Super happy to see the last paper of my PhD published in @natureportfolio.nature.com journal Nature Communications! Here is a graphical summary and a short thread of our findings.
David Walzik
@davidwalzik.bsky.social
PhD student at TU Dortmund University | Medical student University of Cologne | Studying the molecular impact of exercise on immune cells | Sports enthusiast 🚴🏽🏋🏽🏃🏽
One of the most-viewed PNAS articles in the last week is “Antioxidants prevent health-promoting effects of physical exercise in humans.” Explore the article here: www.pnas.org/doi/10.1073/... For more trending articles, visit ow.ly/Me2U50SkLRZ.
PhD candidates and postdocs of all disciplines: Would you like to lead an independent junior research group? In our online talk you will get first-hand information about the aims of our Emmy Noether Programme, its eligibility requirements and more. Questions welcome! ➡️ www.dfg.de/en/research-...
The exerkine meteorin Metrnl is a potential therapeutic target for preserving human beta cell function and survival in type 1 #diabetes @diabetologiajnl.bsky.social link.springer.com/article/10.1...
Exercise-induced meteorin-like protein protects human pancreatic beta cells from cytokine-induced apoptosis - Diabetologia
Aims/hypothesis Inflammation-driven pancreatic beta cell death is a hallmark of type 1 diabetes progression. We have previously shown that serum obtained from individuals after high-intensity interval...
link.springer.com
Fruit flies demonstrate a mechanism that immune cells can use to control the availability of nutrients when fighting infections. buff.ly/NXOfE4a
Energizing immune cells
Experiments in fruit flies reveal a mechanism that immune cells can use to control the availability of nutrients when fighting infections.
buff.ly
'Bluesky has overtaken its flailing rival X in hosting posts related to new academic research, indicating the platform is fast becoming the go-to place for scholars to share their work.'
X’s dominance ‘over’ as Bluesky becomes new hub for research
Data indicates more scholars turning to alternative social media site to post about their work after Elon Musk’s Twitter takeover
timeshighereducation.com
Check out our new paper now out in Acta Physiologica on the tryptophan metabolite 3-HAA in the aging and exercise context 👇 @50823zimmer.bsky.social @davidwalzik.bsky.social onlinelibrary.wiley.com/doi/full/10....
Exercise training restores longevity‐associated tryptophan metabolite 3‐hydroxyanthranilic acid levels in middle‐aged adults
Aim Recent pre-clinical evidence suggests that the tryptophan metabolite 3-hydroxyanthranilic acid (3-HAA) and the related enzyme activity along the kynurenine metabolic pathway (KP) are associated ...
onlinelibrary.wiley.com
A study in Nature Medicine provides a comprehensive map of the contributions of environment and genetics to mortality and incidence of common age-related diseases, suggesting that the exposome shapes distinct patterns of disease and mortality risk. #Medsky 🧪
Integrating the environmental and genetic architectures of aging and mortality - Nature Medicine
Based on a systematic analysis of environmental exposures associated with aging and mortality in the UK Biobank, the relative contributions of such exposures and genetic risk for mortality and a range of age-related diseases were compared, highlighting the potential beneficial effects of environment-focused interventions.
go.nature.com
Protein organ clocks, as assessed in over 6,000 people (~4,000 plasma proteins, 8 organs) with 20-year follow-up are predictive for over 30 age-related diseases www.thelancet.com/journals/lan...
Peto's Paradox—that cancer does not increase with body size of mammals—was wrong. A new, comprehensive study of 263 species documents higher cancer prevalence with increasing body mass. Some large animals (e.g. elephants) have some built-in genetic adaptations www.pnas.org/doi/10.1073/... @pnas.org
No evidence for Peto’s paradox in terrestrial vertebrates | PNAS
Larger, longer-lived species are expected to have a higher cancer prevalence compared to smaller, shorter-lived species owing to the greater number...
pnas.org
A deep dive into the heterogeneity of human muscle fibers using transcriptomics and proteomics, now online @naturecomms.bsky.social. This was an amazing collaboration between our team @wimderave.bsky.social and the team @adeshmukh.bsky.social www.nature.com/articles/s41...
