Christina Faherty
@christinafaher1.bsky.social
Bacterial geneticist 🧫 🦠 🧬 focusing on #Shigella, #enteric #pathogens & #phage. Using host signals & #organoids to study #pathogenesis. Assist Prof at USUHS. Views my own. https://medschool.usuhs.edu/profile/christina-faherty-phd
We’ve been cooking something for a while, but we’re very happy to share the preprint now in its current form: "An autologous human duodenal IEL–organoid co-culture platform for studying immune–epithelial interactions" Link and threat below www.biorxiv.org/content/10.6... 🧵👇
🧵 GETCampy Stories #3 Campylobacter is the leading cause of bacterial gastroenteritis worldwide. Yet we still don't have a licensed human vaccine, and reducing infections remains surprisingly difficult. Why? 👇 #MicroSky #OneHealth #Campylobacter
New Preprint 🥳 Here we wondered how phages that have been extensively studied in laboratory E. coli strains actually behave when they encounter a real pathogen such as O157:H7 strain...one with a far more complex cell surface & one of the most consequential foodborne pathogens in the United States.
Animated E. coli Bacteria Drawing
Alt: Animated E. coli Bacteria Drawing
static.klipy.com
New Research The spread of sexually transmissible drug-resistant shigellosis in England: a genomic epidemiology study www.thelancet.com/journals/lan...
The spread of sexually transmissible drug-resistant shigellosis in England: a genomic epidemiology study
Our study shows the distinct and intensifying sexual transmission of shigellosis, highlighting the urgent need to address sexually transmissible shigellosis as a distinct health threat. Traditional in...
thelancet.com
Interested in microbiology, immunology, and host-pathogen interactions? Come work with us! Our department at OHSU is opening a search for a new tenure-track faculty position. See the job advertisement for details. Please share within your networks! www.nature.com/naturecareer...
Faculty Position in Molecular Microbiology and Immunology - Portland, Oregon job with Oregon Health & Science University (OHSU) - Molecular Microbiology and Immunology | 12858852
The Department of Molecular Microbiology and Immunology at OHSU invites applications for a tenure-track Assistant or Associate Professor position.
nature.com
We hope you all had as wonderful a time in Paris last week as we did - please do fill out the EMBO feedback form that was emailed out this morning to help us improve the meeting! #Shigella2026
Russell Vance taking leaps and bounds with the mouse knock out model - happy to share mice and test vaccines #Shigella2026
@christinafaher1.bsky.social talks us through benefits and insights from organoid models, including malnourished organoids!
Cecilia Toro now giving us a tour or Shigella AMR molecular epi in Latin America
@yekwah.bsky.social launches FlexIt: the S. flexneri genotyping scheme at @shigellameeting.bsky.social 🎉
Karen Kotloff follows Philippe’s molecular talk with a tour de force in Shigella clinical and epidemiological features
Keynote #1 is off with Philippe Sansonetti taking us on an incredible tour of Shigella research in the last half century
The CDC warns that extensively drug-resistant (XDR) Shigella is on the rise in US. The prevalence of XDR Shigella isolates in US surveillance data rose from 0% during 2011-2015 to 8.5% in 2023. Read more: ow.ly/VXee50YLphl 📷: CDC, Stephanie Rossow
#Shigella in the #news. We've known about #MDR, now we're seeing a rise in #XDR isolates @shigellameeting.bsky.social #Microsky #AMR #IDsky thehill.com/homenews/nex...
Cases of drug-resistant infection that causes diarrhea are rising: What to know
Cases of drug-resistant Shigella infections are increasing in the United States in a trend that the Centers for Disease Control and Prevention (CDC) are calling a “public health threat.”…
thehill.com
Passengers watch Artemis II blast off from commercial plane. 🔭 🧪 www.bbc.co.uk/news/videos/...
Passengers watch Artemis II blast off from commercial plane
People on a commercial flight were treated to a rare view of the launch of Nasa's first crewed mission to the Moon in half a century.
bbc.co.uk
Quick takes: -More sick in the E coli outbreak linked to raw cheese & raw dairy products -Increase in Shigella cases in UK, some drug-resistant -The Global Fund approved funds to support the diagnosis and treatment of tuberculosis in Sudan Read more: ow.ly/gcWG50YzXYe.
