Debbie Caswell
@caswelldrm.bsky.social
UKRI Future Leaders Fellow @UCL | Lung cancer prevention laboratory
Our lab is hiring! Please come join our lab in the department of @UCLRespiratory in @uclmedsci.bsky.social We have another fully funded postdoctoral position available, focusing on delineating the earliest stages of lung cancer development 🧪! Please apply using the link below: lnkd.in/gN4UK785
This link will take you to a page that’s not on LinkedIn
lnkd.in
@caswelldrm.bsky.social is lead author of a recent opinion paper bringing tog evidence on how #lungcancer in never smokers differs in its biology & risk profile. People with no smoking history now account for a growing share of diagnoses. UK data show cases in never-smokers doubling 2008-14. #LCSM
Fears over adverse consequences and associated policy restrictions mean that pregnant people have been largely excluded from clinical trials go.nature.com/465wTDk
What drugs are safe during pregnancy? There’s a shocking lack of data
Nature - Drug trials have typically excluded pregnant people for safety reasons. But that’s now starting to change.
go.nature.com
If you are interested in how oncogenic RAS signalling influences the immune landscape of lung adenocarcinoma, our latest preprint on the subject is out on @biorxiv-cancer.bsky.social #KRAS #lung #immuno-oncology #preprint 🧪
bioRxiv Cancer Bio@biorxiv-cancer.bsky.social · 8mo agoOncogenic RAS activity is linked to immune priming and adenosine-driven immune evasion in lung adenocarcinoma https://www.biorxiv.org/content/10.1101/2025.11.25.690426v1
While smoking rates fall, lung cancer among non-smokers is on the rise. Experts discuss the need to better understand lung cancer detection and treatment in never-smokers. spkl.io/63329AtDKN @Deborah Caswell & colleagues @cp-trendscancer.bsky.social
Read "how tumours trick the #brain into shutting down cancer-fighting cells". A signalling pathway, from the tumour to the brain and back again, allows the cancerous cells to proliferate unchecked. 🧪 #Science #Biology #Cancer 1- www.nature.com/articles/d41... 2- www.nature.com/articles/s41...
In the United States and elsewhere, there’s been a major shift in patients treated for lung cancer. www.statnews.com/2026/02/11/l...
Lung cancer in ‘never-smokers’ draws new focus — and questions
In the United States and elsewhere, there’s been a major shift in patients treated for lung cancer.
statnews.com
The changes announced by a major UK science funder UKRI are putting scientists — and the future of research — in a difficult position, says John S. Tregoning go.nature.com/45ZO1KL
Science funding needs fixing — but not through chaotic reforms
The changes announced by a major UK science funder are putting scientists — and the future of research — in a difficult position.
go.nature.com
Targeting extrachromosomal DNA in human cancers www.nature.com/articles/s41... rdcu.be/e2kVS This new Review discusses ecDNA biology, challenges faced by current therapeutic and detection approaches and discoveries that highlight emerging therapeutic vulnerabilities
Targeting extrachromosomal DNA in human cancers - Nature Reviews Drug Discovery
Extrachromosomal DNA (ecDNA) drives oncogene amplification, tumour evolution and therapy resistance across cancers. This Review summarizes advances in ecDNA biology, highlights emerging therapeutic vu...
nature.com
We are hiring!! Lab Assistant II position to work with the killifish! 🐟🐟🐟 This is an amazing model to study aging and 'suspended animation' careersearch.stanford.edu/jobs/lab-ass... Come and join our fantastic team at Stanford!! 🤩 Please share!
Excited to share this review article written primarily during my mat leave. Lots of late nights with this one! Thanks to my colleague and mentor Charles Swanton and to Crispin Hiley, Cian Murphy, and Loc Carlo-Bao for all the hard work on this. Please Enjoy🧪: www.cell.com/trends/cance...
Lung cancer in never smokers: from early detection to prevention
Lung cancer in never smokers (LCINS) is a growing global health challenge. Unlike smoking-related lung cancer, LCINS is characterized by distinct epidemiological patterns and unique molecular pathogen...
cell.com
We are seeking a motivated postdoctoral fellow to investigate mechanisms of DNA damage response, APOBEC-mediated mutagenesis, innate immunity, and double-stranded RNA sensing. Located in Southern California, UCI offers an outstanding scientific environment and exceptional quality of life.
Honoured to have been included in @natcancer.nature.com's 2025 generation: www.nature.com/articles/s43...
The 2025 generation - Nature Cancer
Twelve early-career researchers who started their independent research groups in 2025 reflect on their experiences from this first year of the journey, describe the opportunities they have had and the...
nature.com
I chatted with @philiprlang.bsky.social on his podcast about how a virus might be involved in bladder cancer. Since "Phil Lang is Not a Scientist", we made this really accessible. If you're interested in how small sneaky DNA viruses might contribute to the origins of cancers, give it a listen.
Episode 13 - Simon Baker by Phil Lang is Not a Scientist
In this podcast I speak to Simon about his important research into the causes of bladder cancer, as well as his life and career.Story from Kidney Research UK about Simon's important breakthrough: http...
creators.spotify.com
Our lab is hiring! This is for a postdoctoral position @ucl.ac.uk in Respiratory Medicine. Please check out the link for more details: www.ucl.ac.uk/work-at-ucl/...
