Had a cracking lab meeting this morning with our latest epigenome editing results (new tools we're trying for the 1st time). Reminded me we're organizing an awesome symposium in Paris in Nov! Here's our updated flyer (new speaker @dfachinetti.bsky.social). Please share! ctrlepiedit.sciencesconf.org

👋 To all aneuploidy and chromosome instability aficionados check out the Consequences of Aneuploidy FASEB conference (Florida-USA 🏖️) co-organised with @peterlylab.bsky.social, Mike Lampson, Alison Taylor and myself: events.faseb.org/event/Aneupl... 👉 Deadline for abstract submission: August 3rd.

International Day of Women and Girls in Science! The core of the Fachinetti lab

Still some time to register to this great meeting! Great science and great location for a very affordable registration cost!

@dfachinetti.bsky.social · 9mo ago

Happy to share the “International Symposium on Chromosome Dynamics: from Structure to Cellular Function” that will be held in Japan 31st of May 2026 www.fbs.osaka-u.ac.jp/labs/fukagaw.... Registrations will open on December 1st! Plenty of opportunities to present your work! Hope to seeing you

#Post-doc position available in our lab at I. Curie, Paris Application and job details here: emploi.cnrs.fr/Offres/CDD/U...

Registrations are now open!!

@dfachinetti.bsky.social · 9mo ago

Happy to share the “International Symposium on Chromosome Dynamics: from Structure to Cellular Function” that will be held in Japan 31st of May 2026 www.fbs.osaka-u.ac.jp/labs/fukagaw.... Registrations will open on December 1st! Plenty of opportunities to present your work! Hope to seeing you

Happy to share the “International Symposium on Chromosome Dynamics: from Structure to Cellular Function” that will be held in Japan 31st of May 2026 www.fbs.osaka-u.ac.jp/labs/fukagaw.... Registrations will open on December 1st! Plenty of opportunities to present your work! Hope to seeing you

The 21st Course on Epigenetics which will take place from March 25th to April 1st, 2026 at the Institut Curie (Paris). The Course is open to M2 and PhD students. Application via the Advanced Training Office website before December 15th, 2025 at: minilien.curie.fr/3avv47

Very excited and honored that our project CenAGE with @manellab.bsky.social and Elsa Logarinho was granted! Looking forward to discover how centromere instability affects the immune cells contributing to systemic ageing. More Info here: curie.fr/actualite/no... Open positions soon, stay tuned!

European Research Council (ERC)@erc.europa.eu · 9mo ago

The newly announced ERC Synergy Grant includes research on: ✴️ genetic drug design ✴️ the Big Bang's first microseconds ✴️ crowd movement ✴️ nature-society interactions 👉 buff.ly/ZQhLp4h Congrats to the 66 awarded research teams! #FrontierResearch

My team is recruiting a Study Engineer (IE) with experience in mammalian cell culture - ideally human iPSCs - to work on a project exploring the role of aneuploidy and centromere regulation in neuroblastoma initiation and progression. info and application here institut-curie.org/job/study-en....

Thanks to @erhardtlab.bsky.social for the news and views on our paper on DNA methylation&centromere www.nature.com/articles/s41....

Dipping into the function of DNA methylation at centromeres - Nature Genetics

Human centromeres contain a small chromatin region with low levels of DNA cytosine methylation that resides with CENP-A. Salinas-Luypaert et al. find a role of DNA methylation in maintaining the size and function of centromeres by controlling the binding affinity of key centromere components.

nature.com

10-year celebration of the Fachinetti team! Thank you to all my amazing current and former members for making these two days so special for me! I feel so lucky to have met you all!

#ResultatScientifique🔎| La méthylation de l’ADN agit comme un code caché des centromères, garantissant une division cellulaire stable et freinant l’instabilité génomique 🧬 🤝@cnrs-paris.bsky.social @institutcurie.bsky.social ✍️ @dfachinetti.bsky.social 📕 @natgenet.nature.com |https://buff.ly/hxb1yxh

📢ONLINE @natgenet.nature.com 📰DNA methylation influences human centromere positioning and function. By Catalina Salinas-Luypaert, @dfachinetti.bsky.social, @naltemose.bsky.social and colleagues. ⬇️ www.nature.com/articles/s41...

DNA methylation influences human centromere positioning and function - Nature Genetics

Genome-wide and targeted perturbation of DNA methylation at centromeres affects CENP-A positioning and centromere structure, resulting in aneuploidy and reduced cell viability.

nature.com

▶️ Pour en savoir plus ⏩ Lire l'actu : curie.fr/actualite/di... ⏩ Lire la publication : www.nature.com/articles/s41...

