Ever wonder why some cancer models don’t quite match real patients? Here's the truth. 🧬Knock-in mouse models show that natural mutation levels matter—and that biallelic TP53 loss is what truly drives leukemia #CancerResearch https://hsphere.pub/d3z

Happy to share my new commentary in @bloodjournal.bsky.social highlighting two papers by Di Giacomo et al. & Mimura et al. that define a novel, high-risk leukemia subtype driven by BCL11B enhancer hijacking and FOXF1 activation. www.sciencedirect.com/science/arti...

OutFOXing a FENDRR bender in T-ALL

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Abstract submission just opened for #ISEH2026 in Frankfurt. Outstanding scientific program; welcoming community; and more than double the number of short talk slots for abstract to be presented in. Looking forward to seeing you there. @isehsociety.bsky.social

ISEH - International Society for Experimental Hematology@isehsociety.bsky.social · 6mo ago

Submit an abstract by 2 April for opportunities to present your work at #ISEH2026 🏙️! With over 45 short talk slots, don't miss this opportunity to share your findings with the international scientific community. Learn more: iseh.org/Annual-Meeti...

A wonderful discussion with Anika Sijs-Szabó from Erasmus MC and Leiden University Medical Center and Roger Mulet Lazaro from Erasmus MC on their work improving the classification of #ALAL cases published in @hemasphere-journal.bsky.social . Tune in to find out how collaboration fuels discovery!

HemaSphere Journal@hemasphere-journal.bsky.social · 10mo ago

Sneak peek of the next podcast episode! Host Dr Charles de Bock chats with Aniko Sijs-Szabo and Roger Mulet-Lázaro,  co-authors of "Transcriptional profiling directs the classification of acute leukemias of ambiguous lineage into AML, B-ALL or T-ALL"

Another great conversation on NUP98-rearranged #AML and the use of #Menin inhibitors. Plus some hot tips on how to measure cytotoxicity in co-culture systems and finally, how to pronounce #MEIS1. Listen below and subscribe where ever you get your podcasts from @hemasphere-journal.bsky.social

HemaSphere Journal@hemasphere-journal.bsky.social · 11mo ago

🎙️New Episode!  Dr Charles de Bock hosts Prof Michel Zwaan and Prof Olaf Heidenreich,  two co-authors from the 2025 HemaSphere Award - Top Cited: Biology paper "The MLL-Menin Interaction is a Therapeutic Vulnerability in NUP98-rearranged AML." 🎧 https://bit.ly/3HJbmr6

🎧REPLAY! In this episode host Dr Charles de Bock discusses the role of mouse models in understanding leukemogenesis & hematopoiesis w/ Prof Richard Lock: https://bit.ly/40Ch3NP Listen & enjoy casual, insightful discussions about #hematology research.

We are honoured to welcome Professor John D. Crispino, from @stjude.bsky.social as speaker to #NDLR2026. John’s research focuses on mechanisms of #Leukemia development in children with Down syndrome and the malignant progression of #MyelodysplasticSyndrome and #MyeloproliferativeNeoplasms.

The NIC welcomes speakers Hanna Mikkola and Elizabeth Ng who will present their latest research on stem cell development and regeneration at the 20 August webinar on Human HSC Ontogeny. Register now www.iseh.org/ISEHWebinars

So the latest @hemasphere-journal.bsky.social Podcast is out! This time all about Metabolism. You can subscribe podcasts.apple.com/au/podcast/h... to get all the podcasts direct into your feed. Each is around 30 min, perfect for that commute to work.

HemaSphere Podcast

Medicine Podcast · Updated Monthly · HemaSphere is the official online, open access journal of the European Hematology Association (EHA). HemaSphere publishes exciting basic, translational, and clinic...

podcasts.apple.com

I'm pleased to share that Leukemia have published our analysis of heterogeneous responses to hypomethylating agents #HMAs in Acute Myeloid Leukaemia #AML www.nature.com/articles/s41...

Hypomethylating agents induce epigenetic and transcriptional heterogeneity with implications for acute myeloid leukemia cell self-renewal - Leukemia

Leukemia - Hypomethylating agents induce epigenetic and transcriptional heterogeneity with implications for acute myeloid leukemia cell self-renewal

nature.com

This was very happy news to arrive to today! Thank you to our authors, reviewers, and readership for your continued support. We are glad to know that everyone's hard work is well-appreciated.

Jan Cools@jancools.bsky.social · last yr.

Exciting to share the new impact factor of @hemasphere-journal.bsky.social, the #openaccess journal of the European Hematology Association (EHA). The 2024 Journal Impact Factor is 14.6 - ranking as number 5 of 99 hematology journals (Source: Journal Citations Reports, Clarivate).

