The next #DGZ Focus Workshop on #Cilia & #Centrosomes will take place November 25 (end of October is our DGZ meeting in HD). Join us for a great speaker line-up, and big thanks to David Mick @mick-lab.bsky.social & Dagmar Wachten @wachtenlab.bsky.social for organizing!

🤯🤯🤯🤯🤯🤯🤯🤯🤯🤯🤯🤯 Transcription factors SP5 and SP8 drive primary cilia formation in mammalian embryos | Science www.science.org/doi/10.1126/...

Transcription factors SP5 and SP8 drive primary cilia formation in mammalian embryos

Although specific transcription factors (TFs) are known to regulate cell fate decisions, the degree to which they can stimulate formation of specific cell organelles is less clear. We used a multiomic...

science.org

If you're finishing PhD soon and thinking of postdocs, see below! Especially if you're keen on combining biochemistry, imaging and cell biology, we are onto some exciting findings on molecules and mechanisms underlying a cytoplasmic division cycle autonomously of CDKs!!

Aydogan Lab@aydoganlab.bsky.social · last yr.

#Postdoc-opportunity at Columbia U. in New York!! Looking for a postdoc position? We are interested in candidates from biochemistry background & excited about fractionation, purification and reconstitution to study autonomous clocks in the cell cycle, in colab. with @aydinlab.bsky.social at NYU!

New paper on DYRK kinases and primary cilium! This project began with our interest in DYRK3’s relationship to centriolar satellites. But what started as a CS-focused story soon evolved into studying DYRK kinase activity during ciliogenesis. nature.com/articles/s42...

Kinase activity of DYRK family members is required for regulating primary cilium length, stability and morphology - Communications Biology

DYRK3 kinase interacts with multiple centriolar satellites and ciliary components to regulate axoneme length dynamics in cooperation with DYRK2.

nature.com

The #PrimaryCilium dynamically assembles & disassembles, but how is this controlled? @cytolabkoc.bsky.social shows that #ciliopathy linked protein Ccdc66 regulates both #cilium stability & length in epithelial cells via microtubules, actin & vesicular trafficking @plosbiology.org 🧪 plos.io/4mdTS4A

Exciting new preprint alert! Our latest research is a tour de force exploring the biology of centriolar satellites, membrane-less organelles essential for development and physiology. Below is a summary of our findings; dive into the full paper through this link 👇 biorxiv.org/content/10.1...

Our paper uncovering the role of the microtubule-associated protein CCDC66 in primary cilium stability and disassembly is now published in @plosbiology.org ! We discovered exciting new links between CCDC66, microtubules, actin, vesicular trafficking, and Wnt. 🔗 journals.plos.org/plosbiology/...

CCDC66 regulation of cytoskeleton and cilia stability is important for signaling and epithelial organization

The primary cilium dynamically assembles and disassembles while maintaining structural stability and tightly regulated length, but the mechanisms that control this remain unclear. This study shows tha...

journals.plos.org

I’ll be visiting @wachtenlab.bsky.social’ lab at the Institute of Innate Immunity in Bonn this August for a mini‑sabbatical! I would love to connect with scientists in Bonn and beyond; please reach out if you’d like to chat, collaborate, or host a seminar.

EMBL Cell Biology and Biophysics department is searching for a new director. A major position to lead this field in Europe and beyond. embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

Head of the Cell Biology and Biophysics Unit

The European Molecular Biology Laboratory (EMBL) is Europe’s flagship life sciences organisation, and one of the world’s leading research institutions. An intergovernmental organisation of 29 Member S...

embl.wd103.myworkdayjobs.com

ERC eligibility rules have changed! I'm among the last researchers awarded the ERC Starting Grant twice. The new rules could broaden applications but also increase competition, let's see how funding rates evolve!

As the incoming Chair of Biochemistry and Biophysics at Weill Cornell Medicine, I am looking for a Director of Research. Exciting opportunity for a PhD scientist to shape the future of this new Department! Apply here: jobs.weill.cornell.edu/NY/job/New-Y...

