Neil Rajan
@derm-scientist.bsky.social
Professor of Dermatogenetics + Consultant Dermatologist #genetics #raredisease #dermatology Views are mine; he/him/his
Recombinant DNASE1L3 therapy reduced symptoms in a patient with severe lupus with DNASE1L3 deficiency. Antidrug antibodies caused effects to wane, but findings support NET-targeted therapy as a nonimmunosuppressive approach. Read the full report: https://nej.md/3Rlv5Sm
Ancient DNA from grape seeds spanning 4,000 years reveals the domestication, cultivation, and trade of grapes in France over this period, according to research in Nature Communications. The authors find that one Medieval sample is genetically identical to modern Pinot Noir grapes. 🧬 🏺 🧪
Ancient DNA reveals 4000 years of grapevine diversity, viticulture and clonal propagation in France - Nature Communications
Here, the authors present aDNA from 49 grape pips spanning the Bronze Age to Medieval period in France and surrounding areas. They find evidence of long-distance exchange of domestic varieties through vegetative clones and one Medieval sample that is nearly identical to modern Pinot Noir.
go.nature.com
“Sakura” in Japan. Cherry blossoms symbolize the fleeting nature of life, mortality, renewal, and spring in Japanese culture. ☺️ TT: ThaoThao Yodo station, Kyoto
After 20 years, 58 generations and more than 30,000 cloning attempts, a team of researchers has hit the limit on the number of times a single mouse can be serially re-cloned go.nature.com/3Pue5Iz
Can a mouse be cloned indefinitely? Decades-long experiment has answers
Repeated cloning from a single mouse failed after 58 generations. Researchers say harmful DNA changes are to blame.
go.nature.com
A 47-year-old woman presented to the dermatology clinic with a 1-year history of a crawling sensation on her chin that caused her to scratch the area. The right corneal reflex was decreased, and pinprick and temperature sensation around the mouth, lip, and chin on the right side was reduced. 1/2
Women in Science 2026 by ESDR Did you know that in research, women are still underrepresented even though this may affect treatment outcomes? Explore the campaign to learn more: esdr.org/women-in-sci... #womeninscience #dermatology #dermresearch @derm-scientist.bsky.social
Women in Science 2026 by ESDR For this year’s International Day of Women and Girls in Science, we’re highlighting why inclusive data is essential for robust science. Better data means better science for everyone. Explore the campaign: esdr.org/women-in-sci... @derm-scientist.bsky.social
Women in Science 2026 by ESDR By making underrepresentation visually, scientifically & socially visible, we aim to contribute to a future where medical research truly reflects the diversity of the patients it serves. esdr.org/women-in-sci... @derm-scientist.bsky.social
Women in Science 2026 by ESDR For this year’s “International Day of Women and Girls in Science” day, we’re highlighting why inclusive data is essential for robust science. Explore the campaign: esdr.org/women-in-sci... #womeninscience @derm-scientist.bsky.social @dr-cganier.bsky.social
Nice preprint from @derm-scientist.bsky.social! Ubiquitin system is key for tissue architecture in CYLD cutaneous syndrome (CCS) skin tumours. "Comparative ubiquitinomics of human skin reveals insulin receptor ubiquitination as a regulator of collagen secretion." www.biorxiv.org/content/10.6...
A paper in Nature reports the details of a 60-year-old male individual from Germany who achieved sustained HIV remission after a stem cell transplant, the seventh-known case reported to date. go.nature.com/4rNjedx #medsky 🧪
This case report describes a child with lesions that initially appeared as vesicles and progressively spread in a centrifugal pattern, forming concentric, spiraled rings. ja.ma/48dpF1s
Why do whales and elephants have much lower rates of cancer than expected? "Species with a lower cancer prevalence and mortality risk are those with a higher presence of cooperative and caring habits, while the opposite is found....:" www.science.org/doi/10.1126/...
Coevolution of cooperative lifestyles and reduced cancer prevalence in mammals
While cooperative mammals evolve reducing cancer prevalence, oncogenes can be maintained by selection in competitive species.
science.org
Personalized therapies hold tremendous promise but challenge traditional models of drug and biologic development. The @fda.gov outlines a path to market entry for products where a randomized trial is not feasible. Learn more: nej.md/4nUQdcl
Previous multiple sclerosis, now the potential role of Epstein Barr virus for driving lupus (SLE) science.org/doi/10.1126/...
With support from the NIHR Newcastle BRC, researchers Professor Neil Rajan @derm-scientist.bsky.social and Dr Mark Eisner from the Skin Disease, Oral Disease and Immunogenomics Theme attended the recent Ichthyosis Support Group (ISG) Family Day. 🔗 newcastlebrc.nihr.ac.uk/our-research...
