Amazing high-speed AFM recordings of microtubule lattice collapse and catastrophe. It looks very much like processes in the lattice of crystals (which I believe MTs actually are). pubs.acs.org/ancac3/artic...

I've been steadily developing our image compression software over the past month and now you can try it out in your browser, without needing to install anything, thanks to the magic of WebAssembly! beryl.mrc-lmb.cam.ac.uk/radelta/ No data is uploaded anywhere, it all stays on your computer.

James Manton@jamesdmanton.bsky.social · last mo.

I've been working on a fast, high-ratio image compressor to try and alleviate the data storage issues myself and some of my colleagues have recently been facing. Before I 'release' version 1, it'd be great to gain some feedback regarding performance and missing features. github.com/jdmanton/rad...

Lead the next discovery at the LMB. We’re recruiting Group Leaders to join our Structural Studies and @cellbiol-mrclmb.bsky.social Divisions. Benefit from long-term support, access to outstanding core-facilities and a collaborative environment where science thrives. ➡️ mrclmb.ac.uk/research-lea...

Curious about how life works? | MRC Laboratory of Molecular Biology

The LMB's Structural Studies and Cell Biology Divisions are each looking for a new Group Leader, at tenured or tenure-track level, to help solve the pu ...

mrclmb.ac.uk

🚨🧬 We are seeking a PhD student and a postdoc to join our team @mrclmb.ac.uk and investigate co-transcriptional splicing using cryoEM and biochemistry! PhD project: mrclmb.ac.uk/careers-and-... Postdoc call will open soon. Please feel free to get in touch directly. #RNA #cryoEM #PhD #postdoc

I am a truly abysmal mathematician, but I have been very fortunate to know many excellent, kind, patient and thoughtful mathematicians over the years. I would be extremely interested to know what they and others make of these recently released results: github.com/openai/math

GitHub - openai/math

Contribute to openai/math development by creating an account on GitHub.

github.com

We have a position open in our core facility in the @pasteur.fr . Please share it and / or apply! forum.image.sc/t/research-e...

Research engineer in Bioimage Analysis. Institut Pasteur, Image Analysis Hub - 2026

Dear all Below is an announcement for a permanent position as a Research Engineer in the Institut Pasteur, Paris. There is a flyer attached at the bottom. We are looking ideally for a Bioimage An...

forum.image.sc

Preprint is out! Our BakingTray software turns a 2-photon microscope into a serial-section tomography system for automated whole-organ imaging. ~€35k to convert an existing scope. 11 systems worldwide, >7,000 samples at SWC alone #neuroskyence #microscopy www.biorxiv.org/content/10.6...

I've been working on a fast, high-ratio image compressor to try and alleviate the data storage issues myself and some of my colleagues have recently been facing. Before I 'release' version 1, it'd be great to gain some feedback regarding performance and missing features. github.com/jdmanton/rad...

GitHub - jdmanton/radelta

Contribute to jdmanton/radelta development by creating an account on GitHub.

github.com

We are looking for a research assistant! Come join the team: www.jobs.ac.uk/job/DSZ826/r...

Research Support Officer | Cell Biology | Dr Buzz Baum | LMB 2904 at MRC Laboratory of Molecular Biology

Start your UK & international job search for academic jobs, research jobs, science jobs and managerial jobs in leading universities and top...

jobs.ac.uk

I very much enjoyed Lisa Cuneo's talk at FOM2026 on a new approach to deconvolution, so it's great to see the preprint is now out: www.biorxiv.org/content/10.6... @vicidominilab.bsky.social

Independent noise realizations enable morphologically agnostic image reconstruction in single-photon-sensitive microscopy

Advances in single-photon sensitive detectors are rapidly expanding the adoption of photon-counting fluorescence microscopy. Under the Poisson photon-counting statistics, iterative Richardson-Lucy (RL...

biorxiv.org

I am looking for postdoc candidates for two opportunities in my lab at Lund University. 1. Co-application for a two-year postdoc scholarship on method development in 3D spatial biology, with applications in lung physiology, cancer and neuroscience.

Michel Goedert and myself are looking for two postdocs to work on #cryoEM and #masspec of #alphasynuclein filaments from neurodegenerative disease. Come join our bubbly and friendly team at the @mrclmb.ac.uk in lovely Cambridge, UK. www.nature.com/naturecareer...

Postdoctoral Scientist | Neurobiology | Dr Michel Goedert | LMB 2842 - Cambridgeshire job with MRC Laboratory of Molecular Biology | 12864505

Postdoctoral Scientist Salary £42,694 per annum Fixed term, 3 years MRC Laboratory of Molecular Biology, Cambridge, UK To work in the group of Dr M...

nature.com

Registration is closing tomorrow, 9th September, for our 10th Next Generation Biophysics Symposium. Join us either in-person or on-line by clicking here: www3.mrc-lmb.cam.ac.uk/sites/nextge...

📢 We are looking for a Junior Group Leader to join us at @institutcurie.bsky.social! Having joined the department just over a year ago, I can honestly say that it is an exceptionally stimulating and supportive scientific environment, filled with outstanding colleagues — all in the heart of Paris.

Looking to solve complex, technical challenges across hardware, software and large-scale computing systems? Join our Scientific Computing team and use open-source software and custom-built systems to support the LMB's computing infrastructure. Closes 17 SEP Read more: www.jobs.ac.uk/job/DSR455/s...

