Jeremy Day
@daylab.bsky.social
Neuroscientist at UAB interested in molecular and genetic mechanisms in brain function. Director, UAB Comprehensive Neuroscience Center.
Great song, great album. If you are new to this band also check out the last 3 songs on The Sunset Tree album - for my money the best album ending trio of all time.
the Mountain Goats@themountaingoats.bsky.social · 2d agoI don't even know what to say. This is real, this is true, so, like, thank you all, from the bottom of my heart. This took over 25 years to happen so if there's any lesson here it's either "keep at it, who knows" or "many people are divorced"
Starting in Spring or Summer 2027 K99/R00 (under its new activity code KT1/R00) will only be available to US citizens, permanent residents, and non-citizen nationals. I am hearing this from many program officers, but NIH has yet to make an official statement to my knowledge.
Announcing #engramsensembles '27, to be held at @tcddublin next May. Registration and abstract submission will open in autumn 2026.
Tomás Ryan@tjryan.bsky.social · last yr.Slán go fóill - we look forward to welcoming you all back to Dublin for the 3rd installment in May 2027 #engramsandensembles
The final version of our amygdala dopamine paper is out! BLA dopamine dynamically tracks emotional salience and not value or reward prediction error. Congrats to Dr. Megan Brickner!! www.nature.com/articles/s41...
Basolateral amygdala dopamine transmits emotional salience - Nature Communications
The basolateral amygdala dopamine system has received little attention. Here, authors show that BLA dopamine plays a unique role in learning, by encoding the emotional salience of sensory cues to supp...
nature.com
Join us for Brain Chats this Saturday! Dr. Clay will present, "An Introduction to the UAB Alzheimer's Disease Research Center: The Importance of Brain Aging Research." Come learn why brain aging research matters and how you can help advance Alzheimer's research! Free & open to all! 🧠📚
A conserved population of genetically defined striatal neurons gates opioid reward https://www.biorxiv.org/content/10.64898/2026.07.28.741269v1
Very cool paper systematically characterizing dopamine neuron development and striatal arborization in the mouse brain. www.sciencedirect.com/science/arti...
Single-neuron resolution mapping of dopaminergic connectivity across development, adulthood, and degeneration
Individual midbrain dopamine (mDA) neurons exhibit complex morphologies, a feature that may underlie their different functions and disease vulnerabili…
sciencedirect.com
📣NAR is recruiting a new Executive Editor!📣Seeking an established researcher with expertise in RNA biology and translation mechanisms to help shape the journal's scientific direction, oversee peer review, and support its growth. Apply by 30 Sept 2026: academic.oup.com/nar/pages/ex...
Very excited about this new preprint from @odrake.bsky.social, an incredibly talented MD/PhD student in the lab. 🧵 below, but the TL;DR: we found a rare striatal neuron subtype with unique transcriptional, spatial, and circuit properties that gates opioid reward.
Olivia Drake@odrake.bsky.social · 6d agoOur new preprint from @daylab.bsky.social characterizes Chst9-MSNs, a specialized NAc population with high Oprm1 expression and opioid sensitivity that is required for fentanyl reward learning. Excited to share this work! 🧠🧬 www.biorxiv.org/content/10.6...
Congratulations to CNC faculty members Dr. Kauê Costa (@kmcostalab.com) and Dr. Rui Zhang on being selected for the 2026 @acnporg.bsky.social travel award class to attend the annual ACNP conference in San Diego, California!
Congratulations to the 2026 @acnporg.bsky.social travel award recipients! Good to see a lot of familiar names on this list, including @mictott.bsky.social, @jtuscher.bsky.social, @kmcostalab.com, @laurenmac.bsky.social, @chanjenerational.bsky.social, and @outraajeous.bsky.social!
Excited for our 2026-2027 seminar series lineup, including @touchyourbrain.bsky.social, @aliciaizquierdo.bsky.social, @bjmarlin.bsky.social, @meghasehgal.bsky.social @pegmccarthy.bsky.social, @stephenturner.us, @alisonbernstein.bsky.social, Meaghan Creed, and many others!
