Crump Lab
@crumplab.bsky.social
Studying development, evolution, and regeneration of the vertebrate head skeleton, one fish at a time
Wonderful to see this paper finally out from my brilliant colleague Qilong Ying. www.cell.com/cell/fulltex...
Expansion and CAR engineering of granulocyte-monocyte progenitors for cellular immunotherapy
This study establishes granulocyte-monocyte progenitors as a renewable upstream platform for engineered myeloid cell therapy and introduces a CAR-Fc strategy that couples direct tumor targeting to hos...
cell.com
Still time to register for this webinar tomorrow (13th March)!
Society for Developmental Biology@socdevbio.bsky.social · 5mo agoThe next the Ethel Browne Harvey Postdoc Seminar will be held this Friday, March 13 at 3 pm Eastern Time with Martha Echevarría-Andino @uwmadison.bsky.social and M. Fernanda Palominos @ucberkeleyofficial.bsky.social. Register today and join us. bit.ly/47QVIEK #SDBPostdocSeminar
Honoured to receive this recognition from @isscr.org along with excellent colleagues- particularly since they noted the ethical advances which @nicolasrivron.bsky.social and I have tried to support in the growing SCBEM field alongside our research, showing the community’s value of ethical leadership
ISSCR@isscr.org · 5mo agoThe ISSCR also recognizes five outstanding scientists with Honorable Mention distinctions for the 2026 Early Career Impact Award. The award is supported by the @cheninstitute.bsky.social. Learn more: https://ow.ly/ivGb50YoFaZ
😍 🔗 to paper: journals.biologists.com/dev/article/...
Gene regulatory programs underlying diversification of facial ligaments and tendons in zebrafish
Summary: Single-cell analysis and toolkit generation in zebrafish identifies gene regulatory codes and growth dynamics of distinct facial ligaments and tendons.
journals.biologists.com
Biomedical Picture of the Day BPoD@bpodaily.bsky.social · 6mo agoPulling a Face: Zebrafish face development study identifies genetic & epigenetic regulatory mechanisms distinguishing tendons & ligaments 📷 Ryan R. Roberts et al, @crumplab.bsky.social @keck.usc.edu in @dev-journal.bsky.social ➡️ bpod.org.uk/archive/2026/2/16
Fantastic program and initiative by @socdevbio.bsky.social for postdocs going on the job market - register! #devbio #PILife
Society for Developmental Biology@socdevbio.bsky.social · 7mo ago#Postdocs! Going on academic job market? Apply for SDB GetHIRED! Take stock of what you want, know your options, prepare an outstanding job packet, organize your research & chalk talks, perfect your interview. Deadline: March 5 sdbonline.org/gethired
A method to produce embryonic stem cells for a range of bird species opens up opportunities in agriculture, developmental biology and species conservation #NBTNV go.nature.com/4ntGnih rdcu.be/eJagy
Embryonic stem cells across bird species - Nature Biotechnology
A method to produce embryonic stem cells for a range of bird species opens up opportunities in agriculture, developmental biology and species conservation.
go.nature.com
Wonderful collaboration of Claire Arata and co-first-author Elena Vasileva from Amatruda lab. Claire provided the neural crest driver and Elena the EWS oncofusion. Best combination since PB&J. Amazing that expression of a single oncofusion in crest produces ectopic fins. www.cell.com/cell-reports...
Origin of Ewing sarcoma by embryonic reprogramming of neural crest to mesoderm
Using a zebrafish genetic model of Ewing sarcoma, Vasileva et al. provide evidence for a neural crest origin of the disease. These findings offer new insight into how a single oncogenic fusion can hij...
cell.com
Beautiful atlas of fish gill development from the Lecaudey lab. There are few structures more amazing in biology than gills! journals.biologists.com/dev/article/...
A developmental atlas of zebrafish gills links early vascular patterning to adult architecture
Gills are essential for fish respiration and have a highly specialized cellular architecture enabling efficient gas exchange. Surprisingly, the developmental processes underlying gill formation in zeb...
journals.biologists.com
1) I am delighted to present this terrific tour de force research conducted by my post-doc Dr. Gayani Senevirathne @gayani.bsky.social and published today in Nature - www.nature.com/articles/s41...
