Incredible to see our work out today in Cell: "Plasma signals of lung tumor promotion for molecular cancer prevention." www.cell.com/cell/fulltex...

Plasma signals of lung tumor promotion for molecular cancer prevention

A 14-protein plasma signature identifies individuals benefiting from anti-IL-1β-based lung cancer risk reduction and demonstrates how diverse tumor-promoting factors converge on the induction of an al...

cell.com

New paper in Immunity shows microplastics are disrupting efferocytosis. We're changing our environment faster than our biology can adapt. Understanding the immunological consequences of pollution is central to human health.

Polystyrene microplastic-induced pathophysiology is driven by disruption of efferocytosis

Microplastics (MPs), microparticles from plastic degradation, pose a substantial threat to human health. Macrophages, the body’s immune sentinels, are…

sciencedirect.com

Of Barriers and Loops—How Evolution Limits Most Cancer Risks to Older Ages url: aacrjournals.org/cancerdiscov...

Incredible work demonstrating a functional role for malignant cell states in preclinical lung cancer models www.nature.com/articles/s41...

Critical role for a high-plasticity cell state in lung cancer - Nature

The high-plasticity cell state (HPCS) is a critical hub that enables reciprocal transitions between cancer cell states, and targeting the HPCS may suppress cancer progression and eradicate treatment r...

nature.com

Cytokines are tricky to study, let alone in vivo. New tool to study cells that respond to cytokine receptor activation

Cell - a Cell Press journal@cp-cell.bsky.social · 7mo ago

Now online! In vivo detection of immune responses via cytokine activity labeling

It’s time to talk about epithelial geometry and cancer. How can the architecture of an epithelium affect how tumors will grow and spread? In this thread, @jorgealmagro.bsky.social

Paul Nurse describing the main job of a PI (From ‘The Thinking Game’, 2024)

6 incredible years. So grateful for the opportunity to work with such brilliant people. What an adventure. Goodbye @crick.ac.uk

To better treat cancer, we need to understand its underlying biology. Despite decades of research, some fundamental questions remain unanswered. One is why certain key tumor suppressor or oncogenes lead to cancer predominantly in single tissue: e.g. Rb in the retina, or APC in the colon 1/n 🧪

Thrilled to announce I'm moving to Manchester to lead the Cancer Origins group! If you're interested in how mutations and exposures drive tumourigenesis — come join the adventure

Cancer Research UK Manchester Institute@cruk-mi.bsky.social · last yr.

We are recruiting two exciting #Postdoctoral roles: 🧪 Work with @clausjorgensen.bsky.social on targeting the tumour #microenvironment in #PancreaticCancer 🥼 Join @drwilliamhill.bsky.social to study air pollution & #LungCancer Full details of both positions at: www.cruk.manchester.ac.uk/careers/

William Hill is presenting his work on air pollutants in lung adenocarcinoma in a fascinating session exploring ageing and environmental factors in the development and spread of lung cancer. #AACR25 | @drwilliamhill.bsky.social | @crick.ac.uk

Fantastic insight into NSCLC, going from biology to interception

Translating premalignant biology to accelerate non-small-cell lung cancer interception - Nature Reviews Cancer

While progress has been made in treating advanced non-small-cell lung cancer, patients would further benefit from methods that detect progressive premalignant lesions and strategies that effectively i...

nature.com

Imaging mass cytometry of 122 early stage lung adeno patients explores the balance of of the tumour microenvironment and changes in malignant cell fate.

Simultaneous immunomodulation and epithelial-to-mesenchymal transition drives lung adenocarcinoma progression

Lung cancer remains the deadliest cancer in the United States, with lung adenocarcinoma (LUAD) as its most prevalent subtype. While computed tomography (CT)-based screening has improved early detectio...

biorxiv.org

New to bluesky, but I’m excited to share my work over the last few years with @jbuenrostro.bsky.social! Chronic inflammation creates an epigenetic memory in colonic stem cells, priming them for tumor growth: tinyurl.com/ColitisNagar.... Here’s a walkthrough of what we found (🧵)

It is with great sadness to hear that the great Tim Radford has died. He was, unequivocally, the best science journalist, and a kind and generous man. I used his Manifesto for the Simple Scribe in lectures for student this very week. It’s faultless. www.theguardian.com/science/blog...

A manifesto for the simple scribe – my 25 commandments for journalists | Tim Radford

Former Guardian science editor, letters editor, arts editor and literary editor Tim Radford has condensed his journalistic experience into a handy set of rules for aspiring hacks

theguardian.com

I had a fantastic day at the CRUK workshop last week at the intersection between aging and cancer.

British Society for Research on Ageing@bsrageing.bsky.social · 2y ago

Can ageing research be used to prevent cancer? BSRA Chair @dweinkove.bsky.social shares his thoughts after an excellent @cancerresearchuk.org “From Biology of Ageing to Cancer Prevention”. bsra.org.uk/preventing-c... #WorldCancerDay #UnitedByUnique #Ageing #Aging

That's cool

Eric Topol@erictopol.bsky.social · 2y ago

How exercise during pregnancy can improve metabolic health of offspring: a key mediator (Serpina3c) from mother's white adipose tissue gets into fetal circulation, suppresses inflammation, as demonstrated in the mouse model www.nature.com/articles/s42... www.nature.com/articles/s42...