UAB Comprehensive Neuroscience Center@uabneuro.bsky.social · last wk.Get ready for the 2026-2027 UAB Neuroscience Seminar Series! Coordinated by @kacummings.bsky.social, this CNC-sponsored series brings external speakers to campus for weekly seminars at the cutting edge of neuroscience.
“Seven days after the girl’s medical team infused trillions of viruses carrying the recipe for the base editor into her spinal fluid, she died of a severe immune reaction linked to the therapy…” This, in @science.org, is an important and tragic story. (It’s also an incredibly well reported one.) 🧪
Exclusive: Death of girl in Chinese gene-editing trial was never made public
Parents want accountability after study went disastrously wrong, Science and Retraction Watch investigation reveals
science.org
I love this photo from Simon: the finches are perched on a thorny tree that evokes the basal ganglia medium spiny neurons we identify as the postsynaptic locus of learning. Full paper thread 👇
Drew Schreiner@schreinerdrew.bsky.social · 3mo agoWhere, exactly, does learning happen in the brain? Out today in @nature.com, we identify a synaptic locus of birdsong learning and show that the circuit can be tuned to make birds learn faster - but at a cost. Read on👇 #neuroskyence 🧪 #prattle 💬 #bioacoustics Shareable link: rdcu.be/fiyrS
Dopamine and sodium appetite! Sodium appetite causes a 'sign change' in the taste of hypertonic NaCl solutions. We've previously shown that generation of the appetite recruits phasic dopamine to the taste of NaCl; here we show the 'derecruitment' process during satiation.
bioRxiv Neuroscience@biorxiv-neursci.bsky.social · 2w agoRapidly decreasing phasic dopamine responses precede a hedonic switch during satiation of sodium appetite https://www.biorxiv.org/content/10.64898/2026.07.16.738888v1
Notice of Award Monday! Grateful to NIDA for supporting some very exciting work defining the cellular and circuit mechanisms that opioids target to produce rewarding effects.
This analysis of the public comments suggests overwhelming opposition to the OMB grant making take over plan www.techpolicy.press/the-public-r...
The Public Rejects OMB's Federal Financial Assistance Rule
Tens of thousands of scientists, clinicians, and ordinary citizens warned OMB about putting political appointees in charge of which research gets funded.
techpolicy.press
New preprint led by @christineliu.art! How do psychedelics improve cognitive flexibility? Psilocybin prevents inflexibility caused by aberrant mesocortical error signaling (but not inflexibility due to other mechanisms); this is tied to plasticity of PFC-MD neurons: www.biorxiv.org/content/10.6...
Psilocybin selectively rescues cognitive flexibility impairments caused by aberrant prefrontal error signaling
Psychedelic drugs show remarkable potential for treating psychiatric disorders, but the mechanisms underlying their therapeutic effects remain relatively unknown. Here, we demonstrate that psilocybin ...
biorxiv.org
it's crazy when you see a photo for the first time and recognize it's gonna be used as a shorthand for the era you're living in right now by historians in 100 years
Phil Lewis@phillewis.bsky.social · last mo."Members of the group Patriot Front ride the metro as a commuter looks on, during the 250th anniversary of U.S. independence in Washington, D.C., U.S., July 4, 2026. REUTERS/Cheney Orr"
New paper out online today!! We identify two previously unrecognized transcripts at the BDNF locus, BDNF-DT and BDNF-AS-DT, that are developmentally regulated, coordinated with BDNF expression, and associated with schizophrenia risk. www.nature.com/articles/s41...
BDNF-DT and BDNF-AS-DT: novel genes in the BDNF locus - Molecular Psychiatry
Molecular Psychiatry - BDNF-DT and BDNF-AS-DT: novel genes in the BDNF locus
nature.com
The final version of our paper examining how the CeA gates exogenous GLP-1 signals is now online: www.sciencedirect.com/science/arti... Thanks to the funders (NIDDK and Whitehall) and all the lab members that made this happen.