The evolution of hominin bipedalism in two steps - Nature
The human pelvis exhibits distinct spatiotemporal ossification patterns and an ilium cartilage growth plate that is shifted perpendicularly compared with those of other mammals and non-human primates—...
nature.com
Wonderful to have my second ever grad student stop by the lab today. Elizabeth Zuniga. She is now faculty working on eye development at Baylor College of Medicine. Such joy to see your former trainees doing so well.
New paper from the lab: Our teeth arose as sensory organs on the outside of the body of ancient jawless fish.!! Congrats to Yara Haridy and the team! Background and video: phys.org/news/2025-05... Open Access Paper: www.nature.com/articles/s41... News and Views: www.nature.com/articles/d41...
Teeth first evolved as sensory tissue in the armored exoskeletons of ancient fish, fossil scans find
Anyone who has ever squirmed through a dental cleaning can tell you how sensitive teeth can be. This sensitivity gives important feedback about temperature, pressure—and yes, pain—as we bite and chew ...
phys.org
Wonderful backstory of this gem by @mathithiru.bsky.social & @crumplab.bsky.social from earlier this year... 🔗 to original research: www.nature.com/articles/s41... 🔗 to the Node article: thenode.biologists.com/fish-frogs-f...
the Node@the-node.bsky.social · last yr.Fish, Frogs, Friends, Lend me your Ears. 🐟🐸🐁🦎 Read this 'Behind the paper' story from @mathithiru.bsky.social about her PhD work with @crumplab.bsky.social: thenode.biologists.com/fish-frogs-f... #DevBio #EvoDevo
Worthy event to support the engine of innovation in our country.
When did the lubricated joints that allow our skeleton to swivel, rotate and bend evolve? @crumplab.bsky.social explores a new @plosbiology.org paper by @neelimasharma.bsky.social &co that pinpoints their origin to the earliest jawed vertebrates 🧪 Paper: plos.io/3CTC8La Primer: plos.io/4kkhXa6
This is the most relevant article to NIH and research cuts I’ve seen. Imagine if this was today , how many people would be saying “Why are we studying Gila Monsters and their impact on diabetes ? That’s wasted money !” globalnews.ca/news/9793403...
How a Canadian scientist and a venomous lizard helped pave the way for Ozempic - National | Globalnews.ca
In 1984, Dr. Daniel Drucker, an endocrinologist from the University of Toronto, discovered a hormone that helped pave the way for popular diabetes drugs such as Ozempic.
globalnews.ca
Not only does Bennu contain all 5 of the nucleobases that form DNA and RNA on Earth and 14 of the 20 amino acids found in known proteins, the asteroid’s amino acids hold a surprise https://go.nature.com/4hDJnFM
Asteroid fragments upend theory of how life on Earth bloomed
Nature - Samples from Bennu contain the chemical building blocks of life — but with a twist.
go.nature.com
Nice article in Scientific American about our work on outer ear evolution and a complimentary study from the lab of Maksim Plikus on role of unique lipids in mammalian ear cartilage. www.scientificamerican.com/article/our-...
Our Ears Share a Common Ancestry with Fish Gills
The genes that build the cartilage of fish gills were repurposed to build the cartilage in mammals’ outer ears
scientificamerican.com
The outer ear is a mammalian innovation but where did it come from? In our study in Nature, Mathi Thiruppathy and colleagues find that the outer ear arose from modification of an ancestral gill program first originating in marine invertebrates. www.nature.com/articles/s41... 1/n
Repurposing of a gill gene regulatory program for outer ear evolution - Nature
Nature - Repurposing of a gill gene regulatory program for outer ear evolution
nature.com
📢🧪For your holiday travel reading, check out our new pre-print! Using a new joint resection injury model, we describe an innate regeneration program in adult #zebrafish that reestablishes all major synovial joint cell types, including lubricated articular cartilage. www.biorxiv.org/content/10.1...
biorxiv.org
How can some vertebrates naturally recover from deafness? In work in PNAS, Tuo Shi finds that enhancers for sensory genes remain open but silent in sister cells of zebrafish and lizards, allowing these to make new inner ear sensory hair cells upon damage. www.pnas.org/doi/10.1073/...
NPR's Short Wave features @USCStemCell PhD student Tuo Shi from the @CrumpLab, & Gnedeva and Lozito Labs, talking about his new paper in @PNASnews and how some animals can restore their hearing naturally, even though other animals like us cannot. @NPR @KECKSchool_USC www.npr.org/2024/12/12/n...
npr.org
Congratulations to newly minted PhD Tuo Shi. Some exciting news from Tuo is imminent. Stay tuned!
