@davidweinshenker.bsky.social

Starting September 1, I will be working with a team to start a new research center at the Max Planck Institute for Human Development in Berlin. We currently have a couple of positions posted but there will be more so if you are interested stay tuned and feel free to get in touch.

Max Planck Institute for Human Development@mpib-berlin.bsky.social · 2mo ago

📣 New research center on the horizon! The Center will study how midlife autonomic changes may contribute to #neurodegenerative disease risk, focusing on the locus coeruleus, #Alzheimer’s biomarkers, and emotion–cognition interactions. Interested? CAAN-Job openings 👇 www.mpib-berlin.mpg.de/career

In a new study in @cp-neuron.bksy.social we demonstrate how sparse genetic labeling enables comprehensive reconstruction of individual dopamine neurons in mice; Subtypes exhibit distinct developmental and adult morphologies, as well as responses to axon degeneration. www.cell.com/neuron/fullt...

Single-neuron resolution mapping of dopaminergic connectivity across development, adulthood, and degeneration

Using a novel intersectional genetic strategy for sparse neuronal labeling, Grossouw, Heijmink, et al. reconstruct individual midbrain dopamine neurons throughout development, adulthood, and degenerat...

cell.com

An important paper done really carefully by great scientists (I hope that is clear!). I encourage people in the field to read it carefully and understand what it does/doesn't show, and thus what limitations on other people's work it should/shouldn't impose in peer review. For example:

Anthony Ramnauth@philoneurosci.bsky.social · 3w ago

This seems super important for in vivo experiments #Norepinephrine and #dopamine #sensor crosstalk depends on local innervation density doi.org/10.1038/s415...

This award officially puts me on the job market and my research program will broadly focus on how our social relationships shape health during aging and in dementia. If your university/department is planning a faculty search for the upcoming cycle, please get in touch!

Studying norepinephrine? Have cool results to share? Want to join an online community of norepinephrine researchers? We are organizing our fall schedule for the Blue Spot Slack! We have monthly virtual seminars where you can share your work and get feedback in a supportive environment. Apply/join ⬇️

Immunohistochemical staining showing noradrenergic neurons of the locus coeruleus

Lovely RNAscope image of the rostromedial tegmental nucleus with DAPI (blue), GAD1 (green), galanin 1 receptor (orange), and mu opioid receptor (red). Courtesy of postdoc Brittany Pate.

Bild

Excited to share this new Addiction Neuroscience Special Issue on Transcriptomics in Addiction. Edited by Laura Saba and Dayne Mayfield with articles from Ana-Clara Bobadilla, Ryan Logan, Giordano de Guglielmo, José Sotelo-Silveira, and Tamara Phillips labs. www.sciencedirect.com/special-issu...

Addiction Neuroscience | The Role of Transcriptomics in Addiction | ScienceDirect.com by Elsevier

The generation of RNA transcripts in a cell is one of the first opportunities for interaction between DNA sequence and the environment (both at the organism and cellular level). Although many RNA transcripts get translated into proteins that are active in the cell, many other types of transcripts play critical roles in both the transcription and translation processes and ultimately, in how our bodies respond to our environment. Brain transcriptomics has the potential to mediate our acute responses to drugs of abuse and to reflect the changing cellular environment across the addiction cycle. Furthermore, RNA-based therapeutics are emerging as a significant treatment resource for many diseases. However, our knowledge about non-coding RNA transcripts, differences in transcript processing, and the interdependence among networks of transcripts is far from complete. This Special Issue features novel research into the role of transcriptomics and epigenetics in the neuroscience of addiction including predisposing factors and changing molecular phenotypes across the addiction cycle with the ultimate goal of identifying novel treatment and prevention approaches.

sciencedirect.com