📣 #JobAlert The Faculty of Biology of @uni-freiburg.de invites applications for a Professorship (W3) for Bioinformatics and Molecular Genetics. ❗ Application Deadline: 15 August, 2026 🔗 kurzlinks.de/roi8 #Biology #Bioinformatics #MolecularGenetics
Chaitanya Dingare
@chaitanyadingare.bsky.social
Postdoctoral researcher at Cambridge University studying Developmental Metabolism | PhD at Freiburg University | 🇬🇧🇩🇪🇮🇳
New paper from the lab! We show that laminin α5 and two integrin receptors (α3, α6) team up to guide a group of cells moving together inside a living embryo (doi.org/10.1242/dev....) Congrats Anna & Nicola. Thanks to @chaitanyadingare.bsky.social and all authors, and to @dev-journal.bsky.social.
doi.org
Genetic and functional analysis in zebrafish shows that Vgll4 limits tissue growth by inhibiting Yap1–Tead–mediated activation and promoting Tead-dependent repression, providing a framework for how Hippo pathway output regulates organ size in vivo. @vlecaudey.bsky.social go.sn.pub/gxi8wg
Two distinct modes of Vgll4-mediated Tead regulation control organ size in zebrafish - Communications Biology
Genetic and functional analysis in zebrafish shows that Vgll4 limits tissue growth by inhibiting Yap1–Tead– mediated activation and promoting Tead-dependent repression, providing a framework for how H...
go.sn.pub
Mitochondrial activity directs nutrient uptake and patterning in human gastrula models. https://www.biorxiv.org/content/10.64898/2026.05.20.725854v1
It’s not review unless it comes from the Review region of France, otherwise it’s just sparkling criticism
🚨Last days to apply!🚨 The Frenster Lab is hiring to study how cell competition is regulated in early embryonic development. We use 3D Gastruloids from multiple species and have exciting crossovers of developmental and cancer biology! Join us at University of Freiburg #cellcompetition #gastruloid
I'm SO excited to see this new paper from our lab's first PhD graduate @wangjianxiong.bsky.social. An outstanding student with a promising career ahead! A PCP-independent role for Prickle1 in junctional neural tube formation. 🧪🐣 Check it out: www.nature.com/articles/s41...
Concomitant DNA hydroxymethylation and histone H2B O-GlcNAcylation are prerequisites for zygotic genome activation in mice https://www.biorxiv.org/content/10.64898/2026.04.23.720328v1
Part of my PhD thesis is published as an article. Congratulations to all the authors and huge thanks to @vlecaudey.bsky.social and everyone involved in taking this study forward and get it published.
@vlecaudey.bsky.social · 3mo agoNew paper from the lab @ @commsbio.nature.com : rdcu.be/ffjng!! A project initiated years ago by @chaitanyadingare.bsky.social and taken over by Alicia and Veronika with the help of great students and other lab members @goetheuni.bsky.social and collaborators. Enjoy the reading!!
Happy to share this work from @alexneaverson.bsky.social where she has dissected the timing and relative contribution of the organiser and its derivates to multiple aspects of early neural development: www.biorxiv.org/content/10.6...
The Frenster Lab is here! 🍾 I am so excited to start my #EmmyNoether funded group at @uni-freiburg.de this summer. Our group studies #CellCompetition dynamics during embryonic development using #gastruloids from multiple species. Thanks to the @dfg.de for creating this opportunity! FrensterLab.com
Frenster Lab | Cell Competition Dynamics
We study Cell Competition during Embryonic Development using 3D Gastruloids at the University of Freiburg. We view cells as interactive societies in development and cancer. Research, stem cells, Gastr...
frensterlab.com
Very happy to announce that I will be joining the Faculty of Biology & @cibss.bsky.social at @uni-freiburg.de as an Emmy-Noether funded group leader. We will tackle the molecular and genetic basis of developmental timing and size control using diverse Oryzias species. We are hiring at all levels !
Evo-Devo-Tempo Lab
seleit-lab.com
Hi bsky! How do cells coordinate fate with migration during development? 🐣 Turns out EMT doesn't just drive cell behaviour changes... it actively primes BMP signalling competence, creating a reciprocal coupling that drives collective invasion! (@bensteventon.bsky.social lab) tinyurl.com/2ncc8zap
Metabolic environment-driven remodeling of mitochondrial ribosomes regulates translation and biogenesis: Molecular Cell www.cell.com/molecular-ce...
Metabolic environment-driven remodeling of mitochondrial ribosomes regulates translation and biogenesis
Zheng et al. demonstrate that mitochondria remodel the structure and composition of mitochondrial ribosomes in response to metabolic state. This structural “gear-switching” mechanism fine-tunes mitoch...
cell.com
Our study, just published in #ScienceAdvances and funded by @hfspo.bsky.social, explores the post metamorphic cell composition of the sea urchin juvenile, revealing that its body is head-like. Long considered brainless creatures, they’re all brain instead! www.science.org/doi/10.1126/...