🚨Today! @ 15:45, MiCo room CORAL 6  We warmly invite you to the HemaSphere Scientific Session where we will dive into 3 of our exciting + cutting-edge biology publications. Hope to see you there! 🕰️: 15:45 - 16:45 📍: Room CORAL 6, #EHA2025 🎤: https://bit.ly/4koLwXk

Don’t miss the second YERM Session on „New insights into clonal hematopoiesis“ at 10 o‘clock in Brown Hall 2! #EHA2025 #YoungEHA #Hematology

The team representing @kidscancerinst.bsky.social at #EHA2025 @hansenjk.bsky.social Faezeh Khalili, Jackie Huang, Yashna Walia

We are HemaSphere proud at #EHA2025, where 2 of our editors received special EHA awards! Congrats to Jan Cools, Ed in Chief, for the education & mentoring award; and to Mandy Lauw, Scientific Ed, for the YoungEHA award. Well deserved 👏 @jancools.bsky.social @mandylauw.bsky.social

Honoured to have been a mentee of @jancools.bsky.social who is this years #EHA2025 Education and Mentoring award winner. Amazing and recognising his unwavering support for so many researchers!

Dr C de Bock hosts co-authors Dr F Fioredda & Dr E Papadaki to discuss Guidelines for treating neutropenias. Delve into the importance of international guidelines, challenges  ➕ more. 🎧 https://bit.ly/42O9l4v. Part 1: 2023 neutropenia Guidelines, diagnosis &management #2025HemaSphereAward winner 🏆

Next up is Dr Hansen Kosasih @hansenjk.bsky.social looking at cis-regulome of AKR1C3 which activates super prodrug ACHM-025 and can eradicate T-ALL. He is speaking today at #EHA2025 molecular Hematopoiesis workshop. Plus poster PS1332 @kidscancerinst.bsky.social

For #EHA2025 our group has Phd Candidate Yashna Walia doing in vivo PDX dual gRNA screen of epigenetic regions looking into GR resistance. Check out Poster PS1334 @kidscancerinst.bsky.social

Hello #EHA2025. Happy to be here with my group this week. Connecting with old friends and colleagues and making new friends this week. Let me know if you are around!

Hello #EHA2025. Happy to be here with my group this week. Connecting with old friends and colleagues and making new friends this week. Let me know if you are around!

Looking forward to attend the #EHA2025 @hemasphere-journal.bsky.social sessions next week!

HemaSphere Journal@hemasphere-journal.bsky.social · last yr.

Attention fundamental #hematology researchers: we warmly invite you to the HemaSphere Scientific Session at #EHA2025. Dive into 3 of our exciting + cutting-edge biology publications. Mark your cals & see you there! 📆: Saturday, June 14 🕰️: 15:45 - 16:45 📍: MiCo, Room CORAL 6 🎤: https://bit.ly/4koLwXk

Heading to #EHA2025 in Milan in 1.5(ish) weeks? HemaSphere has 2 exciting sessions on the program! 📌Peer Review Workshop: Fri 13 June, 13:30 - 15:00 💡Learn + master the peer review role/process 📌HemaSphere Scientific Session: Sat 14 June, 15:45 - 16:45 💡Dive into 3 of our cutting-edge biology papers

This HemaTopic by Sci Ed C de Bock discusses using PDXs for testing leukemia therapies, focusing on PDX model maintenance, immunodeficient mice & standardized reporting for preclinical drug testing. It also ties in a recent HemaSphere podcast with Prof Richard Lock.  See both👉

New Episode! Dr. Charles De Bock hosts Prof Jan Cools, Prof Heidi Segers & Dr Margo Aertgeerts to discuss advancements in ALL treatment, challenges of relapse & innovative use of SCS to uncover genetic mutations & clonal composition. Listen to their insightful discussion 🎧 bit.ly/42N3cWx

We are recruiting!! Ads now live for a Data Coordinator and 2 Research Assistants/biobankers to join a new @ludwigcancer.bsky.social - @imm.ox.ac.uk joint initiative to prevent progression from early- to advanced blood cancer. Joint posts with Adam Mead+others in Oxford Ludwig. Links below

We have put together an amazing line-up of invited speakers and talks selected from abstracts for the 2nd Annual ISEH Mini-Symposium!!! Join us online on March 26th (free for ISEH members) to learn what’s new and exciting in Experimental Hematology!!! @isehsociety.bsky.social

ISEH - International Society for Experimental Hematology@isehsociety.bsky.social · last yr.

The Junior Faculty Committee is excited to share the full program for next week's Mini Symposium. Find out whose research earned them an oral presentation and a chance at an #ISEH2025 🏯 travel grant here 👉 www.iseh.org/2025MiniSymposium & don't forget to register!

Huge congratulations to this incredible group!!! 👏👏👏

ISEH - International Society for Experimental Hematology@isehsociety.bsky.social · last yr.

ISEH is thrilled to announce the recipients of the 2025 Society Awards, which will be presented at the ISEH 54th Annual Scientific Meeting. Read more about each award recipient on www.simplyblood.org

One week left for abstract submission!

ISEH - International Society for Experimental Hematology@isehsociety.bsky.social · last yr.

Have a research story you can't wait until #ISEH2025 🏯 in September to present? Submit an abstract to the ISEH Mini Symposium before next week's deadline! ➡️www.iseh.org/2025MiniSymposium

We are very proud of this new content spearheaded by @alessandrodonada.bsky.social! Our lab is very grateful to Alessandro for highlighting our two recent preprints.

ISEH - International Society for Experimental Hematology@isehsociety.bsky.social · last yr.

This month's #PreprintWatch covers some exciting new results on the impact of microenvironment on hematopoietic progenitors and novel approaches to long-standing questions like self-renewal and stem cell activity! Read now on https://www.simplyblood.org/