Even in the 'good' days, students/PDs on visas were always worried that they would run afoul of the law and be asked to leave. I know - I was on a student visa myself. I can't even begin to imagine their fear and anxiety now. Time for all university leaders to collectively step up and speak out!!

The MIT McGovern Institute’s story celebrating the 10th birthday of expansion microscopy (ExM). One highlight: ExM is not only easy to do, it’s easy to modify - so lots of people are altering and applying ExM for custom purposes, leading to unexpected innovations: mcgovern.mit.edu/2025/03/03/t...

Proud to share our work spear-headed by PhD student Tommy Sroka with major contributions by #xenopus expert Kerstin Feistel. Our iAPEX #ProximityLabeling method for #MassSpec based subcellular #proteomics works by locally generating H2O2 using a D-amino acid oxidase that activates APEX2 in situ.

iAPEX: Improved APEX-based proximity labeling for subcellular proteomics using an enzymatic reaction cascade

Ascorbate peroxidase (APEX) is a versatile labeling enzyme used for live-cell proteomics at high spatial and temporal resolution. However, toxicity of its substrate hydrogen peroxide and background la...

biorxiv.org

We had a wonderful New Year’s dinner! 2024 was full of great moments: I became an EMBO member, Leyla was born, we published important papers, presented at conferences, organized #advimaging2024, got a new microscope, welcomed new team members. Here is to more in 2025!

Sorry to miss #cellbio2024 as my 5-month-old isn't quite ready for transatlantic flights, But Cytolab is still represented! Don't miss Efe’s microsymposium talk & poster on centriolar satellites and Basak’s poster on non-ciliary functions of ciliopathy proteins.

🧪 Lab's latest!! Work by PD (and now PI) Alison Philbrook. C. elegans sensory neurons have gorgeous #cilia. We’ve always thought that a) no cilia = no sensory responses, & b) no IFT = no cilia. Punchline is we thought wrong. Read paper for more! #neuroscience journals.plos.org/plosbiology/...

Cilia structure and intraflagellar transport differentially regulate sensory response dynamics within and between C. elegans chemosensory neurons

The relative contributions of intraflagellar transport (IFT) and cilia structure to sensory neuron responses remains unclear. This study reveals unexpected complexity in the contribution of IFT and ci...

journals.plos.org

I'm excited to see that a photo of Leyla with me receiving my EMBO member certificate along with other members and EMBO Director Fiona Watt was shown in the photo gallery for the EMBO 60th anniversary celebration. What a wonderful memory for her!

Thank you Ula and the rest if the organizers for putting together such a fantastic meeting.

UK Cilia and Centrosome Network@ukcilianetwork.bsky.social · 2y ago

UK Cilia and Centrosome Network autumn meeting in Liverpool was a success! 1) Great ECR representation+diveristy✓ 2) Talks from leading experts inc. EMBO-YIP Elif @cytolabkoc.bsky.social ✓ 3) Superb networking opportunities ✓ Thanks to Ula @urszulamcclurg.bsky.social for pulling it all together

I look forward to visiting the University of Liverpool this Thursday to present our findings on centriolar satellites. I will also give the keynote talk and share our latest cilia findings at the UK Cilia Meeting on Friday.

Thankful to have an office for pumping, so much better than the microscope room or other awkward spots I used during my PhD/postdoc. Dedicated nursing rooms are essential for supporting women’s return to work. It’s a simple change that can make a huge difference for working moms.

Leyla participated our meeting on how to address reviewer comments.

Since I last logged into Bluesky, the number of kids in my profile has changed from 3 boys to 3 boys and a girl! Time to update my profile and build my community here.

To all UK cilia enthusiasts! Our autumn meeting this year will be in Liverpool on 22nd November. Registration is now open at forms.gle/S7VtCpyUXAGa... and abstract submission will open soon. This is an ECR focused event so priority for talks/posters will be given to trainees. Come along!