🚨 2x PhD opportunities: single-molecule/super-resolution microscopy & image analysis of membrane proteins 🔬(DM for details) 👉🏻 tinyurl.com/5dt7ncby 👉🏻 tinyurl.com/5e52dth2 🙏 Dear colleagues & friends, pls distribute - Thank you! 🙏 @crc1507.bsky.social imol.uni-frankfurt.de @goetheuni.bsky.social

GCHQ strikes again and deems knowledge of our new approach to tissue clearing too dangerous for public consumption! We're still working on the information included on the website, so hopefully we're unblocked by the time we've finished. If you never hear from me again you know what's happened...

James Manton@jamesdmanton.bsky.social · 5mo ago

It's not every day you set up a new website and have it blocked by the Government Communications Headquarters (GCHQ), an intelligence service so secretive the UK government didn't formally acknowledge its existence until 1994, 75 years after it was founded...

Yey, I figured out how to display 3D movie stacks in #ChimeraX, thanks to @dabiophysicist.bsky.social for the suggestion. My original tiff was not ome-tiff so you'll need to convert it first (do this with #Python), then adjust voxelsize in ChimeraX so the image isn't flat, record, and voila!

Anh Hoang Le, PhD 🏳️‍🌈🏴󠁧󠁢󠁳󠁣󠁴󠁿🇻🇳@anhhle2702.bsky.social · 3mo ago

One drawback tho and unless I'm not aware of an alternative, it seems if you want to display a time series stack, you have to save each time frame as a separate stack before loading them into #ChimeraX. If you don't, it will superimpose all timepoints into 1 single 3D stack. This, #napari is better!

New preprint! Using multiscale ExM/OPM/ASLM, we show that oncogenic drivers leave distinct 3D architectural fingerprints in intact liver tissue: NRAS primarily remodels cell shape, whereas CTNNB1 shifts mitochondrial architecture toward a pericentral-like state. tinyurl.com/kepy33m6

Deciphering the Multiscale Morphology of Somatic Oncogenic Alterations in Hepatocellular Carcinoma

Somatic oncogenic mutations are typically defined by their molecular alterations, yet how they reorganize cellular architecture within intact tissues remain largely unknown. Here, we demonstrate that ...

biorxiv.org

2026 marks the tenth edition of the Next Generation Biophysics Symposium! Registration for this year’s event, happening at the LMB on Wednesday 16th September, is open now ➡️ https://www3.mrc-lmb.cam.ac.uk/sites/nextgen/#intro

We've updated our cleared-tissue direct-view oblique plane microscopy preprint to include our latest resolution-enhancing results. Now the Nyquist sampling of our camera is no longer a limitation and so we obtain a diffraction-limited 2 μm lateral resolution! www.biorxiv.org/content/10.6...

James Manton@jamesdmanton.bsky.social · 5mo ago

We present: Index-agnostic oblique plane light sheet microscopy of centimetre-scale cleared tissues at subcellular resolution www.biorxiv.org/content/10.6...

Excited to share our first lab preprint! We enabled fast wide-field FLIM with low noise and high dynamic range. We built compact resonant modules for EO-FLIM that fit into your hand and developed methods to capture multi-exponential phasor plots at up to 500 Hz. www.biorxiv.org/content/10.6...

In a series of 3 papers and preprints, we’re thrilled to share with you the working laser phase plate. In collaboration with research led by Holger Müller at UC Berkeley, this is a huge innovation in imaging to make small and faint objects inside cells visible. bit.ly/4vK9LVn

🔬 Happy to share our new paper showing that fluorophore brightness open a new dimension in SMLM microscopy ! Thanks to all authors @laurent-le.bsky.social S. K. Sreenivas @emmanuelfort.bsky.social ! @ismolab.bsky.social @instlangevin.bsky.social @cnrs.fr rdcu.be/fmIeD doi.org/10.1038/s415...

Want to build some of the most advanced light-sheet microscopes in the world to watch life assemble itself cell by cell? The Royer Lab @ Biohub is hiring an Optical Engineer (Advanced Light Sheet Microscopy). 🧪🔬💻🔧 #Hardware + #Python + Advanced #Optics job-boards.greenhouse.io/biohub/jobs/...

Optical Engineer, Advanced Light Sheet Microscopy

San Francisco, CA (Hybrid)

job-boards.greenhouse.io

Hello #world, meet 1,000× Expansion Microscopy. A small gel would grow to the size of an Olympic swimming pool, while amino-acid-scale distances become visible with ordinary light microscopy. Led by Helena Hu from @eboyden3.bsky.social's lab, in collab with us. Story: www.biorxiv.org/content/10.6...

Directional elements: the preprints are out! 1/n Congratulations to our amazing team: biorxiv.org/content/10.6... biorxiv.org/content/10.6... biorxiv.org/content/10.6... We screened for principles governing global brain dynamics by developing a set of new methods: 1) conformal immersion microscopy;

Excited to announce big steps for electrical imaging in the brain! In 4 preprints, we and collaborators present 2 new GFP-based voltage sensors: ASAP6c for high-throughput spike recordings, and ASAP7y for subthreshold 1P and 2P imaging bit.ly/4x3k3kX bit.ly/3RKZhq3 bit.ly/4o4fKl3 bit.ly/4uHXuk3 🧵

We present: Index-agnostic oblique plane light sheet microscopy of centimetre-scale cleared tissues at subcellular resolution www.biorxiv.org/content/10.6...

It's not every day you set up a new website and have it blocked by the Government Communications Headquarters (GCHQ), an intelligence service so secretive the UK government didn't formally acknowledge its existence until 1994, 75 years after it was founded...