Aydogan Lab
@aydoganlab.bsky.social
Columbia University & HHMI We study principles of biological time control with a focus on the emerging concept of autonomous clocks. See more at: aydoganlab.com
🔍 Meet AMIGa: a newly characterized #Yeast mitochondrial complex required for assembly of both cytochrome c oxidase & ATP synthase. Without it, respiratory intermediates pile up & cells lose respiratory growth 👉 critical coordination role 🧬 #YeastResearch 🧪 #SGD 🔬 www.yeastgenome.org/reference/S1...
📣Huge preprint 🔔 Today we share something our group has been working toward for a long time, led by @lucasmoriniere.bsky.social We asked can we predict which receptor a phage targets from its genome sequence alone? For most phages, we couldn’t. So Lucas set out to do something I had only dreamed of.
Are you looking for a postdoc exploring the cell biology of development, defining how cells change shape and move? Do you want to develop a research program & teaching skills preparing you for a position at a college or small University? Our new NIH grant will support those goals 1/n Please share
♻️ Our new review explores how multiciliated cells repurpose the cell cycle for ciliogenesis ♻️ Congrats Gonzalo Ortiz Álvarez & @adelaljord.bsky.social, and many thanks to @aydoganlab.bsky.social ! Read the paper here : link.springer.com/chapter/10.1... @crg.eu @prbb.org @springernature.com
The curious case of the placental genome In this Review, Zoé Ducarne, @agathechaigne.bsky.social and @myanhtruong.bsky.social highlight the placenta, the only mammalian organ that harbors a cancer-like genome while remaining functional and healthy. doi.org/10.1242/dev....
Just noticing this very cool work from @osman-lab.bsky.social! Highly important for our understanding of how the nucleus could gauge the needs of mitochondria (or vice versa) by coupling a critical nuclear-encoded mitochondrial enzyme to the translation of mitochondrially encoded mRNAs!
Osman Lab@osman-lab.bsky.social · 2mo agoPreprint now up on bioRxiv: www.biorxiv.org/content/10.6.... Full author list and details in the paper. Comments and feedback very welcome! #lmu #mtdna #mitochondria
🧬 New preprint from our lab! After years of work, we're excited to share our story: the pyruvate dehydrogenase complex (PDHc) — best known for feeding the TCA cycle — has a second, non-catalytic role supporting mitochondrial DNA gene expression in yeast.
Did you know that enhancers transcribe?? Wonder why? Check out this very exciting work out from our department colleague and friend @philippebatut.bsky.social!!!
Philippe Batut@philippebatut.bsky.social · last mo.🧬🔬 Why are enhancers transcribed and how does that impact gene regulation? I’m really excited to share our new paper in @science.org showing that noncoding RNAs control the timing of gene activation in embryos. With Mike Levine #ScienceResearch @columbiamed.bsky.social A few highlights below... 🧵👇
Our article is on the COVER of this month’s issue of @cp-devcell.bsky.social! Congrats to all the authors for the hard work, especially Shota, Despina and @jamesbriscoe.bsky.social
Transcription stops. RNA splicing takes over 🧬 ✨ Our new preprint uncovers the post-transcriptional RNA splicing landscape powering mammalian oocyte development. Read it here 👇 www.biorxiv.org/content/10.6...
Kinetic Control of Nuclear-encoded Mitochondrial mRNA Localization and Local Translation https://www.biorxiv.org/content/10.64898/2026.08.22.746448v1
A bacterial metabolite rewires fungal metabolism, triggering the hyphae-to-yeast transition @currentbiology.bsky.social by Manasa Bharathwaj @mbharathwaj.bsky.social et al from Ana Traven www.cell.com/current-biol...
A bacterial metabolite rewires fungal metabolism, triggering the hyphae-to-yeast transition
The hyphae-to-yeast morphological transition promotes dissemination of the pathogen Candida albicans, but the mechanisms underlying this process are poorly defined. By identifying a bacterial metaboli...
cell.com
Cellularization as a mechanism to build cells. #CellBio #DevBio Supported by @girishkalephd.bsky.social, Anne Ruess highlights a #preprint of @margaridaaraujo.bsky.social et al. @hiralshah.bsky.social @gautamdey.bsky.social @dudinlab.bsky.social #preLight⬇️ prelights.biologists.com/highlights/m...
Microtubules sustain the fidelity of cellularization in a coenocytic relative of animals - preLights
Cellularization as a mechanism to build cells
prelights.biologists.com
Our work on the role of the proteasome in developmental tempo is out!!!! 🐭⌛️👤⏳ Six years after identifying an association between protein stability and developmental tempo, we now demonstrate a causal link between protein turnover and developmental tempo through proteasomal degradation
Developmental Cell@cp-devcell.bsky.social · 2mo agoOnline now: Proteasome-dependent protein degradation shapes developmental tempo in mouse and human neural progenitors #biology #science
Long-timescale simulations reveal multi-ion flux through wide pore gap junction channels -– and an unexpected transition involving loop–NT domain interactions that suggest a dynamic ensemble of micro-states define the “open” channel www.biorxiv.org/content/10.6...
Battistolli, M., Varponi, I., Romoli, O., Sandrelli, F. (2025). The circadian clock gene period regulates the composition and daily bacterial load of the gut microbiome in Drosophila melanogaster. Scientific reports, 15(1):1016 www.nature.com/articles/s41...