UCL – University College London
UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).
ucl.ac.uk
I am pleased to present a new paper from my lab led by Hari Shankar Sunil showing that the transmembrane serine protease TMPRSS11B promotes an acidified tumor microenvironment and immune suppression in squamous lung cancer, OUT NOW in EMBO Reports👇: embopress.org/doi/full/10....
We are recruiting two exciting #Postdoctoral roles: 🧪 Work with @clausjorgensen.bsky.social on targeting the tumour #microenvironment in #PancreaticCancer 🥼 Join @drwilliamhill.bsky.social to study air pollution & #LungCancer Full details of both positions at: www.cruk.manchester.ac.uk/careers/
Thrilled to announce I'm moving to Manchester to lead the Cancer Origins group! If you're interested in how mutations and exposures drive tumourigenesis — come join the adventure
Cancer Research UK Manchester Institute@cruk-mi.bsky.social · last yr.We are recruiting two exciting #Postdoctoral roles: 🧪 Work with @clausjorgensen.bsky.social on targeting the tumour #microenvironment in #PancreaticCancer 🥼 Join @drwilliamhill.bsky.social to study air pollution & #LungCancer Full details of both positions at: www.cruk.manchester.ac.uk/careers/
Our lab is hiring! This is for a postdoctoral position @ucl.ac.uk in Respiratory Medicine. Please check out the link for more details: www.ucl.ac.uk/work-at-ucl/...
UCL – University College London
UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).
ucl.ac.uk
🧬 Glasgow researcher Dr Alexander Raven has been awarded a prestigious UKRI Future Leaders Fellowship to advance understanding of how liver cancer develops, with the aim of improving detection and treatment 📍 University of Glasgow 👇 Learn more glasgowcityofscienceandinnovation.com/glasgow-canc...
Glasgow Cancer Scientist Awarded Prestigious UKRI Future Leaders Fellowship | Glasgow City Of Science & Innovation
Alexander Raven, an early career researcher from the School of Cancer Sciences, has been awarded one of UK Research and Innovation’s (UKRI) flagship Future Leaders Fellowships.
glasgowcityofscienceandinnovation.com
Please apply to our tenure-track faculty position at @stanford-chemh.bsky.social! We are searching for a new colleague working at the interface between computation and molecular sciences. See post below and pls forward widely! chemh.stanford.edu/opportunitie...
Faculty Recruitment
chemh.stanford.edu
My main PhD project is now up on bioRxiv! If you’re interested in somatic evolution or machine learning for simulation-based inference, read on… doi.org/10.1101/2025... [1/15]
Recovery of human upper airway epithelium after smoking cessation is driven by a slow-cycling stem cell population and immune surveillance
The upper airway epithelium in humans is maintained in homeostasis by a resident population of basal stem cells. In the presence of tobacco smoke these gain mutations that significantly increase their...
doi.org
I am thrilled to have received a UKRI Future Leaders Fellowship! This award will enable my laboratory to uncover how our body's natural antiviral defences, including APOBEC3 enzymes, contribute to the earliest stages of lung cancer. 🧪 www.ukri.org/news/ukri-an...
UKRI announces winners of £120 million Future Leaders Fellowships
Research into the causes of lung cancer and Alzheimer’s disease are among 77 projects to be funded by UKRI’s Future Leaders Fellowships.
ukri.org
A study led by @jeffreytownsend.bsky.social reveals #tobacco alters lung #adenocarcinoma evolution: smokers’ tumors favor KRAS/KEAP1/STK11, never-smokers’ favor EGFR/PIK3CA—revealing distinct treatment vulnerabilities. biorxiv.org/content/10.1... @toomuchvitamink.bsky.social
Tobacco smoke alters the trajectory of lung adenocarcinoma evolution via effects on somatic selection and epistasis
Background Tobacco smoke is a known mutagen. However, its physiological effects on the lung may also influence the somatic selective pressures acting on mutations, further shaping cancer evolution. Th...
biorxiv.org
🚨 PhD Position available in our lab 🚨 exploring the power of blood immune multi-omics to detect lung cancer years prior to clinical diagnosis in a unique cohort of >10,000 CT screened individuals. ✅ Wet & dry lab ✅ September 2025 enrolment ✅ UK tuition fees only www.ucl.ac.uk/medical-scie...
Pre-Cancer Immunology
The Pre-Cancer Immunology Lab (James Reading Lab) is mapping pre-invasive T cell dynamics during carcinogenesis to detect and intercept cancer development.
ucl.ac.uk
A study in Nature shows that respiratory viruses trigger metastatic breast cancer cells to proliferate in lungs in mouse models of breast cancer. These findings are supported by human observational data. go.nature.com/4l7NZ8l #medsky 🧪
Beautiful work!
Rémi Buisson@buissonlab.bsky.social · last yr.Today, we report that APOBEC3B targets unprotected single-stranded DNA at replication forks upon ATR inhibition, triggering a reaction cascade involving UNG2 and APE1 that leads to fork collapse and hyperactivation of PARP1, causing replication catastrophe. www.science.org/doi/10.1126/...
