Colin Jackson
@cjjackson.bsky.social
Science bad photos https://scholar.google.com/citations?user=47-aiVEAAAAJ&hl=en
Join us at the hybrid Crystal36-AXAA 2026 conference in the beautiful Adelaide Hills. www.crystal36axaa2026.org/registration Focused on structural biology, we are delighted to present Dr Rosemary Cater, UQ, on biophysical and structural interrogation of proteins at the blood-brain barrier.
Excited to present sampleworks: a modular platform for generating biomolecular conformational ensembles by coupling AI structure predictors to experimental data. Our first publication of @diffuseproject.bsky.social, led by @karsonchrispens.bsky.social + Marcus Collins. thestacks.org/publications...
sampleworks: A Modular Platform for Experimentally Guided Biomolecular Ensemble Generation
thestacks.org
Aggregating many experiments into one zero-shot protein language model score obscures that current models cannot meaningfully rank a set of fit mutations or prioritize new-to-nature functions @clauswilke.com www.biorxiv.org/content/10.6...
We just preprinted DropSynth-Gold where we replaced PCA with Golden Gate Assembly (GGA) inside emulsion droplets, extending multiplexed gene synthesis to ~3 kb constructs assembled from up to 12 fragments while preserving the scalability of DropSynth. 1/n
bioRxiv Synthetic Biology@biorxiv-synthbio.bsky.social · 2mo agoDropSynth-Gold: Golden Gate Assembly in Emulsions Extends Multiplexed Gene Libraries to Greater Lengths https://www.biorxiv.org/content/10.64898/2026.05.29.728538v1
I will probably be hiring either a PhD or a Postdoc in the near future. If you are interested in deep biochemical history or molecular mechanisms of evolution please get in touch.
We are recruiting! If you are passionate about technology development, protein engineering, computational design, directed evolution, chemical biology - please reach out! (The setting is pretty nice too…)
Excited to share Sampleworks led by @karsonchrispens.bsky.social with @diffuseproject.bsky.social. It's a modular framework connecting structure predictors to experimental data and guidance methods. Swap predictors or guidance methods. All open and made to be built upon. t.co/fvNHH3gfVu
https://diffuse.science/posts/sampleworks/
t.co
Radial is live! A new organization at @asterainstitute.bsky.social bringing together structural biologists, engineers, and ML scientists to redesign how we do science. @statnews.com has the story: www.statnews.com/2026/03/11/r...
New nonprofit launches with at least $500 million to modernize scientific process for AI era
A new nonprofit called Radial is launching with at least $500 million to modernize the scientific process for the AI era.
statnews.com
We made FLIP2, a protein fitness benchmark spanning seven new datasets, including enzymes, protein-protein interactions, and light-sensitive proteins, as well as splits that measure generalization relevant to real-world protein engineering campaigns.
Crystal structure of malaria parasite fusogen PfHAP2 domain 3 and nanobodies - unsolved mysteries galore! 🦟🦙💎 PfHAP2 is part of family of ancient fusogens involved in fertilisation processes in algae, plants to malaria parasites. Check out the first crystal structure of PfHAP2 D3 and nanobodies
Crystal structure and nanobodies against domain 3 of the malaria parasite fusogen Plasmodium falciparum HAP2
Malaria parasites are transmitted to humans through a bite from an infected female Anopheles mosquito. Within the mosquito midgut, malaria parasite gametes are activated and undergo fertilisation. If ...
portlandpress.com
Beginning 2026 with a flipping good paper🚀 OSCA/TMEM63 proteins do double duty: they’re ion channels and mechanically activated lipid scramblases helping reshape membranes and survive mechanical stress. 👏 @yiechanglin.bsky.social @charlesdcox.bsky.social doi.org/10.1038/s414...
Pfs48/45 nanobodies block malaria parasite transmission 🦟 and crystal structures provide structural insight to how they bind 💎 Pfs48/45 is one of the leading transmission blocking vaccine candidates and a critical fertilisation antigen 💕 Please share widely- love to hear your feedback!