The circadian clock gene period regulates the composition and daily bacterial load of the gut microbiome in Drosophila melanogaster - Scientific Reports
Scientific Reports - The circadian clock gene period regulates the composition and daily bacterial load of the gut microbiome in Drosophila melanogaster
nature.com
Excited to share our newest work! We asked whether RNA molecules need to be in a specific place in the cell to do their job. We found that a single RNA must reach the midbody, the structure that pinches two dividing cells apart, for cell division to finish efficiently. 🧵⬇️
Thrilled to share our new work, co-developed w/Adrian Salic's lab: bioorthogonal probes for labeling PE, a multifunctional membrane lipid and source of important protein modifications. Congrats to Yuan-Ting Cho, Brittany White-Mathieu, Jade Xia, & Cindy Jao! onlinelibrary.wiley.com/doi/10.1002/...
Bioorthogonal Tools for Ethanolamine Lipids and Protein Conjugates
An alkyne-tagged ethanolamine analog (AlkEA) enables bioorthogonal, metabolic labeling of endogenous phosphatidylethanolamine (PE) and its protein modifications. AlkEA is incorporated into PE via the...
onlinelibrary.wiley.com
We are looking to hire a technician to join the team. This project focuses on the nuclear lamina, a cellular structure that protects and organizes the genome. Will build skills in genetic screening, genomics, and stem cell culture. Please share, please apply! aprecruit.ucsf.edu/JPF06185
Junior Specialist, Buchwalter Laboratory, Cardiovascular Research Institute
University of California, San Francisco is hiring. Apply now!
aprecruit.ucsf.edu
Our Dispatch "Evolution: Ancient monoamines in a neuron-less animal" out in @currentbiology.bsky.social. Monoamine signaling and behavioral responses in placozoans suggest this system predates bilaterians. authors.elsevier.com/a/1nYJl3QW8S... @annaferraioli.bsky.social @msarscentre.bsky.social
🧵Heartfelt congratulations to our lab’s first PhD student—and soon-to-be graduate—Andrew Alamban on receiving the 2026 ASCB | EMBO Porter Prize for Research Excellence! 👇In celebration of his work, here is a brief thread highlighting Andrew’s accomplishments in the lab!
American Society for Cell Biology@ascbiology.bsky.social · 3mo agoCongratulations to the 2026 ASCB Honorific Award Winners! ASCB is proud to recognize scientists whose research, mentorship, education & leadership are helping shape the future of cell biology. See all the awardees: https://www.ascb.org/society-news/ascb-announces-2026-honorific-award-winners/
We are looking for talented graduate students to join our group for Fall 2026 studying the role and regulation of Hsp70 PTMs! If you are interested please check out www.trumanlab.org
Cancer Research Laboratory | Trumanlab | UNC Charlotte | United States
The Trumanlab at UNC Charlotte incorporates protein biochemistry, molecular biology, proteomics, systems biology, bacterial and yeast genetics as well as cell culture technologies to identify novel an...
trumanlab.org
To all lipid-curious cell biologists: check out this comprehensive overview of lipid-based methods by @gerryhammond.bsky.social and colleagues in @jcb.org — a school of Babel fish for #lipidtime: rupress.org/jcb/article/...
The cell biologist’s guide to detecting and modulating membrane phospholipids | Journal of Cell Biology | Rockefeller University Press
Worcester et al. describe a suite of molecular tools and approaches that can be used to probe and experimentally study lipids.
rupress.org
Proximity labeling users: check out this study by @zhixingchen2.bsky.social and Peng Zou, which establishes how much contact-dependence vs. diffusion is responsible for biotinylation — tl;dr TurboID has a much smaller effective radius! www.nature.com/articles/s41... 1/2
Spatial barcoding reveals reaction radii and contact-dependent mechanism of proximity labeling - Nature Chemical Biology
A DNA nanoruler platform enables precise measurement of the labeling radii of TurboID and APEX2, uncovering their contact-dependent mechanisms. These findings redefine the enzymology of proximity labe...
nature.com
Modern biology research is biased towards investigating genes that are widely conserved and present in humans. What about genes that ARE widely conserved but NOT present in humans? Can genes missing from humans tell us something about what makes our biology different from that of other animals? 1/8
Bad antibodies are such a huge problem. It’s not just the money wasted on buying them. It’s the amount of time spent trying to validate them.
Nikolai Slavov@slavov-n.bsky.social · 10mo agoMany articles reported using an antibody ... that didn’t even bind the key protein in Laflamme’s testing. Those articles had been cited over 3,000 times. A key question is: ◼️ 𝐂𝐚𝐧 𝐩𝐫𝐨𝐭𝐞𝐢𝐧 𝐛𝐢𝐧𝐝𝐞𝐫𝐬 𝐚𝐜𝐡𝐢𝐞𝐯𝐞 𝐡𝐢𝐠𝐡 𝐬𝐩𝐞𝐜𝐢𝐟𝐢𝐜𝐢𝐭𝐲 𝐟𝐨𝐫 𝐞𝐯𝐞𝐫𝐲 𝐞𝐩𝐢𝐭𝐨𝐩𝐞 & 𝐩𝐫𝐨𝐭𝐞𝐨𝐟𝐨𝐫𝐦?
I was today years old when I learned that there is a superb (freely available) documentary from 1961 on early zebrafish development by J.V. Durden. collection.nfb.ca/film/embryon... (1/2)
#Mastodon, the Command Center for Large-Scale Lineage-Tracing Microscopy Datasets, is finally heading for publication (well, let's see). To #cite or not to cite shall no longer be the question 🙃, because the #preprint. Software is available in every #Fiji near you. www.biorxiv.org/content/10.6...
I was just wondering about this the other day!! A timely print!
Claudio Cantù@claudiocantu81.bsky.social · 10mo agoCan one map the genome-wide binding (1) and its protein partners (2) simultaneously from the same sample? Yes, one can. with CUT&ID ✂️🪪 Spearheaded — singlehandedly — by @annanordin.bsky.social No need of transgenesis, cloning and overexpression. Check it out, it's fast and its works.
