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UK Cilia and Centrosome Network

@ukcilianetwork.bsky.social

A supportive network for the cilia and centrosome research community to share research and expertise. https://www.cilianetwork.org.uk/

24 Posts258 Follower48 Folgt
Wieczorek Lab@mike-wieczorek.bsky.social · 2mo ago

New preprint! In collaboration with @xujwet.bsky.social, @pedrobeltrao.bsky.social, and Akhmanova and Beekman groups, we determined the structure of the transition zone microtubule doublet in mammalian motile cilia, providing potential insights into the regulation of IFT: tinyurl.com/fssnevuc

Structure of the mammalian ciliary transition zone microtubule doublet

The ciliary transition zone gates bidirectional protein trafficking to maintain the specialized ciliary proteome using microtubule doublets as a scaffold. While ciliary axonemal doublets are well-char...

tinyurl.com

EuroCilia2027@eurocilia.bsky.social · 2mo ago

Big congratulations to our winners: Smilla-Maria Koy (1st), Chandrama Ghosh (2nd), and Anthony Rabaté (3rd)! Check out their breath-taking micrographs and the rest of the Top 15 entries in the stunning poster attached. The future of cilia research looks beautiful. 📸 #Cilia2027

micrographs depicting cilia in different forms
Simon Bullock@simonbullock11.bsky.social · 3mo ago

Thrilled to see this work published. Thanks to helpful reviewer suggestions, there are some exciting new insights that were not in the preprint (particularly in Figure 4). www.nature.com/articles/s41...

Structural basis for recognition of diverse localizing mRNAs by Egl–BicD - Nature Structural & Molecular Biology

Singh et al. combine cryo-electron microscopy and functional studies to reveal how a single protein complex selects diverse mRNAs for subcellular localization using a combination of shape, positional ...

nature.com

MRC Laboratory of Molecular Biology@mrclmb.ac.uk · 3mo ago

The hidden rules behind mRNA transport. A collaborative study between @simonbullock11.bsky.social & @carter-lab.bsky.social’s groups has found a structural code that explains how cells selectively transport mRNAs. Read more: mrclmb.ac.uk/news-events/... #LMBNews @cellbiol-mrclmb.bsky.social 🧪

Structural representation of the Egl-BicD-dynein-dynactin complex transporting an mRNA molecule along a microtubule, with a magnified inset of the Egl-BicD-RNA structure.
Nature Structural & Molecular Biology@natsmb.nature.com · 3mo ago

New online: Structural basis for recognition of diverse localizing mRNAs by Egl–BicD

Structural basis for recognition of diverse localizing mRNAs by Egl–BicD

Nature Structural & Molecular Biology, Published online: 05 May 2026; doi:10.1038/s41594-026-01794-8Singh et al. combine cryo-electron microscopy and functional studies to reveal how a single protein complex selects diverse mRNAs for subcellular localization using a combination of shape, positional sequence information and number of structured RNA elements.

dlvr.it

Prof Paula Salgado@pssalgado.bsky.social · 4mo ago

A welcome and much needed reopening of pplicant-led grants today at MRC, with no closing date. It brings massive changes to assessment, with more details now available. Focus is on evaluation by a "college of experts" but its composition is still not clear. 1/6 www.ukri.org/opportunity/...

MRC: research grant: applicant-led

Apply for funding to support exciting and ambitious research within the remit of the Medical Research Council, to transform our understanding of human health and disease

ukri.org

UK Cilia and Centrosome Network@ukcilianetwork.bsky.social · 4mo ago

🥁Calling all Cilia & Centrosome enthusiasts! Registration for the UK Cilia & Centrosome Network Spring meeting in Leeds is open. A homecoming to the place where '9+2' was discovered! Great opportunity for trainees + ECRs to share work + get community feedback. www.eventbrite.co.uk/e/uk-cilia-c...

UK Cilia & Centrosomal Network Meeting Spring Meeting 2026

Join us for the annual in-person meeting of the UK Cilia & Centrosomal Network meeting, which for 2026 will be at the University of Leeds!

eventbrite.co.uk

@sudiya14.bsky.social · 4mo ago

1/3 Lab #Preprint alert…A cool study led by @MullickSan22454 in collab with @ms_chirps lab showing how tubulin glycylation regulates ciliary motors and MAPs in vitro. @biorxiv_biochem. #glycylation #tubulinPTMs #cilia #Intraflagellartransport. Read more biorxiv.org/content/10.648…

bioRxiv Biochemistry@biorxiv-biochem.bsky.social · 4mo ago

Tubulin glycylation regulates microtubule-protein interactions that are key for ciliary stability and trafficking https://www.biorxiv.org/content/10.64898/2026.03.26.714406v1

Vladimir Volkov 🇺🇦@vladimirvolkov.bsky.social · 5mo ago

Happy to see the first paper from the lab published in the EMBO J today: link.springer.com/article/10.1... In it, we reconstitute self-assembling cooperative oligomers of human Ndc80 and Ska kinetochore complexes that stabilise microtubule ends, and study these samples using cryoET and TIRF

Microtubule end stabilisation by cooperative oligomers of Ska and Ndc80 complexes - The EMBO Journal

During mitosis, properly aligned chromosomes stabilise microtubule ends with the help of kinetochores to ensure timely segregation of chromosomes. Microtubule-binding components of the human outer kin...

link.springer.com

Matthew Freeman@mjafreeman.bsky.social · 5mo ago

Interested in one of the top jobs in European biology? @embo.org has opened a call for its next Director, to succeed Fiona Watt Really spectacular opportunity! Spread the word... www.embo.org/features/emb...

EMBO starts search for its next Director – Features – EMBO

The process to appoint the next EMBO Director is underway. The incoming Director will take office in February 2028, succeeding Fiona Watt, who has led the organization since January 2022

embo.org

The EMBO Journal@embojournal.org · 5mo ago

Microcephaly-associated protein WDR62 supports purine metabolism by interacting with co-chaperone BAG2 Dominic Ng and coworkers link.springer.com/article/10.1...

Microcephaly-associated protein WDR62 supports purine metabolism by interacting with co-chaperone BAG2 - The EMBO Journal

Inherited mutations in the spindle pole-associated scaffold protein WDR62 cause autosomal recessive primary microcephaly. Previous research has characterised the roles of WDR62 in the regulation of sp...

link.springer.com

Kelly Nguyen@kellythd-nguyen.bsky.social · 5mo ago

I am so grateful to the Blavatnik Family Foundation and the New York Academy of Sciences for this honor. Can’t wait to be back to the lab and celebrate with lab members on this special recognition of their hard work.

MRC Laboratory of Molecular Biology@mrclmb.ac.uk · 5mo ago

Congratulations to @kellythd-nguyen.bsky.social, Group Leader in the LMB’s Structural Studies Division, who has been named the Life Sciences Laureate at the 2026 Blavatnik Awards in the UK 🎉 Read the full news story here: mrclmb.ac.uk/news-events/... #LMBNews #Blavatnik2026

Kelly Nguyen announced as Laureate in Life Sciences at the 2026 Blavatnik Awards in the UK.