Selena Gomez has shared her experiences living with #lupus since 2015 - writes Foundation-funded researcher @bcellsrosser.bsky.social for @uk.theconversation.com. To learn more, you can meet Dr Lizzy Rosser at our New Scientist Live stand (C20) on 18-19 October! shorturl.at/BusFG
Medical Research Foundation
live.newscientist.com
The Conversation UK@uk.theconversation.com · 10mo agoThe autoimmune disease lupus, which affects mainly women, can have wide-ranging impacts on health and quality of life.
Review | Spatial architecture of development and disease www.nature.com/articles/s41...
Spatial architecture of development and disease - Nature Reviews Genetics
Spatial omics has empowered the discovery of developmental and disease-associated molecular signatures, cell states and multicellular niches, as well as the evaluation of disease heterogeneity within and across organs. The authors review spatially resolved molecular changes across diseases and discuss the potential of spatial multi-omics for clinical applications, including the recent impact of artificial intelligence.
nature.com
BREAKING: The Nobel Prize in Physiology or Medicine has been awarded jointly to Mary E. Brunkow, Fred Ramsdell, and Shimon Sakaguchi "for their discoveries concerning peripheral immune tolerance" Stay tuned for more. #NobelPrize
We're delighted to see immunologists once again recognised by the #NobelPrize! 🏆 Warm congratulations to the winners - their contributions have been vital in shaping our understanding of the immune system. More here: www.immunology.org/news/british...
British Society for Immunology response to 2025 Nobel Prize for Physiology or Medicine | British Society for Immunology
immunology.org
📅 Wed 3 Dec | Immunology in the balance with Prof. Lydia Lynch How does the immune system walk the line between protection & pathology? Join this session on the regulation of innate & adaptive immunity in infection, cancer, and inflammatory disease. #Immunology #BSI25
www.genomicseducation.hee.nhs.uk/news/dermato... Calling all #dermatologists! We've just launched our new #GeNotes collection of resources to support you in accessing #GenomicTesting for your patients. Developed by Dr fellow dermatology experts, this is one not to miss!
Dermatology joins GeNotes as 12th specialty - Genomics Education Programme
New dermatology collection covers a wide range of clinical scenarios, underpinned by extended opportunities for learning Dermatology professionals now have access to a fantastic new set of useful reso...
genomicseducation.hee.nhs.uk
🚀 Excited to share our new Review in @jacionline.bsky.social ! We summarize the current evidence on IL-18 in atopic dermatitis. 📊 Links to barrier dysfunction & disease severity 💡 Potential biomarker & therapeutic target Read here 👉 www.jacionline.org/article/S009... #IL18 #atopicdermatitis
IL-18 in atopic dermatitis—a multifaceted driver of skin inflammation
Atopic dermatitis (AD) is a common chronic inflammatory skin disease characterized by pruritus, barrier dysfunction, and immune cell infiltration. Despite significant progress in our understanding of ...
jacionline.org
We’re thrilled to introduce our four official Social Media Ambassadors for the 54th Annual ESDR Meeting! esdrmeeting.org/some2025/ @dr-hanat.bsky.social @dr-cganier.bsky.social @derm-scientist.bsky.social @drarmpit.bsky.social
Videos show pronuclear transfer, which was performed in a series of women with pathogenic mtDNA variants to reduce the transmission of these variants to their children. Read the full study about this method: nej.md/455eer6 #MedSky #Genetics
The potential for 2 cancer drugs in combination to impact Alzheimer's disease as an outgrowth or single-cell RNA -seq, review of electronic health records from 1.4 million patients, and whittling down 1,300 potential repurposed drugs to 2. www.cell.com/cell/fulltex...
Cell-type-directed network-correcting combination therapy for Alzheimer’s disease
A multi-cell-type drug discovery strategy targeting dysregulated gene networks in neurons and glia identified letrozole and irinotecan as a combination therapy that significantly improved memory and r...
cell.com
Amazing podcast on the mitochondrial donation babies. Great work by wonderful colleagues@mitonewcastle.bsky.social at @newcastleuni.bsky.social and the @lilyfoundation.bsky.social www.theguardian.com/science/audi...
The babies born with DNA from three parents – podcast
Doctors in the UK have announced the birth of eight healthy babies after performing a groundbreaking procedure that creates IVF embryos with DNA from three people. Ian Sample tells Madeleine Finlay ab...
theguardian.com
One-shot prime genome editing ("CRISPR 3.0") of the brain in vivo corrected AHC, a rare genetic disorder, in the mouse model. Another big step forward in the genome editing field. www.cell.com/cell/fulltex...
In vivo prime editing rescues alternating hemiplegia of childhood in mice
Prime editing and base editing in mouse models and human cells effectively correct mutations in a gene that causes a childhood neurodevelopmental disorder called alternating hemiplegia of childhood. I...
cell.com
