Great talk from Prof John Spencer, part of the Sussex Universe series, on developing rezatopopt to stabilize mutated P53 in cancer. For his latest paper see: www.nature.com/articles/s41...

'Huge' congratulations to Dr Luke Yates, on being awarded a highly competitive Academy of Medical Sciences' Springboard programme — for research investigating how cells coordinate the process of DNA repair, using advanced molecular imaging and genetic tools @acmedsci.bsky.social

Fantastic talk by Max Douglas @icr.ac.uk on telomere replication and protection at Sussex @sussex.ac.uk @gdsc-sussex.bsky.social today! Check out his latest work on bioRxiv: doi.org/10.1101/2025...

Congratulations to a truly amazing team!

Goodbye Breasts!, a powerful documentary by Prof Joanna Callaghan, launches its national tour on 14 April at Duke’s @ Komedia. A deeply personal, creative look at life after breast cancer, followed by a live Q&A exploring medicine, community & creativity in cancer recovery. https://ow.ly/sQnk50YFCzA

#ArtemisII A photo from a passing airliner of the Artemis II launch yesterday. 📸unknown

Dear all, please see link below for Milano et al, describing a role for BRCA2 (& BRCA1) in the maturation of nascent DNA strand gaps during DNA replication in the presence of PARP inhibitor. Congratulations Larissa and all ! authors.elsevier.com/a/1mtQe3vVUP...

Delighted to see our study finally out in "print". Thanks to all the (many) contributors, collaborators and reviewers! Mismatch repair disturbs meiotic crossover control in S. cerevisiae academic.oup.com/nar/article/...

Mismatch repair disturbs meiotic crossover control in S. cerevisiae

Abstract. Crossover formation during meiosis generates genetic diversity. In many species most crossovers display interference, meaning they are spaced mor

academic.oup.com

Tonight was the U.K. premier of ‘Goodbye Breasts’ written, directed and produced by Joanne Callaghan, documenting her remarkable breast cancer story. A must see! @gdsc-sussex.bsky.social @sussexcancer.org @sussexbcr.bsky.social sussexcancerfund.co.uk

Delighted to wave the flag for @gdsc-sussex.bsky.social @sussexcancer.org @sussexbcr.bsky.social sussexcancerfund.co.uk together with Rhys Morgan at the Science Cafe, MacMillan Horizon centre today. Thanks to Rebecca Herbertson and Stephen Robinson for organizing. @rhysmorganlab.bsky.social

🧬🧪 A research technician position - Protein Biochemistry (6 months) is available in my lab @gdsc-sussex.bsky.social investigating structure and function of fusion kinase complexes in Leukaemia. 📅 Deadline: 29th September 2025. 🙏 Please share with anyone who might be interested.

Research Technician – Protein Biochemistry at University of Sussex

Explore an exciting academic career as a Research Technician – Protein Biochemistry. Don't miss out on other academic jobs. Click to apply and explore more opportunities.

jobs.ac.uk

So pleased to see my PhD project published, great work by everyone involved! Together we uncovered how regulation of the BTRR complex is crucial to protect centromeres during mitosis.

Genome Damage and Stability Centre (GDSC)@gdsc-sussex.bsky.social · last yr.

#NEW_PAPER In this study, the Chan Lab uncover the molecular mechanisms by which human cells safeguard centromeric chromatin during mitosis, via tight dynamic control of the Bloom Syndrome complex (BTRR). rdcu.be/eCGxF

#New-Paper Rass laboratory reveal DNA2 to be a gatekeeper to homologous recombination at stalled DNA replication forks, rrequired to stave off cellular senescence. Their findings provide a molecular explanation for the association of DNA2 with primordial dwarfism and cancer. doi.org/10.1038/s415...

DNA2 enables growth by restricting recombination-restarted replication - Nature

DNA2 suppresses recombination-restarted replication and checkpoint activation at stalled forks, and its loss triggers recombination-dependent synthesis, checkpoint signalling and cell-cycle exit, high...

doi.org

My first post on bsky to share our latest research in @nature.com: “DNA2 enables growth by restricting recombination-restarted replication” - defines DNA2’s essential function & elucidates links with primordial dwarfism and cancer. Thanks to the lab, collaborators & @ukri.org @acmedsci.bsky.social

DNA2 enables growth by restricting recombination-restarted replication - Nature

DNA2 suppresses recombination-restarted replication and checkpoint activation at stalled forks, and its loss triggers recombination-dependent synthesis, checkpoint signalling and cell-cycle exit, high...

nature.com

🧬 The 2025 Emma Whitelaw ECR publication award is now open! Full T&Cs and application form are on the AEpiA website www.aepia.org.au/emma-whitela... We can't wait to see the exciting research that has been published over the last year! #epigenetics #ECR #research #AEpiA

Prof. Evi Soutoglou describing what happens when DNA breaks, and when to cut, and when not to — on Brighton seafront, as part of Soapbox Science 2025 — a public outreach platform that promote women and non-binary scientists and the science that they carry out. ‪@soapboxscience.bsky.social‬

Dr. Luke Yates, along with Prof. Zhang and Prof. Burgers, summarise our current mechanistic understanding of the DNA damage checkpoint; inc. structural studies of ATM and ATR and how these work together to prevent cancer. doi.org/10.1146/annu... @layates.bsky.social @crick.ac.uk @washu.bsky.social

Exciting to see SCRC Creative Community Engagement project led by Deborah Humphrey, and Karina Patfield, highlighted on BBC news. "Words from the Waiting Room offers cancer patients, survivors, and supporters a safe environment to express themselves" sussexcancer.org/news/bbc-new...

BBC News, South East covers Words from the Waiting Room. — Sussex Cancer Research Centre

Creative Community Engagement project led by Deborah Humphrey, and Karina Patfield highlighted on BBC news. Words from the Waiting Room offers cancer patients, survivors, and supporters a safe enviro...

sussexcancer.org

Congratulations to Dr Stephen Robinson for launching the Sussex Brain Tumour Research Group. @sussexcancer.bsky.social

It is #WorldCancerDay We are excited to announce our funded research projects, a new community engagement strategy, creative award winners, and interviews. sussexcancer.org/news/announc... @bsmsmedschool.bsky.social @sussexuni.bsky.social @uniofbrighton.bsky.social @eshtnhs.bsky.social

Updates from the Sussex Cancer Research Centre on World Cancer Day. — Sussex Cancer Research Centre

The theme of World Cancer Day 2025 is “United by Unique”, which places people at the centre of care and their stories at the heart of the conversation. Today the Sussex Cancer Research Centre (SCR...

sussexcancer.org

Great start to 2025. Tumor hypoxia promotes immune evasion by autophagy-mediated downregulation of MHC class I expression leading to reduced antigen presentation. Great work from @halaestephan.bsky.social www.embopress.org/doi/full/10....

Hypoxia promotes tumor immune evasion by suppressing MHC-I expression and antigen presentation | The EMBO Journal

imageimageHypoxia contributes to cancer resistance to both standard therapies and immunotherapy. This work demonstrates that tumor hypoxia promotes immune evasion by autophagy-mediated downregulation ...

embopress.org

Today we celebrate our inspirational co-director Professor Melanie Flint m as she gives her inaugural lecture @brightonuni.bsky.social An incredible scientist, leader, mentor, and all around amazing person.

Co-directors @humphreylab.bsky.social and @siftw.bsky.social were at Parliament today, celebrating 20 years of Brighton and Sussex Medical School, and working to make sure cancer research is at the centre of the next 20 years. @sussexuni.bsky.social @brightonuni.bsky.social

Great to join you here today and looking forward to some blue sky science chat!