Innate immunity was long thought to be devoid of immunological memory until a landmark study a decade ago. Our new Focus Issue curates reviews and research in the field of Trained Immunity. buff.ly/OoqVRjM
Franziska Auer
@franziskaauer.bsky.social
Group Leader at Technical University Munich, Germany. Focus on 🧪 childhood cancer predisposition / leukemia / prevention / genetics / genomics 🧬
A Review in Nature Reviews Genetics examines how omics approaches and methods are improving crime scene analyses being applied for the identification of perpetrators and their relatives or victims, the prediction of phenotypic traits, and the determination of trace characteristics. 🔒
Forensic genetics in the omics era - Nature Reviews Genetics
Recent advances in forensic genetics have improved the range, precision and reliability of forensic information obtainable from biological trace material. The author reviews how non-targeted and targeted omics approaches and methods are improving crime scene analyses being applied for the identification of perpetrators and their relatives or victims, the prediction of phenotypic traits, and the determination of trace characteristics.
go.nature.com
Part 2 of the joint EHA/ISEH session at #ISEH2025 Kumamoto: Zuzana Tothova on therapeutic targeting of cohesin-mutant myeloid malignancies @isehsociety.bsky.social
New online! Methods and applications of in vivo CRISPR screening
Methods and applications of in vivo CRISPR screening
Nature Reviews Genetics, Published online: 29 July 2025; doi:10.1038/s41576-025-00873-8In vivo CRISPR screens generate high-throughput, unbiased genotype–phenotypes maps for complex biological processes that cannot be studied in vitro. This Review outlines key criteria for understanding, designing and implementing such screens and discusses their potential impact on basic and translational research.
nature.com
This is a great set of methods for studying combinatorial effects of cancer mutations on spatial phenotypes. Clever experimental design by @breinigmarco.bsky.social hijacking Visium and elegant analysis by @lomakinai.bsky.social and @elihei.bsky.social www.nature.com/articles/s41...
Integrated in vivo combinatorial functional genomics and spatial transcriptomics of tumours to decode genotype-to-phenotype relationships - Nature Biomedical Engineering
A method integrates perturbation mapping with 10X Visium spatial transcriptomics to map tumour genetic complexity and heterogeneity.
nature.com
In a new article on measles, the authors review the epidemiology, clinical presentation, and associated illnesses as well as treatment and prevention strategies. Read the full article: nej.md/4lmC1Ir #MedSky @lshtm.bsky.social
Make sure not to miss the last #YERM Session on „New frontiers in preclinical development of cellular therapies and other immunotherapies“ at 15.45 pm. #EHA2025 #Hematology Interested in actively participating in YERM next year? Check out the link below!
🚨Today! @ 15:45, MiCo room CORAL 6 We warmly invite you to the HemaSphere Scientific Session where we will dive into 3 of our exciting + cutting-edge biology publications. Hope to see you there! 🕰️: 15:45 - 16:45 📍: Room CORAL 6, #EHA2025 🎤: https://bit.ly/4koLwXk
Don’t miss the second YERM Session on „New insights into clonal hematopoiesis“ at 10 o‘clock in Brown Hall 2! #EHA2025 #YoungEHA #Hematology
🎉 Congratulations to Jon Salmanton-García on his appointment to the Young EHA Committee, representing Germany! A well-earned recognition of his dedication and expertise in hematology. Looking forward to the fresh perspectives he'll bring. #YoungEHA #Hematology #EHA2025 #Germany
BCG revaccination failed to protect HIV-negative adolescents from sustained QFT test conversion and caused more adverse reactions. by Schmidt AC, Fairlie L (...) Hatherill M et 13 al. in N Engl J Med #MedSky 👉 get more here 📖 read the article: https://www.nejm.org/doi/10.1056/NEJMoa2412381
Free online AlphaFold training on May 7, thanks to Fabian Glaser, Salomé Llabrés & Rune Matthiesen! They'll start from the very basics & explore how this powerful tool is reshaping protein science. Register here (required): forms.office.com/e/Hg3fe2Depm Open to all, feel free to share! #AlphaFold
Mutational signature catalogue (MUSIC) of DNA double-strand break repair https://www.biorxiv.org/content/10.1101/2025.04.29.650617v1
A high polygenic risk score (PRS) for screening prostate cancer was superior to a PSA test or MRI for detecting clinically significant disease (Gleason ≥7). A big step forward for supporting utility of PRS @nejm.org www.nejm.org/doi/full/10....
