Excited to share our new preprint! Using D2B “degrader-first” screening, we uncovered two unexpected routes to protein degradation involving DCAF11/16 and CRL3–SPOP. Our work adds to growing evidence that TPD can extend far beyond canonical PROTAC mechanisms. chemrxiv.org/doi/abs/10.2...

Excited to share a new preprint - We identify a characterize a functional interaction between SLC15A4 and LAMTOR1, providing new insights how this transporter regulates mTOR activation & inflammatory responses downstream of endolysosomal TLRs. Congrats to the team! www.biorxiv.org/content/10.6...

The SLC15A4-LAMTOR1 interaction licenses endolysosomal TLR-mediated mTOR signaling and inflammatory cytokine production

Endolysosomal Toll-like receptors (TLRs) 7-9 are critical mediators of antimicrobial immunity, but their dysregulation drives pathogenic inflammation in autoimmune diseases such as systemic lupus eryt...

biorxiv.org

How do PTMs affect the binding of small molecule drugs to their target proteins? Great to see @dereklowe.bsky.social highlight the recent paper by the group of @chrisgparker.bsky.social in "In the Pipeline". Blog post: www.science.org/content/blog... Paper: www.nature.com/articles/s41... (1/4)

Posttranslational modifications remodel proteome-wide ligandability - Nature Chemical Biology

A chemoproteomic strategy reveals how posttranslational modifications reshape protein ligandability across the human proteome, uncovering more than 400 state-dependent interactions, including phosphor...

nature.com

Findings from Prof. Chris Parker's lab show that post-translational modifications (PTMs) can determine whether proteins bind drug-like molecules. Published in Nature Chemical Biology, the study identified 400+ proteins whose druggability depends on modification state. More: https://ow.ly/3OQj50YVecw

Happy to share the final version of this work is now out in @natchembio.nature.com. Lots of additional exciting data! Congrats to all the authors!

Posttranslational modifications remodel proteome-wide ligandability - Nature Chemical Biology

A chemoproteomic strategy reveals how posttranslational modifications reshape protein ligandability across the human proteome, uncovering more than 400 state-dependent interactions, including phosphor...

nature.com

Chris Parker@chrisgparker.bsky.social · last yr.

Excited to share a new preprint from the lab. We show that PTMs like phosphorylation & glycosylation dynamically reshape proteome-wide ligandability in cells, including proteins like KRAS. Great collaboration with the Huang Lab, @forlilab.bsky.social and BMS. www.biorxiv.org/content/10.1...

New preprint from @kutseikin.bsky.social showing how pharmacologic inhibition of SLC33A1 activates IRE1/XBP1s signaling. w/ @enriquesaez.bsky.social @chrisgparker.bsky.social @landerlab.bsky.social @forlilab.bsky.social & the Birsoy lab (Rockefeller) Check it out👇 www.biorxiv.org/content/10.6...

Congrats Ben!

National Academy of Sciences@nasonline.org · 9mo ago

Congratulations to #NASmember Benjamin F. Cravatt of @scripps.edu, winner of the 2026 NAS Award in Chemical Sciences for providing foundational insights into enzyme function and dysregulation in disease! Learn more about his discoveries: www.nasonline.org/award/nas-aw... #NASaward #chemistry

Using proximity labeling and a derivatized galectin-3, scientists in the lab of Professor Mia Huang mapped glycan–protein interactions that drive placental cell fusion, published in @pnas.org, offering new insight into placental development.

Scripps Research team identifies sugar molecules that trigger placental formation

ow.ly

How can we study target engagement and selectivity of covalent inhibitors? Which electrophilic probes are best suited to study a certain amino acid? Our study on "Profiling the proteome-wide selectivity of diverse electrophiles" is published in Nature Chemistry.(1/7) www.nature.com/articles/s41...

