Coloff Lab
@colofflab.com
We study cancer and metabolism at the University of Illinois College of Medicine and University of Illinois Cancer Center.
Another successfully published manuscript from Dr. Philippa Burns! Check out her work regarding the effects of serine starvation on RNA splicing 👀 aacrjournals.org/cancerres/ar...
Serine Starvation Modulates mRNA Splicing through Translational Inhibition of SRSF Proteins
Abstract. Serine is a critical nutrient for cancer cell proliferation due to its numerous downstream biosynthetic functions. Given the ongoing clinical efforts to utilize dietary serine starvation as ...
aacrjournals.org
Hot off the press!! 🚨📰 Check out @palpurab.bsky.social work focusing on the effect of ceramides on breast cancer cells aacrjournals.org/mcr/article/...
Ceramide-induced endoplasmic reticulum stress reveals a targetable vulnerability in endocrine therapy-resistant breast cancer
Abstract. Despite the success of endocrine therapy (ET) in treating hormone receptor-positive breast cancer, a significant proportion of patients relapse during or after treatment, making ET resistanc...
aacrjournals.org
New @nature.com The brains of Super Agers produce more neurons than people some 50 years younger, a neurogenesis resilient signature linked to exceptional cognitive health and memory skills nature.com/articles/s41...
Human hippocampal neurogenesis in adulthood, ageing and Alzheimer’s disease - Nature
Mapping of neurogenesis in human hippocampi across ages and different cognitive abilities using multiomic single-cell sequencing reveals distinct signatures between cognitive preservation and decline.
nature.com
The conference (agreement between House and Senate) appropriations bill that includes HHS and NIH was released this morning. www.appropriations.senate.gov/news/majorit... 1/5
Committee Releases Conferenced Defense, Homeland Security, Labor, Health and Human Services, Education, and Related Agencies, and Transportation, Housing and Urban Development, and Related Agencies Bi...
United States Senate Committee on Appropriations
appropriations.senate.gov
Interested in stable isotope infusions but daunted by jugular catheter surgery? New from postdoc @kimyumi0201.bsky.social: our simple tail vein catheter method enables anesthesia-free infusions in awake, freely moving mice. 🧵
Amid NIH funding delays, reversals and uncertainty, a scientist at Harvard who studies breast cancer has lost one-third of her lab employees and wonders if she can continue her research experiments. n.pr/4a4N3zD
After NIH grant cuts, breast cancer research at Harvard slowed, and lab workers left
Amid NIH funding delays, reversals and uncertainty, a scientist at Harvard who studies breast cancer has lost one-third of her lab employees and wonders if she can continue her research experiments.
n.pr
Had a lovely time talking science with our peers at #MidwestMetabolism - until next year!! @palpurab.bsky.social @vipinrawat482.bsky.social @meteozgurses.bsky.social
If you’re at the Midwest Metabolism Meeting, make sure you stop by our posters! We have 6 lab members presenting today @meteozgurses.bsky.social @vipinrawat482.bsky.social @palpurab.bsky.social @juliannasupplee.bsky.social @linalietuv.bsky.social
Excited to share our work @nature.com! Postdoc @mariopalma.bsky.social, with major contributions from @retickerflynn.bsky.social and collaborators, discovered melanoma cells in lymph nodes gain a targetable FSP1 dependency that limits progression. #TeamFSP1 www.nature.com/articles/s41...
Lymph node environment drives FSP1 targetability in metastasizing melanoma | Nature
nature.com
Excited to share our latest work out today in @cp-molcell.bsky.social, revealing a molecular link between succinate dehydrogenase and purine synthesis, connecting two fundamental metabolic pathways. Huge congratulations to the first author, Mushtaq Nengroo! www.sciencedirect.com/science/arti... !
Accumulation of succinate suppresses de novo purine synthesis through succinylation-mediated control of the mitochondrial folate cycle
The de novo purine synthesis pathway is fundamental for nucleotide production, yet the role of mitochondrial metabolism in modulating this process rem…
sciencedirect.com
Working on some very important, very serious experimental procedures…
@thermofishersci.bsky.social vendor show today 🤪 can you guess who unwillingly stood for the picture????