DNA methylation influences human centromere positioning and function - Nature Genetics

Genome-wide and targeted perturbation of DNA methylation at centromeres affects CENP-A positioning and centromere structure, resulting in aneuploidy and reduced cell viability.

nature.com

#1 Centromeres are epigenetic loci defined by CENP-A, positioned in unmethylated DNA flanked by highly methylated regions. Our work, published in @natgenet.nature.com in collaboration with @naltemose.bsky.social investigates the role of DNAme at human centromeres www.nature.com/articles/s41...

DNA methylation influences human centromere positioning and function - Nature Genetics

Genome-wide and targeted perturbation of DNA methylation at centromeres affects CENP-A positioning and centromere structure, resulting in aneuploidy and reduced cell viability.

nature.com

Great time with @hirofunabiki.bsky.social @rockefelleruniv.bsky.social with amazing discussion with @prasad.bsky.social , @johnmaciejowski.bsky.social @agnelsfeir.bsky.social and Simona Giunta. Thanks also to Hiro’s lab for all the great chat! Happy to have seen my PhD friend Fabio Vanoli

Congrats to the team! Happy that we could help!

Nicolas Manel Lab@manellab.bsky.social · last yr.

Thrilled to share our latest @cp-cell.bsky.social. We present VICAR (VIral-induced Centromeric DNA Amplification and Recognition), a new defense system to detect viruses in the nucleus based on nuclear cGAS. www.cell.com/cell/abstrac...

Hi all, my team institut-curie.org/team/fachine... @institutcurie.bsky.social is looking for a Bioinformatician. You can find more details about the position here: euraxess.ec.europa.eu/jobs/344508 Is anyone looking for a job in the lovely Paris?

The @embo.org #chromoploidy2025 is over. It was an amazing workshop organized by a perfect match of scientists and friends @mcclellandlab.bsky.social @bendavidlab.bsky.social @stesantaguida.bsky.social @foijer-lab.bsky.social, Elsa Logarinho, Caroline Audouin and myself

So thrilled to participate in the #EMBO workshop on aneuploidy in the magnificient Stresa. Cheers to the many organizers including @dfachinetti.bsky.social

Excited to get the #EMBOChromoploidy meeting started! 3 days of fantastic science and fun in beautiful Stresa are beginning now! meetings.embo.org/event/25-ane...

Chromosome Segregation and Aneuploidy

Aneuploidy is a hallmark of cancer and developmental disorders such as Down syndrome. Understanding how cells accomplish faithful chromosome segregation and how chromosomal instability (CIN) impacts …

meetings.embo.org

The Fachinetti team was there! #UneJonquilleContreleCancer

Institut Curie@institutcurie.bsky.social · last yr.

🌼 Faites fleurir l'espoir contre le #cancer avec l'Institut Curie ! Tout au long du mois de mars, participez à la campagne #UneJonquilleContreleCancer et devenez acteurs de la lutte contre le #cancer aux côtés de nos équipes 🤝 👉 unejonquillecontrelecancer.fr

“Stand up for Science” demonstration in Paris!

Last week to register (March 2nd) to the next Genome Instability and Human Disease international course at @institut_curie! Gain knowledge of mechanisms ensuring genome stability, from fundamental molecular pathways up to large scale approaches.

A chance to raise our voices!

Bardin Lab@bardinlab.bsky.social · 2y ago

A sit-in Monday Jan 27th 16h30 will happen in front of the College de France in protest against the government cuts to higher education and research.

We have a research laboratory technician post available in my group - the role will support plant work, and molecular biology, associated with our research on centromeres. www.jobs.cam.ac.uk/job/47342/

Thanks to Elsa and Reto for inviting me at I3S, Porto! A blast to see old friends and great time with @carloscondetv.bsky.social

Carlos Conde@carlos-conde.bsky.social · 2y ago

Beautiful seminar by @dfachinetti.bsky.social

Thanks to @cnrsbiologie.bsky.social for covering our work from @sol-herve.bsky.social and Andrea Scelfo with @katemiro.bsky.social

CNRS Biologie@cnrsbiologie.bsky.social · 2y ago

#RésultatScientifique🔎 Une étude publiée dans @naturecellbiology.bsky.social révèle comment sont détectés des anomalies chromosomiques. Des résultats qui mettent en lumière un rôle inédit de la mécanique du noyau. 🤝 @dfachinetti.bsky.social @institutcurie.bsky.social

Excited to share the first paper from my lab 🤩 - a great collaboration with Dani Fachinetti lab - we discover a #mechanosensitive nuclear envelope #checkpoint that arrests cells directly post chromosome mis-segregation rdcu.be/d5AC9 👇🧵 #cancer #mechanics #p53 #chromatin