Preprint alert‼️ Tracing how CTCF evolution influenced 3D chromatin across species, and how and when loop extrusion became possible 🧬 Everything with functional experiments‼️ 🤩 More than happy to have contribuited to it! Thanks and congrats to everyone involved 🥂 www.biorxiv.org/content/10.6...

Evolution of CTCF underlies the establishment of loop extrusion as a predominant chromatin folding mechanism in vertebrates

CTCF is a DNA-binding protein that emerged in the last bilaterian ancestor and that plays a central role in 3D genome organization. Yet, despite its relevance, genomic studies have revealed notable di...

biorxiv.org

Darío Lupiáñez@dariloops.bsky.social · 4d ago

🚨Preprint from our lab🚨 How and when did TADs emerge during evolution? 🐁🐟🪰 HINT: the diversification of CTCF regulation and functions enabled new mechanisms of 3D chromatin folding 🧬 With Liene Astica & @rdacemel.bsky.social Link: www.biorxiv.org/content/10.6... Bluetorial 1/15👇

At #SEDB2026 we're excited to welcome Francisca Martínez Real @cabd-upo-csic.bsky.social Her research explores how gene regulatory networks and chromatin architecture shape early animal development, revealing how non-coding genomic elements coordinate gene expression during embryogenesis. #DevBio

📢 Save the date for the 2027 @embo.org workshop: ** Beyond the standard: unconventional vertebrate models in biomedicine ** at @i3suporto.bsky.social in Porto Amazing speakers, diverse models spanning fields of biomedical research. C U in Porto ☀️ register for updates 👉 tinyurl.com/s9c4ncjn

Happy to share that our previous preprint showing that KMT2B controls the enhancer-like activity of LINE-1 elements is now published in @natcomms.nature.com 🎉 Thanks to all co-authors and to @ibbtec.bsky.social @csic.es @univcantabria.bsky.social www.nature.com/articles/s41...

Rada-Iglesias Lab@radaiglesiaslab.bsky.social · last yr.

#Preprint alert! 📣 We are thrilled to share the work led by Lara Zorro-Shahidian and Lucio di Filippo, in which we show that #MLL2 controls gene expression in both #ESC and upon #differentiation by facilitating the #enhancer like activity of #LINE1 elements www.biorxiv.org/cgi/content/...

🚨 Job Alert - Please share 🙏 Interested in 3D gene regulation in development & evolution? 🤓🧬 💥 Our lab @cabd-upo-csic.bsky.social is expanding! ✅ 4 years fully funded PhD position 🧪 Experimental backgrounds welcome 👇 Details below #PhDPosition #PhDOpportunity #AcademicJobs

Are weak TF motifs important? Weilert et al use deep learning to systematically map low-affinity pioneer binding sites in mESCs and show that they cooperate with strong pioneer motifs to drive chromatin opening. Paper: www.cell.com/cell-genomic... Preview w/ Grace Bower: www.cell.com/cell-genomic...

Deep learning uncovers hidden power of low-affinity motifs

Low-affinity transcription factor binding sites are functionally important but difficult to map and mechanistically poorly understood. In this issue of Cell Genomics, Weilert et al. leverage sequence-...

cell.com

@fany-real.bsky.social hosted today a great talk by Michael Wilson from @utoronto.ca at #CABDseminars. Michael talked about the studies that use comparative and functional genomics to understand cardiovascular development and disease gene regulation.

#CABDseminars "Using comparative and functional genomics to understand cardiovascular development and disease gene regulation" by Michael Wilson, @utoronto.ca 🗓️ October 1st (THURSDAY) ⏰12 pm 📍Rosalind Franklin Auditorium, CABD Hosted by @fany-real.bsky.social

Have you ever wondered why developmental genes are often regulated by enhancers located at long distances? In this @natgenet.nature.com perspective, we speculate that long-range enhancer positioning may provide regulatory properties essential for proper gene expression www.nature.com/articles/s41...

Mechanisms and functional implications of long-range enhancer-dependent gene regulation - Nature Genetics

Development depends on gene regulation by enhancers across long genomic distances. This Perspective discusses mechanisms enabling long-range enhancer–promoter communication and the potential advantage...

nature.com

We’re hiring! Experimental #Postdoc and computational and/or experimental #PhD positions in evolutionary genomics are available in our lab in Heidelberg: home.kaessmannlab.org/openPositions Please repost and spread the word!

I'm very excited to share the preprint of the central project of my postdoc, titled "Sequence-to-function deep learning decodes human cis-regulatory evolution" available today on BioRxiv. Preprint: www.biorxiv.org/content/10.6...

First synthetic mouse enhancers active in defined embryonic tissues! Great collaboration led by @alex-stark.bsky.social lab now at @natgenet.nature.com

Shenzhi Chen@shenzhichen1999.bsky.social · 2mo ago

Excited to share our paper in @natgenet.nature.com on the de novo design of tissue-specific mammalian enhancers that function in vivo in mouse embryos. 🧬🐭 www.nature.com/articles/s41...

🚨the latest from the lab! 😃👇🏻 www.science.org/doi/10.1126/...

