Joshua Tran

@joshuatran.bsky.social

PhD @rouxlab.bsky.social at UNIGE🇨🇭👨‍🔬 | @UCBerkeleyOfficial.bsky.social MCB Biochemistry Alum 🐻 | here I post science 🧪, travels ✈️, and more fun! 🤩 | views are my own

A stress response can be a great starting point for discovering new biology! By following genes regulated during the chloroplast unfolded protein response, we’re discovering novel factors involved in chloroplast homeostasis. Here’s the first one we characterized: www.pnas.org/doi/10.1073/...

VIA1 is a conserved regulator of thylakoid membrane integrity that acts through VIPP1 | PNAS

Thylakoid membranes are indispensable for oxygenic photosynthesis, yet the mechanisms that protect these membranes from photooxidative damage remai...

pnas.org

💡New Preprint! How does a cell control which way a membrane bends? ESCRT-III has the remarkable ability to reshape membranes and drive reverse-topology fission, yet a fundamental question has remained: what determines the direction of membrane remodeling? www.biorxiv.org/content/10.6...

Direction of ESCRT-III-dependent membrane bending emerges from bilayer asymmetry

In cells, ESCRT-III is unique in mediating fission of membrane necks from inside, a process called reverse-topology fission. Yet, in vitro, the complex primarily assembles outside membrane necks and m...

biorxiv.org

During #NeuronalDifferentiation, #organelles dramatically reorganize. #Microtubules are essential tracks for transport. But are they just highways, or can they instruct organelle behavior? Are tubulin modifications a regulatory code that guides organelle position or function? 1/9

bioRxiv Cell Biology@biorxiv-cellbio.bsky.social · 8mo ago

Tubulin acetylation governs organelle remodeling and lysosomal reformation during neuronal differentiation https://www.biorxiv.org/content/10.64898/2026.02.13.705749v1

Excited to share a new story that transformed how we think about membrane domains in the ER! rdcu.be/eR7Cn ER exit sites mediated by the COPII adaptor sec24D selectively recruit lipid raft-preferencing proteins for rapid ER export Wondering what’s so new and exciting? Skytorial below! 1/9

ER exit sites mediated by the COPII adaptor sec24D selectively recruit lipid raft-preferring proteins for rapid ER export

Nature Communications - Through synchronized cargo traffic experiments, the authors explore the role of raft partitioning in ER efflux. Raft-preferring cargos show specific preferences for ER exit...

rdcu.be

🚨 Want to know how we demonstrated the importance of sterol-rich membrane microdomains for M. marinum infection? Check out our latest paper published in Science Advances 👇 www.science.org/doi/10.1126/... ✨ Big thanks to everyone, especially Cristina Boehm-Bosmani, @soldatilab.bsky.social ! ✨

Membrane microdomains are crucial for Mycobacterium marinum EsxA-dependent membrane damage, escape to the cytosol, and infection

Sterol-rich microdomain accumulation at the MCV is crucial for Mm-induced damage and infection in D. discoideum and BV-2 cells.

science.org