Single-nucleus profiling highlights the all-brain echinoderm nervous system
A sea urchin is a head with a brain-like organization and a vertebrate-type retinal signature.
science.org
Hi bsky! Do embryonic tissues have backup plans🔀? Gastruloids (model of body elongation) can build an axis through different cellular mechanisms when on adherent substrates instead of free floating. A case of developmental plasticity! w/ A. Delahaye & @bensteventon.bsky.social shorturl.at/v01DO
Which features of tissue flows are most robust and how do they emerge from #EpithelialMechanics? I’m @alex-plum.bsky.social (@mattiaserra.bsky.social group) and I’ll be sharing some papers on characterizing and controlling avian gastrulation flows.
Speaking of time, @osvaldo-chara.bsky.social 's lab recently developed a new method, ForSys, that uses all available dynamic information. It also tracks the elements of the tissue over time and uses their movement to further inform the stress inference algorithm. bsky.app/profile/epim...
Live imaging of late-stage preimplantation human embryos reveals de novo mitotic errors - @niakanlab.bsky.social @loke-ctr.bsky.social go.nature.com/3JdRdu8
Live imaging of late-stage preimplantation human embryos reveals de novo mitotic errors - Nature Biotechnology
A method to label cultured human embryos finds chromosome segregation errors in placenta-fated cells.
go.nature.com
Congratulations Ahmed and colleagues in the @niakanlab.bsky.social on this beautiful work tracking mitotic errors by live imaging the human embryos!
Niakan Lab@niakanlab.bsky.social · 10mo agoThrilled to see this published! Well done Ahmed on spearheading a project revealing mitotic errors in human embryos arise much later than anticipated. Thank you to collaborators @bensteventon.bsky.social Leila Muresan and all of the wonderful teams at Bourn Hall and Create Fertility clinics!
Like Wnt signalling? How about Notch? How about both together (Wntch!)... in gastruloids? Come and and apply for a PhD studentship with us in Liverpool! Applications open 30th October! tinyurl.com/3bpx3y2b
MRC DiMeN Doctoral Training Partnership: How does Wnt and Notch (Wntch) signalling coordinate cell fate assignment during gastrulation? at University of Liverpool on FindAPhD.com
PhD Project - MRC DiMeN Doctoral Training Partnership: How does Wnt and Notch (Wntch) signalling coordinate cell fate assignment during gastrulation? at University of Liverpool, listed on FindAPhD.com
tinyurl.com
A developmental atlas of zebrafish gills links early vascular patterning to adult architecture Read this #LifelongDevSI #OA Research Article by Mathieu Preußner @mathpreu.bsky.social, Virginie Lecaudey @vlecaudey.bsky.social and colleagues: journals.biologists.com/dev/article/...
Congratulations @vlecaudey.bsky.social @mathpreu.bsky.social
Development@dev-journal.bsky.social · 10mo agoA developmental atlas of zebrafish gills links early vascular patterning to adult architecture Read this #LifelongDevSI #OA Research Article by Mathieu Preußner @mathpreu.bsky.social, Virginie Lecaudey @vlecaudey.bsky.social and colleagues: journals.biologists.com/dev/article/...
1🧵 Excited to share my first PhD paper, published in @dev-journal.bsky.social What if fish gills —often overlook —hold secrets about development, patterning, and function? We uncovered how early patterning shapes adult gill architecture. journals.biologists.com/dev/article/... #DevBio #Zebrafish
New preprint from the Lecaudey lab by first authors Anna Mertens and Nicola Moratscheck, with the help of other former members including @chaitanyadingare.bsky.social uncovering the role of integrin-laminin interactions during epithelial collective cell migration!
bioRxiv Developmental Biology@biorxiv-devbio.bsky.social · 11mo agoPatterned integrin-laminin adhesion coordinates epithelial collective cell migration https://www.biorxiv.org/content/10.1101/2025.09.12.675859v1
(1/8) Very Happy to share our lab’s 3D post-implantation human embryo model, made via signalling reprograming! 🙌 Huge thanks to the entire team and our collaborators, special shout-out to @cc0447.bsky.social (led the work) and @jinjin-0101.bsky.social (comp. analysis). www.cell.com/cell-stem-ce...
Signaling reprogramming via Stat3 activation unravels high-fidelity human post-implantation embryo modeling
Enhanced STAT3 activation combined with TGF-β inhibition reprograms human PSCs into cells specifying all early embryonic lineages. Upon 3D suspension culture, these cells self-organize within 6 days i...
cell.com
www.biorxiv.org/content/10.1... late post! Parts of my PhD thesis are now in a preprint. Just imagine if each cell of your organs decides to undergo some extra divisions while being formed, how would they look and what prevents that from happening? This is exactly what I have shown in my work.
Vgll4 Proteins limit Organ Size in Zebrafish through Yap1-Dependent and -Independent Mechanisms
Precise control of organ size is crucial during development and homeostasis. Dysregulation of the underlying mechanisms can result in organ malformation and tumorigenesis. Although the Hippo signaling...
biorxiv.org
Patterned integrin-laminin adhesion coordinates epithelial collective cell migration https://www.biorxiv.org/content/10.1101/2025.09.12.675859v1
Paper alert! I am really pleased to share the final version of the work led by Irène Amblard in the team on a regulatory switch controlling Cdx2 expression during posterior body development! #regulatorylogic #devbio @mrc-lms.bsky.social @imperialmed.bsky.social
