A new and fascinating story from @bencarty.bsky.social and the group, with crucial help from the teams of @naltemose.bsky.social, Simona Giunta, and @dfachinetti.bsky.social. Many thanks to all for a fantastic collaboration. www.nature.com/articles/s41...

📢ONLINE @natgenet.nature.com 📰DNA methylation influences human centromere positioning and function. By Catalina Salinas-Luypaert, @dfachinetti.bsky.social, @naltemose.bsky.social and colleagues. ⬇️ www.nature.com/articles/s41...

DNA methylation influences human centromere positioning and function - Nature Genetics

Genome-wide and targeted perturbation of DNA methylation at centromeres affects CENP-A positioning and centromere structure, resulting in aneuploidy and reduced cell viability.

nature.com

#1 Centromeres are epigenetic loci defined by CENP-A, positioned in unmethylated DNA flanked by highly methylated regions. Our work, published in @natgenet.nature.com in collaboration with @naltemose.bsky.social investigates the role of DNAme at human centromeres www.nature.com/articles/s41...

DNA methylation influences human centromere positioning and function - Nature Genetics

Genome-wide and targeted perturbation of DNA methylation at centromeres affects CENP-A positioning and centromere structure, resulting in aneuploidy and reduced cell viability.

nature.com

Are you preparing to go on the biomedical faculty job market? Do you have a track record of excellence in research, leadership, mentorship, & community engagement? Apply to the 2025 Next Generation Faculty Symposium: www.berkeleystanfordnextgensymposium.com! The deadline is May 30. Please repost!

Federal research funding not only advances healthcare and technology, but it also reliably grows the economy. These are some of the best-spent dollars in our government! Divesting from this golden goose will sacrifice future economic growth and make us all worse off. www.forbes.com/sites/johndr...

Trump’s NIH And NSF Cuts Could Cost The U.S. Economy $10 Billion Annually

Economists find public R&D drives a quarter of U.S. productivity growth — and pays for itself

forbes.com

I am proud to share my first preprint working with @naltemose.bsky.social, where we redesign DiMeLo-seq from the ground up. Thankful for the help and input of collaborators in @astraight.bsky.social and Aaron streets’ lab at Berkeley. More to come soon! www.biorxiv.org/content/10.1...

DiMeLo-cito: a one-tube protocol for mapping protein-DNA interactions reveals CTCF bookmarking in mitosis

Genome regulation relies on complex and dynamic interactions between DNA and proteins. Recently, powerful methods have emerged that leverage third-generation sequencing to map protein-DNA interactions...

biorxiv.org

🚨Pre-Print Tired of losing valuable DNA-protein interaction information from your long-read seq data during wash steps? New wash-free, one tube DiMeLo-cito protocol from @naltemose.bsky.social @astraight.bsky.social @ngamarra.bsky.social for max quality + yield! 🧪🖥️🧬 #STS 👇 doi.org/10.1101/2025...

DiMeLo-cito: a one-tube protocol for mapping protein-DNA interactions reveals CTCF bookmarking in mitosis

Genome regulation relies on complex and dynamic interactions between DNA and proteins. Recently, powerful methods have emerged that leverage third-generation sequencing to map protein-DNA interactions...

biorxiv.org

@bencarty.bsky.social and the team did a fantastic job in a wonderful collaboration with @naltemose.bsky.social as well as Dani Fachinetti and Simona Giunta’s teams to help define the molecular basis for maintaining centromeric chromatin size and position. www.biorxiv.org/content/10.1...

New conference that will explore gene regulation mechanisms at molecular resolution. We bring bring together a fine crowd that uses microscopy, genomics and theory to chart the future of the booming fields of #singlemoleculegenomics and #singlemoleculemicroscopy. Join us July 15-18th 2025 at EMBL

@arnaudkr.bsky.social and I have been talking about organizing a single-molecule genomics meeting for years! We're excited to do so at EMBL while bridging the fields of single-molecule genomics and microscopy with our co-organizers. Hope to see you there! July 15-18 www.embl.org/about/info/c...

Arnaud Krebs@arnaudkr.bsky.social · 2y ago

New conference that will explore gene regulation mechanisms at molecular resolution. We bring bring together a fine crowd that uses microscopy, genomics and theory to chart the future of the booming fields of #singlemoleculegenomics and #singlemoleculemicroscopy. Join us July 15-18th 2025 at EMBL

The latest from our group, led by Megan Ostrowski and @martyyang.bsky.social, is now published in final form (www.cell.com/cell/fulltex...! Many thanks to our excellent peer reviewers for suggesting several experiments (including CAF-1 perturbation) to really improve the study =) #epigenetics

The single-molecule accessibility landscape of newly replicated mammalian chromatin

By developing a long-read sequencing method to simultaneously map replication status and protein-DNA contacts in cells, Ostrowski, Yang, et al. show that newly replicated chromatin is enriched for unw...

cell.com