Quick takes: More E coli tied to raw cheese, drug-resistant Shigella in UK, TB funds for Sudan
The CDC and FDA continue to investigate the E coli outbreak, which has sickened 9 people in 3 states.
ow.ly
New paper from my lab! First (as far as we know) comprehensive review of the Shigella outbreak data collected by CDC between 2009 and 2022. This is going to become my favorite class example of the struggle of dealing with state-reported data at a national level
Frontiers | Temporal trends of Shigella outbreaks in the United States, 2009–2022
BackgroundShigella infections remain a significant public health threat in the United States because of their diverse outbreak patterns and high disease impa...
frontiersin.org
Well done @xosematanza.bsky.social and Clements lab! Happy that I was able to contribute to this nice new publication, using TraDIS to gain insights into how Shigella sonnei can survive long-term nutrient starvation. journals.asm.org/doi/10.1128/...
journals.asm.org
Ever wonder what really goes down in the microscopic battleground of a catheter-associated UTI? 🦠⚔️ Our new review unpacks the Host-Pathogen Interactions during CAUTIs. Thank you, Kurt Kohler and Alyssa La Bella @alabella14.bsky.social for putting this together!!! pubs.acs.org/doi/full/10....
Host Pathogen Interactions during Catheter-Associated Urinary Tract Infections
As a leading cause of healthcare-associated infections, catheter-associated urinary tract infections (CAUTIs) present a unique challenge due to the high prevalence of multidrug-resistant and polymicrobial pathogens. Distinct from uncomplicated UTIs, the insertion of a urinary catheter provokes tissue damage that triggers inflammation, plasma extravasation, and the deposition of host fibrinogen. This inflammatory response drives the robust recruitment of immune cells and plasma extravasation, leading to the accumulation of fibrinogen─a key coagulation protein─on the device and bladder epithelium. This fibrinogen-rich environment creates a unique niche for intricate host–pathogen interactions. Crucially, uropathogens exploit these deposits to establish persistent biofilms, while the protein scaffold simultaneously modulates host immunity. Understanding these mechanisms, particularly the role of fibrinogen-binding adhesins, is vital for developing targeted, antimicrobial-sparing therapeutics. In this perspective, we examine the strategies uropathogens employ to persist in the catheterized bladder, the corresponding host immune response, and emerging strategies to prevent CAUTI.
pubs.acs.org
A fabulous undergraduate researcher I mentor is graduating this spring and is looking for a job as a lab technician! She's interested in bacterial pathogenesis and is planning to go to grad school after getting more research experience. Please let me know if you or anyone you know is hiring!
Differential targeting of human pyroptotic caspase-5 and caspase-4 by Shigella OspC2 and OspC3 | mBio journals.asm.org/doi/10.1128/...
Differential targeting of human pyroptotic caspase-5 and caspase-4 by Shigella OspC2 and OspC3 | mBio
Shigella species are human-specific gram-negative pathogens that establish a replicative niche in intestinal epithelial cells by blocking pyroptosis, a key inflammatory cell death pathway. We reveal t...
journals.asm.org
Call for #poster #abstracts is open for the #Shigella meeting @shigellameeting.bsky.social thru Feb! Secure your spot by #registering! #ShowUsYourScience #MicroSky #IDSky 🦠 🧫🔬 www.shigella2026.conferences-pasteur.org/call-for-abs...
Call for abstracts - EMBO Workshop Shigella: from biology to prevention
EMBO Workshop Shigella: from biology to prevention
shigella2026.conferences-pasteur.org
We are current investigating Shigella cases linked to travel to Cape Verde. Regular handwashing with soap and water (especially after the toilet, changing nappies, and before handling food) is the best way to prevent the bacteria from spreading.
Upcoming seminar : EMBO Workshop Shigella: from biology to prevention at Institut Pasteur, Monday 20 April 2026 at 14:00. More info
Did you know shigellosis also transmits as a sexually transmissible illness? This has increased since the early 2000s with marked AMR. Read the back story on ST shigellosis emergence here, and come to Paris for #Shigella2026 to find out more! doi.org/10.1099/mgen...
The natural history of the emergence of sexually transmissible shigellosis
Shigellosis is a gastrointestinal illness caused by bacteria belonging to one of four species of Shigella. Sexually transmissible (ST) shigellosis was first reported in 1974, but recently there has be...
doi.org
#XDR Shigella is a serious, emerging global health threat. This topic is one of many we'll be discussing at #TheShigellaMeeting Registration is open! www.shigella2026.conferences-pasteur.org/registration... #AMR #MicroSky #IDSky 🔬🧫🦠
CIDRAP@cidrap.bsky.social · 9mo agoNovel XDR Shigella strain identified in Los Angeles Researchers say the strain of XDR Shigella sonnei appears to be spreading beyond high-risk groups into the broader population, which could lead to more treatment failure. www.cidrap.umn.edu/a...
Here’s a quick way to make sure that your elected representatives know to NOT to support multiyear NIH funding which will significantly reduce the number of new grants supported each year.
American Physiological Society@apsphysiology.bsky.social · 9mo agoAs Congress finalizes FY 2026 appropriations bills, lawmakers need to hear from scientists about the importance of supporting a strong budget for NIH. Let your reps know why NIH funding is important to you: https://ow.ly/aOCO50Y0ioG #advocacy #SciPol #FundScience 🧪 📷: iStock
