There hasn't previously been a treatment vs pancreatic cancer this successful. Striking improved (a doubling) survival results @nejm.org and @ascocancer.bsky.social published today with daraxonrasib, which also became available via an FDA-approved early access program nejm.org/doi/full/10....

Nature research paper: Safety and efficacy of intratumoural anti-CTLA4 with intravenous anti-PD1 go.nature.com/3OW2mCt

Safety and efficacy of intratumoural anti-CTLA4 with intravenous anti-PD1 - Nature

The phase 1b NIVIPIT trial shows that in combined therapy with intravenous nivolumab (anti-PD1), intratumoural administration of ipilimumab (anti-CTLA4) offers improved safety and greater efficacy compared with intravenous delivery.

go.nature.com

This researcher created a fictional illness, and fake studies funded by the Professor Sideshow Bob Foundation and University of the Fellowship of the Ring and the Galactic Triad. LLMs warned people the illness was real. go.nature.com/4cQabS5

Scientists invented a fake disease. AI told people it was real

Nature - Bixonimania doesn’t exist except in a clutch of obviously bogus academic papers. So why did AI chatbots warn people about this fictional illness?

go.nature.com

Reminder: deadline to apply for the Stem Cell Summer School is 30th May. And it's May already! So you have to apply this month! A limited number of bursaries are available. p.s. this year, the summer school coincides with the Spetses Armata Festival, so there will be a big party on the island 🙂

Stem Cell Summer School@stemcellsummer.bsky.social · last yr.

The 2025 European Summer School in Stem Cell Biology and Regenerative Medicine will take place 12-19 Sept 2025, on the beautiful Greek island of Spetses. Keep an eye on our website www.stemcellsummerschool.org for updates, or give us a follow 😀 Deadline for applications: 30th May 2025

Thrilled to share that my 2nd first-author paper from my PhD is now published in @narjournal.bsky.social ! After >9 years of work and an amazing collaboration with Koen Theunis, this project holds a special place in my heart (1/9) #SingleCell #MultiOmics academic.oup.com/nar/article/...

Single-cell genome and transcriptome sequencing without upfront whole-genome amplification reveals cell state plasticity of melanoma subclones

Abstract. Single-cell multi-omics methods enable the study of cell state diversity, which is largely determined by the interplay of the genome, epigenome,

academic.oup.com

This week, my focus was mostly on bioinformatics developments, with one exception—the Seq-Scope-X preprint. It appears to be the first sequencing-based spatial method to achieve the same resolution as imaging-based techniques, which is an exciting breakthrough. open.substack.com/pub/behindth...

Weekly reads 10/2/25

Week 3!

open.substack.com

Plus un parti est à droite, plus il diffuse des fake news Conclusion d'une étude néerlandaise qui a analysé 32 millions de messages postés sur Twitter par des parlementaires de 26 pays, dont la France ➡️ bit.ly/40MucD2

The 2025 Stem Cell Summer School! We get outstanding feedback each year & should probably update our testimonials page 🙃 www.stemcellsummerschool.org/testimonials This is an advanced course for experienced PhD students (2nd yr & up), postdocs & Junior PIs It will be great. Please spread the word

Mekayla Storer@storerlab.bsky.social · last yr.

Calling all students. The registration for the European Summer School on Stem Cell Biology and Regenerative Medicine is now open.

Il semble que dès qu’1 enquête publique est lancée pour réaliser des aménagements corrects, elle déchaîne les passions 🔥 C’est visiblement le cas pour celle concernant le RP Louise avec avalanche d’articles de presse & campagne en ligne agressive des associations pro-🚗 1/

Just rewrote my 2020 blog post on how to stay on top of the never-ending stream of scientific articles & preprints! Whether you're already drowning in your "to-read" folder or just starting out, I hope these tips help! Let me know what you think—or share your own tips!

Finding “relevant” papers in today’s scientific world

For my first blog post, I decided to revisit and rewrite some advice I originally shared in 2020 on how to stay up-to-date with scientific publications.

open.substack.com

How oncogenic clones can eliminate their neighbours to take over space ? There are different ways combining growth and interfacial tension induced compaction. Check out our latest preprint led by Léo Valon and Alexis Matamoro-Vidal to learn more about this 👇 www.biorxiv.org/content/10.1...

The oestrous cycle stage affects mammary tumour sensitivity to chemotherapy www.nature.com/articles/s41...

The oestrous cycle stage affects mammary tumour sensitivity to chemotherapy - Nature

In three mouse models of breast cancer, we show reduced responses to neoadjuvant chemotherapy when treatment is initiated during the dioestrus stage, when compared with initiation during the oestrus s...

nature.com