🥜🦀 A research group @jourdainlab.bsky.social @dib-unil.bsky.social @fbm-unil.bsky.social @unil.bsky.social has identified a new mechanism that exposes the vulnerability of #tumor #cells when they are deprived of #vitamin B7, also known as #biotin. Press release here 👉 www.unil.ch/news/en/1770...

Vitamins: a tool to exploit against cancer

A research group at Unil has identified a new mechanism that exposes the vulnerability of tumor cells when they are deprived of vitamin B7.

unil.ch

Our story on #FBXW7 and #biotin in #glutamine_addiction is now peer-reviewed and published in Molecular Cell! Heroic work led by the very first postdoc of the lab @miriamlisci.bsky.social. Have a look! www.cell.com/molecular-ce...

Functional nutrient-genetic profiling reveals biotin and FBXW7 are essential to bypass glutamine addiction

Lisci et al. present a unified model revealing how cells escape glutamine addiction, a metabolic vulnerability of several cancers. Combining systematic genetic and nutrient screens, they show that bio...

cell.com

Happy to share that the our manuscript "Cyclin CLB2 mRNA localization and protein synthesis link cell cycle progression to bud growth" is now finally out in its final form @natcomms.nature.com www.nature.com/articles/s41... Below a short🧵 with the key findings!

10 days left to apply! 👇

Alexis A. Jourdain@jourdainlab.bsky.social · 9mo ago

We are hiring a postdoc! 🧪 ▶️ Project: nucleotide metabolism (genomics & biochemistry) ▶️ Start date: spring 2026 (flexible) ▶️ More info and application: tinyurl.com/3kjrbb2x Please share 🌏 @fbm-unil.bsky.social @dib-unil.bsky.social @unil.bsky.social @snsf.ch

One month left to apply to the open postdoc position in our lab! 👇

Alexis A. Jourdain@jourdainlab.bsky.social · 9mo ago

We are hiring a postdoc! 🧪 ▶️ Project: nucleotide metabolism (genomics & biochemistry) ▶️ Start date: spring 2026 (flexible) ▶️ More info and application: tinyurl.com/3kjrbb2x Please share 🌏 @fbm-unil.bsky.social @dib-unil.bsky.social @unil.bsky.social @snsf.ch

👏 Bravo à Alexis Jourdain qui rejoindra l’EMBO Young Investigator Programme @embo.org au 1er janvier 2026. L’initiative européenne soutient des scientifiques en début de carrière dirigeant leur propre équipe de recherche. 🔗 www.unil.ch/news/fr/1764... @jourdainlab.bsky.social @dib-unil.bsky.social

Alexis Jourdain nommé EMBO Young Investigator

Professeur assistant à la FBM, Alexis Jourdain a été sélectionné pour l’EMBO Young Investigator Programme. Cette distinction offre au spécialiste du métabolisme un soutien important pour consolider le...

unil.ch

Thrilled and incredibly honored to be selected as an @embo.org Young Investigator! Still can’t quite believe it 🎉 Huge thanks to EMBO and to all the amazing mentors, colleagues, and collaborators who made this possible! @fbm-unil.bsky.social @unil.bsky.social @snsf.ch

EMBO@embo.org · 8mo ago

Congratulations to the new cohort of 28 EMBO Young Investigators! They are joining an international network of more than 800 life scientists – Welcome! Read the press release here: https://www.embo.org/press-releases/twenty-eight-group-leaders-become-embo-young-investigators/

Rich collections of papers on #mitochondrialdisease from the last 2 weeks! 📚 biomed.news/bims-mitdis/... biomed.news/bims-mitdis/... @biomednews.bsky.social @mitoscientist.bsky.social @gavinmcstay.bsky.social Demethoxy-CoQ and NUDT5 in nucleotide synthesis www.nature.com/articles/s42...

Uridine-sensitized screening identifies demethoxy-coenzyme Q and NUDT5 as regulators of nucleotide synthesis - Nature Metabolism

A uridine-sensitized CRISPR-Cas9 screening identifies demethoxy-CoQ as an alternative electron acceptor in the absence of CoQ, and NUDT5 as a regulator of de novo pyrimidine synthesis via its interact...

nature.com

Very excited to announce that the first paper from the lab is now live @natcomms.nature.com #mitochondria #immunometabolism This work was led by postdoc Eloise marques with many important contributions from all of our co-authors. Please check it out! www.nature.com/articles/s41...

