Leaving Blackburn after a really wonderful week discussing all things Golgi and glycobiology! So many new things learned and ideas to be explored - it’s an excellent time to have a thesis discussion to write..!
Nick Riley
@nmriley.bsky.social
Assistant Professor, University of Washington, Dept. of Chemistry. PI of the Riley Research Group, @riley-research.bsky.social. Glyco, mass spec, chembio. Sports, food, travel, dogs. riley-research.com
Nick Riley @nmriley.bsky.social is just starting his @biochemsoc.bsky.social Early Career Research Award Lecture during the 95th Harden Conference! #glycotime #TeamMassSpec
“The project of freedom, Juneteenth reminds us, is precarious, and we should regularly remind ourselves how many people who came before us never got to experience it, and how many people there are still waiting.” - Clint Smith, How the Word Is Passed
Writing from the airport. Sad to miss it, but out preprint just dropped in time! Have a great discussion tonight! www.biorxiv.org/content/10.6...
biorxiv.org
If you are looking for a Tuesday evening #ASMS2026 workshop to attend, consider joining us for fun discussions about real time mass spectrometry.
The Riley Research Group is excited to be at #ASMS2026. There will be a lot of cool science this week, and we hope to add to the conversation with presentations from our group!
I don't remember seeing an image of Earth before that captures the (thin, fragile, tiny layer of) atmosphere so clearly. I mean, look at that.
David Ho@davidho.bsky.social · 4mo agoThe last time human eyes were far enough from Earth to see the whole globe was December 1972. www.nasa.gov/image-detail...
The next iteration of O-MAP targeting genomic loci is now at eLife!! DNA O-MAP enables proximity labeling at specific DNA loci took a ton of work from many lab members and collaborators, so it's really exciting to wrap up this paper with @oligopain.bsky.social! elifesciences.org/articles/102...
DNA O-MAP uncovers the molecular neighborhoods associated with specific genomic loci
DNA O-MAP enables proximity labeling at specific genomic loci in fixed cells using programmable oligonucleotides, revealing locus-proximal proteomes and chromatin interactions without genetic modifica...
elifesciences.org
It is very cool to see this piece from a former student of mine, @mnicolen.bsky.social, in Nature's Career Feature section: www.nature.com/articles/d41...
My PhD student is stuck. How do I teach them perseverance and problem solving?
A new principal investigator wants to help PhD students to develop resilience and creativity in the laboratory without hovering or doing the work for them.
nature.com
A big congratulations to the 2026 I. M. Kolthoff Award Winners! acsanalytical.org/2026/03/12/2... This @acs.org award for undergraduate researchers supported 4 outstanding students (Damon Chan, Alex Szczepankiewicz, Katelyn Barnes, & Zane Alsebai) attending @pittcon.bsky.social and #ACSspring 2026
2026 I. M. Kolthoff Award Winners
The I.M. Kolthoff Award is given annually to deserving undergraduates who have done undergraduate research in the field of analytical chemistry, broadly defined, in celebration of the life and accompl...
acsanalytical.org
Check out the newest entry in the ACS Div. of Analytical Chem. Education Committee's "Meet an Analytical Chemist" initiative. This quarter we highlight Dr. Christina Jones, Partnerships and Outreach Strategist at NIST: acsanalytical.org/2026/02/26/m...
Meet an Analytical Chemist – February 2026
Christina Jones, Ph.D.National Institute of Standards and Technology, Office of Advanced Manufacturing, Partnerships and Outreach Strategist How did you get started in the field of Analytical Chemistr...
acsanalytical.org
A big congratulations to the 2026 I. M. Kolthoff Award Winners! acsanalytical.org/2026/03/12/2... This @acs.org award for undergraduate researchers supported 4 outstanding students (Damon Chan, Alex Szczepankiewicz, Katelyn Barnes, & Zane Alsebai) attending @pittcon.bsky.social and #ACSspring 2026
2026 I. M. Kolthoff Award Winners
The I.M. Kolthoff Award is given annually to deserving undergraduates who have done undergraduate research in the field of analytical chemistry, broadly defined, in celebration of the life and accompl...
acsanalytical.org
Fantastic new resource for glycoproteomics from @nmriley.bsky.social and coworkers #glycotime
Nick Riley@nmriley.bsky.social · 5mo agoThe complexity of glycoproteomics data creates a bottleneck in data interpretation and communication. We (@timveth.bsky.social, @riley-research.bsky.social) built GlycoDiveR as a step toward bridging gaps between search-engine output and biological interpretation through #glycotime visualizations.
As always, we appreciate authors like Rebeca and Morten (and many in our field) who make raw data publicly available. Data sharing streamlines #glycotime tool building and helps us advance together as a field.
Nick Riley@nmriley.bsky.social · 5mo agoGlycoDiveR is an open-source, modular R framework with >25 customizable glycoproteome- and glycosite-scale visualizations that can be generated with minimal programming expertise. We reanalyzed data from Kawahara et al. to demonstrate GlycoDiveR's features: www.mcponline.org/article/S153...
