Can #gene-loss fuel future #adaptation? Check out this exciting new study from @balazs-papp-lab.bsky.social showing that #compensatory-evolution can generate unexpected metabolic gains. Delighted to have contributed! Congratulations to everyone involved! 👏

@balazs-papp-lab.bsky.social · 2mo ago

Can harmful gene loss become an evolutionary opportunity? In our new work in @molbioevol.bsky.social , lab-evolved E. coli lines recovering from metabolic gene loss did more than return to normal: some surpassed wild type on nutrients never seen during lab evolution. 📎 doi.org/10.1093/molb...

🎓 Warm congrats to Elvin Maharramov @m-elvin.bsky.social on a successful PhD defense on the principles of designing #antibiotics with limited #resistance. A timely and elegant contribution to the field of #DrugDevelopment on how to design less resistance-prone antibiotics. More info below👇

Excited to share our collaborative work led by the Szilvia Juhasz and Mate Manczinger @matemanc.bsky.social labs: #cancer mutations converge into five protein-level “fingerprints” that shape tumor immune visibility. Mutation burden alone fails to predict #immunotherapy response! @molsystbiol.org

Máté Manczinger@matemanc.bsky.social · 6mo ago

Our new paper is out: Five dominant amino acid substitution signatures shape tumour immunity link.springer.com/article/10.1... Thread 🧵⬇ #cancer #tumor #immunity #immunotherapy #oncology

C > U mutations generate immunogenic peptides in SARS-CoV-2 @natcomms.nature.com @matemanc.bsky.social @csabapallab.bsky.social www.nature.com/articles/s41...

C > U mutations generate immunogenic peptides in SARS-CoV-2 APOBEC enzymes—key players of the innate immune system—induce mutations that become fixed in viral genomes and enhance immune recognition. nature.com/articles/s41... #COVID_19 #Immunology #virus #infectiousdiseases #vaccine #Genetics

A dual-target antibiotic strategy, combining membrane disruption with another cellular pathway, shows promise in reducing bacterial resistance, offering a new direction in combating antimicrobial resistance. doi.org/g855sh

Study uncovers the core principles of low-resistance antibiotics

A study published in Nature Communications has revealed novel insights into bacterial resistance and offers a promising strategy for developing antibiotics that minimize the evolution of resistance.

phys.org

We are looking for a postdoc in #EvolutionarySystemsBiology. Exciting science, amazing team, wonderful city! landrylab.ibis.ulaval.ca/research-opp... #evolution #synbio #systemsbiology #genomics

🚨 Our latest research in @naturecomms.bsky.social shows a promising strategy for less resistance-prone #antibiotics. For details, see the thread below and read the paper “Exploring the principles behind antibiotics with limited resistance” here: #MEvoSky www.nature.com/articles/s41...

Exploring the principles behind antibiotics with limited resistance - Nature Communications

This study shows that only those dual-targeting antibiotics limit resistance in Gram-negative pathogens that also target the membrane of the bacteria. This mechanism provides a basis for designing fut...

nature.com

Two recent studies led by 🇭🇺 @csabapallab.bsky.social find that resistance can develop against new 💊 antibiotics even before they are widely used, compromising their effectiveness from the start. #antibioticresistance #AMR

New antibiotics can develop resistance before even hitting the market

Researchers from the HUN-REN Biological Research Centre, Szeged (Hungary), have made a concerning discovery about the future of antibiotics.

dlvr.it

Alternative drug modalities/approaches are desperately needed to supplement the pipeline of antibiotics.

Csaba Pal Laboratory@csabapallab.bsky.social · 2y ago

🚨 Excited to share that our new study, “ESKAPE pathogens rapidly develop resistance against antibiotics in development in vitro” is published in @naturemicrobiol.bsky.social. For details, see the 🧵below and read the paper here: www.nature.com/articles/s41...

ESKAPE pathogens are outsmarting us. Our latest paper in @naturemicrobiol.bsky.social reveals alarming ease of resistance evolution to antibiotics in development. Collaborative work with @csabapallab.bsky.social‬ and Kintses Lab

Csaba Pal Laboratory@csabapallab.bsky.social · 2y ago

🚨 Excited to share that our new study, “ESKAPE pathogens rapidly develop resistance against antibiotics in development in vitro” is published in @naturemicrobiol.bsky.social. For details, see the 🧵below and read the paper here: www.nature.com/articles/s41...

💊🦠OUT NOW - comprehensive analysis of the propensity of ESKAPE pathogens to evolve resistance to new and in development antibiotics by Csaba Pal, Balint Kintses, Balazs Papp and colleagues. Dive in here... www.nature.com/articles/s41...

ESKAPE pathogens rapidly develop resistance against antibiotics in development in vitro - Nature Microbiology

An extensive experimental analysis of resistance to antibiotics in development or introduced post-2017 in ESKAPE bacteria reveals the dynamics of resistance acquisition, mutational targets and the pre...

nature.com

🚨 Excited to share that our new study, “ESKAPE pathogens rapidly develop resistance against antibiotics in development in vitro” is published in @naturemicrobiol.bsky.social. For details, see the 🧵below and read the paper here: www.nature.com/articles/s41...

ESKAPE pathogens rapidly develop resistance against antibiotics in development in vitro - Nature Microbiology

An extensive experimental analysis of resistance to antibiotics in development or introduced post-2017 in ESKAPE bacteria reveals the dynamics of resistance acquisition, mutational targets and the pre...

nature.com

Awesome! Many thanks ‪@thealexknapp.bsky.social‬ for spotlighting our recent work!

Alex Knapp@thealexknapp.bsky.social · 2y ago

Easily one of the more depressing scientific papers I've read this week - researchers found that Staph bacteria readily developed resistance to antibiotics in the development pipeline thanks to mutations already present in the population. www.science.org/doi/10.1126/...

Thrilled to share our latest work, "Antibiotic candidates for Gram-positive bacterial infections induce multidrug resistance" in Science Translational Medicine! For details, see the thread below and read the paper here: www.science.org/doi/10.1126/...

Antibiotic candidates for Gram-positive bacterial infections induce multidrug resistance

Antibiotic candidates induce multidrug resistance in Staphylococcus aureus without compromising bacterial viability.

science.org

Thrilled to share our latest work, "Antibiotic candidates for Gram-positive bacterial infections induce multidrug resistance" in Science Translational Medicine! For details, see the thread below and read the paper here: www.science.org/doi/10.1126/...

Antibiotic candidates for Gram-positive bacterial infections induce multidrug resistance

Antibiotic candidates induce multidrug resistance in Staphylococcus aureus without compromising bacterial viability.

science.org

While writing papers and grants, we received many comments on the role of CNVs in antifungal resistance. We thought we should formally assess how important they are. Here is what we found. #AMR #fungi #evolution rdcu.be/d5rbN

The role of gene copy number variation in antimicrobial resistance in human fungal pathogens

npj Antimicrobials and Resistance - The role of gene copy number variation in antimicrobial resistance in human fungal pathogens

nature.com