Thomas Gorochowski
@chofski.bsky.social
Synthetic biologist, programmer of cells, and lover of all things visual. Wakes up in the morning to learn some of natures secrets and do a spot of fly fishing.
Using recombinases to build robust cross-kingdom genetic circuits? 🧬 Need to know what they are *actually* doing? We got you covered! In the latest from the lab, we show the power of nanopore sequencing for unraveling the inner workings of these circuits. doi.org/10.1038/s414...
Characterization of recombinase-based genetic parts and circuits using nanopore sequencing doi.org/10.1038/s414...
Hey, if anyone wants to support my SpliceCraft project, where proceeds go to paying for Claude Code Max, I set up a Ko-Fi account. No pressure, of course. This project is born free and will remain free forever. TYIA! 💚 ko-fi.com/atinygreencell
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🤖📚🧪#AI is having such a big impact on #synbio and science more broadly. Check out our latest perspective "Knowledge preservation in the era of big science and AI" on this topic that emerged from a workshop led by Penn Rainford a year or so ago! doi.org/10.1038/s414...
Knowledge preservation in the era of big science and AI: strategies for sustainable scientific research - Nature Communications
Science routinely discards valuable knowledge, from unpublished negative results to the tacit expertise lost when researchers move on. Here, the authors propose a roadmap for preserving this hidden kn...
doi.org
New scientific publication by the group of Thomas Gorochowski on DNA synthesis
Thomas Gorochowski@chofski.bsky.social · 6mo ago🧬Want to synthesise kilobase-scale DNA? We got you covered!🥳 In latest from the lab we explore the "doodling" capabilities of DNA polymerases and ways to guide the sequences produced. Loads of data + beautiful AFM of the molecules themselves. #synbio ... doi.org/10.1038/s414...
🧬Want to synthesise kilobase-scale DNA? We got you covered!🥳 In latest from the lab we explore the "doodling" capabilities of DNA polymerases and ways to guide the sequences produced. Loads of data + beautiful AFM of the molecules themselves. #synbio ... doi.org/10.1038/s414...
Analysis and control of untemplated DNA polymerase activity for guided synthesis of kilobase-scale DNA sequences doi.org/10.1038/s414...
New on @biorxiv!!!!!! We’re excited to share our latest paper on combining cell-free systems and machine learning to express full genome in vitro. Check it out now! 👉 www.biorxiv.org/content/10.1... Catch us at SEED in Houston this June to discuss this work. #CellFree
Faculty position in Plant Molecular Biology (Associate Professor or Tenure-Track Assistant Professor) at Aarhus University, Denmark mbg.au.dk/aktuelt/ledi...
A fun (and mostly coherent!) discussion with Ezra Chapman on the intersection of AI and engineering biology. We live in such exciting times and I hope some of that excitement came across. Thanks Ezra for the invite. #engbio #synbio #ai www.youtube.com/watch?v=SC4X...
The Immense Power Of Combining AI With Engineered Biology | Thomas Gorochowski #0037
YouTube video by Curious with Ezra Chapman
youtube.com
Many microorganisms modify their movement in response to light. This new #JRSocInterface paper has developed an integrated pipeline capable of acquiring temporal imaging data and extracting kinematics to create digital twins: doi.org/10.1098/rsif... @chofski.bsky.social
🫣 Now for something a little different from the lab: a data-centric approach to building digital twins as a route to control of emergent population level behaviours in microbial swarms 🤔 If that means nothing to you, then just check out the video! doi.org/10.1098/rsif... #engbio #control
Next in Lab's conference agenda: AI, Engineering Biology and beyond. It starts today in Bristol hosted by @chofski.bsky.social. Looks great: aiebab.github.io. From our side, @lewisgrozinger.bsky.social will be talking about our approach to the use of evolutionary algorithms for biocomputation.
AIEBaB-2026
aiebab.github.io
In Bristol for the week for the AI, Engineering Biology and Beyond conference hosted by @chofski.bsky.social. Very excited to meet the UK synthbio community. First day hackathon event was a blast!
