Our structure determination of a dopamine-binding DNA aptamer yielded surprising results. The structure had only 2 Watson-Crick base pairs, but lots of base pairs normally only seen in RNA folds. Check out our crazy DNA structure in the recent bioRxiv preprint, along with other binding details.

bioRxiv Biochemistry@biorxiv-biochem.bsky.social · 8mo ago

Unconventional DNA architecture in a dopamine-bound aptamer complex https://www.biorxiv.org/content/10.1101/2025.11.27.690961v1

Functional relevance of CASP16 nucleic acid predictions as evaluated by structure providers https://www.biorxiv.org/content/10.1101/2025.04.15.649049v1

Welcome to the new Bluesky account for the Bordeaux RNA Club @rnabordeaux.bsky.social We will soon be announcing details for the next symposium to be held 17-18 June.

We are looking to hire: 1. Skilled molecular biologist, specific expertise in SELEX or aptamers 2. Computational biologist wanting to take deep seq training data to crack the aptamer-target prediction problem My DMs are open - it is to drive this project forwards: www.nature.com/articles/s41...

Quantifying metabolites using structure-switching aptamers coupled to DNA sequencing - Nature Biotechnology

Metabolites can be quantified using a combination of aptamers and DNA barcodes.

nature.com

Now official: We have another opening for a fully funded #PhDposition in the Beusch lab (www.beuschlab.org) at @uniwuerzburg.bsky.social! More details here: tinyurl.com/947xcw85 If you or someone you know is curious about #splicing please apply or contact me for more information! #RNAsky #RNAbiology

Architecture and RNA binding properties of the trypanosome nuclear cap-binding complex - key complex in the parasite’s RNA metabolism. Final peer-reviewed version is public! #RNAsky #trypsky www.nature.com/articles/s41...

Structural basis of Spliced Leader RNA recognition by the Trypanosoma brucei cap-binding complex - Nature Communications

Bernhard et al. reveal the architecture of the tetrameric Trypanosoma brucei nuclear cap-binding complex. Using cryo-electron microscopy and biochemical assays, the researchers characterize its bindin...

nature.com

My NMR center is looking for a new staff scientist. It’s an amazing work environment at Uppsala University, Sweden. Come join us! www.uu.se/en/about-uu/...

NMR research engineer - Uppsala University

NMR research engineer , Disciplinary Domain of Science and Technology, Faculty of Chemistry, Department of Chemistry - BMC, Uppsala University

uu.se

It's been great working with the groups of @mazna.bsky.social and Davide Mercadante on this project. And already looking forward to the next experiments on eIF4B

bioRxiv Biophysics@biorxiv-biophys.bsky.social · 2y ago

Disordered regions of human eIF4B orchestrate a dynamic self-association landscape https://www.biorxiv.org/content/10.1101/2024.06.21.600094v1

First night at the yearly conference in the Swiss Alps after a lively poster session. The scenery is as pretty as always, and the snow this year looks great!

A Post Doctoral position is open in my team @AFMBLab . We are looking for motivated researchers to help us understanding viral replication mechanisms in membranes by emerging RNA viruses. See the call in here => www.afmb.univ-mrs.fr/offre-de-con...

Happy to share our research on using AlphaFold2 to predict how peptides from disordered regions bind proteins, just published in NatureComms rdcu.be/dwlLa Work done with Hélène Bret and Raphael Guerois and for the revised version with great contributions from @diegozea.bsky.social and Jinmei Gao. 🧬🧶

Interested in small molecules 🧪 ⚗️ & 3D macromolecular structures? 'Accessing Enhanced Small Molecule Information in the Protein Data Bank in Europe' by @preeti_cy (Winter 2023 @RSC_CICAG Newsletter) ⬇️ Quick read ⬇️ www.rsccicag.org/newsletters....

We’re delighted to have joined BlueSky to engage with the scientific community about macromolecular structures and related data. Follow us for updates on PDB and #AlphaFold DB databases, more info on our resources such as #PDBeKB, and for lots of beautiful structure images!