At individual level those who vape more likely to go on to smoke (but causality not proven) but at population level higher levels of youth vaping could mean lower levels of youth smoking - really important work from @jhb19.bsky.social showing how carefully we need to keep the evidence under review

Lion Shahab@lionshahab.bsky.social · 2y ago

New expansive CRUK-funded systematic review led by the brilliant @jhb19.bsky.social on youth transitions between vaping & smoking doi.org/10.1111/add..... It’s complex: there’s potential inverse associations between vaping & smoking at population level but positive association at individual level.

Today our study using copy number alterations (CNAs) from low-coverage WGS to predict FUTURE colorectal cancer in patients with IBD is published, details in thread! 1/5 gut.bmj.com/content/earl...

Low-coverage whole genome sequencing of low-grade dysplasia strongly predicts advanced neoplasia risk in ulcerative colitis

Background The risk of developing advanced neoplasia (AN; colorectal cancer and/or high-grade dysplasia) in ulcerative colitis (UC) patients with a low-grade dysplasia (LGD) lesion is variable and dif...

gut.bmj.com

One of my frustrations with our work to understand the causes of #cancer #cachexia as part of Cancer Grand Challenges Team #CANCAN is the limitation of animal models that don't reflect the realities of the patient population. This development helps. #LCSM #lungcancer www.biorxiv.org/content/10.1...

Concurrent PIK3CA mutant drives cachexia through inflammatory signaling in EGFR mutant lung cancer

PIK3CA mutation is frequently concurrent with known oncogenic drivers such as EGFR mutation in lung cancer, raising an interesting question about its real function. Cachexia is a systemic disease invo...

biorxiv.org

Ultrasensitive ctDNA detection for preoperative disease stratification in early-stage lung adenocarcinoma https://buff.ly/4akMe3C While further prospective validation is required, this approach could significantly enhance risk stratification and treatment planning in early-stage LUAD.

Ever wonder if the innate immune system protects against cancer in premalignancy? My lab reports that the inflammasome in bone marrow stroma suppresses Ras in preleukemic stem cells restraining lymphomagenesis. Happy to share here: www.nature.com/articles/s41...

A stromal inflammasome Ras safeguard against Myc-driven lymphomagenesis - Nature Immunology

Blander and colleagues report a homeostatic regulatory effect played by inflammasomes in the bone marrow stromal compartment that suppresses premalignant stages of lymphomagenesis.

nature.com

I'm delighted to announce that the Pharma Proteomics Project will commence full-scale proteomic profiling of the UK Biobank in 2025. We have selected the Olink Proteomics Explore HT platform and Ultima Genomics UG 100 sequencers for this unprecedented study. www.ukbiobank.ac.uk/learn-more-a...

Launch of world’s most significant protein study set to usher in new understanding for medicine

ukbiobank.ac.uk

"unlike type 1 immune responses, type 2 immunity is perceived as a potential promoter of tumorigenesis. Emerging evidence challenges this perspective, painting a more nuanced picture in which type 2 immunity might protect against or even actively suppress tumour growth and progression." #ImmunoSky

Reinventing type 2 immunity in cancer - Nature

This Review addresses the roles of type 2 immunity in cancer and the potential for cancer immunotherapies targeting this pathway.

nature.com

Metabolic changes at the interface between mutant and normal skin epidermis www.nature.com/articles/s41...

Metabolic rewiring in skin epidermis drives tolerance to oncogenic mutations - Nature Cell Biology

Hemalatha et al. track the endogenous redox ratio (NAD(P)H/FAD) with live imaging in the mouse skin to study the interface of wild-type stem cells with oncogenic mutant cells. They find that maintaini...

nature.com

Acquisition of discrete immune suppressive barriers contributes to the initiation and progression of preinvasive to invasive human lung cancer. https://www.biorxiv.org/content/10.1101/2024.12.31.630523v1

Beyond excited to share that the main work of my PhD on how aspartate signaling drives metastasis is finally out in @nature.com ✨ -> go.nature.com/4gCYtuL A huge thank to the @fendtlab.bsky.social and all our collaborators for the terrific team work 🙏 A brief 🧵

Aspartate signalling drives lung metastasis via alternative translation - Nature

Aspartate in the tumour environment activates the N-methyl-d-aspartate receptor in cancer cells to induce cellular programmes that increase the aggressiveness of metastasis.

go.nature.com

2024 was a year of exciting discoveries and scientific discussions! A thread 🪡 of this years’ publications from our lab 👇🏼

Breathing polluted air increases the risk of osteoporosis. #Science Open Access www.science.org/doi/epdf/10....

New insights for brain aging via spatial clocks and A.I.: rare, neighboring cells can have big impact (T cells for promoting inflammation + aging; neural stem cells for slowing aging) www.nature.com/articles/s41...