Lifelong restriction of dietary valine has sex-specific benefits for health and lifespan in mice - Nature Aging

Calubag et al. report that reduced dietary intake of the branched-chain amino acid valine is sufficient to improve healthspan in both male and female mice, as well as to extend lifespan in male mice.

nature.com

Ceramide-induced endoplasmic reticulum stress reveals a targetable vulnerability in endocrine therapy-resistant breast cancer

Abstract. Despite the success of endocrine therapy (ET) in treating hormone receptor-positive breast cancer, a significant proportion of patients relapse during or after treatment, making ET resistanc...

aacrjournals.org

Python metabolomics uncovers a conserved postprandial metabolite and gut–brain feeding pathway - Nature Metabolism

Leveraging pythons as an extreme model of feeding and fasting behaviour, this study uncovers para-tyramine-O-sulphate as a conserved postprandial metabolite that links nutrient intake to energy balanc...

nature.com

Succinate calls a time-out on pyrimidine biosynthesis - Nature Metabolism

Cell metabolism is a dynamic network of highly interconnected biochemical reactions. In this issue of Nature Metabolism, time-lapse analysis of the amino acid aspartate revealed an unexpected regulati...

nature.com

Emergence of oncofetal plasticity is ubiquitous in early colorectal cancers - Nature

Metastasis-associated oncofetal cell states emerge at the earliest stages of colorectal cancer and spatial profiling shows stereotypic patterning of fibroblast subtypes resembling normal tissue archit...

nature.com

Adipocyte NADH dehydrogenase reverses circadian and diet-induced metabolic syndrome - Nature Metabolism

Circadian clock in adipocytes maintains metabolic health by regulating mitochondrial complex I respiration.

dlvr.it

Irisin ameliorates obesity and insulin resistance via adipose tissue IL-33 and regulatory T cells

Nature Metabolism, Published online: 03 April 2026; doi:10.1038/s42255-026-01491-2This study demonstrates that overexpression of irisin, an exercise-induced myokine, ameliorates obesity and insulin resistance in high-fat-diet-fed mice by increasing local IL-33 production and preserving ST2+ regulatory T cells in white adipose tissues.

dlvr.it

a drawing of a man with glasses and gloves with the words science mode written above him

ALT: a drawing of a man with glasses and gloves with the words science mode written above him

media.tenor.com

FEBS Press

Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors ...

febs.onlinelibrary.wiley.com

Citrate clearance is a major function of aconitase 2 in the canonical TCA cycle

Beyond its traditional role in supporting bioenergetic and biosynthetic demands, the canonical TCA cycle is also essential for nutrient clearance. When pyruvate oxidation and citrate production increase, aconitase 2 becomes essential to prevent mitochondrial citrate accumulation, which can trigger the integrated stress response and impair cell fitness.

dlvr.it

Language model-guided anticipation and discovery of mammalian metabolites - Nature

Chemical language models trained on known metabolites can identify previously unknown metabolites from mass spectrometry-based metabolomics data with high accuracy.

nature.com

CLCC1 promotes hepatic neutral lipid flux and nuclear pore complex assembly - Nature

CRISPR–Cas9 screening identifies CLCC1 as a factor that increases neutral lipid flux to prevent hepatic steatosis and promotes nuclear pore complex assembly by promoting membrane bending and fusi...

nature.com

A genetically encoded bifunctional enzyme mitigates redox imbalance and lipotoxicity - Nature Metabolism

The authors present a genetically encoded tool based on a bifunctional enzyme that can regenerate NAD+ while executing an engineered glycerol shunt. The tool successfully restored redox imbalance and ...

nature.com

Thinking Like a Scientist, Part Three: Hypothesis Retrofitting

Scientific papers are more complex than ever, but are we gaining deeper understanding or losing sight of the hypothesis? In this third part of Thinking like a scientist, I reflect on data-driven scien...

network.febs.org

Nucleotide metabolic rewiring enables NLRP3 inflammasome hyperactivation in obesity

Obesity is a major disease risk factor due to obesity-associated hyperinflammation. We found that obesity induced Nod-like receptor pyrin domain–containing 3 (NLRP3) inflammasome hyperactivation and e...

science.org

Metabolic adaptations rewire CD4+ T cells in a subset-specific manner in human critical illness with and without sepsis - Nature Immunology

Rathmell and colleagues show that metabolic reprograming of regulatory T cells is associated with severity of critical illness in patients with and without sepsis.

nature.com

MetaboList – December 2025

Diet and cancer Dual impacts of serine/glycine-free diet in enhancing antitumor immunity and promoting evasion via PD-L1 lactylation Tong et al, Zhen Lei Hubing Shi ∙ Xuelei Ma. Dietary restriction…

metabolist.wordpress.com

Elevated FGF21 and triglycerides in SLC25A13 carriers support the G3P-ChREBP Citrin Deficiency disease hypothesis

People with Citrin Deficiency (CD), inactivated for both copies of SLC25A13 , have lean metabolic dysfunction-associated steatotic liver disease (MASLD) and an aversion to sweets. The mouse model of C...

medrxiv.org

In vivo models bring FSP1 inhibitors to life - Nature Cell Biology

FSP1 is a key suppressor of lipid peroxidation and ferroptosis, yet it is largely dispensable in standard cell culture models. Two new studies now show that FSP1 becomes essential for tumour growth in...

nature.com