Congratulations to @meisellab.bsky.social & @rh-lab.bsky.social on new funding from the NCI and @niaidnews.bsky.social to further research on the relationship between exercise, the gut microbiome, and cancer immunotherapy & how gut microbes influence tolerance to dietary gluten in celiac disease.

I’m truly honored and deeply grateful to receive the Young Investigator Award from the SMI. Thanks to my mentors, collaborators, trainees, and everyone who has supported our work. I’m excited to continue exploring how the intestinal microbiome shapes mucosal immunity.

Pitt Department of Immunology@pitt-immunology.bsky.social · 3w ago

Congratulations to Reinhard Hinterleitner (@rh-lab.bsky.social) on receiving the @societymucosalimm.bsky.social Young Investigator Award! #ICMI2026 Learn more about this award and Dr. Hinterleitner's research: www.immunology.pitt.edu/news/reinhar...

Congratulations to Victor S. Cortez & @catmphelps.bsky.social, grad student in the @meisellab.bsky.social, on receiving awards from @cytokinesociety.bsky.social. They will both give talks at #Cytokines2026. Read more: www.immunology.pitt.edu/news/pitt-im...

Congratulations to Alok V. Joglekar on promotion to associate professor with tenure! Learn about Dr. Joglekar his research: www.immunology.pitt.edu/news/alok-v-...

We're back with another Trainee Spotlight, this time featuring Ariadna Soto, a postdoc in the Hinterleitner Lab (@rh-lab.bsky.social) investigating how non-pathogenic gut protozoa shape immune responses in IBD and other gastrointestinal diseases. www.immunology.pitt.edu/news/trainee...

New review in @cp-immunity.bsky.social by @meisellab.bsky.social & @pitt-pmi.bsky.social ‬grad student @catmphelps.bsky.social synthesizes how exercise reshapes the immune system & the potential of exercise-based therapies for cancer, autoimmunity, and other diseases. www.cell.com/immunity/ful...

Congratulations to @pitt-immunology.bsky.social faculty and trainee recipients of @niaidnews.bsky.social funding, which will advance understanding of immune mechanisms & new approaches for diagnosing and treating inflammatory conditions & autoimmunity! www.immunology.pitt.edu/news/departm...

Good things come in threes! Please join us in congratulating @gottschalklab.bsky.social, @rh-lab.bsky.social, and @meisellab.bsky.social on promotion to associate professor! (1/2)

Congratulations to Jishnu Das for his promotion to Associate Professor with tenure! Learn more about Dr. Das and his work: www.immunology.pitt.edu/news/jishnu-...

Introducing the Pitt Department of Immunology's new quarterly newsletter, ImmunoSurveillance! We're excited to share the incredible research happening in the department and our amazing immunology community that makes it all possible. bit.ly/4j1RIok

Excited to share research co-led by Gabby & Adam in @jem.org! Grateful to the NIH & @scripps.edu for support.

Journal of Experimental Medicine@jem.org · 8mo ago

LeBlanc, Sobel, Constantinides et al. @scripps.edu show that antibiotic treatment in early life can deplete riboflavin-synthesizing commensals & impair #MAIT cell development, rendering adult animals more susceptible to bacterial #pneumonia. rupress.org/jem/article/... #Microbiome

Myeloid IL-1β and stress exert opposing control over colitis severity through the α₁-adrenergic-enterochromaffin axis, uncovering a neuro-immune-epithelial circuit that shapes intestinal inflammation @cp-immunity.bsky.social www.cell.com/immunity/ful...

How did #TyphoidMary infect dozens of people with typhoid-causing Salmonella bacteria while remaining asymptomatic? New research in mice led by Dr. Blanda Di Luccia suggests that #Tregs play a role. Learn more: tinyurl.com/28k78fw9

A very warm welcome to Dr. Blanda Di Luccia, who joined the department this month as a Research Assistant Professor! Her research focuses on understanding host-microbe interactions in the gut and how the immune system maintains tolerance during chronic infection. Learn more: bit.ly/3WXgr2V

Check out our new publication, a collaboration with Giovanni Luchetti and Vishva Dixit @ Genentech. We show that the E.coli effector NleL inhibits intestinal epithelial cell extrusion after #inflammasome activation via degrading the kinases ROCK1 and 2!! www.nature.com/articles/s41... Explainer 1/8

Enteropathogenic bacteria evade ROCK-driven epithelial cell extrusion - Nature

The bacterial ubiquitin ligase NleL evades host defence mechanisms both by inhibiting pyroptosis and by preventing infected intestinal epithelial cells from being extruded into the lumen and expelled ...

nature.com

Preview @cp-immunity.bsky.social Cutting the Gordian knot: Untangling gasdermin C from pyroptosis www.cell.com/immunity/ful... on www.cell.com/immunity/ful...

