Congratulations to Victor S. Cortez & @catmphelps.bsky.social, grad student in the @meisellab.bsky.social, on receiving awards from @cytokinesociety.bsky.social. They will both give talks at #Cytokines2026. Read more: www.immunology.pitt.edu/news/pitt-im...

Diet soda could be sabotaging cancer treatment. Exercise could be boosting it. It all comes down to the gut microbiome. Pitt and @upmchillmancc.bsky.social researchers are figuring out how to harness gut bacteria and protists to improve cancer outcomes: www.immunology.pitt.edu/news/trust-y...

New review in @cp-immunity.bsky.social by @meisellab.bsky.social & @pitt-pmi.bsky.social ‬grad student @catmphelps.bsky.social synthesizes how exercise reshapes the immune system & the potential of exercise-based therapies for cancer, autoimmunity, and other diseases. www.cell.com/immunity/ful...

Exercising through cancer: Physical activity as medicine for cancer care

Exercising through cancer: Physical activity as medicine for cancer care

Exercise holds significant potential as an adjunct therapy in cancer, extending beyond quality-of-life improvements to influencing tumor progression, treatment response, and survival. Its clinical integration remains limited by variability in models, heterogenous interventions, and the absence of predictive biomarkers. As the field progresses, identifying molecular effectors of exercise, in addition to emphasizing practical clinical translation, is essential. This commentary highlights the anti-tumor effects of exercise and evaluates how exercise can advance from supportive care to a targeted, evidence-based component of cancer treatment.

dlvr.it

Catherine Phelps from @upmc.com representing #SITC Talks on how #exercise can improve outcome - role for #microbial #metabolite #formate on mediating #anticancer #immunity / #WIC2025 #SITC2025

What a fantastic opportunity to share our work! Thank you organizers for a great pre-conference event at #SITC25 Looking forward to even more awesome science in the days to come!

Society for Immunotherapy of Cancer@sitcancer.bsky.social · 11mo ago

Bernard A. Fox, Michael Geuenich, Catherine Phelps and other international investigators highlight groundbreaking IO advances during the 6th World Immunotherapy Council #SITC25

What a great opportunity to share our story! Thank you to all the organizers for putting this event together!

Pitt BGSA@pittbgsa.bsky.social · last yr.

Our first talk is this year’s Stephen L Phillips Scientific Achievement Awardee, Catherine Phelps @catmphelps.bsky.social (PMI) #symposium #GSR #bgsa

Check out PMI talks tomorrow at the SOM Grad Student Symposium: @catmphelps.bsky.social (in @meisellab.bsky.social ), Daria Jelic (Doug Reed lab), Kelsey Ertwine (Abby Overacre lab), @febrigunawan48.bsky.social (in Renfeng Li lab), and @dariavantyne.bsky.social !

Pitt BGSA@pittbgsa.bsky.social · last yr.

Tomorrow from 8am-6pm, The Assembly transforms into a celebration of graduate research, innovation, and sustainability at the 30th School of Medicine Graduate Student Research Symposium. See you tomorrow—bring your energy, your ideas, and join a scientific experience that is setting new standards!

Congratulations to PMI student @catmphelps.bsky.social who is the recipient of the 23rd Stephen L. Phillips Scientific Achievement award for a Pitt School of Medicine graduate student who authored the best peer-review scientific journal author this year!

Congrats, @catmphelps.bsky.social !

Pitt Program in Microbiology & Immunology@pitt-pmi.bsky.social · last yr.

Congratulations to PMI student @catmphelps.bsky.social who is the recipient of the 23rd Stephen L. Phillips Scientific Achievement award for a Pitt School of Medicine graduate student who authored the best peer-review scientific journal author this year!

Awesome write-up! 🦠 🏃‍♀️ 💨

Nature Reviews Cancer@natrevcancer.nature.com · last yr.

#ResearchHighlight In a study published in #Cell, Phelps et al. find a mechanism connecting exercise, gut microbiota & anti-tumour immunity; exercise induces microbiota to produce formate, which in turn enhances CD8+ T cell functionality. 👇

Excited to share our new publication in collaboration with Yi-Nan Gong: Gasdermin C cleavage by Cathepsin S modulates Rab7 vesicles in intestinal epithelial cells to amplify anti-helminth immunity: Immunity www.cell.com/immunity/ful...

