Cryo-ET is often framed as a tool for in situ protein structure. But what if the real revolution is contextualization? I explore how #teamtomo is redefining what "local" means in organelle biology, revealing membrane states rather than just protein structures. tinyurl.com/localmembrane

Think globally, act locally: Redefining organellar membrane environments through cryo-electron tomography

Early enthusiasm for the “cellular revolution” in cryo-electron tomography (cryo-ET) was largely driven by the promise of resolving protein structures…

sciencedirect.com

The Lippi lab is hiring a postdoctoral associate! We built new technologies to study post-transcriptional regulation in the healthy and diseased brain. We are recruiting motivated and talented scientists who will use these tools to discover new biology and new therapies.

We identified the maltoside detergent DM as an effective and easy solution to address preferred orientation in cryo-EM. Helped me switch from graphene grids. Special congrats to Maria Rafiq! @landerlab.bsky.social @nanigrotjahn.bsky.social @wisemanlab.bsky.social #cryoEM doi.org/10.64898/202...

Excited to share that our lab’s first preprint is now available! This work reflects a huge effort from graduate student Abeera Mehmood and coauthors! If you are interested in what B cells make all antibodies against norovirus take a look! www.biorxiv.org/content/10.6...

We're hiring at NTU SBS, Singapore. Tenure-track faculty position in Biomedical Data Science (computational biology, AI in biology, bioinformatics). Great infrastructure, great place to do science. Please share. apply.ap1.interfolio.com/119013

🆕 publication! The @gekaragoz.bsky.social lab shows how cells clear stalled ribosomes at the ER, preventing harmful 'traffic jams' during protein synthesis🚦Their new @embojournal.org study reveals how quality control and UFMylation team up to keep translation moving ➡️ tinyurl.com/2czj8fvp

I’m excited to share that our review article, co-authored with my colleague Dr. Decio Eizirik, is out today in Science Translational Medicine. www.science.org/doi/10.1126/...

Beyond bystanders: How β cell stress shapes the autoimmune response in T1D

β cell stress not only drives loss of functional β cell mass but also may fuel autoimmunity in type 1 diabetes.

science.org

Pharmacological Inhibition of SLC33A1 Promotes Endoplasmic Reticulum Hyperoxidation and Induces Adaptive IRE1/XBP1s Signaling https://www.biorxiv.org/content/10.64898/2026.02.17.706344v1

SLC33A1 exports oxidized glutathione to maintain endoplasmic reticulum redox homeostasis https://www.biorxiv.org/content/10.64898/2026.02.01.703113v1

New preprint from @kutseikin.bsky.social showing how pharmacologic inhibition of SLC33A1 activates IRE1/XBP1s signaling. w/ @enriquesaez.bsky.social @chrisgparker.bsky.social @landerlab.bsky.social @forlilab.bsky.social & the Birsoy lab (Rockefeller) Check it out👇 www.biorxiv.org/content/10.6...

One review. Many journals. Less redundancy. Check out this conversation with our head Dr. Thomas Lemberger on the vision behind @reviewcommons.org and what it means for authors and journals alike @embopress.org @embo.org www.embo.org/people/revie...

De novo design of protein binders that target DELE1 to inhibit the mitochondrial stress response https://www.biorxiv.org/content/10.64898/2025.12.22.695711v1

JCB’s Cover of the Year voting is open! I’ll just say… they are all gorgeous, but April has my heart 😍❄️🔬 #teamtomo @attychang.bsky.social

Journal of Cell Biology@jcb.org · 8mo ago

Vote for JCB’s cover of the year! Explore 12 breathtaking images submitted by our talented authors and pick a favorite. Voting closes on Wednesday, December 31! 👉 www.surveymonkey.com/r/JCB2025Cov... #ScienceArt

⚡️Mitochondria make ATP, the energy that powers life. But in neurons, with axons up to a meter long, how do these tiny power plants stay functional in the right places? We went looking. 1/n www.biorxiv.org/content/10.6...

Self-renewal of neuronal mitochondria through asymmetric division

Mitochondrial ATP production is essential for life. Mitochondrial function depends on the spatio-temporal coordination of nuclear and mitochondrial genome expression, yet how this coordination occurs ...

biorxiv.org

In collaboration with @enginlab.bsky.social, Khahani Eynullazada, a grad student from @sroyyors.bsky.social Lab identified gene regulatory networks capturing shared and perturbation-specific stress pathways in Type 1 diabetes using GRN inference tools on scRNA-seq data from in vivo mouse models.

How disabling one gene protects mice against Type 1 diabetes

UW–Madison researchers have discovered a mechanism that could one day help people at risk of developing the metabolic disease.

news.wisc.edu

If you're at #CellBio2025, please join us tomorrow at 9AM in Room 122 for a fantastic speaker lineup at the #EndoplasmicReticulum Minisymposium! Immediately following our session will be the keynote presentations by Eva Nogales & Jennifer Lippincott-Schwartz! @ascbiology.bsky.social

#CellBio2025 This Wednesday, Dec 10 at 9:00 AM in Room 122 Please add it to your schedule!

Eric (“VJ”) Rubenstein@vjrubenstein.bsky.social · 8mo ago

Just one week away until #CellBio2025! Please plan to join us for a sUPeR speakER lineup at the #EndoplasmicReticulum Minisymposium! Dec 10 at 9 AM @ascbiology.bsky.social

Postdoc position available in my lab in Jena (Germany. jobs.leibniz-fli.de/jobposting/6... If you're interested in protein biochemistry of amyloid proteins and chaperones, this job may be for you. B2 Level German is required as the candidate will be involved in teaching in German.