Human skeletal muscle fiber heterogeneity beyond myosin heavy chains - Nature Communications
Moreno-Justicia and colleagues report transcriptomic and proteomic pipelines to explore heterogeneity within human skeletal muscle fibers, identifying sources of fiber heterogeneity in healthy individ...
nature.com
Pretty cool!
Daniel Drucker@danieljdrucker.bsky.social · last yr.A combination of #exercise physiology, molecular biology & biochemistry studies identifies the Ergothioneine-3-mercaptopyruvate sulfurtransferase axis as a molecular mechanism for regulating mitochondrial function and #exercise performance @cp-cellmetabolism.bsky.social www.cell.com/cell-metabol...
Cellular crosstalk in skeletal muscle? A surprising role for mast cells? Histamine as a signal transducer during exercise? Check out the story in @cp-cellmetabolism.bsky.social 🧵 @wimderave.bsky.social, @ugent-fge.bsky.social, @fwovlaanderen.bsky.social www.sciencedirect.com/science/arti...
New #Cell_Metabolism paper: Cellular deconstruction of the human skeletal muscle microenvironment identifies an exercise-induced histaminergic crosstalk. #MyoBlue tinyurl.com/ymc5ha3w
Cellular deconstruction of the human skeletal muscle microenvironment identifies an exercise-induced histaminergic crosstalk
Van der Stede et al. identified a role for mononuclear cells in the skeletal muscle microenvironment to steer the response to exercise. Mast cells locally secrete histamine during exercise, triggering...
tinyurl.com
Happy to share our new preprint, where we investigate the impact of acute exercise on the proteome of immune cell! Comparing high-intensity interval exercise (HIIE) and moderate-intensity continuous exercise (MICE), we found numerous proteins that were differentially expressed in PBMCs. (1/12)
Acute exercise rewires the proteomic landscape of human immune cells
Exercise-driven alterations of the immune system are a key mechanism in the prevention and treatment of various diseases. Here, we performed mass spectrometry-based proteomics analysis on peripheral b...
medrxiv.org
✨New issue!✨ Check out the latest in #metabolism research from across all disciplines 🧫🐭👥 Read about #Obesity, #Diabetes, #Epidemiology, #Myokines, #Cancer, #Aging - and many more topics! www.nature.com/natmetab/vol...
Welcome immigrants from X interested in science to the friendlier skies of @bsky.app, as documented by a new @nature.com survey (but you already knew that 😉) "Bluesky is much better for science. There is much less toxicity, misinformation, and distractions." www.nature.com/articles/d41...
#CardioSky #MedSky community, I am reposting this because posts are still being “liked”. Pls “repost” if you like to share with others.
We have a feeling you'll be interested in this one. Nature is keen to find out how scientists are using Bluesky and whether it has become their go-to social-media platform. Take the survey! 🧪
Has Bluesky replaced X for scientists? Take Nature’s poll
The research community has flocked to the social-media platform Bluesky. Tell us about your experience.
go.nature.com
There are already many articles for which there is more attention on Bluesky than on other comparable micro-blogging sites, meaning the academic community and the general public have clearly adopted Bluesky as one of its core places to disseminate and discuss new research. A Place of Joy.
Happy to share our new article on the effect of acute exercise on NAD⁺ metabolism of human immune cells, published in Brain, Behaviour, and Immunity: www.sciencedirect.com/science/arti... Short 🧵 on this, here we go: (1/13)
Acute exercise boosts NAD+ metabolism of human peripheral blood mononuclear cells
Nicotinamide adenine dinucleotide (NAD+) coenzymes are the central electron carriers in biological energy metabolism. Low NAD+ levels are proposed as …
sciencedirect.com
How does exercise exert preventive and therapeutic effects in different diseases? What is the molecular basis of these effects and how are exercise signals mediated on a cellular level? A 🧵on our lates review in Signal Transduction and Targeted Therapy: (1/13)