The central amygdala gates exogenous glucagon-like peptide 1 signals
Nuclei within the limbic system like the central amygdala (CeA) play a critical role in mediating fear, motivation, reward, and appetitive behavior. A…
sciencedirect.com
Andrew Hardaway@andrewhardaway.bsky.social · 4mo agoReally thrilled to share my lab's latest work where we characterize the role of the CeA in integrating exogenous GLP-1 signals. www.biorxiv.org/content/10.6...
The comment period on the proposed OMB rule closes July 13. Your input can help protect merit-based science funding. Join fellow #NeuroAdvocates and submit a comment today: vist.ly/59mbt #neurosky #neuroskyence #scisky #medsky
Very excited for our new paper, now out in @cellcellpress.bsky.social! /🧵 The protein Tau forms intracellular toxic tangles in neurons in Alzheimer’s disease and Tauopathies. Tau pathology slowly spreads from cell-to-cell but the mechanisms are not clear /1 authors.elsevier.com/sd/article/S...
Arc mediates intercellular tau transmission via extracellular vesicles
Tau pathology spreads cell to cell, but the mechanisms of intercellular tau transmission remain unclear. We find that the neuronal gene Arc is critica…
authors.elsevier.com
Excited to share this new Addiction Neuroscience Special Issue on Transcriptomics in Addiction. Edited by Laura Saba and Dayne Mayfield with articles from Ana-Clara Bobadilla, Ryan Logan, Giordano de Guglielmo, José Sotelo-Silveira, and Tamara Phillips labs. www.sciencedirect.com/special-issu...
Addiction Neuroscience | The Role of Transcriptomics in Addiction | ScienceDirect.com by Elsevier
The generation of RNA transcripts in a cell is one of the first opportunities for interaction between DNA sequence and the environment (both at the organism and cellular level). Although many RNA transcripts get translated into proteins that are active in the cell, many other types of transcripts play critical roles in both the transcription and translation processes and ultimately, in how our bodies respond to our environment. Brain transcriptomics has the potential to mediate our acute responses to drugs of abuse and to reflect the changing cellular environment across the addiction cycle. Furthermore, RNA-based therapeutics are emerging as a significant treatment resource for many diseases. However, our knowledge about non-coding RNA transcripts, differences in transcript processing, and the interdependence among networks of transcripts is far from complete. This Special Issue features novel research into the role of transcriptomics and epigenetics in the neuroscience of addiction including predisposing factors and changing molecular phenotypes across the addiction cycle with the ultimate goal of identifying novel treatment and prevention approaches.
sciencedirect.com
A new $10 million philanthropic investment will establish the Frances Gorrie Alzheimer’s Disease Center at UAB, supporting clinical care and research into this neurodegenerative condition affecting over 7 million Americans. Read more here. www.uab.edu/medicine/new...
Building momentum in memory disorder care and research | Heersink School of Medicine News
uab.edu
Registration and abstract submission is now open for the 2026 UAB Neuroscience Retreat! Our program will feature faculty and trainee presentations, presentation awards, program updates, and a keynote lecture from Dr. Hongkui Zeng, Director of Brain Science at the Allen Institute.
UAB's Heersink School of Medicine is actively recruiting neuroscientists at early stage and established investigator levels to help grow basic research in this school-wide priority area. Apply below! uab.peopleadmin.com/postings/27132 uab.peopleadmin.com/postings/27135
Heersink School of Medicine-Open Rank (Investigators)-Neuroscience
The University of Alabama at Birmingham* (UAB) Heersink School of Medicine (HSOM)** is recruiting up to 16 investigators as part of a major strategic initiative in the Neurosciences to build on a stro...
uab.peopleadmin.com
Very cool original artwork by lab MD/PhD student Olivia Drake for Caroline Fiore’s successful master’s thesis defense in the lab. Congratulations Caroline! Much more to come soon on some really important findings that Caroline contributed to.
(1/n) Very excited to share tri-lab collab (Mirny & Zechner) led by Harvey, Henrik & Jack: Q: How do enhancers & promoters interact in space (contact vs. action-at-a-distance) and time (stable vs. transient)? A: Transient E-P contact (~25-42 nm lasting ~10-20 sec): www.biorxiv.org/content/10.6...