Latest lab photo from celebrating Dr. Coloff’s birthday earlier this month!!!! 🥳
Congrats to @meteozgurses.bsky.social for being selected to present his work at Chicago Mass Spec Day last month!!
Ceramide-induced Endoplasmic Reticulum Stress as a Targetable Vulnerability in Endocrine Therapy-Resistant Breast Cancer https://www.biorxiv.org/content/10.1101/2025.08.18.670862v1
The Hormone Dependent Cancer Gordon Research Conference got a sneak peak at Purab’s new work before it hits the journals - watch this space, publication dropping soon!!!! 👀 @palpurab.bsky.social
Even MORE exciting Coloff lab news!!! 🥳 after graduating with her PhD from Penn, @juliannasupplee.bsky.social has moved to Chicago to continue her work in cancer lipid metabolism with us as a postdoc!!! Welcome Julianna!!! 🤩
Join us in at Moffitt! The Metabolism Program is recruiting at the Assistant Member (Assistant Professor) level. Review of applications starts September 1st. Please share! Details here: moffitt-cancer-center-careers.hctsportals.com/jobs/1883440...
Tenure-Earning Assistant Member Metabolism & Physiology Faculty in Tampa, FL - Moffitt Cancer Center CareersTenure-Earning Assistant Member Metabolism & Physiology Faculty in Tampa, FL - Moffitt Cance...
Working at Moffitt Cancer Center is both a career and a mission. All employees are dedicated to patient care, research and education to advance our fight against this disease.
moffitt-cancer-center-careers.hctsportals.com
We also have to give a shoutout to @linalietuv.bsky.social for completing her preliminary exam!! She will now enter the next phase of her program: PhD candidacy 😱
EXCITING COLOFF LAB NEWS: Philippa successfully defended her thesis, “Serine Starvation Modulates mRNA Splicing Through Depletion of SR Proteins,” last month and is officially Dr. Burns!!! Congratulations Philippa!! 🍾
We had the pleasure of hosting Christian Guerrero, a high school student part of @uicancercenter.bsky.social CHESS program, for several weeks this summer. Thank you Christian for your curiosity and hard work, and we can’t wait to see what you do in your future!!
Proudly presenting Simon’s @simonsterson.bsky.social paper on asymmetric apportioning of old mitochondria biasing intestinal stem cells for the Paneth cell linage through aKG-dependent metabolism @naturemetabolism.bsky.social www.nature.com/articles/s42... @helsinki.fi @metastem.bsky.social 🧵1/8
Old mitochondria regulate niche renewal via α-ketoglutarate metabolism in stem cells - Nature Metabolism
Andersson et al. show that intestinal stem cells enriched for old mitochondria are metabolically distinct and have enhanced ability to regenerate the epithelial niche.
nature.com
From Nobel prize winning cancer researcher Bill Kaelin Killing the Science Golden Goose - The American Journal of Medicine www.amjmed.com/article/S000...
Killing the Science Golden Goose
In the 1970’s I was probably one of the last American high school students who was told that if you wanted to go to medical school, you should learn to speak German. This was because in the late 19th ...
amjmed.com
Congrats to Rushika and Gilles on this really cool work!
Rushika M. Perera@rushika-perera.bsky.social · last yr.Online today in @nature.com - our latest study led by superstar postdoc Gilles Rademaker detailing the role of PSCK9 in driving sterol dependent metastatic organ choice in pancreatic cancer nature.com/articles/s41... full text available here 👉 rdcu.be/em0VG and thread 👇
1/3 PLEASE READ, LIKE, REPOST this "1/3" post There is a Senate Hearing May 14th with RFK Jr to discuss Trump's proposed HHS budget. Please find call/email the members of the committee every day until then (I have compiled contact info for the members in post 2/3)
Last but not least, Mete will be presenting his work at this afternoon’s poster presentation as well. Make sure to check him out!! @meteozgurses.bsky.social
Loooooove single cell RNAseq???? So does Lana! Come talk with her at her poster in the afternoon session #AACR25
Make sure to stop by our resident ceramide nerd’s poster tomorrow between 9-12!
