Our recent review on i-motifs reflects on our current insights on i-motifs and methodological challenges! #DNA

Department of Medical Biochemistry and Biophysics (MBB)@mbb-umu.bsky.social · 4mo ago

New review out in Genome Biology by Dr. Sengupta & @nasimsabouri.bsky.social on i-motifs—four-stranded DNA structures with emerging roles in gene regulation. 👉 rdcu.be/feK1J #GenomeBiology #DNA #Research #UmeåUniversity

Great to be back in Cambridge for this year's GSN. Some amazing talks and so great to reconnect with colleagues and to make new acquaintances. #GSN #genomestability #chromatin #DNA

I really enjoyed putting this review together - great teamwork! Check it out if you’re curious to learn more about the immediate consequences of replication forks encountering DNA secondary structures! We hope it’s a useful resource for the field of genome replication and stability.

Aditya Sethi@adityasethi.bsky.social · 8mo ago

Excited to share our review where we propose models for how DNA secondary structures destabilise the replication fork and lead to ssDNA gaps — it’s comprehensive but genuinely a thought-provoking piece. Hope it’s useful to the community. @costerlab.bsky.social www.sciencedirect.com/science/arti...

Our @costerlab.bsky.social review is out! It’s a great read on the impact of DNA secondary structures on eukaryotic replication fork progression - a totally unbiased opinion, of course! www.sciencedirect.com/science/arti... @adityasethi.bsky.social @billiedelpino.bsky.social

How DNA secondary structures drive replication fork instability

DNA secondary structures, such as hairpins, cruciforms, triplexes, G-quadruplexes and iMotifs, are common, dynamic features that replication forks rou…

sciencedirect.com

Registrations are now open!!

@dfachinetti.bsky.social · 9mo ago

Happy to share the “International Symposium on Chromosome Dynamics: from Structure to Cellular Function” that will be held in Japan 31st of May 2026 www.fbs.osaka-u.ac.jp/labs/fukagaw.... Registrations will open on December 1st! Plenty of opportunities to present your work! Hope to seeing you

Our new review, looking into the roles of SWI/SNF in the chromatin environment around centromeres, is just out in Open Biology! @kezlane.bsky.social @thedownslab.bsky.social

Karen Lane@kezlane.bsky.social · 8mo ago

Some Friday reading...new review in Open Biology where we discuss how SWI/SNF maintains the chromatin environment around centromeres, building on recent work from ourselves and others. Lots of fun putting this together with @alison-harrod.bsky.social and @thedownslab.bsky.social!

Contact us to join our group with support of a Juan de la Cierva post-doctoral fellowship (#JDC2025) and delve into the mechanisms that protect genome integrity during replication using advanced genomics and AI-based modelling of replication fork structures! 📢 t.co/lA3HGPYM8w

🧪📣 PhD studentship available! Please repost. Our lab has a fully funded PhD position, starting Oct 2026. We provide a supportive environment and top notch facilities, helping you develop into an independent scientist. Project details: tinyurl.com/CosterPhD How to apply: tinyurl.com/ApplyICR

Typos in the genome: Defining the molecular mechanism of replication slippage

Typos in the genome: Defining the molecular mechanism of replication slippage

icr.ac.uk

My first post on bsky to share our latest research in @nature.com: “DNA2 enables growth by restricting recombination-restarted replication” - defines DNA2’s essential function & elucidates links with primordial dwarfism and cancer. Thanks to the lab, collaborators & @ukri.org @acmedsci.bsky.social

DNA2 enables growth by restricting recombination-restarted replication - Nature

DNA2 suppresses recombination-restarted replication and checkpoint activation at stalled forks, and its loss triggers recombination-dependent synthesis, checkpoint signalling and cell-cycle exit, high...

nature.com

Online Now: Biochemical reconstitution of sister chromatid cohesion establishment during DNA replication Online now:

Biochemical reconstitution of sister chromatid cohesion establishment during DNA replication

Genome inheritance during cell divisions relies on replicated sister DNAs being connected by cohesin rings. Minamino et al. reconstitute sister chromatid cohesion establishment during DNA replication using purified budding yeast proteins. The experiments yield molecular insight into more than one way in which sister chromatid cohesion can be built.

dlvr.it

Now out! Led by @susana-sousa.bsky.social and Noa Amin, and thanks to our collaborators in the Harrington @icr.ac.uk and Stucki and Choudhary @jc4-jyoti.bsky.social labs www.cell.com/cell-reports...

ARID1A stabilizes non-homologous end joining factors at DNA breaks induced by the G4 ligand pyridostatin

The ARID1A subunit of the BAF chromatin remodeling complex is frequently mutated in cancer. Simões-Sousa et al. demonstrate that ARID1A promotes the assembly of repair factors on chromatin and promote...

cell.com

The Downs Lab@thedownslab.bsky.social · last yr.

New preprint from the lab on ARID1A, G quadruplexes, and repair: www.biorxiv.org/content/10.1...

Checkout our latest research in @natcomms.nature.com rdcu.be/eBqBI A high-resolution, nanopore-based artificial intelligence assay for DNA replication stress in human cancer cells. A collaboration with Mike Boemo’s team

A high-resolution, nanopore-based artificial intelligence assay for DNA replication stress in human cancer cells

Nature Communications - Determining how replication forks move across the human genome is critical for the effective use of agents that target replication stress. Here, the authors present...

rdcu.be

A fantastic week of science (and nature) at the CSHL Eukaryotic DNA Replication & Genome Maintenance meeting ! #cshldnarep

Duxin lab@duxinlab.bsky.social · 11mo ago

This week we’re at CSHL #cshldnarep where the DNA replication & genome maintenance community has gathered for a week of science, discussions, and late-night brainstorming.

Genome Centre throughout the years! @gdsc-sussex.bsky.social #GDSC #Brighton #ArchiveShot

So pleased to see my PhD project published, great work by everyone involved! Together we uncovered how regulation of the BTRR complex is crucial to protect centromeres during mitosis.

Genome Damage and Stability Centre (GDSC)@gdsc-sussex.bsky.social · 11mo ago

#NEW_PAPER In this study, the Chan Lab uncover the molecular mechanisms by which human cells safeguard centromeric chromatin during mitosis, via tight dynamic control of the Bloom Syndrome complex (BTRR). rdcu.be/eCGxF

Looking forward to the next Helicase Conference! #HelicasesandNucleicAcidBasedMachines #Lisboa2025

Great to be at the Helicase Conference in Lisbon this week! 🧬 #HelicasesandNucleicAcidBasedMachines #CentroDeCongressos #Lisboa2025 #Unwinding @costerlab.bsky.social

New lab member joining is a great excuse to eat out and take a new lab photo 🎉🍜📷