1128/...
A proteomic and functional view of intrabacterial lipid inclusion biogenesis in mycobacteria | mBio
This study sheds light into the complex process of intracellular lipid accumulation and storage in the survival and persistence of pathogenic mycobacteria, which is of clinical relevance. By identifying the proteins involved in the formation of ...
journals.asm.org
Nice work congratulations Alexandre and co authors 👏👏👏
Tiago Beites@tiagobeites.bsky.social · 2y agoA very special one. My dear friends @healycl.bsky.social and @alexandregouzy.bsky.social published a paper with our common mentor @saehrt.bsky.social. On top of that, this is Alex’ first corresponding authorship!! And, of course, excellent bacterial physiology science.
You are perfectly right !!! Authors please do not use this nomenclature anymore !!!!
Olivier Neyrolles@oneyrolles.bsky.social · 2y agoWhen the title of a paper makes it painfully clear that no expert in the field was involved in its review... Bravo #MolecularMicroEditors 👏 #PeerReview #MicroSky onlinelibrary.wiley.com/doi/abs/10.1...
Happy that @map-proteomique.bsky.social has participated oh this nice story from @canaanlab.bsky.social in collaboration with @lkremer1.bsky.social @pierresantucci.bsky.social @jefcavalier.bsky.social link.springer.com/article/10.1...
Cyclophostin and Cyclipostins analogues counteract macrolide-induced resistance mediated by erm(41) in Mycobacterium abscessus - Journal of Biomedical Science
Background Mycobacterium abscessus is an emerging pathogen causing severe pulmonary infections, particularly in individuals with underlying conditions, such as cystic fibrosis or chronic obstructive p...
link.springer.com
After a BioRxiv preprint, here is the final published version of our article dealing with the ph-driven mode of action of salicylic acid derivatives @pierresantucci.bsky.social @canaanlab.bsky.social and more febs.onlinelibrary.wiley.com/doi/10.1002/...
FEBS Press
Salicylic acid (SA), its two iodinated analogues 5ISA and 3,5diISA, as well as the anti-inflammatory drug aspirin (ASP), are anti-TB drugs that disrupt the intrabacterial pH homeostasis of Mycobacter...
febs.onlinelibrary.wiley.com
Our last article dealing with Cyclipostin & Cyclophostins compounds to counteract macrolide-induced resistance in Mabscessus is out! Great collaborative work @lkremer1.bsky.social @canaanlab.bsky.social @pierresantucci.bsky.social @camoinluc.bsky.social jbiomedsci.biomedcentral.com/articles/10....
Cyclophostin and Cyclipostins analogues counteract macrolide-induced resistance mediated by erm(41) in Mycobacterium abscessus - Journal of Biomedical Science
Background Mycobacterium abscessus is an emerging pathogen causing severe pulmonary infections, particularly in individuals with underlying conditions, such as cystic fibrosis or chronic obstructive p...
jbiomedsci.biomedcentral.com
Happy to share scientific @pierresantucci.bsky.social paper useful to facilitate screening of CrispRi mutants @Febs letters Doi: 10.1002/1873-3468.15071
Interesting paper showing different M tuberculosis strains induce varying levels of IL-1beta via inflammasome activation. Curious to understand how that relates to infection clearance & disease severity. #TBSky #IDSky #ImmunoSky #Immunometabolism
Genetically diverse Mycobacterium tuberculosis isolates manipulate inflammasome activation and IL-1β secretion independently of macrophage metabolic rewiring
The glycolytic pathway is required for maximum IL-1β production by macrophages infected with live distinct M. tuberculosis isolates, but mitochondria metab
academic.oup.com