Cold and "nippy" 🥶 start to the #AIEBaB26 Hack-a-thon 💻. The students helping with the organisation have done an amazing job in pulling this all together. A big thank you to the @jgibristol.bsky.social and @aibio-uk.bsky.social for the support!
If you work with R6K plasmids for transient DNA delivery, our latest SHARK strains might be of use! Work out at ACS Synthetic Biology led by Shivang Joshi and strains plus plasmids for their assembly will be available @addgene.bsky.social very soon! doi.org/10.1021/acss...
If you are looking to integrate your latest genetic creation into the genome of your favourite bug, you might find our latest review now out in OUP Synthetic Biology useful. 🧬⚒️ Work led by Riesa Rohmat with input from Thea Irvine and Shivang Joshi. #genome #synbio doi.org/10.1093/synb...
So you think your mammalian plasmids have nothing to fear from cloning and propagation in E.coli? Quantitative profiling of millions of nucleotides by Tom Copeman will prove you wrong! Supervised with the amazing @proftomellis.bsky.social and AZ, now on BioRxiv: doi.org/10.64898/202...
Quantitative profiling of millions of nucleotides reveals sequence-encoded interactions that govern plasmid propagation
Plasmids are central to modern biotechnology, especially therapeutic development, yet their propagation in Escherichia coli remains difficult to predict. Although expression-induced burden is well und...
doi.org
Emerging trends in genome integration tools for precision engineering of diverse bacterial species doi.org/10.1093/synb...
Emerging trends in genome integration tools for precision engineering of diverse bacterial species
Abstract. The ability to precisely insert DNA payloads into a genome enables the comprehensive engineering of cellular phenotypes and the creation of new b
doi.org
🚨 Last call for the 'AI, Engineering Biology and Beyond' conference taking place in Bristol on the 15-16 January 2026. There is a limited capacity and some places are still left, but worth signing up soon before the 19th December deadline! Register at: aiebab.github.io
📕My review for Jane Calvert's latest book, 'A Place for Science and Technology Studies' is out in Interdisciplinary Science Reviews! I really enjoyed the stories and learnt so mcuh. Well worth a read if you are interested in the ways that that study of science works: doi.org/10.1177/0308...
End of year Science Bonanza is always something I look forward to, not only for hearing about what the team has been up to all year, but also for the amazing food everyone brings. Christmas has started proper now 🎅
Very excited for this project with @pierrebuscaill.bsky.social! Will bring together a lot of exciting tools we have up and running in the lab for working with diverse biology and put them to use in building new technologies to trace gene expression across plants. 🧬 🔍 Applications open!
Pierre Buscaill@pierrebuscaill.bsky.social · 10mo ago🚀 PhD opportunity! Join us (@pierrebuscaill.bsky.social & @chofski.bsky.social) in Bristol 🌱✨ Design, test & model synthetic promoters in Nicotiana benthamiana, focusing on plant immunity. Apply now! 🔗 www.findaphd.com/phds/project... #PlantSci #SyntheticBiology #PhD #PlantBioDesign #BristolUni
The initial lineup of keynotes and spotlight talks is finalised, with 10 contributed talks still up for grabs! Come join us in Bristol on 15-16 Jan 2026 for AI, Engineering Biology and Beyond to shape the future of these fields🤖🧬🦠Register now at: aiebab.github.io
🚨Interested in the intersection of AI and Engineering Biology? 🤖🧬 If so, come join us in Bristol, UK from 15-16 Jan 2026 for the latest instalment of the "AI, Engineering Biology and Beyond" conference! It's going to be a "banger" and registration is open NOW! #synbio #ai aiebab.github.io
Université Grenoble Alpes opens a full professorship in microbiology in 2026. The selected candidate will develop their research program on quantitative approaches in microbiology in the Laboratoire Interdisciplinaire de Physique. More info: liphy.univ-grenoble-alpes.fr/en/join-us/r...
Professorship (tenure) in 'Quantitative approaches in microbiology' (CNU Sections 64/65) | LIPhy - Université Grenoble Alpes
liphy.univ-grenoble-alpes.fr
SHARK: a specialized host for assembling R6K plasmids https://www.biorxiv.org/content/10.1101/2025.10.06.680659v1