Assessment of a Polygenic Risk Score in Screening for Prostate Cancer | NEJM
The incidence of prostate cancer is increasing. Screening with an assay of prostate-specific antigen (PSA) has a high rate for false positive results. Genomewide association studies have identified...
nejm.org
Review @cp-trendsimmuno.bsky.social @ostunilab.bsky.social IL-1β+ macrophages and the control of pathogenic inflammation in cancer www.cell.com/trends/immun...
Once more, exciting times ahead for young_eha 🌱 It was great to finally meet in person all new members & have time to discuss all the projects. Specially excited with the kick-off of the mentorship program at the Congress 👏 📢 We have one vacancy, application is open!
Another Great Youtube Tutorials by Biostatsquid GSEA Explanation youtu.be/egO7Lt92gDY?... GSEA Interpretation youtu.be/Yi4d7JIlAsM?...
Gene Set Enrichment Analysis (GSEA) – simply explained!
YouTube video by Biostatsquid
youtu.be
Thrilled to finally share our paper on how sex hormones and sex chromosomes interact to affect B cell class-switching!🥳 Diversity & inclusion in research recruitment = better science for all!😎 Thanks to @bcellsrosser.bsky.social@emmaschambers.bsky.social@arrdept-ucldom.bsky.social for ++ hard work!🌟
Estrogen influences class-switched memory B cell frequency only in humans with two X chromosomes | Journal of Experimental Medicine | Rockefeller University Press
Sex hormones and chromosomes work in tandem to impact immune responses, with estrogen influencing class-switched memory B cell frequency exclusively in ind
rupress.org
🧪 AI-written peer reviews are quietly reshaping science. Despite bans, reviewers are using LLMs to draft critiques, raising fears about shallow analysis, lost peer insight, and the erosion of trust. As @carlbergstrom.com states in the piece "Writing is thinking." #AcademicSky
AI is transforming peer review — and many scientists are worried
Artificial intelligence software is increasingly involved in reviewing papers, provoking interest and unease.
nature.com
Es war mir eine Ehre und Freude, einen Teil beizutragen.
Bayerische Akademie der Wissenschaften (BAdW)@badw.de · last yr.Die erste Folge ist da! 🥳 #Krebs besiegen: Folge 1 - Bilder und Zellen 🎧 badw.de/die-akademie... Die weiteren Folgen erscheinen im 2-Wochen-Rhythmus. #Krebsmedizin #Krebsforschung #Brustkrebs #Leukämie #Krebsdiagnostik
Discovery of a new class of natural antibiotics with a new mode of action to address antimicrobial resistance, a major unmet need @mcmasteruniversity.bsky.social @nature.com www.nature.com/articles/s41...
A broad-spectrum lasso peptide antibiotic targeting the bacterial ribosome - Nature
A new lasso peptide antibiotic exhibits broad-spectrum activity against Gram-negative and Gram-positive bacteria by interfering with bacterial protein synthesis, is unaffected by common resistanc...
nature.com
The human RIF1-Long isoform interacts with BRCA1 to promote recombinational fork repair under DNA replication stress https://www.biorxiv.org/content/10.1101/2025.03.17.643278v1
A powerful story about familial cancers and one person's struggle with a genetic diagnosis before disease onset. Thanks to the author (Jennifer Lai Remmel) for sharing: press.asimov.com/articles/fam...
Healing My Family’s Future
How genetics and IVF empowered a family to leave cancer behind.
press.asimov.com
Structural basis for DNA double-strand break sensing by human MRE11-RAD50-NBS1 and its TRF2 complex https://www.biorxiv.org/content/10.1101/2025.03.14.643254v1
Last month I did a little experiment. I wanted to see how the exact same post would perform on both X (Twitter) and Bluesky. The results were...interesting... [Thread]
Amazing collection of reviews on developmental hematopoiesis from leaders in the field. Just out in @iseh.bsky.social journal, Experimental Hematology www.exphem.org/content/edit...
Editorial_Making_blood_Early_Hematopoietic_Development
exphem.org
#Medsky🧪#oncosky a fascinating research @NIH’s study found that cancer cells can cooperate with each other to extract and share key molecules from their environment in order to survive … www.nih.gov/news-events/... @nature.com www.nature.com/articles/s41...
Cancer cells can cooperate to grow
Scientists found that, when deprived of amino acids, cancer cells cooperated to extract and share them from their environment.
nih.gov