3D genome organization in tissue regeneration involves long-range chromatin loops

Chromosome conformation analysis in Drosophila wing discs reveals the requirement of specific meta-loops during regeneration.

science.org

What happens when evolution adds an extra pair of eyes? Male mayflies evolve an extra pair of dorsal compound eyes, the Turbanate eyes, thought to help males detect females during mating swarms. we have investigate how this remarkable evolutionary novelty develops. www.biorxiv.org/content/10.6...

🚨 Job Alert - Please share 🙏 Interested in 3D gene regulation in development & evolution? 🤓🧬 💥 Our lab at @cabd-upo-csic.bsky.social is expanding! ✅ 4 years fully funded PhD position 💻🧪 Experimental or computational backgrounds welcome 👇 Details below #PhDPosition #PhDOpportunity #AcademicJobs

For me this paper is a career highlight..truly astonishing biology! www.nature.com/articles/s41...

A queen odour mediates reproductive suppression in a eusocial mammal - Nature

Naked mole-rat (Heterocephalus glaber) queens produce isopropyl myristate, a low-volatility ester that high-ranking animals detect and avoid, which alters prolactin and progesterone in other females t...

nature.com

🚨 Early Bird registration and abstract submission deadline for #SEBD2026 extended!! 📅 Early registration and abstract submission deadline: 10th July 📅 Scholarship application deadline: 29th June www.sebd2026.com #SEBD #DevBio @sebioldev.bsky.social 👇👇👇

Applications are open for the international course “Developmental Biology” organized by the Institut Curie in partnership with @sorbonne-universite.fr 📅 Oct. 19–28, 2026 (Paris) ⏳ Jul. 19 & Sept. 18 🔗 training.institut-curie.org/courses/developmental-biology-2026

Have you enrolled to join us at #SEBD2026 yet? Don’t forget to do it now for the best prices and to be eligible for an oral communication!

SEBD@sebioldev.bsky.social · 7mo ago

Registration for the 19th meeting of the #SEBD is now open! Please join us at El Rompido for 3 days full of excellent #DevBio and plenty of opportunities to present your work at #SEBD2026 share.google/2llY3VlS5fQA...

Evolution and mechanism of MEIS2-mediated forelimb specialization in bats https://www.biorxiv.org/content/10.64898/2026.06.03.729816v1

Outstanding talk last Friday at #CABDseminars by @margaridamcm.bsky.social about the evolution of new cell types and organs! Margarida was hosted by @fany-real.bsky.social Thanks for coming Margarida! @crick.ac.uk

Cool study showing how alternative cell types can synthesize hormones in the vertebrate gonad! A previously unrecognized role for this relatively new cell type. Congrats to the authors 🥂🥂

Darío Lupiáñez@dariloops.bsky.social · 5mo ago

🚨Preprint🚨 An unexpected source of sex hormones in mammalian gonads: Supporting-like cells (SLCs) 🐇 SLCs have latent steroidogenic potential and may be an ancestral lineage conserved beyond mammals Led by @ivan-barbera-aura.bsky.social & V Chung Bluetorial 1/15👇 www.biorxiv.org/content/10.6...

#CABDseminars "The evolution of new cell types and organs" by @margaridamcm.bsky.social, @crick.ac.uk, London (UK) 🗓️ May 29th ⏰12 pm 📍Rosalind Franklin Auditorium, CABD Hosted by @fany-real.bsky.social

Tomorrow Thursday May 21st! Come and enjoy!

Now accompanied by a lovely write-up from our communications office @unibas.ch - thanks @angelikajacobs.bsky.social 🙏 ! : www.unibas.ch/en/News-Even...

You are what you eat: how diet drives evolution

A University of Basel study shows how different diets shape the evolution of intestinal cells in cichlid fishes.

unibas.ch

Tschopp Lab@tschopplab.bsky.social · 6mo ago

One of my dream projects, ever since joining here in Basel, out now in @nature.com : single-cells 🤝 eco-morphological proxies rdcu.be/fiyso How cells and tissues adapt to dietary niches... Thanks and congrats to Antoine, Walter, and all the other co-authors for this great collaboration!! 🙏🥳

Hello all, our lab is recruiting a PhD candidate to study how 3D genome folding impacts gene regulation in development. We're located at the Center for Integrative Genomics department of the University of Lausanne, Switzerland. Please email me if interested. #PhDPosition, #PhDOpportunity

Amazing couple of days enjoying & discussing science in the best possible company during the Barcelona meeting of the 'EvoDevOmics Network', funded by @ageinves.bsky.social. Really happy to see how the EvoDevo community in Spain is thriving & fostering a fantastic new generation of PhDs & Postdocs.

Exhausted but extremely happy for the two past days of very exciting Science! The EvoDevOmics Spanish Network gathered together in BCN to discuss about evodevo & omics, lots of great talks, discussions and future collaborations. 🤩 #evodevo

The groups of @fany-real.bsky.social @bpernaute.bsky.social @malmuedocas.bsky.social & @obog.bsky.social were present in this scientific meeting with amazing talks…(2/3)

What should Europe do when demand for #ERC funding keeps rising? Restrict access or invest in excellence? Please read our open letter calling for reconsideration of the ERC 2027 resubmission restrictions & for constructive alternatives that preserve openness Consider to share & sign - see below 🧪

#erc | Johanna Joyce

What should Europe do when demand for its most successful frontier research programme keeps rising? Restrict access, or invest in the excellence it has created? A new open letter, spearheaded by Sara...

linkedin.com