Very happy to see this new and improved IG genetic resource for Rhesus Macaque published today in Immunity! An enjoyable and fruitful collaboration with Steve Bosinger & team (Emory), @guryaari.bsky.social, @ayeletperes.bsky.social and @williamlees.bsky.social - More to come! doi.org/10.1016/j.im...

Happy to see this work on IG light chains from @e-engelbrecht1.bsky.social in press www.nature.com/articles/s41... How else will germline variation impact the expressed repertoire? Can't wait to see! Thanks to awesome collabs: @williamlees.bsky.social @guryaari.bsky.social @ayeletperes.bsky.social

If you thought human IG was complicated, ruminant IG wants to change your mind! Awesome overview of the ruminant IG genomic landscape by Yana Safonova (Penn State) www.annualreviews.org/content/jour...

Immunogenomics Approaches to Studying Antibody Repertoires and Vaccine Responses in Ruminants

Ruminant species are vital for agriculture, ecosystems, and conservation and remain vulnerable to infectious and zoonotic diseases. Advances in genome sequencing and genomics now enable high-resolutio...

annualreviews.org

🧬 VDJbase and OGRDB: 3000+ IG/TR samples across human and rhesus macaque with curated AIRR-seq and long-read genomic data. LET'S CHANGE THE WAY WE UTILIZE IG/TR GENOMIC AND REPERTOIRE DATA! @guryaari.bsky.social @williamlees.bsky.social @ayeletperes.bsky.social academic.oup.com/nar/advance-...

The current landscape of adaptive immune receptor genomic and repertoire data: OGRDB and VDJbase

Abstract. Accurate characterization of adaptive immune receptor repertoires through high-throughput sequencing is critical for understanding immune respons

academic.oup.com

Query by ancestry, tissue, chain, or study. Explore allele usage, haplotypes, and gene presence/absence with interactive tools. Download via API or browser. Fully FAIR, MiAIRR-compliant, open, and versioned. vdjbase.org #AIRR #Immunogenetics

New manuscript out in NAR! tinyurl.com/4rrbuesn 🧬 VDJbase and OGRDB now support 3000+ IG/TR samples across human and rhesus macaque with curated AIRR-seq and long-read genomic data. From population analysis to precision annotation. @guryaari.bsky.social @cdubsig.bsky.social @williamlees.bsky.social

The current landscape of adaptive immune receptor genomic and repertoire data: OGRDB and VDJbase

Abstract. Accurate characterization of adaptive immune receptor repertoires through high-throughput sequencing is critical for understanding immune respons

academic.oup.com

LifeSciKY has welcomed three biotech startups to the new OneNKY Center in Covington. Learn more about the companies and their work in cancer research, immune profiling, and fertility innovation. linknky.com/business/ent...

LifeSciKY welcomes three biotech startups to Covington’s new OneNKY Center

LifeSciKY’s new lab at the OneNKY Center in Covington welcomed three biotech startups focused on cancer therapy, genomics and fertility.

linknky.com

Excited to see our work on IGHC diversity out! Huge shoutout to @uddalok.bsky.social for leading this study. 🧬 The data is now available on VDJbase, our open resource for exploring B and T cell germline variation across populations. 🧑‍🔬 Go and Explore vdjbase.org! #immunogenetics #VDJbase

Corey Watson@cdubsig.bsky.social · 9mo ago

Happy to announce the publication of our work exploring under-appreciated genetic diversity in the human IGHC region. Awesome work by @uddalok.bsky.social. So grateful for our amazing co-authors. @williamlees.bsky.social @guryaari.bsky.social @ayeletperes.bsky.social www.cell.com/cell-genomic...

Happy to announce the publication of our work exploring under-appreciated genetic diversity in the human IGHC region. Awesome work by @uddalok.bsky.social. So grateful for our amazing co-authors. @williamlees.bsky.social @guryaari.bsky.social @ayeletperes.bsky.social www.cell.com/cell-genomic...

The human IG heavy chain constant gene locus is enriched for large structural variants and coding polymorphisms that vary among human populations

Genetic variation within immunoglobulin heavy chain constant (IGHC) genes modulates interactions between antibodies and other immune receptors and effector cells, directing cell killing and the cleara...

cell.com

'The mechanisms controlling the inclusion of new B cell clones into spontaneous germinal centers (GCs) remain unclear. Using CRISPR-Cas9, we generated 2 autoreactive B cell receptor knock-in strains, M05 and G55, based on B cell receptors from WT GC B cells in WT:564Igi chimeras'

Dynamic control of autoreactive B cells from spontaneous germinal centers

Abstract. Systemic lupus erythematosus is characterized by activation of many self-reactive B cell clones that produce autoantibodies. This can be modeled

academic.oup.com

I've got a PSA to the T cell receptor researchers of #immunosky to let you know about a new paper we've just got out: doi.org/10.1016/j.im... This covers how our field is handling the sets of germline #TCR genes used in our research. Maybe not the most glamorous topic, but it’s kind of a big deal…

FFS.

Robert Reich@rbreich.bsky.social · 11mo ago

The CDC is gutting a program that monitors foodborne illnesses. The program will now only track infections caused by two pathogens, rather than eight. Hello? How does this “Make America Healthy Again”?

Hi. If you're interested in learning more about the state of play in IG and T cell receptor gene curation, check out these articles: www.sciencedirect.com/science/arti... @jamieheather.bsky.social @guryaari.bsky.social @williamlees.bsky.social @ayeletperes.bsky.social @elisarosix.bsky.social

The gremlin in the works: why T cell receptor researchers need to pay more attention to germline reference sequences

The rise of T cell receptor (TCR) sequencing technologies is driving both new understandings of the immune system and the development of novel clinica…

sciencedirect.com

Check out this week's newsletter, featuring @clareobio.bsky.social!