Postdoc (m/f/x)

Our Research Group led by Janine Kirstein, Professorin at Friedrich-Schiller-University Jena, is looking for a highly motivated and talented Postdoctoral Researcher (m/f/x) to join a research project ...

jobs.leibniz-fli.de

Scripps is conducting a tenure track assistant professor search. This is a broad search across multiple departments for outstanding individuals that could integrate into the multi-disciplinary environment at Scripps Research. All interested should apply! Please share. apply.interfolio.com/174756

🚨 #teamtomo!🚨 Did you know there's a dedicated cryoEM/ET Mini-Symposium at the upcoming ASCB/EMBO meeting in Philly (Dec 6–10)??

Thrilled to share a new preprint! 📝 🎉 Lewis lab PhD student Casadora wondered: Do mtDNA synthesis and lipid droplet biogenesis co-occur at the same membrane contact sites? Or can we discern distinct ER-mito contact classes? Evidence suggests the latter, relevant in overnutrition!

Sam Lewis, Ph.D.@samlewis.bsky.social · last yr.

www.biorxiv.org/content/10.1...

New work from the lab (w/ @preronabora.bsky.social @mashiatzaman.bsky.social @mitomorph.bsky.social @nanigrotjahn.bsky.social) identifying a compound that activates OMA1-DELE1-HRI signaling to induce mitochondrial remodeling in MFN2-deficient cells. Check it out 👇 www.biorxiv.org/content/10.1...

Drug Repurposing Screen Identifies an HRI Activating Compound that Promotes Adaptive Mitochondrial Remodeling in MFN2-deficient Cells

Pathogenic variants in the mitochondrial outer membrane GTPase MFN2 cause the peripheral neuropathy Charcot-Marie-Tooth Type 2A (CMT2A). These mutations disrupt MFN2-dependent regulation of diverse as...

biorxiv.org

TMED9 mediates export of misfolded #prion proteins from the ER. @pskcellbio.bsky.social &co show that TMED9 also helps capture #misfolded GPI-anchored proteins that are released by calnexin in the ER and moved into the Golgi for degradation via the RESET pathway @plosbiology.org 🧪 plos.io/44kURu5

I know print journals aren't exactly on everyone's radar these days, but we’re still geeking out that our latest study—led by the brilliant @attychang.bsky.social—landed the cover of the April issue of JCB! 🤩 @zidlab.bsky.social @tomo.science @hamid13r.bsky.social

Journal of Cell Biology@jcb.org · last yr.

Our April issue is here! rupress.org/jcb/issue/22... The cover shows a segmented model of cytoplasmic #ribosomes associated with mitochondrial membrane in a Saccharomyces cerevisiae cell. From Ya-Ting Chang, @nanigrotjahn.bsky.social and colleagues (doi.org/10.1083/jcb....)

Published an op-ed for @cnn.com: “Nobel laureate: I owe America my success. Today, its scientific future is in danger.” A personal reflection on what’s at stake as science funding gets slashed. I’d be grateful if you could amplify both in and beyond the science world. www.cnn.com/2025/04/09/h...

Nobel laureate: I owe America my success. Today, its scientific future is in danger | CNN

Dr. Ardem Patapoutian says he watches “with deep sadness as the United States’ remarkable scientific enterprise, which took generations of hard work and national investment to build, faces a concerted...

cnn.com

🚨 The April 13 deadline to submit abstracts for short talk consideration is coming up fast! Trainees and early-career researchers—don’t miss your chance to present your work and be eligible for talk and poster prizes at @faseborg.bsky.social #FASEB2025 #ERSRC

Guillaume Thibault@gthibault.bsky.social · 2y ago

🌟 Registration is now OPEN for the #FASEB Endoplasmic Reticulum Conference 2025 #ERSRC! 🎉 Join us June 8-12, 2025, in Melbourne 🏖️, FL, for cutting-edge science and networking. Check out the program and register here 👇 events.faseb.org/event/endoplasmic-reticulum-function-disease

New work from Zaman et al., in the Shutt Lab @mitomorph.bsky.social, describes a novel variant in MFN2 linked to mtDNA-mediated inflammation and muscle myopathy www.life-science-alliance.org/content/8/6/...

Fantastic article from Linda Hendershot—an incredible scientist and one of the most supportive and inspiring researchers I've had the pleasure of meeting. www.sciencedirect.com/science/arti...

A BiP-centric view of endoplasmic reticulum functions and of my career

After completing my post-doctoral training at the University of Alabama, Birmingham and a brief period on the faculty there, I joined the Department o…

sciencedirect.com

OpEd by @scripps.edu Pres. Pete Shultz: "the consequences would extend beyond Scripps Research, threatening the broader San Diego life sciences ecosystem, which contributes over $27 billion to the regional economy and supports tens of thousands of jobs." www.sandiegouniontribune.com/2025/02/25/o...

Opinion: Science funding cuts are based on flawed logic. Here’s the truth.

Earlier this month, the National Institutes of Health issued supplemental guidance indicating it would immediately impose a 15% cap on indirect costs for research grants, an unprecedented and abrup…

sandiegouniontribune.com

Past few weeks of Unfolded Protein Response papers! #ERStress @biomednews.bsky.social biomed.news/bims-unfpre/... biomed.news/bims-unfpre/... biomed.news/bims-unfpre/...