Tenure-track Assistant Professor position in Bioinformatics in the Department of Biology at the University of San Francisco usfca.wd5.myworkdayjobs.com/en-US/USF_Fu...

Assistant Professor, Tenure-Track, Department of Biology, University of San Francisco

Job Title: Assistant Professor, Tenure-Track, Department of Biology, University of San Francisco Job Summary: The Department of Biology at the University of San Francisco invites applications for a fu...

usfca.wd5.myworkdayjobs.com

Looking forward to the 23rd annual Department of Immunology retreat tomorrow! It's always a great time to catch up on #immunology research and connect with colleagues. Shout out to the organizing committee and grad student Sarah Bradley for designing this year's poster.

Congrats, @catmphelps.bsky.social !

Pitt Program in Microbiology & Immunology@pitt-pmi.bsky.social · 11mo ago

Congratulations to PMI student @catmphelps.bsky.social who is the recipient of the 23rd Stephen L. Phillips Scientific Achievement award for a Pitt School of Medicine graduate student who authored the best peer-review scientific journal author this year!

👋 Hello Bluesky! We are the Pitt Department of Immunology. From autoimmune disease and cancer immunotherapy to vaccine development to infectious disease, our work spans the spectrum of immunological science. Follow along for updates on the latest publications and other news!

Excited to share our new publication in collaboration with Yi-Nan Gong: Gasdermin C cleavage by Cathepsin S modulates Rab7 vesicles in intestinal epithelial cells to amplify anti-helminth immunity: Immunity www.cell.com/immunity/ful...

Gasdermin C cleavage by Cathepsin S modulates Rab7 vesicles in intestinal epithelial cells to amplify anti-helminth immunity

Pandey et al. identify Cathepsin S (CTSS) as the direct protease that cleaves Gasdermin C (GsdmC) in the intestine. Type 2 immune-promoting microbes trigger CTSS-dependent GsdmC activation in intestin...

cell.com

The Global Grants for Gut Health are now open. If your research explores how nutrition affects the gut #microbiome or barrier function, you may be eligible to apply for one of three grants each offering up to USD$100K. Apply here: go.nature.com/4kb9cO1 #Academicsky 🍎📃

Welcome to #InnovationsSymposium2025! We’re excited to be together again—this year on the beautiful island of Oʻahu—to hear the latest #IBD research and encourage dialogue and connections that continue to move the work forward.

Our lab just completed a +6 year #marathon, describing for the first time that the #microbiome is critical for #exercise - induced increases in antitumor CD8 T cell immunity and improved of #cancer #immunotherapy. www.cell.com/cell/fulltex...

Exercise-induced microbiota metabolite enhances CD8 T cell antitumor immunity promoting immunotherapy efficacy

Exercise enhances antitumor immunity and immunotherapy effectiveness by increasing microbiota-derived formate, which boosts CD8 T cell function and may serve as a biomarker of melanoma suppression.

cell.com

The unintended consequences of a gut microbiome transplant www.cell.com/cell/abstrac...

Microbiome mismatches from microbiota transplants lead to persistent off-target metabolic and immunomodulatory effects

Fecal microbiota transplants (FMTs) may not always effectively restore small bowel microbiota due to regional differences in gut environments, potentially causing unintended effects on metabolism and ...

cell.com

Immunoglobulin A controls intestinal virus colonization to preserve immune homeostasis www.cell.com/cell-host-mi...

Let's not forget that apart from science advocacy the Rauch lab also does kick-ass science! Together with the @psmitchej.bsky.social and Tait Wojno labs, we show that #tuftcells can induce specific protective signaling after recognition of intracellular bacterial infection via the #inflammasome!

Journal of Experimental Medicine@jem.org · last yr.

First authors Madeline Churchill and Ankit Pandeya @nkeet50.bsky.social from @rauchlab.bsky.social show that tuft cells, known for their role in anti-parasite defenses, can also contribute to anti-bacterial responses in the small intestine. rupress.org/jem/article/... #InfectiousDisease

Stand Up for Science Rally in Pittsburgh

#KSHostMicrobe25 in beautiful Banff-such an awesome meeting. Was great to talk at the @keystonesymposia.bsky.social about exciting work from the lab about how we can take advantage of the microbiota metabolites to improve cancer immunotherapy efficacy #microbiota #immunometabolism #cancer

Homeostatic antiviral protection of the neonatal gut epithelium by interferon lambda: Cell Reports www.cell.com/cell-reports... Newborns lack immune memory to viral pathogens, so wouldn't it make sense to pre-emptively turn on antiviral defenses in barrier tissues such as the intestine at birth?

Homeostatic antiviral protection of the neonatal gut epithelium by interferon lambda

Enteric viral infections are a major public health problem in newborns. Ramirez Reyes et al. find that the immature intestinal epithelium of newborn mice is developmentally programmed for the homeosta...

cell.com