Cesar Cobaleda
@cjchcm.bsky.social
Researcher in rare diseases, cancer, hematopoiesis, epigenetics and bioinformatics, at CBM (CSIC)
Obituary: Susumu Tonegawa, Japan’s first Nobel prizewinner in physiology or medicine www.nature.com/articles/d41...
Obituary: Susumu Tonegawa, Japan’s first Nobel prizewinner in physiology or medicine
Fearless molecular biologist who revealed the workings of antibodies and memories.
nature.com
📣 New article by #SEBD member @marianros.bsky.social research group @csic.es and collaborators now out @currentbiology.bsky.social on the origin and evolution of dorsal determination mechanisms in vertebrate paired appendages: Current Biology www.cell.com/current-biol...
The origin and evolution of dorsal determination mechanisms in vertebrate paired appendages
Limbs have distinct sidedness, with dorsal-ventral flexure allowing diverse movements that permit nuanced articulation and function. Hawkins et al. demonstrate that the genetic foundation of this patt...
cell.com
🎉 Proud of our colleague for successfully defending his PhD thesis yesterday. So much work and heart behind it. Congratulations Dr. Javier Isoler Alcaraz! Thanks to the committee @vaquerolab.bsky.social, Maria Villa Morales and @davidlandeira.bsky.social for an engaging and enriching discussion!
🩸La leucemia linfoblástica aguda B es uno de los cánceres infantiles más frecuentes 🧬Una alteración en el cromosoma 9 está presente en el 10% de los pacientes 🔬Un estudio de @ciccancer.bsky.social muestra el papel clave de esta mutación en la evolución de la enfermedad ➡️ http://tiny.cc/4bw0101
Fresh from the oven! Our new perspectives article where we discuss the interplay between lagging strand DNA replication and the replication stress response. An updated view on lagging strand DNA replication: implications for the replication stress response www.tandfonline.com/doi/full/10....
An updated view on lagging strand DNA replication: implications for the replication stress response
The process of DNA replication is inherently asymmetric. While the leading strand is synthesized continuously, the lagging strand is copied in small fragments, the Okazaki fragments, requiring the ...
tandfonline.com
We welcome our first global fellows: Sakshi Shambhavi and @jmartcan.bsky.social. Our new Global Fellow Postdoctoral Program brings researchers into multiple labs at once. 👉 Details: www.mdc-berlin.de/news/news/ou... @leifludwig.bsky.social @simonhaas.bsky.social @helmholtz.de
Institutions are phasing out gamma-irradiators, but can X-ray irradiators replace them for mouse transplant models? We report that with proper dose calibration, X-ray conditioning produces equivalent hematopoietic chimerism and AML transplant outcomes. Encouraging news! 🔗 doi.org/10.1016/j.ex...
Functional equivalence of γ- and x-ray irradiation for long-term peripheral blood chimerism and acute myeloid leukemia transplant outcomes in mice
Total body irradiation is routinely used for myeloablation before a mouse hematopoietic cell transplant. Widespread transition from 137Cs γ irradiator…
sciencedirect.com
Este viernes, a las 19:30, en Alcobendas, hablaremos de Enfermedades Raras: Qué son y Cómo se Investigan
Ciencia A Banda@cienciaabanda.bsky.social · 8mo agoDespedimos el año de la mejor forma posible: anunciando nuestra charla de enero 😊 🤒Las enfermedades raras: Qué son y cómo se investigan 🧑🏫 @cjchcm.bsky.social de @cbm-csic-uam.bsky.social 🗓️V 16-Enero-26 📍Arrocería Casa Valentina (Alcobendas) ¡Tenemos un ponente excepcional! No te lo pierdas ⬇️
Despedimos el año de la mejor forma posible: anunciando nuestra charla de enero 😊 🤒Las enfermedades raras: Qué son y cómo se investigan 🧑🏫 @cjchcm.bsky.social de @cbm-csic-uam.bsky.social 🗓️V 16-Enero-26 📍Arrocería Casa Valentina (Alcobendas) ¡Tenemos un ponente excepcional! No te lo pierdas ⬇️
📢¡Oferta de trabajo en el CBM! El grupo de César Cobaleda busca postdoc para estudiar cómo se origina la leucemia infantil (B-ALL). 💡 Proyecto “la Caixa” Research Health 2025 🧬 Modelos murinos, epigenética, célula única 📅 Deadline: 5 dic 2025 www.cbm.uam.es/index.php/jo... @cjchcm.bsky.social
Molecular Mechanisms of Childhood Leukemia Development - Centro de Biología Molecular Severo Ochoa
Job Description We are seeking a highly motivated postdoctoral researcher to join our laboratory to study the early steps of development of childhood B-cell Acute Lymphoblastic Leukemia (B-ALL). The p...
cbm.uam.es
On #WorldBlood#CancerDay, let’s remember those affected and raise awareness about these diseases. Explore the main types of blood cancer and how they impact the body 👇 🔗 https://bit.ly/4kkBfvA #HemeSky #MedSky #HemeOnc
📣 We are super happy to share our new preprint! We show how an imbalance between replication and transcription elongation rates can be uncoupled genome-wide without replicative stress 1/3
Once you have enough knowledge of the literature in your research field, you realize you’ll never have enough knowledge of the literature in your research field.
I am not necessarily against the initiative, but would a chimpanzee with 20 gene edits be human? If you lined up a dire wolf genome with a gray wolf genome there would be millions of differences. These individuals seem optimistically 1/100,000th dire wolf. (No paper or preprint available though).
Carl Zimmer@carlzimmer.com · last yr.It's not a dire wolf. It's a gray wolf clone with 20 dire-wolf gene edits, and with some dire wolf traits. And here's my story! Gift link: www.nytimes.com/2025/04/07/s...
www.nature.com/articles/s41...
Engineering synthetic signaling receptors to enable erythropoietin-free erythropoiesis - Nature Communications
Shortages of donor blood for transfusions can have severe medical consequences, and ex vivo production of red blood cells offers a potential solution. Here authors developed synthetic EPO receptors, w...
nature.com
Meinrad Busslinger, Emeritus Senior Group Leader at the IMP, received the Silver Medal for Meritorious Service to Vienna for his outstanding scientific achievements & key role in establishing the IMP and Vienna BioCenter. 🎖️👏 Read more: www.imp.ac.at/news/article... @viennabiocenter.bsky.social
www.nature.com/articles/s41...
Long-term lineage commitment in haematopoietic stem cell gene therapy - Nature
Haematopoietic stem cell (HSC) clonogenic activity, lineage output, lineage commitment and somatic mutation rates are influenced by the underlying disease, patient age, extent of genetic defect correc...
nature.com
We used to hear the term "tired blood." [Geritol] Now it's tired proteins. Proteolethargy. Reduced protein mobility as an underpinning for chronic diseases www.cell.com/cell/abstrac...
In the end, it comes down to whether one believes the system generally allocates resources in ways that predict rather than fuel success. Between the tails of the distribution, I don’t think it does.
No planet for old animals 😢 www.science.org/doi/10.1126/...
Loss of Earth’s old, wise, and large animals
Earth’s old animals are in decline. Despite this, emerging research is revealing the vital contributions of older individuals to cultural transmission, population dynamics, and ecosystem processes and...
science.org
