Carolina Parada-Borja
@caroparadab.bsky.social
Developmental biologist studying how embryos build limbs. Permanent researcher at J. Gros lab, Institut Pasteur @pasteur.fr
Heterochronic limb patterning in marsupials reveals flexibility in the processes underlying lateral plate mesoderm morphogenesis | Science Advances www.science.org/doi/10.1126/...
Heterochronic limb patterning in marsupials reveals flexibility in the processes underlying lateral plate mesoderm morphogenesis
Accelerated limb formation in marsupials reveals canonical developmental landmarks aren’t strict prerequisites for initiation.
science.org
Closing out today's MAGIC session: Caroline Parada (Institut Pasteur) presents "Building digits: mechanochemical control of phalanx-joint development." How do our fingers actually form? A beautiful look at the precise balance of mechanics and chemistry. 🖐️🧪 #Morphogenesis #DevelopmentalBiology
After a quite long process, we are happy to share the last version of our article describing unexpected results regarding the coupling between local cell death and proliferation (heroic revision effort from @ralitzastaneva.bsky.social ) urldefense.com/v3/__https:/...
A global response contributes to tissue size robustness upon local induction of apoptosis
Tissue resilience requires tight coupling between cell proliferation, growth, and death.1,2,3,4It is assumed to be based on compensatory proliferation…
urldefense.com
🚨Job alert in theory/math devbio 🚨 I’m currently advertising postdoc positions to join my group. We’re building reaction-diffusion models to understand some of the amazing things embryos can do. We are based in a beautiful part of Scotland! Please share! www.abdn.ac.uk/jobs/vacanci...
New edition of the great Quintay Developmental Biology Course !!! More information at: biodesarrollo.unab.cl
New Pre-Print Alert! Evolving initial conditions: an alternative developmental route to morphological diversity with Shannon Taylor and @jamesehammond.bsky.social www.biorxiv.org/content/10.6...
Proud to share this work with @kevinchalut.bsky.social and Byron Mui. Why do some injuries scar while others regenerate? Using digit tip models, we show the ECM is a key driver. HA-rich ECM promotes regeneration, and boosting it can shift healing away from fibrosis. www.science.org/doi/10.1126/...
science.org
🚨 Why can’t mammals regenerate limbs like frog tadpoles or salamanders? In our new paper in @science.org , we show that species-specific oxygen sensing acts as a gatekeeper for initiating limb regeneration 🐭🐸 🔗 www.science.org/doi/10.1126/... #EvoDevo
Species-specific oxygen sensing governs the initiation of vertebrate limb regeneration
Why mammals cannot regenerate limbs like amphibians do presents a long-standing puzzle in biology. To uncover the underlying differences, we compared amputation responses of embryonic mouse (Mus musculus) and Xenopus laevis tadpole limbs. Lowering ...
science.org
We updated our manuscript "Mechanochemical instabilities drive digit morphogenesis in organoids" on BioRxiv. Integration of our novel organoids and mathematical modeling revealed that the emergence of digit morphogenesis could be explained as "fingering instability". www.biorxiv.org/content/10.1...
biorxiv.org
Amazing work. Bravo Pedro and team!
Pedro Hernandez@zebragut.bsky.social · 4mo agoVery happy to share this study from our group and colleagues now out in Science! We found that in zebrafish, before the immune system is mature, gut epithelial cells perform immune functions by producing the cytokine IL-22 to shape the microbiota to promote early life gut function #Zebrafish #Gut
In Tokyo, excited for the “Limb Development and Regeneration” conference starting tomorrow!
Final version @nature.com of our paper describing unconventional multicellular development in a choanoflagellate inhabiting an extreme environment. A ton of new data since the first @biorxivpreprint.bsky.social preprint (which we've kept updating). A brief 🧵 (carried over from the old place)
Nature Portfolio@natureportfolio.nature.com · 5mo agoA study in Nature shows that the single-celled form of a tiny, aquatic organism can turn into a multicellular version by three different routes. The discovery adds insight to the possible origins of multicellular life, suggesting a previously unrecognized degree of flexibility. 🧪
Apply now: Connections to Sustain Science in Latin America Symposium 2026 in São Paulo (Aug 25–27). For early/mid-career researchers across the Americas. Travel fully funded. Apply by Apr 15: https://ow.ly/ZzMy50Yqb4i #NASEMCapacity #LatinAmerica #LAConnections
🔬✊ One year later, we #StandUpForScience again. Attacks multiply. Funding shrinks. But our determination doesn't. Science isn't opinion, it's the foundation of democracy. Institut Pasteur researchers are mobilizing. Join us. #StandUpForScience2026 #ScienceMatters #ResearchMatters
One year after, we Stand Up for Science one more time at @pasteur.fr #StandUpForScience @standupforscifr.bsky.social ✊
Tissue phase transitions in development: more than just mechanics url: journals.biologists.com/dev/article-...