Clareo! Aging, RPM and more...

Neat!

liverpoollane.beehiiv.com

Thrilled to be featured in GenomeWeb! 🧬 Stuck behind the paywall? We got you. Here's the TL;DR on how Clareo is pioneering the next generation of immune profiling with full-length antibody sequencing. Find it here: lnk.bio/clareobio #Biotech #Genomics #LongReads #Immunology

🌟 Meet "Rosie" - our new @pacbio.bsky.social Vega sequencer! Named after Rosalind Franklin, she'll supercharge our ProfilAIR & GenotypAIR services with faster, more comprehensive B & T cell receptor profiling. Better data = better biomarkers, faster vaccine design, and more precise therapeutics!

Big win for science: The US senate rejects 40% cuts to NIH funding and instead proposes $400M increase. A clear sign that Congresd is standing behind biomedical research www.nature.com/articles/d41...

‘Congress has your back’: US senators tell scientists they want to protect NIH budget

Senate budget bill includes small increase for the health-research agency — but faces a long road before being signed into law.

nature.com

Pospelova et al. present a comparative analysis of full-length sequences of IG/TR loci across 46 mammalian species, demonstrating these as rapidly evolving genomic regions, with implications for immunogenomics. 🔗 doi.org/10.1093/molbev/msaf152 #evobio #molbio

Know an Evolutionary Genomicist looking for a faculty position? Join us in EEB @utknoxville.bsky.social Position is open for studying any organism, but personally I have some botany bias. 🌱 Apply before Sept 19 for full consideration. apply.interfolio.com/170735 Please share widely. Thanks!

Are you an immunologist working towards your first R01? Please join @aai.org and take advantage of programs like our Grant Review for Immunologists Program www.aai.org/Careers/GRIP We pair early career principal investigators with established mentors. Send me a chat for more info

5/6 What can we do now? We outline strategies in the paper: ✔️ Clear, provisional reporting formats ✔️ Transparent criteria for future naming ✔️ Global dialogue to shape consensus Let’s build something better—together. 🧠🌍 iuis.org/committees/n...

T-cell Receptor and Immunoglobulin Nomenclature Sub-Committee » IUIS

Since this Sub-Committee has not addressed MHC/HLA nomenclature for several decades, the name of the Sub-Committee has been changed to “T-cell Receptor and Immunoglobulin Nomenclature Sub-Committee”…

iuis.org

6/6 📄 Read the full commentary: “Challenges for the Immunoglobulin and T cell receptor gene nomenclatures in the modern genomics era” 👉 www.sciencedirect.com/science/arti... ✍️ By Andrew Collins, @cdubsig.bsky.social, Luc Teyton, Henk-Jan van den Ham, Elisa Rosati, @yanasafonova.bsky.social

Challenges for the Immunoglobulin and T cell receptor gene nomenclatures in the modern genomics era

For over thirty years, an approach to the nomenclatures of human immunoglobulin (IG) and T cell receptor (TR) genes has operated successfully and has …

sciencedirect.com

1/6 🧬 NEW COMMENTARY 🧬 Let’s talk about the challenges in immunoglobulin (IG) & T cell receptor (TR) gene nomenclature in the era of modern genomics. A 🧵 on why it’s time to rethink how we name these genes—and what it means for immunogenetics. #IGTR #Genomics #Immunology

An overview of the future of IG and TR gene nomenclature www.immunoinformaticsjournal.com/article/S266... @yanasafonova.bsky.social @elisarosix.bsky.social

Challenges for the Immunoglobulin and T cell receptor gene nomenclatures in the modern genomics era

Antibodies were at the forefront of protein and gene research in the 1970s and 1980s [1–3]. At that time, every report of a new antibody gene or even a partial antibody gene was eagerly awaited, and s...

immunoinformaticsjournal.com

A major KI initiative to recruit new assistant professors with outstanding proposals in all areas of medicine, biomedicine and public health. We offer an amazing research environment, great colleagues and generous startup packages. Check it out and get working on your applications! (repost please!)

Karolinska Institutet@ki.se · last yr.

Applications are now open! We are recruiting 20 Assistant Professors in a wide range of subject areas. We're looking for early-career researchers with strong scientific merits and future potential. 🔗 All positions: ki.se/en/about-ki/...

@guryaari.bsky.social giving awesome overview of ML approaches for AIRR-seq data - FOCiS 2025 @airr-community.bsky.social

@ayeletperes.bsky.social providing excellent overview of AIRR-seq tools at FOCiS 2025 @airr-community.bsky.social

@williamlees.bsky.social highlighting useful AIRR-C resources at FOCiS 2025 in Boston @airr-community.bsky.social @focisimmunology.bsky.social

Turns out...just like in the antibody heavy chain repertoire, germline variants in the immunoglobulin lambda and kappa loci influence the composition of light chain B cell receptors! Way to go Eric @e-engelbrecht1.bsky.social !!!! www.biorxiv.org/content/10.1...

Germline polymorphism in the immunoglobulin kappa and lambda loci explain variation in the expressed light chain antibody repertoire

Variation in antibody (Ab) responses contributes to disease outcomes and therapeutic responsiveness, the determinants of which remain incompletely understood. This study demonstrates that polymorphism...

biorxiv.org