Profiling the proteome-wide selectivity of diverse electrophiles - Nature Chemistry

Covalent inhibitors are powerful entities in drug discovery. Now the amino acid selectivity and reactivity of a diverse electrophile library have been assessed proteome-wide using an unbiased workflow...

nature.com

During these uncertain times, I’m very happy to see that my institution, @scripps.edu has an open tenure-track Assistant Professor position. Any field in Chemistry or Biology is welcome. I’d especially love to see fellow neuroscientists apply. Please repost! apply.interfolio.com/174756

Happy to share the final version of this work out in ACS CS. Inspired by ‘binding-focused’ chemoproteomic methods, we developed a ‘function-focused’ strategy to agnostically identify degradable proteins. This was a big team effort led by @inesforrest.bsky.social and in collaboration with AbbVie.

Proteome-Wide Discovery of Degradable Proteins Using Bifunctional Molecules

Targeted protein degradation (TPD) is an emergent therapeutic strategy with the potential to circumvent challenges associated with targets unamenable to conventional pharmacological inhibition. Among ...

pubs.acs.org

Check out our recent collaboration with @abbvie.bsky.social in @cp-cellchembiol.bsky.social. We identifed compounds that potently clear tau aggregates. After chemoproteomics and functional studies, we found it covalently targets ER protein P4HB (after metabolic activation).

Discovery of a tau-aggregate clearing compound that covalently targets P4HB

The improper folding and aggregation of tau are linked to several neurodegenerative diseases affecting millions worldwide. However, the pathogenesis o…

sciencedirect.com

Happy to share the finalized version of this work out in @angewandtechemie.bsky.social. onlinelibrary.wiley.com/doi/10.1002/...

Fully‐Functionalized Natural Product Probes to Expand the Chemical Tractability of the Human Proteome

Herein, we exploit the inherent structural complexity of natural products (NPs) to access a unique library of photoaffinity (PA) probes, which we term fully functionalized natural products (FFNPs). U...

onlinelibrary.wiley.com

Chris Parker@chrisgparker.bsky.social · 2y ago

Check out our recent efforts in chemrxiv to expand the chemical tractability of the proteome through NP-inspired photoaffinity probes chemrxiv.org/engage/chemr...

Happy to share our contribution to this special issue dedicated to "Proximity-Induced Chemical Biology". We provide our take on targeted protein acetylation. Nice work Wesley and Roy! pubs.acs.org/doi/10.1021/...

Targeted Protein Acetylation Through Chemically Induced Proximity

ConspectusProtein acetylation is a pervasive and reversible post-translational modification (PTM) that impacts various protein features including stability, localization, and interactions and regulate...

pubs.acs.org

Congrats to Benjamin Cravatt on receiving the 2025 Tetrahedron Prize for Creativity in Bioorganic & Medicinal Chemistry from @elsevierconnect.bsky.social, honoring his pioneering activity-based protein profiling (ABPP) to study and target disease-relevant proteins.

Benjamin Cravatt awarded Tetrahedron Prize for Creativity - Scripps Research Magazine

Benjamin Cravatt, the Norton B. Gilula Chair in Biology and Chemistry at Scripps Research, will receive the 2025 Tetrahedron Prize for Creativity in Bioorganic and Medicinal Chemistry. Established in ...

magazine.scripps.edu

Excited to share a new preprint from the lab. We show that PTMs like phosphorylation & glycosylation dynamically reshape proteome-wide ligandability in cells, including proteins like KRAS. Great collaboration with the Huang Lab, @forlilab.bsky.social and BMS. www.biorxiv.org/content/10.1...

Post-Translational Modifications Remodel Proteome-Wide Ligandability

Post-translational modifications (PTMs) vastly expand the diversity of human proteome, dynamically reshaping protein activity, interactions, and localization in response to environmental, pharmacologi...

biorxiv.org

“Probing the proteome” www.nature.com/articles/s41...

Probing the proteome - Nature Biotechnology

Chemical proteomics has brought rigor to covalent drug discovery and drugs to the clinic. Can it deliver a new generation of drug targets?

nature.com

A big congratulations to the newly minted Dr. Forrest @inesforrest.bsky.social. Super proud! A big thanks to her committee members @michael-erb.bsky.social @wisemanlab.bsky.social @fleurmferguson.bsky.social @shenvi.bsky.social

Published an op-ed for @cnn.com: “Nobel laureate: I owe America my success. Today, its scientific future is in danger.” A personal reflection on what’s at stake as science funding gets slashed. I’d be grateful if you could amplify both in and beyond the science world. www.cnn.com/2025/04/09/h...