Tissue phase transitions in development: more than just mechanics
Summary: Tissue material phase transitions are classically thought to regulate tissue deformability. This Review emphasises their unexpected roles in directly influencing growth and patterning signall...
journals.biologists.com
🟣 Today, on the International Day of Women and Girls in Science ( #11February), we’re excited to share a milestone: women PIs are now the majority at the #PRBB for the first time. 1/6 #WomenInSTEM #SomPRBB
Most of the principal investigators in the PRBB are women - El·lipse
The upward trend of previous years continues, with women now holding 51% of senior positions in research groups.
ellipse.prbb.org
Ancient origin of the dorso-ventral patterning system of vertebrate paired fins https://www.biorxiv.org/content/10.64898/2026.02.08.704681v1
I’m pleased to share our latest preprint (my first as 1st-author) from Jérôme Gros’ group (@jeromegros.bsky.social), now on bioRxiv. It reports actin and myosin dynamics during epithelial remodeling in avian gastrulation. (doi: doi.org/10.64898/202...)
Actin and myosin dynamics during epithelial remodeling in avian gastrulation
Epithelial remodeling is powered by contractile forces exerted by the actomyosin cytoskeleton. In invertebrates, pulsatile contractile flows of the medio-apical actomyosin cortex have been shown to be...
doi.org
🥳🥳🥳 Pretty fab start to 2026!!
Franze Lab@franzelab.bsky.social · 7mo agoPaper alert: Our study led by @evapillai.bsky.social and @sudimukherjee.bsky.social showing that mechanical properties of the #brain actively shape the molecular landscape during development and #axonpathfinding is finally out! www.nature.com/articles/s41... @pdncambridge.bsky.social @fau.de @MPZPM
Preprints without borders 🌎 Carolina Tanigushi explains how @scielo.org & SciELO Preprints boost #OpenScience across Latin America & beyond, increase visibility for regional research + what (early-career) researchers can do to benefit. Read the interview: prelights.biologists.com/news/preprin...
Preprints without borders: SciELO Preprints’ push for multilingual, Open Science in Latin America and beyond - preLights
preLights recently spoke with Carolina Tanigushi who now looks after SciELO Preprints, the preprint server that is part of the SciELO Network. We talked about SciELO’s shift into an Open Science progr...
prelights.biologists.com
Want to discover LimbNET? 🦵 A platform created by EMBL Barcelona scientists to visualize limb development. Explore the “Morphomovies” 👉 tuit.cat/M8Kjg
LimbNET, an open platform to visualise limb development - El·lipse
A new open access platform for the limb development community will close the gap between experiments and mathematical models.
tuit.cat
Register now for the EMBO Workshop "Limb development and regeneration: Quantitative, ecological, and diversification studies" in #Tokyo, Japan, 23–27 March 2026. Abstract submission/Registration deadline: 12/15 December 2025 https://meetings.embo.org/event/26-limb-dev #EMBOLimbDev #EMBOevents 🧪
Hey everyone! I’m excited to share that one of my thesis projects was just published in @currentbiology.bsky.social and featured on phys.org! In this paper, we use an old statistical approach developed by the US Navy in WW2 to predict the aquatic habits of various dinosaurs and marine reptiles 🦖🐊
The talks (in english) can be accessed from the @college-de-france.fr website. A great journey through ‘Our ancestors the fish’, from 380 Mio years ago to their hidden presence inside ourselves. Lessons #1 and #2 👇🏼 www.college-de-france.fr/en/agenda/gu... www.college-de-france.fr/en/agenda/gu...
Neil Shubin (1) | Collège de France
college-de-france.fr
The Friday crème brûlée is back! @institutpasteur.bsky.social
A newly uncovered set of 1.5-million-year-old fossils that includes the first unambiguous Paranthropus boisei hand bones are reported in Nature. The findings offer insights into the evolution of hominin hands. go.nature.com/495cW1I 🧪 🏺
transport yourself to the late 90s with this really cool paper on digit number regulation by Shh and BMP, ZPA and AER. www.pnas.org/doi/10.1073/...
Dual Bmp-negative feedback loops modulate function of both AER and ZPA to buffer and constrain postaxial digit number | PNAS
Several lines of evidence indicate that posterior (postaxial) digit number in tetrapod vertebrates is constrained to the pentadactyl state by inter...
pnas.org