An inherited mitochondrial DNA mutation remodels inflammatory cytokine responses in macrophages and in vivo in mice - Nature Communications

Inherited mitochondrial DNA mutations can result in diverse clinical phenotypes. Here, the authors characterise a heteroplasmic tRNAAla mutation (m.5019A>G) in mice and demonstrate that macrophages...

nature.com

We are hiring a postdoc! 🧪 ▶️ Project: nucleotide metabolism (genomics & biochemistry) ▶️ Start date: spring 2026 (flexible) ▶️ More info and application: tinyurl.com/3kjrbb2x Please share 🌏 @fbm-unil.bsky.social @dib-unil.bsky.social @unil.bsky.social @snsf.ch

Good Sunday!. A wonderful selection of papers in #cancermetabolism and #mitochondrialbiology is waiting for you here: biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading "99.9 per cent of everything you think, and of everything you do, is for yourself—and there isn't one." -Wei Wu Wei

🔦 Flash #Recherche 🧬🦀 Des scientifiques @dib-unil.bsky.social @unil.bsky.social identifient un nouveau #mécanisme susceptible de faire dérailler certains #traitements du #cancer. En jeu ? La perte du gène 𝘕𝘜𝘋𝘛5. 🔗 www.unil.ch/news/fr/1762... @jourdainlab.bsky.social

Ce gène qui sauve les chimiothérapies

Des scientifiques du Département d’immunobiologie de l’Unil mettent en évidence un nouveau mécanisme susceptible de faire dérailler certains traitements du cancer.

unil.ch

Very excited to share the published version of our #uridine #CRISPR screen in naturemetabolism.bsky.social! 🎉 Led by Abigail Strefeler with @pagliarini-lab.bsky.social @zakbaker.bsky.social and team! #NUDT5 #DMQ @dib-unil.bsky.social @fbm-unil.bsky.social 🔗 www.nature.com/articles/s42... 🧵1/17

Uridine-sensitized screening identifies demethoxy-coenzyme Q and NUDT5 as regulators of nucleotide synthesis - Nature Metabolism

A uridine-sensitized CRISPR-Cas9 screening identifies demethoxy-CoQ as an alternative electron acceptor in the absence of CoQ, and NUDT5 as a regulator of de novo pyrimidine synthesis via its interact...

nature.com

‼️ We're looking for a postdoc to join our team starting January 1st, 2026! ‼️ Are you curious about how exercise promotes positive changes at the molecular level in obesity and diabetes? If so, consider applying or reach out with any questions. ddz.de/job/postdoct... ddz.de/en/research/...

Postdoctoral Researcher (Ph.D./Dr. rer. nat., m/f/div., E13 TV-L, 100%) - Deutsches Diabetes-Zentrum (DDZ)

Institut für Klinische Biochemie und Pathobiochemie (Direktor: Univ.-Prof. Dr. rer. nat. Hadi Al-Hasani), Nachwuchsforschungsgruppe Crosstalk (Leiterin: Melanie Mittenbühler, Dr.) (25019)

ddz.de

Our updated inventory of genes required for #OXPHOS & findings on #mito defects in #Menieres is now out at Cell Reports! 🎉 🧫 New galactose #CRISPR screen 🎯 481 genes required for #OXPHOS ⚙️ #FAM136A in IMS proteostasis 👂 Mito defects in #Menieres www.cell.com/cell-reports...

An updated inventory of genes essential for oxidative phosphorylation identifies a mitochondrial origin in familial Ménière’s disease

Harhai and collaborators expand the catalog of genes essential for oxidative phosphorylation and implicate FAM136A in mitochondrial proteostasis. Their findings suggest a mitochondrial contribution to...

cell.com

Delighted to share that our work “Uridine Phosphorylase-1 supports metastasis by altering immune and extracellular matrix landscapes” was published today in @emboreports.org, describing how neutrophil metabolism influences niche priming to support metastasis (1/14) www.embopress.org/doi/full/10....

Uridine phosphorylase-1 supports metastasis by altering immune and extracellular matrix landscapes | EMBO reports

imageimageMetastatic primary tumours upregulate Upp1 in neutrophils, which elevates circulating uracil. UPP1-expressing neutrophils accumulate in the lung where they inhibit CD8+ T cells, promote fibr...

embopress.org

Uridine: Trends in Endocrinology & Metabolism www.cell.com/trends/endoc... a great not-to-miss piece from the @lyssiotislab.bsky.social

Uridine

Uridine is a pyrimidine nucleoside composed of an uracil base and a ribose sugar. In cells, uridine is predominantly present in RNA (as uridine monophosphate, UMP). Uridine can be produced through de ...

cell.com

🌿 Bravo aux 12 laboratoires certifiés LEAF @fbm-unil.bsky.social 👏 Arber Lab, Bagni Lab, Chatton Lab, Du Pasquier Lab, Jourdain Lab, LPA, M-Lab, Martinon Lab, Rebsamen Lab, Suter Lab, Thome Lab, Widmann Lab. ➡️ www.unil.ch/news/1747834... #LEAF #recherche #durable

Le programme LEAF reconduit pour une nouvelle année

12 Laboratoires ont reçu une certification LEAF (Laboratory Efficiency Assessment Framework) pour leur participation au programme de mai 2024 à mai 2025.

unil.ch

Powerful new method to diagnose mito disease! (and not only because in my heart proteomics>>>sequencing)

David Stroud@dstroudlab.bsky.social · last yr.

