How does the immune checkpoint TIGIT know when to inhibit a T cell? Our new research suggests the answer is logic: TIGIT needs both its ligand, CD155, and TCR stimulation to signal. A short summary 🧵
Kate O'Donnell
@kateodonnell-lab.bsky.social
Scientist in the Department of Molecular Biology at UT Southwestern Medical Center. We investigate mechanisms of tumorigenesis. https://labs.utsouthwestern.edu/odonnell-lab
Congratulations Trudy, Luke, & team! This is fascinating new biology and a fun collaboration! This work provides new insight into the lineage plasticity underlying intratumoral heterogeneity that may lead to new therapeutic strategies in LUSC.
Trudy G. Oliver@tgoliver.bsky.social · 2mo agoExcited that this story is now published at @theaacr.bsky.social Cancer Research! #Squamous tumors have transcriptional heterogeneity that resembles normal lung cell states, including a lowly-dividing stress-resistant KRT13+ #hillock-like state driven by KLF4. aacrjournals.org/cancerres/ar...
Excited that this story is now published at @theaacr.bsky.social Cancer Research! #Squamous tumors have transcriptional heterogeneity that resembles normal lung cell states, including a lowly-dividing stress-resistant KRT13+ #hillock-like state driven by KLF4. aacrjournals.org/cancerres/ar...
KLF4 Promotes a KRT13+ Hillock-Like State in Lung Squamous Cell Carcinoma
Abstract. Lung squamous cell carcinoma (LUSC) is a basal-like subtype of lung cancer with limited treatment options. While prior studies have identified tumor-propagating cell states in squamous tumor...
aacrjournals.org
Please share this gift article from The New York Times with friends, family, sceptics, and People who think that studying weird things is a waste of money. Then follow up with meaningful discussion about what I call 'free range science'. Free without subscription. www.nytimes.com/2026/06/20/o...
Opinion | The Science That Turned Lizard Venom Into GLP-1s Is Under Attack
nytimes.com
Excited to share our latest study published in Science Advances. With the An & Zhang labs at @uthealthhouston.bsky.social, we show that monoclonal antibodies targeting PCDH7 inhibit tumor growth and enhance immune responses in multiple KRAS-mutant lung cancer models. www.science.org/doi/10.1126/...
Monoclonal antibodies targeting PCDH7 inhibit tumor growth and enhance immune responses in KRAS-mutant non–small cell lung cancer
Antibody targeting of PCDH7 inhibits tumor growth, enhances KRAS-targeted therapy response, and directs tumor immunosurveillance.
science.org
We celebrated Hari’s graduation as he moves on to start a postdoc with J. William Harbour. Good luck Hari!
Thrilled to share that I’ll be starting my lab as an Assistant Professor and Endowed Scholar in the UT Southwestern Molecular Biology Dept this Fall! 🥳 We’ll study #peroxisomes #mitochondria #metabolism via the lens of neonatology 👶🏻, a very exciting frontier in medicine! #neotwitter
new out in Nature www.nature.com/articles/s41...
Ageing promotes metastasis via activation of the integrated stress response - Nature
Ageing reprograms the evolutionary trajectory of KRAS-driven lung adenocarcinoma, limiting primary tumour growth while promoting metastatic dissemination through epigenetic activation of the integrate...
nature.com
Our lab is hiring! This is for a postdoctoral position @ucl.ac.uk in Respiratory Medicine. Please check out the link for more details: www.ucl.ac.uk/work-at-ucl/...
UCL – University College London
UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).
ucl.ac.uk
Congratulations Josh and Fred!!
Josh Mendell@mendell-lab.bsky.social · 10mo agoColliding ribosomes are potent signals of cellular stress. But do cells use ‘programmed’ ribosome collisions to regulate gene expression? I’m excited to present a new story from my lab led by Frederick Rehfeld(@fred-rehfeld.bsky.social) which revealed that the answer is YES! Read on to find out how👇
Congratulations Josh, Collette, and all coauthors!🎉
Josh Mendell@mendell-lab.bsky.social · 9mo agoRegulated decay of microRNAs plays a critical role in controlling body size in mammals! Check out our new paper in @genesdev.bsky.social and see thread previously posted with our pre-print 👇 for more info. Congrats to Collette LaVigne, Jaeil Han, and all authors! genesdev.cshlp.org/cgi/content/...
Congrats to Kate and Hari for a very nice story and wonderful collaboration! TMPRSS11B is a target of KLF4 and part of a chemo-refractory hillock-like state we see in squamous lung cancer. This gene contributes to acidified TME. More coming on the hillock state after addressing FIVE reviewers! 👇🏼
Kate O'Donnell@kateodonnell-lab.bsky.social · 9mo agoI am pleased to present a new paper from my lab led by Hari Shankar Sunil showing that the transmembrane serine protease TMPRSS11B promotes an acidified tumor microenvironment and immune suppression in squamous lung cancer, OUT NOW in EMBO Reports👇: embopress.org/doi/full/10....
I am pleased to present a new paper from my lab led by Hari Shankar Sunil showing that the transmembrane serine protease TMPRSS11B promotes an acidified tumor microenvironment and immune suppression in squamous lung cancer, OUT NOW in EMBO Reports👇: embopress.org/doi/full/10....
Congratulations to all the awardees - but especially my husband Joshua Mendell on this well-deserved recognition. VERY proud!!! 🎉
National Academy of Medicine@nam.edu · 10mo agoCongratulations and welcome to the 100 new members elected today to the National Academy of Medicine! #NAMmtg nam.edu/news-and-ins...
Super pleased to announce our latest suggesting the cell of origin for #SCLC is most likely the basal cell @nature.com, not the accepted neuroendocrine cell. Implications for the earliest events in cancer, & providing new models of tuft-like cancer. rdcu.be/eGUtj
Basal cell of origin resolves neuroendocrine–tuft lineage plasticity in cancer
Nature - Basal cells, rather than neuroendocrine cells, have been identified as the probable origin of small cell lung cancer and other neuroendocrine–tuft cancers, explaining...
rdcu.be
This is my first post here. The past few months have been challenging for science, but I enjoy learning about others' work here and wanted to share our latest study. Congrats to postdoc Shayna Thomas-Jardin on her outstanding work published in Cancer Research @theaacr.bsky.social