Mucin-binding protein shuttles enable delivery of brain-targeted therapeutics https://www.biorxiv.org/content/10.64898/2026.03.22.713512v1
The complexity of glycoproteomics data creates a bottleneck in data interpretation and communication. We (@timveth.bsky.social, @riley-research.bsky.social) built GlycoDiveR as a step toward bridging gaps between search-engine output and biological interpretation through #glycotime visualizations.
bioRxivpreprint@biorxivpreprint.bsky.social · 5mo agoGlycoDiveR: a modular R framework to analyze and visualize highly dimensional glycoproteomics data https://www.biorxiv.org/content/10.64898/2026.03.21.713336v1
GlycoDiveR: a modular R framework to analyze and visualize highly dimensional glycoproteomics data www.biorxiv.org/cont... --- #proteomics #prot-preprint
Exciting new discovery from @jimwellsucsf.bsky.social and coworkers, a new class of potential cancer antigens flipped onto the cell surface via autophagy-associated exocytosis, featuring first author and former PhD student Corleone Delaveris! #proudofalumni
Stella Hurtley@smhsci.bsky.social · 5mo agoJust published in @science.org Autophagolysosomal exocytosis inverts Src kinase onto the cell surface in cancer | Science www.science.org/doi/10.1126/...
Wee thread 🧵⬇️ on our new #glycotime with @siglecdude.bsky.social John Klassen and @glycocode.bsky.social 🥳 where we show Siglecs as molecular precision tools, able to recognise sialylated glycans with surgical precision in their natural environment, not bad for a lectin! 😎 doi.org/10.1038/s420...
GlycoShape@glycoshape.org · 5mo agoSilvia's simulations showed that while all epitopes expose Sia for binding, Siglec-6 recognises and binds only GM1 because of a key interaction with the membrane through W127 and K126, which orientates the V-set domain to bind the Sia through Arg122 and the terminal Gal to the C-C' loop 😎
MS/MS scan range can be an afterthought that doesn't receive attention in method design, but improper settings can affect experimental outcomes. This is especially true in glycoproteomics. A #glycotime thread about a new #JASMS paper on this idea from @riley-research.bsky.social 1/10
One month left to submit abstracts! Deadline is 22nd March - don’t miss out 🤝
Megan Priestley@megtriesscience.bsky.social · 7mo agoHappy new year Proteoglycans lovers! 🦠 We’re calling all early-career scientists diving into the dynamic world of Proteoglycans to register for the 2026 GRS on Proteoglycans – you won’t want to miss it! 🧪 www.grc.org/proteoglycan...
A month behind the times, but I wanted to share an update from @emmajays.bsky.social and other co-authors in @riley-research.bsky.social. Our manuscript "Profiling Glycoproteins Enriched by Multinanoparticle Protein Corona" is now published in Analytical Chemistry: pubs.acs.org/doi/abs/10.1...
Profiling Glycoproteins Enriched by Multinanoparticle Protein Corona
Biofluids, such as plasma and cerebrospinal fluid (CSF), present significant challenges for proteome and glycoproteome analysis due to their complex protein composition and wide dynamic range of prote...
pubs.acs.org
A month behind the times, but I wanted to share an update from @emmajays.bsky.social and other co-authors in @riley-research.bsky.social. Our manuscript "Profiling Glycoproteins Enriched by Multinanoparticle Protein Corona" is now published in Analytical Chemistry: pubs.acs.org/doi/abs/10.1...
Profiling Glycoproteins Enriched by Multinanoparticle Protein Corona
Biofluids, such as plasma and cerebrospinal fluid (CSF), present significant challenges for proteome and glycoproteome analysis due to their complex protein composition and wide dynamic range of prote...
pubs.acs.org
2025 ended with this paper being accepted by Analytical Chemistry! 😁 Please check out our article in its new home and learn how these multinanoparticle protein coronas grant us a deeper insight into the glycoproteome of different biofluids: pubs.acs.org/doi/10.1021/...
pubs.acs.org
Emmajay Sutherland@emmajays.bsky.social · 11mo agoCan nanoparticles help us probe the glycoproteome? The new pre-print from @riley-research.bsky.social seeks to answer this question using the Proteograph technology from Seer Inc. Check out this lovely study on glycoproteins NP-enriched from biofluids here: chemrxiv.org/engage/chemr...
Antibody-lectin chimeras for glyco-immune checkpoint blockade - @jcstark.bsky.social @carolynbertozzi.bskyverified.social go.nature.com/4aRDpk8
Antibody-lectin chimeras for glyco-immune checkpoint blockade - Nature Biotechnology
Cancer immunotherapy benefits from antibody-lectin chimeras that block glyco-immune checkpoints.
go.nature.com
A new jump forward in cancer immunotherapy blocking glycan sugar molecules (antibodies to lectin, AbLec) that releases the immune system brakes against many types of tumors @carolynbertozzi.bskyverified.social @jcstark.bsky.social www.nature.com/articles/s41...
It was a great meeting at OHSU, and it’s always fun to connect with @carolynbertozzi.bskyverified.social alum!
Jeremy Baskin@jeremybaskin.bsky.social · 8mo agoHad a blast at the OHSU Chemical Biology & Physiology meeting this week! Amazing talks, great to see lab alum Brittany White-Mathieu’s developing program at UNH, reconnect with friends and collaborators, meet some of the next generation of #chembio, and explore Portland!
Had a blast at the OHSU Chemical Biology & Physiology meeting this week! Amazing talks, great to see lab alum Brittany White-Mathieu’s developing program at UNH, reconnect with friends and collaborators, meet some of the next generation of #chembio, and explore Portland!
Congratulations former postdoc @jfhevler.bsky.social (in transit to Roche) and the team on their work using thermal proteome profiling along with glycosylation perturbagens to discover glycan-dependent protein functions at the proteome scale 👏 www.biorxiv.org/content/10.6...
Discovering Glycosylation-Dependent Protein Function by Thermal Proteome Profiling
Protein glycosylation regulates essential cellular processes including protein folding, stability, and cell-cell interactions; however, how aberrant glycosylation impacts protein function and interact...
biorxiv.org