Pfs48/45 nanobodies block Plasmodium falciparum transmission
Author summary Malaria is spread when an infected Anopheles mosquito bites a human. Within the female Anopheles mosquito, malaria parasite fertilisation occurs in the mosquito midgut. If you inhibit p...
journals.plos.org
🧵1/3 I created this free 37-hour course, distributed across 10 lectures, to introduce AI-based protein design. For more information about the course and its specific topics, please visit the official course page:
New Preprint!! We show that binding entropy can be quantitatively predicted from crystallographic ensemble models, accounting for both protein conformational entropy and solvent entropy! www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6... most proteins are multi domain but our understanding of how architectures evolve is limited - we mapped 40K chitinases and show a stepwise “grammar” of domain gain/loss and localisation changes that predicts ecological strategy and physiological function.
biorxiv.org
I'm really excited to break up the holiday relaxation time with a new preprint that benchmarks AlphaFold3 (AF3)/“co-folding” methods with 2 new stringent performance tests. Thread below - but first some links: A longer take: fraserlab.com/2025/12/29/k... Preprint: www.biorxiv.org/content/10.6...
Know when to co-fold'em
This is the official web page for the James Fraser Lab at UCSF.
fraserlab.com
Keen to use an open source workflow for nanobody discovery? Check out Alpseq 🦙 Alpseq’s diversity analysis, enrichment counts & clustering allow different approaches for nanobody selection Great collab with bioinformaticians @qgouil.bsky.social Kathleen Zeglinski www.biorxiv.org/content/10.1...
alpseq: an open-source workflow to turbocharge nanobody discovery with high-throughput sequencing
Nanobodies have emerged as promising tools for many biotechnological applications due to their small size, high stability, and remarkable binding specificity. Next-Generation Sequencing (NGS) enables ...
biorxiv.org
H.M. Saffer II (American, b.1942) : Moon Waters, 2023 Oil on canvas 30 × 30 in | 76.2 × 76.2 cm Further description & bio in the alt text 👇
‘Protein evolution as a complex system’ – A new Comment discusses protein evolution in terms of complex systems theory and machine learning approaches to model the dynamics of protein evolution www.nature.com/articles/s41...
Protein evolution as a complex system - Nature Chemical Biology
Viewing protein evolution through the lens of complex systems theory may offer new insights into the principles driving biological adaptation. In this Comment we explore how characteristics such as se...
nature.com
Thank you everyone for the congratulations and the large number of applications! I want to specifically encourage applications for these positions: * Postdoc in structural biology (cryoEM, ideally with X-ray too) * Full time lab manager/technician with wetlab experience
Martin Pacesa@martinpacesa.bsky.social · last yr.I am super excited to announce that I will be starting my lab at the Department of Pharmacology of the University of Zurich in Switzerland next year!
Protein-ligand complexes are all the rage with OpenBind+other efforts launching 3 amazing papers describing 229 protein-ligand structures just dropped in @actacrystd.iucr.org A tremendous teaching text, but I disagree on the discussed potential for misuse. Read more fraserlab.com/2025/07/29/E...
Embrace the Mess
This is the official web page for the James Fraser Lab at UCSF.
fraserlab.com
Very excited about our latest all-atom generative model proteina, check out the project page (research.nvidia.com/labs/genair/...) and stay tuned for the code release soon!
La-Proteina: Atomistic Protein Generation via Partially Latent Flow Matching
La-Proteina: Atomistic Protein Generation via Partially Latent Flow Matching
research.nvidia.com
Kevin K. Yang 楊凱筌@kevinkaichuang.bsky.social · last yr.Partially-latent flow matching enables sequence-structure codesign of large proteins and functional motif scaffolding. @kdidi.bsky.social @machine.learning.bio @karstenkreis.bsky.social @arashv.bsky.social arxiv.org/html/2507.09...
Pleased to announce I have been promoted to the rank of GRANDMASTER thank you for your attention to this matter
Proud to share our work where we resolved a longstanding question regarding the existence of a human telomerase dimer and provided insights into its function. Led by 3 amazing lab members in collaboration with @yiliangding.bsky.social and @rdaslab.bsky.social. www.science.org/doi/10.1126/...
Cryo-EM structure of human telomerase dimer reveals H/ACA RNP-mediated dimerization
Telomerase ribonucleoprotein (RNP) synthesizes telomeric repeats at chromosome ends using a telomerase reverse transcriptase (TERT) and a telomerase RNA (hTR in humans). Previous structural work showe...
science.org