We're super proud to see our study showing utility of proteomics in ultra-rapid variant prioritisation for suspected mito and other rare diseases out in Genome Medicine (rdcu.be/endwE). Too many amazing collabs to thank, so here are the big ones @daniellahock.bsky.social @thorburnmito.bsky.social!

Job alert: My lab at Emory University in vibrant Atlanta is recruiting a postdoc to study #mitochondrialbiology and #metabolism! Please help spread the word!
(1/3) @cp-cellmetabolism.bsky.social @natmetabolism.nature.com

🚀 Boost your brand at EUROMIT 2026! 🎯 Sponsorship opportunities open in May 2025, but you can express your interest now by dropping us a line at 👉 euromit2026@univ-angers.fr Don't miss this unique opportunity for your business! 💼✨ #euromit2026 #mitochondria #sponsorship #businessopportunity

Exciting News: Learn about the Speakers of Euromit 2026! We are happy to announce the amazing speakers for Euromit 2026, the leading congress on mitochondrial pathology.🌍✨ 📢 See the full list ! 👇 #euromit2026 #mitochondria #science #innovation #angers

Interested in #InnateImmunity ? Register now to secure your spot — abstracts can be submitted later! More info: wp.unil.ch/immunobiolog... #ImmunoSky

Rebsamen Lab @UNIL@rebsamenlab.bsky.social · last yr.

🚨Registrations are open🚨 Join us in Lausanne Switzerland October 1-2 for an exciting symposium on innate immunity with oustanding invited speakers, short talks selected from submitted abstracts and poster sessions. Attendance is limited to 150 participants!

🚨 New preprint available! Third and final in the #CRISPR screen series!🚨 👉🏻 Uridine-sensitized screening identifies genes and metabolic regulators of #nucleotide synthesis www.biorxiv.org/content/10.1... By A. Strefeler in collaboration with Dave Pagliarini and team. @DIB_UNIL @FBM_UNIL 🧵 1/9

🚨Registrations are open🚨 Join us in Lausanne Switzerland October 1-2 for an exciting symposium on innate immunity with oustanding invited speakers, short talks selected from submitted abstracts and poster sessions. Attendance is limited to 150 participants!

Rebsamen Lab @UNIL@rebsamenlab.bsky.social · 2y ago

We are excited to announce the 2nd Symposium on the Immunobiology of Pattern Recognition Receptors, Oct 1-2 2025, Lausanne, Switzerland. Registrations open March 1 - Attendance limited to 150 participants. More info: wp.unil.ch/immunobiolog... #ImmunoSky

My lab at #EmoryUniversity is seeking a #Postdoc candidate with expertise in #proteinbiochemistry to continue our exciting work on engineered protein therapies for #MitochondrialDiseases and #MetabolicDiseases. Email me to discuss this further. Please repost! #Proteinengineering #proteintherapy

Anupam Patgiri@apatgiri.bsky.social · 2y ago

My lab at Emory University in vibrant Atlanta is looking for a postdoc candidate in #mitochondrialbiology and #metabolism! This position offers training opportunities in #metabolomics using our in-house Agilent 6546 QTOF LCMS. Please spread the word! (1/3)

New preprint from the lab! 🚨 🧫 New galactose #CRISPR screening strategy 🎯 481 genes required for #OXPHOS ⚙️ #FAM136A in IMS proteostasis 👂Mito defects in #Menieres disease by @marcellharhai.bsky.social @fbm-unil.bsky.social A short thread 1/5 www.biorxiv.org/content/10.1...

▶️ Postdoctoral position in Metabolism University of Lausanne @jourdainlab jobrxiv.org/job/univ... ▶️ Postdoctoral Fellow in Metabolites and Host Antimicrobial Defense Washington University School of Medicine jobrxiv.org/job/wash... 3/4

Postdoctoral position in Metabolism

Post a job in 3min, or find thousands of job offers like this one at jobRxiv!

jobrxiv.org

We are excited to announce the 2nd Symposium on the Immunobiology of Pattern Recognition Receptors, Oct 1-2 2025, Lausanne, Switzerland. Registrations open March 1 - Attendance limited to 150 participants. More info: wp.unil.ch/immunobiolog... #ImmunoSky

Celebrating the New Year in style! Best wishes from the Jourdain Lab 🥌🫕🇨🇭