Gasdermin C cleavage by Cathepsin S modulates Rab7 vesicles in intestinal epithelial cells to amplify anti-helminth immunity

Pandey et al. identify Cathepsin S (CTSS) as the direct protease that cleaves Gasdermin C (GsdmC) in the intestine. Type 2 immune-promoting microbes trigger CTSS-dependent GsdmC activation in intestin...

cell.com

Online now: Gasdermin C cleavage by Cathepsin S modulates Rab7 vesicles in intestinal epithelial cells to amplify anti-helminth immunity

Gasdermin C cleavage by Cathepsin S modulates Rab7 vesicles in intestinal epithelial cells to amplify anti-helminth immunity

Pandey et al. identify Cathepsin S (CTSS) as the direct protease that cleaves Gasdermin C (GsdmC) in the intestine. Type 2 immune-promoting microbes trigger CTSS-dependent GsdmC activation in intestinal epithelial cells, targeting Rab7+ vesicles, altering lipid metabolism, and modulating anti-helminth immunity, revealing a non-pyroptotic function of GsdmC in mucosal immune regulation.

dlvr.it

I am BEYOND excited to share that my PhD thesis research is officially published in Cell @cellcellpress.bsky.social. Read on for an exciting story about how #exercise promotes antitumor #immunity by modulating behavior of the #microbiome to help fight #cancer 🏃‍♀️🦠

Cell - a Cell Press journal@cp-cell.bsky.social · last yr.

Now online! Exercise-induced microbiota metabolite enhances CD8 T cell antitumor immunity promoting immunotherapy efficacy

Exercise enhances antitumor immunity and immunotherapy effectiveness by increasing microbiota-derived formate, which boosts CD8 T cell function and may serve as a biomarker of melanoma suppression @cellcellpress.bsky.social @catmphelps.bsky.social @meisellab.bsky.social www.cell.com/cell/fulltex...

Thanks @nature.com for highlighting our recent study #exercise #microbiota #cancer

Nature@nature.com · last yr.

Exercise helps the immune system to fight tumours by stimulating microbes in the gut to make a compound known as formate go.nature.com/4lIZx2m

📄🧫🔬🐭What are you reading this weekend? Check out @catmphelps.bsky.social, @meisellab.bsky.social, et al’s brand new work! #H2P

meisellab.bsky.social@meisellab.bsky.social · last yr.

Our lab just completed a +6 year #marathon, describing for the first time that the #microbiome is critical for #exercise - induced increases in antitumor CD8 T cell immunity and improved of #cancer #immunotherapy. www.cell.com/cell/fulltex...

Now online! Exercise-induced microbiota metabolite enhances CD8 T cell antitumor immunity promoting immunotherapy efficacy

Exercise-induced microbiota metabolite enhances CD8 T cell antitumor immunity promoting immunotherapy efficacy

Exercise enhances antitumor immunity and immunotherapy effectiveness by increasing microbiota-derived formate, which boosts CD8 T cell function and may serve as a biomarker of melanoma suppression.

dlvr.it

Our lab just completed a +6 year #marathon, describing for the first time that the #microbiome is critical for #exercise - induced increases in antitumor CD8 T cell immunity and improved of #cancer #immunotherapy. www.cell.com/cell/fulltex...

Exercise-induced microbiota metabolite enhances CD8 T cell antitumor immunity promoting immunotherapy efficacy

Exercise enhances antitumor immunity and immunotherapy effectiveness by increasing microbiota-derived formate, which boosts CD8 T cell function and may serve as a biomarker of melanoma suppression.

cell.com

I am BEYOND excited to share that my PhD thesis research is officially published in @cellpress.bsky.social today. Read on for an exciting story about how #exercise promotes antitumor #immunity by modulating behavior of the #microbiome 🏃‍♀️🦠 authors.elsevier.com/c/1lPCrL7PXu...

The remarkable benefit of exercise was just extended to improved survival after cancer in a randomized trial @nejm.org nejm.org/doi/full/10....

A first-of-its kind study adds powerful new evidence to research showing that exercise improves cancer survival. Here's what the trial, in people treated for colon cancer, showed.

Exercise Extends Life for People With Cancer, Study Shows

The trial, in people treated for colon cancer, showed clear evidence that an exercise program lowered the risk of disease recurrence and death.

trib.al

not posting much these days…but this is just too positive not to share- 2 of my trainees (current) Catherine (@Catmphelps.bsky.social) and (former) Mackenzie received the AAI Trainee Achievement Award! Could not be prouder…#WomeninSTEM

Having a great time at #AACR25 in Chicago! Join me Sunday afternoon at the Overcoming Tumor Immune Suppression Minisymposium where I'll be discussing new @meisellab.bsky.social research on #exercise, #microbiome, and cancer immunity🏃 #WICR #WomenInSTEM

So excited to be in Banff for the @keystonesymposia.bsky.social with a focus on #microbiome! Loving the views on a beautiful trail #run today... RIP to my old cramp-ons though 😆