Nobel laureate: I owe America my success. Today, its scientific future is in danger | CNN

Dr. Ardem Patapoutian says he watches “with deep sadness as the United States’ remarkable scientific enterprise, which took generations of hard work and national investment to build, faces a concerted...

cnn.com

Beyond thrilled to share that my PhD work is now available as a preprint! 🥳 A huge thank you to my amazing colleagues, mentors and collaborators at @scripps.edu and @abbvie.bsky.social who supported and contributed to this project!

Chris Parker@chrisgparker.bsky.social · 2y ago

Happy to share a new preprint from our group in collaboration with AbbVie led by graduate student @inesforrest.bsky.social www.biorxiv.org/content/10.1...

The sun is shining in London for the first day of #ABPP2025 ! Really excited to welcome everyone to the Crick later with an incredible lineup for the first session @abpp2025.bsky.social

Happy to share a new preprint from our group in collaboration with AbbVie led by graduate student @inesforrest.bsky.social www.biorxiv.org/content/10.1...

Proteome-Wide Discovery of Degradable Proteins Using Bifunctional Molecules

Targeted protein degradation (TPD) is an emergent therapeutic strategy with the potential to circumvent challenges associated with targets unamenable to conventional pharmacological inhibition. Among ...

biorxiv.org

🚨 Rational discovery of VHL molecular glues. New Preprint from @amgen.bsky.social Induced Proximity group led by postdoc Jonathan Bushman reports the discovery of a VHL molecular glue degrader of GEMIN3 by Picowell RNA-seq. Read on for details. 🧵1/8 www.biorxiv.org/content/10.1...

Discovery of a VHL molecular glue degrader of GEMIN3 by Picowell RNA-seq

Targeted protein degradation (TPD) is an emerging therapeutic modality in which small molecules are used to recruit targets to the natural protein degradation machinery of the cell. Molecular glue deg...

biorxiv.org

OpEd by @scripps.edu Pres. Pete Shultz: "the consequences would extend beyond Scripps Research, threatening the broader San Diego life sciences ecosystem, which contributes over $27 billion to the regional economy and supports tens of thousands of jobs." www.sandiegouniontribune.com/2025/02/25/o...

Opinion: Science funding cuts are based on flawed logic. Here’s the truth.

Earlier this month, the National Institutes of Health issued supplemental guidance indicating it would immediately impose a 15% cap on indirect costs for research grants, an unprecedented and abrup…

sandiegouniontribune.com

I’m a standing member on the Chemical Biology and Probes (CBP) NIH study section that was supposed to meet tomorrow. It just got postponed this afternoon with a date yet to be determined….

🚨 Chemical Biology & Probes study section (formerly SBCB, one of two NIH panels that reviews chemistry #chemsky 🧪) was abruptly POSTPONED w/no specific plans for rescheduling, less than 24h before start. If this affects you call your reps & senators, talk to local news, make your voice heard 📢 👩‍🔬

Today in @nature.com we share our back-to-back stories with Ning Zheng’s lab revealing chemical-genetic convergence between a molecular glue degrader & E3 ligase cancer mutations. 1/5

Check out our recent efforts in chemrxiv to expand the chemical tractability of the proteome through NP-inspired photoaffinity probes chemrxiv.org/engage/chemr...

Insightful perspective by the group of Ben Cravatt with first author @xiaoyuzhang.bsky.social in @nchembio.bsky.social. They discuss reasons, why expanding the repertoire of E3s for TPD has converged on few "frequent hitters" and how additional E3 targets could be identified. doi.org/10.1038/s415...

Congrats Ben!!!

Scripps Research@scripps.edu · 2y ago

Congratulations to Scripps Research Prof. Benjamin Cravatt, PhD, on receiving the 2025 William H. Nichols Medal from @amerchemsociety.bsky.social for his pioneering work in activity-based protein profiling, advancing drug discovery for cancer & neurological disorders.